Click here to switch to the map view.

The map label for this gene is envZ [H]

Identifier: 158425599

GI number: 158425599

Start: 4543106

End: 4544494

Strand: Direct

Name: envZ [H]

Synonym: AZC_3975

Alternate gene names: 158425599

Gene position: 4543106-4544494 (Clockwise)

Preceding gene: 158425598

Following gene: 158425600

Centisome position: 84.61

GC content: 67.6

Gene sequence:

>1389_bases
GTGACCGTGATGGATGCGAGCCGCGCCGGGCTGCGCGGTCTCTGGGACTTCATGCGCGAGGCGAACGCGCGCATCGGCGC
CTGGTTCAACCGCGTCACGCCCAAGGGCCTGTTCCCGCGCTCGCTGCTGATCATCGTGGTGCCGATGGTCATCCTCCAGT
CTGTGGTCGCCTTCGTCTTCATGGAGCGCCACTACAACACCGTGACCCGCCGCCTCTCGGCCGCCGTCAGCCAGGACATC
GCGGCGGTGGTGGAACTCTATGCCGCCTATCCGCAAGAAAAGGATGTCCAGACGCTGCGCCGCATCGTGTGGCAGACCAT
GGAGCTCTCCGTGGACGTGCTGCCCAACGATCCGCTGCCGGTGCAGGGCCCGCGCCCCTTCTTCTCCATCCTCGACAGCG
CCCTCTCCCGCGAGATCAGCCGCAAGGTGAAGGAGCCCTTCTGGATCGACACGGTCGGCCGCTCCAACCTCATCGAGGTG
CGGGTGAAGATGCCCGAGTCGGTCCTGCGCATCTTCGCCCGGCGCAATGCGGCCTATGCCTCCAACTCGCACATCTTCCT
GCTCTGGATGGTGGGCACCTCGCTGGTGCTGCTGGCGGTGGCCATCCTCTTCCTGCGCAATCAGATCCGCCCCATCGAGA
ACCTCGCCGACGCGGCCGAGGCCTTCGGCAAGGGGCGCGACGTGGAAAACTTCCGCCCGCGCGGCGCCCGCGAGGTGCGA
CGCGCCTCCGTCGCGTTCCTGGAGATGAAGCGGCGCATCGAGCGGCAGATCGAGCAGCGCACCGCCATGCTGGCGGGCGT
CTCCCACGACATGCGCACCATCCTCACCCGCTTCAAGCTGGAGCTGGCCTTCCTGCCGGACGGGCCGGAGGTGGAAGCCC
TGCGCAAGGACGTGGACGAACTGCAGGGCATGCTGGAGGCCTATCTGGCCTTCGCGCGCGGCGACGGGGGCGAGCAGACC
CAGCTCACCGATATGGCGCAACTCGTGGAAGATCTGTGCGCCAGCGCCCAGCGCTCCGGCGCCACCGCCACCTGCACCTT
CATGGGGCCACCGCTGGTGCAGGTGAAGGCGGATTCGCTGAAACGCTGCATCGGCAATCTGGTGGGCAATGCCGTGCGCT
ATGCGAAAACACTCCAGATCACCGGCACGCGGGATGCCCGCTGGCTGATCGTCACCGTGGACGACGACGGCCCCGGCATT
CCCGAGGACAAGAGGGAAGACGTGTTCCGCCCCTTCCTGCGCCTCGATGATGCGCGCAATCAAGATGCCGGCGGCTCGGG
CCTCGGCCTCTCCATCGCCCGCGATATCGCCCGCGCCCATGGCGGCGACGTCATCCTCGCTGACAGCCCACTCGGTGGCC
TGCGCGCCAGCATCCGGCTGCCCGTATGA

Upstream 100 bases:

>100_bases
TGCAGGTGAACCGCCTGCGCCGCAAAGTGGAACGCGATCCCGCCAATCCCTCCTTCGTGCAGACCGTGCGCGGCCTCGGC
TACAGGCTGGTGGTGACGCC

Downstream 100 bases:

