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The map label for this gene is invA [H]

Identifier: 15892243

GI number: 15892243

Start: 322147

End: 322632

Strand: Reverse

Name: invA [H]

Synonym: RC0320

Alternate gene names: 15892243

Gene position: 322632-322147 (Counterclockwise)

Preceding gene: 15892244

Following gene: 15892228

Centisome position: 25.43

GC content: 35.8

Gene sequence:

>486_bases
ATGAGCAATTCTTCCAAAAAACATCTTGATTTACCATATAGACCAGGGGTCGGCATGATGATATTAAATGCCAATAACCA
TATATTCGTCGGTAAAAGAATAGATACAAAAATATCTGCATGGCAAATGCCGCAAGGTGGGATAGTTCCCGGCGAAACAC
CAAGTATTGCAGCAATGCGTGAGATGTTAGAAGAAATAGGCAGCGATAAAGGATATATTATTGCCGAAAGCAAATTCTGG
TATAGTTATGATGTACCAAGCTTTTTAATACCTAAACTGTGGAACGGTAATTTTCGTGGACAAAAACAACGCTGGTTTTT
AATTAGGTTTACCGGAAATAACGAAGATATTAATATAAATACCTCTAATCCGGAATTTGACCAATGGCGTTGGGCATCAC
TTGATGAACTCTTATCTATTATAATACCGTTTAAACGTAAACTTTACCAAGCCGTCGTAAAAGAATTTGAATCATTAATT
CAGTAA

Upstream 100 bases:

>100_bases
ATCTTTCATTGAACGTGCTGACAAAGCTATGTATGAAGCTAAAACAACTGGTAAAAATAAAGTAGTAAAATTATAATTGA
TTTTTTAAAGTAAAAAAATA

Downstream 100 bases:

>100_bases
AAATTATATATATATAGTACTTGTAGAACAGCACTATTTACCTCTTTATCACCTTCAATTCATTCATTTATAGCACTAAA
TAATGAAATATCCGTATTAT

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase [H]

Number of amino acids: Translated: 161; Mature: 160

Protein sequence:

>161_residues
MSNSSKKHLDLPYRPGVGMMILNANNHIFVGKRIDTKISAWQMPQGGIVPGETPSIAAMREMLEEIGSDKGYIIAESKFW
YSYDVPSFLIPKLWNGNFRGQKQRWFLIRFTGNNEDININTSNPEFDQWRWASLDELLSIIIPFKRKLYQAVVKEFESLI
Q

Sequences:

>Translated_161_residues
MSNSSKKHLDLPYRPGVGMMILNANNHIFVGKRIDTKISAWQMPQGGIVPGETPSIAAMREMLEEIGSDKGYIIAESKFW
YSYDVPSFLIPKLWNGNFRGQKQRWFLIRFTGNNEDININTSNPEFDQWRWASLDELLSIIIPFKRKLYQAVVKEFESLI
Q
>Mature_160_residues
SNSSKKHLDLPYRPGVGMMILNANNHIFVGKRIDTKISAWQMPQGGIVPGETPSIAAMREMLEEIGSDKGYIIAESKFWY
SYDVPSFLIPKLWNGNFRGQKQRWFLIRFTGNNEDININTSNPEFDQWRWASLDELLSIIIPFKRKLYQAVVKEFESLIQ

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1789194, Length=154, Percent_Identity=38.3116883116883, Blast_Score=110, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 18658; Mature: 18526

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSSKKHLDLPYRPGVGMMILNANNHIFVGKRIDTKISAWQMPQGGIVPGETPSIAAMR
CCCCCCCCCCCCCCCCCCEEEEECCCEEEEECCCCCCEEEEECCCCCCCCCCCCCHHHHH
EMLEEIGSDKGYIIAESKFWYSYDVPSFLIPKLWNGNFRGQKQRWFLIRFTGNNEDININ
HHHHHHCCCCCEEEEECCEEEEECCCHHHHHHHCCCCCCCCCCEEEEEEEECCCCEEEEE
TSNPEFDQWRWASLDELLSIIIPFKRKLYQAVVKEFESLIQ
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure 
SNSSKKHLDLPYRPGVGMMILNANNHIFVGKRIDTKISAWQMPQGGIVPGETPSIAAMR
CCCCCCCCCCCCCCCCCEEEEECCCEEEEECCCCCCEEEEECCCCCCCCCCCCCHHHHH
EMLEEIGSDKGYIIAESKFWYSYDVPSFLIPKLWNGNFRGQKQRWFLIRFTGNNEDININ
HHHHHHCCCCCEEEEECCEEEEECCCHHHHHHHCCCCCCCCCCEEEEEEEECCCCEEEEE
TSNPEFDQWRWASLDELLSIIIPFKRKLYQAVVKEFESLIQ
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA