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The map label for this gene is mdtC [H]

Identifier: 15892488

GI number: 15892488

Start: 557487

End: 558206

Strand: Reverse

Name: mdtC [H]

Synonym: RC0565

Alternate gene names: 15892488

Gene position: 558206-557487 (Counterclockwise)

Preceding gene: 15892489

Following gene: 15892487

Centisome position: 44.0

GC content: 37.36

Gene sequence:

>720_bases
GTGCAGATTGATAGATATAAGGCTGCAAAACTCGGTATATTAGTCGAGCACGTCCAGAATATCTTATATGCAGCTTACGG
TGCTGAGCAGATTTCCACATTATATACCCCAACAGCTCAATATGACGTTATTTTAGAACTAGATCCTAAATATCAAACAG
ATTCATCAATGTTATCTTTAGTCAATATTAACTCCACAAGCGGCAATTTAGTAACGCTAACTACCCTTGCTAAAATTGTT
AACACTGTTGGCCCGCTTAGTATTTCACATTTCGGGCAATTACCTTCAGTTATGGTATCATTTAACCTGCAAGATGGATA
TTCAATTAGTGATGCCGTTCCAAAAGTTAATCAAGCAATAAGAGAGTTACAAATGCTGACTACGATTACGGGAAGCTTCC
AAGACACAGTTCAGGCATGTCAGCCGTCTTTTTCCGATCTTGGCTTATTGCTTGGACTTGCCGTTATAGTTATTTACATC
ATCCTTGGCATGTTATATGAAAGTTTTGTGCATCCTATAACTATACTTTTAGGACTACCTACCGCTATATTGGGAGCATT
ACTCGCTCTACTAATATTTAATAGCGAACTTGATATGTACGGATTTGTCGGACTTATAATGTTAATCGGTATAGTGAAGA
AAAACGCTATCATGATTATCGATTTTGCCTTAGAACTTGAGAGAACTGGCAATAAATCTTCGGCATGCAGCAATTTATGA

Upstream 100 bases:

>100_bases
GCTATTTAGCTTTGCACCGAAATTAAAGGACAAGCTCGCACGACTGCCAGGTTTTATTAACGTAACTTCGGATTTACAAA
TAGCACAGCCATAAACTTTA

Downstream 100 bases:

>100_bases
AGCATGTATTTCAGACCGATTATGATGACTACCCTAGCTGCCTTAATAAGAACTATGCCTATTGCGCTTGGAGTCGGAGC
AACAAGAACAGAGAGAAGAT

Product: RND efflux transporter

Products: NA

Alternate protein names: Multidrug transporter MdtC [H]

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MQIDRYKAAKLGILVEHVQNILYAAYGAEQISTLYTPTAQYDVILELDPKYQTDSSMLSLVNINSTSGNLVTLTTLAKIV
NTVGPLSISHFGQLPSVMVSFNLQDGYSISDAVPKVNQAIRELQMLTTITGSFQDTVQACQPSFSDLGLLLGLAVIVIYI
ILGMLYESFVHPITILLGLPTAILGALLALLIFNSELDMYGFVGLIMLIGIVKKNAIMIIDFALELERTGNKSSACSNL

Sequences:

>Translated_239_residues
MQIDRYKAAKLGILVEHVQNILYAAYGAEQISTLYTPTAQYDVILELDPKYQTDSSMLSLVNINSTSGNLVTLTTLAKIV
NTVGPLSISHFGQLPSVMVSFNLQDGYSISDAVPKVNQAIRELQMLTTITGSFQDTVQACQPSFSDLGLLLGLAVIVIYI
ILGMLYESFVHPITILLGLPTAILGALLALLIFNSELDMYGFVGLIMLIGIVKKNAIMIIDFALELERTGNKSSACSNL
>Mature_239_residues
MQIDRYKAAKLGILVEHVQNILYAAYGAEQISTLYTPTAQYDVILELDPKYQTDSSMLSLVNINSTSGNLVTLTTLAKIV
NTVGPLSISHFGQLPSVMVSFNLQDGYSISDAVPKVNQAIRELQMLTTITGSFQDTVQACQPSFSDLGLLLGLAVIVIYI
ILGMLYESFVHPITILLGLPTAILGALLALLIFNSELDMYGFVGLIMLIGIVKKNAIMIIDFALELERTGNKSSACSNL

Specific function: Could Be A Drug Efflux Pump (By Similarity). [C]

COG id: COG0841

COG function: function code V; Cation/multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AcrB/AcrD/AcrF (TC 2.A.6) family [H]

Homologues:

Organism=Escherichia coli, GI1788391, Length=228, Percent_Identity=43.859649122807, Blast_Score=196, Evalue=1e-51,
Organism=Escherichia coli, GI1788390, Length=226, Percent_Identity=47.3451327433628, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI1788814, Length=234, Percent_Identity=24.3589743589744, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1789666, Length=235, Percent_Identity=25.531914893617, Blast_Score=85, Evalue=3e-18,
Organism=Escherichia coli, GI1786667, Length=230, Percent_Identity=26.9565217391304, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1789930, Length=236, Percent_Identity=22.8813559322034, Blast_Score=74, Evalue=8e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001036 [H]

Pfam domain/function: PF00873 ACR_tran [H]

EC number: NA

Molecular weight: Translated: 25924; Mature: 25924

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIDRYKAAKLGILVEHVQNILYAAYGAEQISTLYTPTAQYDVILELDPKYQTDSSMLSL
CCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCEEEEEEECCCCCCCHHHEEE
VNINSTSGNLVTLTTLAKIVNTVGPLSISHFGQLPSVMVSFNLQDGYSISDAVPKVNQAI
EEECCCCCCEEHHHHHHHHHHHCCCCCHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHH
RELQMLTTITGSFQDTVQACQPSFSDLGLLLGLAVIVIYIILGMLYESFVHPITILLGLP
HHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAILGALLALLIFNSELDMYGFVGLIMLIGIVKKNAIMIIDFALELERTGNKSSACSNL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEEEHHHCCCCCCCCCCC
>Mature Secondary Structure
MQIDRYKAAKLGILVEHVQNILYAAYGAEQISTLYTPTAQYDVILELDPKYQTDSSMLSL
CCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCCCCEEEEEEECCCCCCCHHHEEE
VNINSTSGNLVTLTTLAKIVNTVGPLSISHFGQLPSVMVSFNLQDGYSISDAVPKVNQAI
EEECCCCCCEEHHHHHHHHHHHCCCCCHHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHH
RELQMLTTITGSFQDTVQACQPSFSDLGLLLGLAVIVIYIILGMLYESFVHPITILLGLP
HHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TAILGALLALLIFNSELDMYGFVGLIMLIGIVKKNAIMIIDFALELERTGNKSSACSNL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEEEEEHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA