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The map label for this gene is hemB [H]

Identifier: 15892721

GI number: 15892721

Start: 752047

End: 753048

Strand: Reverse

Name: hemB [H]

Synonym: RC0798

Alternate gene names: 15892721

Gene position: 753048-752047 (Counterclockwise)

Preceding gene: 15892723

Following gene: 15892720

Centisome position: 59.35

GC content: 35.03

Gene sequence:

>1002_bases
ATGAATTTTATGTACCCCCATATTAGACTTAGAAGAAATAGAAAAGCTTTTTGGCTTAGAGAGTTAATATCCGAAAGTAA
TTTATCGGTTAGTGATTTAGTGTTGCCTTTATTTGTTGTTGAAGGACATAATGAAAGGCAAGAAATTAAAACTATGCCTG
GTATATATCGTTTATCGATTGATCAAATAGTAGAAACGGCAAAAGAAGCAGCAGAGCTGGGTATTAATGTTATTGCATTA
TTTCCGAGTATTGATCAAAGTCTAAAAAGTGAAAATGCCGATGAGGCTTATAATTTAGATAATTTAATATGTAGAACTAT
TAGAAGCATCAAAAACGCTAATATCGATATTGGTATAATATGCGATGTAGCACTTGATCCTTATACTACACATGGTCATG
ATGGTATTGTGCATCATGGGGAAGTTGATAATGATAGATCAGTAAGAGCTTTGTGTAATCAGGCATTAGTGCTAGCAAAA
GCTGGAGTAGATATTGTTGCACCTTCCGATATGATGGATGGAAGAATCAGGGCTATAAGGGAATATCTTGACAAAGAGGG
ATTTATAAATGTTGGAATTCTTGCTTATGCCGCTAAATATGCTTCAAGTTTTTACGGTCCGTTTCGCGATGCTGTTAAGA
GTAATAAAAAGAATTATTTAGATAAATCAAGCTATCAAATGGATGTACGTAATATTAAGGAAGCAATGCTTGAGATTGAG
CATGATATAGCAGAGGGAGCCGATATGGTAATGGTGAAGCCTGGTATGCCGTTTTTGGATGTTATTCGTGAAGCGGCAAA
TAAGTTAAATGCTAAAATTTTTGCATATCAGGTTAGTGGAGAATATGCAATGTTAAAATTTGCAGCAGAAGCAGGGGCAA
TGGATTGGGAGAGAGCTTTGATGGAGTCATTAATTAGTTTTAAACGTGCCGGTGCCACAGGTATATTTACCTATGCAGCT
CTTGAAGTAGCTGAAATATTAAAGAACAATAAAATTAAGTAG

Upstream 100 bases:

>100_bases
TGCAAGCAAAATTTCTTTTTGTAATGCAATATTTTTACTATAAGATAGTTAGGTTATATATTGTATATATTAGAATCCAA
GTTATTAACTAAAATGAGAT

Downstream 100 bases:

>100_bases
AAAACGGTTTCTGATATAAAATAAATAATATGTTTTATAATTATATCAAAATTATCAATGTGGTGTAAATCATTATAAAG
AGGCGAAGATGACGCAAAAT

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MNFMYPHIRLRRNRKAFWLRELISESNLSVSDLVLPLFVVEGHNERQEIKTMPGIYRLSIDQIVETAKEAAELGINVIAL
FPSIDQSLKSENADEAYNLDNLICRTIRSIKNANIDIGIICDVALDPYTTHGHDGIVHHGEVDNDRSVRALCNQALVLAK
AGVDIVAPSDMMDGRIRAIREYLDKEGFINVGILAYAAKYASSFYGPFRDAVKSNKKNYLDKSSYQMDVRNIKEAMLEIE
HDIAEGADMVMVKPGMPFLDVIREAANKLNAKIFAYQVSGEYAMLKFAAEAGAMDWERALMESLISFKRAGATGIFTYAA
LEVAEILKNNKIK

Sequences:

>Translated_333_residues
MNFMYPHIRLRRNRKAFWLRELISESNLSVSDLVLPLFVVEGHNERQEIKTMPGIYRLSIDQIVETAKEAAELGINVIAL
FPSIDQSLKSENADEAYNLDNLICRTIRSIKNANIDIGIICDVALDPYTTHGHDGIVHHGEVDNDRSVRALCNQALVLAK
AGVDIVAPSDMMDGRIRAIREYLDKEGFINVGILAYAAKYASSFYGPFRDAVKSNKKNYLDKSSYQMDVRNIKEAMLEIE
HDIAEGADMVMVKPGMPFLDVIREAANKLNAKIFAYQVSGEYAMLKFAAEAGAMDWERALMESLISFKRAGATGIFTYAA
LEVAEILKNNKIK
>Mature_333_residues
MNFMYPHIRLRRNRKAFWLRELISESNLSVSDLVLPLFVVEGHNERQEIKTMPGIYRLSIDQIVETAKEAAELGINVIAL
FPSIDQSLKSENADEAYNLDNLICRTIRSIKNANIDIGIICDVALDPYTTHGHDGIVHHGEVDNDRSVRALCNQALVLAK
AGVDIVAPSDMMDGRIRAIREYLDKEGFINVGILAYAAKYASSFYGPFRDAVKSNKKNYLDKSSYQMDVRNIKEAMLEIE
HDIAEGADMVMVKPGMPFLDVIREAANKLNAKIFAYQVSGEYAMLKFAAEAGAMDWERALMESLISFKRAGATGIFTYAA
LEVAEILKNNKIK

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen. Required for nodule development [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=310, Percent_Identity=38.0645161290323, Blast_Score=223, Evalue=3e-58,
Organism=Escherichia coli, GI87081728, Length=317, Percent_Identity=43.5331230283912, Blast_Score=242, Evalue=2e-65,
Organism=Saccharomyces cerevisiae, GI6321398, Length=322, Percent_Identity=37.5776397515528, Blast_Score=187, Evalue=2e-48,
Organism=Drosophila melanogaster, GI21358291, Length=302, Percent_Identity=39.7350993377483, Blast_Score=230, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 37316; Mature: 37316

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFMYPHIRLRRNRKAFWLRELISESNLSVSDLVLPLFVVEGHNERQEIKTMPGIYRLSI
CCCCCCCHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHEECCCCHHHHHHHCCCEEEEEH
DQIVETAKEAAELGINVIALFPSIDQSLKSENADEAYNLDNLICRTIRSIKNANIDIGII
HHHHHHHHHHHHCCCEEEEECCHHHHHHHCCCCCHHCCHHHHHHHHHHHHHCCCCEEEEE
CDVALDPYTTHGHDGIVHHGEVDNDRSVRALCNQALVLAKAGVDIVAPSDMMDGRIRAIR
EEEECCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHH
EYLDKEGFINVGILAYAAKYASSFYGPFRDAVKSNKKNYLDKSSYQMDVRNIKEAMLEIE
HHHCCCCCEEHHHHHHHHHHHHHHCCHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHH
HDIAEGADMVMVKPGMPFLDVIREAANKLNAKIFAYQVSGEYAMLKFAAEAGAMDWERAL
HHHHCCCCEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCEEEEEEHHHCCCCHHHHHH
MESLISFKRAGATGIFTYAALEVAEILKNNKIK
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNFMYPHIRLRRNRKAFWLRELISESNLSVSDLVLPLFVVEGHNERQEIKTMPGIYRLSI
CCCCCCCHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHEECCCCHHHHHHHCCCEEEEEH
DQIVETAKEAAELGINVIALFPSIDQSLKSENADEAYNLDNLICRTIRSIKNANIDIGII
HHHHHHHHHHHHCCCEEEEECCHHHHHHHCCCCCHHCCHHHHHHHHHHHHHCCCCEEEEE
CDVALDPYTTHGHDGIVHHGEVDNDRSVRALCNQALVLAKAGVDIVAPSDMMDGRIRAIR
EEEECCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHH
EYLDKEGFINVGILAYAAKYASSFYGPFRDAVKSNKKNYLDKSSYQMDVRNIKEAMLEIE
HHHCCCCCEEHHHHHHHHHHHHHHCCHHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHH
HDIAEGADMVMVKPGMPFLDVIREAANKLNAKIFAYQVSGEYAMLKFAAEAGAMDWERAL
HHHHCCCCEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCEEEEEEHHHCCCCHHHHHH
MESLISFKRAGATGIFTYAALEVAEILKNNKIK
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8226669; 12597275 [H]