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The map label for this gene is pyrH [H]

Identifier: 15892121

GI number: 15892121

Start: 205229

End: 205969

Strand: Reverse

Name: pyrH [H]

Synonym: RC0198

Alternate gene names: 15892121

Gene position: 205969-205229 (Counterclockwise)

Preceding gene: 15892122

Following gene: 15892120

Centisome position: 16.23

GC content: 37.11

Gene sequence:

>741_bases
TTGAAGCAGAAAATGATATCAGATATAAACGCTCTAAAGTATAAAAAAGTTTTACTTAAAGTGTCAGGGGAAGCTTTAAT
GGGAGATAAGCAATTTGGGCATGAATATGACGTAATAAAAAAGATTGCCATCGATATTAAAGAAGTTATCGATTTAGGAG
TAGAAGTCGCTATTGTAGTCGGCGGTGGAAATATTTACCGCGGGATTAATGCAGCACTTGTCGGTATGGACCGAGCTTCA
GCGGACTATATAGGTATGCTTGCAACGGTGATTAATGCTTTAACTTTACAAAACGTTATGGAAAGCCTCAATATCTATAC
AAGAGTTCTATCGGCTATTCCTATGATGAGCGTGTGCGAACCTTATATTCGCCGCAAAGCTAAAAGACATATGGAAAAAA
AGCGTGTAGTAATTTTTGCCGGCGGTACGGGTAACCCGTTTTGTACAACCGATAGTGCCGCAGTACTTCGCGCAATCGAA
ATGAATTGCGATATTTTATTAAAAGCAACTCAGGTTGACGGTGTATATGATTCCGACCCTAAAAAAAATCCGGATGCTAA
AAAATATTTCACTATTAGCTATAAAGATGTTATAACTAATAACCTGCAAGTCATGGATACAGCAGCTATTGCAGTTGCAA
GAGAAAATAAATTACCTATAAGGGTATTTTCGATAAAAGAACAGGGAAATTTTGCTAGAGTAATACAAGATAAAGGGGAA
TATACGACAATTGAGGCATAA

Upstream 100 bases:

>100_bases
ATAATAATATGTTATTAGTGCATGCACTCAATAAATCATCGATTACCGACCTACAAAGAGGTATAATGATTAAAAAAATT
AAGCAGATATTAAAAACAAC

Downstream 100 bases:

>100_bases
TATATTGTAGTGTGAATTGTTGTATGATTTTTATGTCATTTCCGCATAGGTGTTGTTGCGTAGAGACTAAATCGTCATTG
CGAGCAGCCGTAGGCTGCGT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MKQKMISDINALKYKKVLLKVSGEALMGDKQFGHEYDVIKKIAIDIKEVIDLGVEVAIVVGGGNIYRGINAALVGMDRAS
ADYIGMLATVINALTLQNVMESLNIYTRVLSAIPMMSVCEPYIRRKAKRHMEKKRVVIFAGGTGNPFCTTDSAAVLRAIE
MNCDILLKATQVDGVYDSDPKKNPDAKKYFTISYKDVITNNLQVMDTAAIAVARENKLPIRVFSIKEQGNFARVIQDKGE
YTTIEA

Sequences:

>Translated_246_residues
MKQKMISDINALKYKKVLLKVSGEALMGDKQFGHEYDVIKKIAIDIKEVIDLGVEVAIVVGGGNIYRGINAALVGMDRAS
ADYIGMLATVINALTLQNVMESLNIYTRVLSAIPMMSVCEPYIRRKAKRHMEKKRVVIFAGGTGNPFCTTDSAAVLRAIE
MNCDILLKATQVDGVYDSDPKKNPDAKKYFTISYKDVITNNLQVMDTAAIAVARENKLPIRVFSIKEQGNFARVIQDKGE
YTTIEA
>Mature_246_residues
MKQKMISDINALKYKKVLLKVSGEALMGDKQFGHEYDVIKKIAIDIKEVIDLGVEVAIVVGGGNIYRGINAALVGMDRAS
ADYIGMLATVINALTLQNVMESLNIYTRVLSAIPMMSVCEPYIRRKAKRHMEKKRVVIFAGGTGNPFCTTDSAAVLRAIE
MNCDILLKATQVDGVYDSDPKKNPDAKKYFTISYKDVITNNLQVMDTAAIAVARENKLPIRVFSIKEQGNFARVIQDKGE
YTTIEA

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=231, Percent_Identity=46.3203463203463, Blast_Score=231, Evalue=3e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 27202; Mature: 27202

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQKMISDINALKYKKVLLKVSGEALMGDKQFGHEYDVIKKIAIDIKEVIDLGVEVAIVV
CCCHHHHHHHHHHHHHHHHEECCCCEECCHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEE
GGGNIYRGINAALVGMDRASADYIGMLATVINALTLQNVMESLNIYTRVLSAIPMMSVCE
ECCCCHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
PYIRRKAKRHMEKKRVVIFAGGTGNPFCTTDSAAVLRAIEMNCDILLKATQVDGVYDSDP
HHHHHHHHHHHHHCEEEEEECCCCCCCCCCCHHHHHHHHHCCCEEEEEEEEECCCCCCCC
KKNPDAKKYFTISYKDVITNNLQVMDTAAIAVARENKLPIRVFSIKEQGNFARVIQDKGE
CCCCCCCEEEEEEHHHHHCCCCEEEEHHEEEEEECCCCCEEEEEEECCCCEEEEECCCCC
YTTIEA
EEEECC
>Mature Secondary Structure
MKQKMISDINALKYKKVLLKVSGEALMGDKQFGHEYDVIKKIAIDIKEVIDLGVEVAIVV
CCCHHHHHHHHHHHHHHHHEECCCCEECCHHCCCHHHHHHHHHHHHHHHHHCCCEEEEEE
GGGNIYRGINAALVGMDRASADYIGMLATVINALTLQNVMESLNIYTRVLSAIPMMSVCE
ECCCCHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
PYIRRKAKRHMEKKRVVIFAGGTGNPFCTTDSAAVLRAIEMNCDILLKATQVDGVYDSDP
HHHHHHHHHHHHHCEEEEEECCCCCCCCCCCHHHHHHHHHCCCEEEEEEEEECCCCCCCC
KKNPDAKKYFTISYKDVITNNLQVMDTAAIAVARENKLPIRVFSIKEQGNFARVIQDKGE
CCCCCCCEEEEEEHHHHHCCCCEEEEHHEEEEEECCCCCEEEEEEECCCCEEEEECCCCC
YTTIEA
EEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA