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The map label for this gene is pntB [H]

Identifier: 15892027

GI number: 15892027

Start: 98518

End: 99915

Strand: Reverse

Name: pntB [H]

Synonym: RC0104

Alternate gene names: 15892027

Gene position: 99915-98518 (Counterclockwise)

Preceding gene: 15892028

Following gene: 15892026

Centisome position: 7.88

GC content: 37.12

Gene sequence:

>1398_bases
ATGTCCCTACAAATTATCCAGTTATTATACTTAGTTGCGGCTGTTTGCTTTATTCTATCACTCAAATTCTTATCCTCACA
GAAACAAGCACGTTTAGGCAGTACCATAGGTATTTTGGGGATGGCGATAGCAGTCATCGTTACTTTTTTCCTACCGGATT
TTACTCATAAATTACCCATTATAGCAACCATATTATTAGGTGCTGTAATCGGCGGGATTATCGCACTTAAAATCTCCATG
ACGGCAATGCCTCAATTAGTAGCGGGATTTCACTCTTTTGTCGGTCTTGCTGCGGTATTTGTAGCTTATGCTACAGTACT
TGCTCCTGAAAATTTTTCTATAGGAATAGCAGGAAGTTTACCGATTAATGCATTAATAGAAATATCAGTAGGCGTCTCTA
TCGGTGCTTTAACTTTTAGCGGTTCGATTATAGCTTTTCTAAAACTACAAGGCTTAATGAAAAGTAGCCCGTTAAAATTC
TACGGTCAGCAATATATATGCTTATTAACGGCAATAATATTGGTTATTCTAGTAATATCGTTTATTCGTTCAGAGAATAT
ATTTTTATTTAATCTAATAGTCTTTTTATCACTGTTAATCGGAGTATTACTAATAATACCGGTAGGCAGTGCAGATATGC
CTGTTATAGTCTCAATGCTAAATTCTTATTCAGGTTTTGCGGCAGCAGGTATAGGCTTTACGCTTAGCAATAGCCTACTT
ATTATTACTGGAGCATTAGTCGGTAGTAGCGGAGCTATACTTAGCTATATAATGTGCAAAGCGATGAATCGCTCATTAAT
TAAGGTTATTTTTGGGGCGTTTTTGCCTGCACCTACTGGAATTAACAAGGATATAGACGACGATAAAATAGCAAAAACAA
GCTGCCCTGAAGATGCGGCACATTTACTACTTAATACATCATCGGTGATAATTGTTCCCGGTTACGGTATGGCAGTAGCC
CAATCTCAGCATATCATAAAAGAGATGGTTGATATATTAGAACGTTCAGATATTAATGTACGTTTTGCCGTACATCCGGT
AGCAGGTAGAATGCCGGGGCATATGAATGTTTTACTTGCAGAAGCTAATATAGATTATGAGAAAGTACTTGAGCTTGAAG
AAATTAATAGAGATTTCGCTACCACTGACGTAGTGCTTGTGATTGGTGCAAATGACGTAACTAATCCTGCTGCTAAAAAT
GATCCGAACAGTCCAATTTACGGTATGCCGGTACTCGATGTCGAAAAAGCACGTACGATCTTGTTTATTAAACGTTCTAT
GGCATCAGGATATGCAGGTATAAAAAATGCGCTATTTTATCACGATAATACTTTTATGTTATTCGGCGATGCTAAGAAAG
TAGTTGAGGAGATAGTTAAGTTTCTAAATGAAGATTGA

Upstream 100 bases:

>100_bases
ACTTGATATCGCGGGATCCAGTTTTTTTATTTTTTTTGGATACCGTGGTCAAGCCGCGGTATGACACTAAATAGCTAATA
ATATAAACATACATTCACCT

Downstream 100 bases:

>100_bases
CTTAAATAACTCTATTTGTTATAACTTCTTAAATTAAGCCAAAAAACAATTATCATGAATTCGCAAAAAACATTACCGCT
TCTGCCAAAAGCCACGGCTA

Product: NAD(p) transhydrogenase subunit beta

Products: NA

Alternate protein names: Nicotinamide nucleotide transhydrogenase subunit beta; Proton-translocating transhydrogenase NADP(H)-binding component; Pyridine nucleotide transhydrogenase subunit beta; dIII [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MSLQIIQLLYLVAAVCFILSLKFLSSQKQARLGSTIGILGMAIAVIVTFFLPDFTHKLPIIATILLGAVIGGIIALKISM
TAMPQLVAGFHSFVGLAAVFVAYATVLAPENFSIGIAGSLPINALIEISVGVSIGALTFSGSIIAFLKLQGLMKSSPLKF
YGQQYICLLTAIILVILVISFIRSENIFLFNLIVFLSLLIGVLLIIPVGSADMPVIVSMLNSYSGFAAAGIGFTLSNSLL
IITGALVGSSGAILSYIMCKAMNRSLIKVIFGAFLPAPTGINKDIDDDKIAKTSCPEDAAHLLLNTSSVIIVPGYGMAVA
QSQHIIKEMVDILERSDINVRFAVHPVAGRMPGHMNVLLAEANIDYEKVLELEEINRDFATTDVVLVIGANDVTNPAAKN
DPNSPIYGMPVLDVEKARTILFIKRSMASGYAGIKNALFYHDNTFMLFGDAKKVVEEIVKFLNED

Sequences:

>Translated_465_residues
MSLQIIQLLYLVAAVCFILSLKFLSSQKQARLGSTIGILGMAIAVIVTFFLPDFTHKLPIIATILLGAVIGGIIALKISM
TAMPQLVAGFHSFVGLAAVFVAYATVLAPENFSIGIAGSLPINALIEISVGVSIGALTFSGSIIAFLKLQGLMKSSPLKF
YGQQYICLLTAIILVILVISFIRSENIFLFNLIVFLSLLIGVLLIIPVGSADMPVIVSMLNSYSGFAAAGIGFTLSNSLL
IITGALVGSSGAILSYIMCKAMNRSLIKVIFGAFLPAPTGINKDIDDDKIAKTSCPEDAAHLLLNTSSVIIVPGYGMAVA
QSQHIIKEMVDILERSDINVRFAVHPVAGRMPGHMNVLLAEANIDYEKVLELEEINRDFATTDVVLVIGANDVTNPAAKN
DPNSPIYGMPVLDVEKARTILFIKRSMASGYAGIKNALFYHDNTFMLFGDAKKVVEEIVKFLNED
>Mature_464_residues
SLQIIQLLYLVAAVCFILSLKFLSSQKQARLGSTIGILGMAIAVIVTFFLPDFTHKLPIIATILLGAVIGGIIALKISMT
AMPQLVAGFHSFVGLAAVFVAYATVLAPENFSIGIAGSLPINALIEISVGVSIGALTFSGSIIAFLKLQGLMKSSPLKFY
GQQYICLLTAIILVILVISFIRSENIFLFNLIVFLSLLIGVLLIIPVGSADMPVIVSMLNSYSGFAAAGIGFTLSNSLLI
ITGALVGSSGAILSYIMCKAMNRSLIKVIFGAFLPAPTGINKDIDDDKIAKTSCPEDAAHLLLNTSSVIIVPGYGMAVAQ
SQHIIKEMVDILERSDINVRFAVHPVAGRMPGHMNVLLAEANIDYEKVLELEEINRDFATTDVVLVIGANDVTNPAAKND
PNSPIYGMPVLDVEKARTILFIKRSMASGYAGIKNALFYHDNTFMLFGDAKKVVEEIVKFLNED

Specific function: The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [H]

COG id: COG1282

COG function: function code C; NAD/NADP transhydrogenase beta subunit

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNT beta subunit family [H]

Homologues:

Organism=Homo sapiens, GI122939155, Length=473, Percent_Identity=43.7632135306554, Blast_Score=359, Evalue=4e-99,
Organism=Homo sapiens, GI122939153, Length=473, Percent_Identity=43.7632135306554, Blast_Score=359, Evalue=4e-99,
Organism=Escherichia coli, GI1787886, Length=468, Percent_Identity=51.4957264957265, Blast_Score=442, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI17550456, Length=460, Percent_Identity=44.1304347826087, Blast_Score=360, Evalue=1e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012136
- InterPro:   IPR004003 [H]

Pfam domain/function: PF02233 PNTB [H]

EC number: =1.6.1.2 [H]

Molecular weight: Translated: 49791; Mature: 49660

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLQIIQLLYLVAAVCFILSLKFLSSQKQARLGSTIGILGMAIAVIVTFFLPDFTHKLPI
CCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHH
IATILLGAVIGGIIALKISMTAMPQLVAGFHSFVGLAAVFVAYATVLAPENFSIGIAGSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
PINALIEISVGVSIGALTFSGSIIAFLKLQGLMKSSPLKFYGQQYICLLTAIILVILVIS
CCCEEEEEEECCEEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
FIRSENIFLFNLIVFLSLLIGVLLIIPVGSADMPVIVSMLNSYSGFAAAGIGFTLSNSLL
HHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHCCCCEECCCEE
IITGALVGSSGAILSYIMCKAMNRSLIKVIFGAFLPAPTGINKDIDDDKIAKTSCPEDAA
EEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHH
HLLLNTSSVIIVPGYGMAVAQSQHIIKEMVDILERSDINVRFAVHPVAGRMPGHMNVLLA
HHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEEE
EANIDYEKVLELEEINRDFATTDVVLVIGANDVTNPAAKNDPNSPIYGMPVLDVEKARTI
ECCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEECCCCCCHHHHHEE
LFIKRSMASGYAGIKNALFYHDNTFMLFGDAKKVVEEIVKFLNED
EEEEHHHHCCCHHHHHCEEEECCEEEEECCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SLQIIQLLYLVAAVCFILSLKFLSSQKQARLGSTIGILGMAIAVIVTFFLPDFTHKLPI
CHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHH
IATILLGAVIGGIIALKISMTAMPQLVAGFHSFVGLAAVFVAYATVLAPENFSIGIAGSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
PINALIEISVGVSIGALTFSGSIIAFLKLQGLMKSSPLKFYGQQYICLLTAIILVILVIS
CCCEEEEEEECCEEEEEEECCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
FIRSENIFLFNLIVFLSLLIGVLLIIPVGSADMPVIVSMLNSYSGFAAAGIGFTLSNSLL
HHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCHHHCCCCEECCCEE
IITGALVGSSGAILSYIMCKAMNRSLIKVIFGAFLPAPTGINKDIDDDKIAKTSCPEDAA
EEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHH
HLLLNTSSVIIVPGYGMAVAQSQHIIKEMVDILERSDINVRFAVHPVAGRMPGHMNVLLA
HHHCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEEE
EANIDYEKVLELEEINRDFATTDVVLVIGANDVTNPAAKNDPNSPIYGMPVLDVEKARTI
ECCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCEECCCCCCHHHHHEE
LFIKRSMASGYAGIKNALFYHDNTFMLFGDAKKVVEEIVKFLNED
EEEEHHHHCCCHHHHHCEEEECCEEEEECCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8075801 [H]