>100_bases
GCACCCTCATCCGCCCGGCGCGGGCCGGGGATGTGCCCGCCGTCACGGCCCTCGTGGCGGCGGCCTATGGCATCTACATT
CCGCGCATCGGCCGTCCGCC

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MTVMDASRAGLRGLWDFMREANARIGAWFNRVTPKGLFPRSLLIIVVPMVILQSVVAFVFMERHYNTVTRRLSAAVSQDI
AAVVELYAAYPQEKDVQTLRRIVWQTMELSVDVLPNDPLPVQGPRPFFSILDSALSREISRKVKEPFWIDTVGRSNLIEV
RVKMPESVLRIFARRNAAYASNSHIFLLWMVGTSLVLLAVAILFLRNQIRPIENLADAAEAFGKGRDVENFRPRGAREVR
RASVAFLEMKRRIERQIEQRTAMLAGVSHDMRTILTRFKLELAFLPDGPEVEALRKDVDELQGMLEAYLAFARGDGGEQT
QLTDMAQLVEDLCASAQRSGATATCTFMGPPLVQVKADSLKRCIGNLVGNAVRYAKTLQITGTRDARWLIVTVDDDGPGI
PEDKREDVFRPFLRLDDARNQDAGGSGLGLSIARDIARAHGGDVILADSPLGGLRASIRLPV

Sequences:

>Translated_462_residues
MTVMDASRAGLRGLWDFMREANARIGAWFNRVTPKGLFPRSLLIIVVPMVILQSVVAFVFMERHYNTVTRRLSAAVSQDI
AAVVELYAAYPQEKDVQTLRRIVWQTMELSVDVLPNDPLPVQGPRPFFSILDSALSREISRKVKEPFWIDTVGRSNLIEV
RVKMPESVLRIFARRNAAYASNSHIFLLWMVGTSLVLLAVAILFLRNQIRPIENLADAAEAFGKGRDVENFRPRGAREVR
RASVAFLEMKRRIERQIEQRTAMLAGVSHDMRTILTRFKLELAFLPDGPEVEALRKDVDELQGMLEAYLAFARGDGGEQT
QLTDMAQLVEDLCASAQRSGATATCTFMGPPLVQVKADSLKRCIGNLVGNAVRYAKTLQITGTRDARWLIVTVDDDGPGI
PEDKREDVFRPFLRLDDARNQDAGGSGLGLSIARDIARAHGGDVILADSPLGGLRASIRLPV
>Mature_461_residues
TVMDASRAGLRGLWDFMREANARIGAWFNRVTPKGLFPRSLLIIVVPMVILQSVVAFVFMERHYNTVTRRLSAAVSQDIA
AVVELYAAYPQEKDVQTLRRIVWQTMELSVDVLPNDPLPVQGPRPFFSILDSALSREISRKVKEPFWIDTVGRSNLIEVR
VKMPESVLRIFARRNAAYASNSHIFLLWMVGTSLVLLAVAILFLRNQIRPIENLADAAEAFGKGRDVENFRPRGAREVRR
ASVAFLEMKRRIERQIEQRTAMLAGVSHDMRTILTRFKLELAFLPDGPEVEALRKDVDELQGMLEAYLAFARGDGGEQTQ
LTDMAQLVEDLCASAQRSGATATCTFMGPPLVQVKADSLKRCIGNLVGNAVRYAKTLQITGTRDARWLIVTVDDDGPGIP
EDKREDVFRPFLRLDDARNQDAGGSGLGLSIARDIARAHGGDVILADSPLGGLRASIRLPV

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=275, Percent_Identity=35.2727272727273, Blast_Score=145, Evalue=6e-36,
Organism=Escherichia coli, GI1790346, Length=270, Percent_Identity=31.8518518518519, Blast_Score=132, Evalue=3e-32,
Organism=Escherichia coli, GI1787894, Length=276, Percent_Identity=32.2463768115942, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1788393, Length=273, Percent_Identity=27.8388278388278, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI87082128, Length=290, Percent_Identity=28.6206896551724, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1787374, Length=297, Percent_Identity=26.2626262626263, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1786912, Length=254, Percent_Identity=28.740157480315, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786600, Length=223, Percent_Identity=26.457399103139, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI87081816, Length=252, Percent_Identity=26.984126984127, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1790861, Length=300, Percent_Identity=26, Blast_Score=72, Evalue=6e-14,
Organism=Escherichia coli, GI1790551, Length=292, Percent_Identity=26.3698630136986, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1788713, Length=227, Percent_Identity=27.3127753303965, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1788549, Length=220, Percent_Identity=26.3636363636364, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1788279, Length=291, Percent_Identity=26.1168384879725, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786783, Length=247, Percent_Identity=26.7206477732794, Blast_Score=66, Evalue=4e-12,
Organism=Escherichia coli, GI1789149, Length=224, Percent_Identity=25, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51423; Mature: 51292

Theoretical pI: Translated: 9.61; Mature: 9.61

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVMDASRAGLRGLWDFMREANARIGAWFNRVTPKGLFPRSLLIIVVPMVILQSVVAFVF
CCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
MERHYNTVTRRLSAAVSQDIAAVVELYAAYPQEKDVQTLRRIVWQTMELSVDVLPNDPLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEEECCCCCCC
VQGPRPFFSILDSALSREISRKVKEPFWIDTVGRSNLIEVRVKMPESVLRIFARRNAAYA
CCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEEEECCCHHHHHHHHHHCCCCC
SNSHIFLLWMVGTSLVLLAVAILFLRNQIRPIENLADAAEAFGKGRDVENFRPRGAREVR
CCCCEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
RASVAFLEMKRRIERQIEQRTAMLAGVSHDMRTILTRFKLELAFLPDGPEVEALRKDVDE
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHH
LQGMLEAYLAFARGDGGEQTQLTDMAQLVEDLCASAQRSGATATCTFMGPPLVQVKADSL
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEECHHHH
KRCIGNLVGNAVRYAKTLQITGTRDARWLIVTVDDDGPGIPEDKREDVFRPFLRLDDARN
HHHHHHHHHHHHHHHHEEEEECCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCC
QDAGGSGLGLSIARDIARAHGGDVILADSPLGGLRASIRLPV
CCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCEECCC
>Mature Secondary Structure 
TVMDASRAGLRGLWDFMREANARIGAWFNRVTPKGLFPRSLLIIVVPMVILQSVVAFVF
CCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
MERHYNTVTRRLSAAVSQDIAAVVELYAAYPQEKDVQTLRRIVWQTMELSVDVLPNDPLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEEECCCCCCC
VQGPRPFFSILDSALSREISRKVKEPFWIDTVGRSNLIEVRVKMPESVLRIFARRNAAYA
CCCCCHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEEEECCCHHHHHHHHHHCCCCC
SNSHIFLLWMVGTSLVLLAVAILFLRNQIRPIENLADAAEAFGKGRDVENFRPRGAREVR
CCCCEEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
RASVAFLEMKRRIERQIEQRTAMLAGVSHDMRTILTRFKLELAFLPDGPEVEALRKDVDE
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHH
LQGMLEAYLAFARGDGGEQTQLTDMAQLVEDLCASAQRSGATATCTFMGPPLVQVKADSL
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCEEECHHHH
KRCIGNLVGNAVRYAKTLQITGTRDARWLIVTVDDDGPGIPEDKREDVFRPFLRLDDARN
HHHHHHHHHHHHHHHHEEEEECCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCC
QDAGGSGLGLSIARDIARAHGGDVILADSPLGGLRASIRLPV
CCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]