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The map label for this gene is livM [H]

Identifier: 158425511

GI number: 158425511

Start: 4438494

End: 4439549

Strand: Reverse

Name: livM [H]

Synonym: AZC_3887

Alternate gene names: 158425511

Gene position: 4439549-4438494 (Counterclockwise)

Preceding gene: 158425512

Following gene: 158425510

Centisome position: 82.68

GC content: 65.25

Gene sequence:

>1056_bases
ATGGCATTCGGCATTCTCACCCGGCTCGAAGGCCCGCAGACGCTGGGGCGCGGCCCCGCCTTCTGGGGCGGCTTCCTCCT
CGTGCTCGCCGCCGCCTGCGCCTATCCGCTGTTTGCGGATGGGTACACGGTGGGCAACACGGTCTATTTCTTCACCTGGG
TCTTCATGGCCCTCGGTCTCAGCGTCATCTGGGGCTATTGCGGCGCGCTCAGTTTCGGTCAAACGGCCTTCTTCGGCATC
GCCGGCTATGGCTATGGCATCCTCACGATCAATTTCGGCAGTGCGTATGGCTTCACGCTGATTGCGCTGGTGATTGCGGT
TGCGCTCGCCTGCCTGTTCGCGGCGCTGCTCGGCTACTTCCTGTTCTACGGACGCATTGCCGGCGTGTTCCTCGGCATCG
TCACCCTCTCCGTCACGCTGGTGCTGGAGCGCTTCATGGCCCAGACGGCGGGGCCGGAGTGGAGGATCGGCGCGGCCCGC
CTCAATGGCTTCAACGGCATGAGCAACATGCCCCAGCTCACCATTCCCTGGCCGGGGGGCGACGTCGTGCTCTTTCCCGA
CGTGGAGCTTTATTACGTGGTGCTGGGCCTGATGGTGCTCGTCTATCTCGCTCTGCGCATCCTGCTCAATTCCAGATTCG
GGAACGTCATCGTCGCCATCCGCGAGAACCCCGAGCGGGCGGAGATGCTGGGCTATGACGTGCGGCGCTATCAACTCGTG
GCCTTCGTCATCGGTGCTGCGCTCGCCGGGCTTTCGGGCGTGCTCTACACCACATGGGGTCAGTACATCACGCCCTCCAG
CATGGGCATGACGGCGGCGGCCCTGCCCATCGTGTGGGTGGCGGTGGGTGGCCGTTCCGACATCACCACCACGCTGGTCG
GCACGCTGGCGGTACTCTCCGGTTTCCAGACGCTCACCATCTACGGCAGCCAGTATGCGCTGGTCGTGATGGGGCTCCTT
CTGGTGGTCACGGTGCTGGCCGCTCCGCGCGGCCTCGTCATGGCACTGGCGGACGTTCTTGCCCGCCCGTTCCGCCGCAA
GGGGGAGGGCGCGTGA

Upstream 100 bases:

>100_bases
GGGCAGATCGGGCTCCTGGTCACGGTCATCGTCGTCATCCGCATCCTGCCGCGGGGGCTGTCCGGCTTCCTGCTGCGCGA
GCGGGCGTGAGGAGGGCGCG

Downstream 100 bases:

>100_bases
TGGCTTTGCTCGAAACCCGTTCCCTCAATAAGCATTTCGGCGGCCTCCACGTCACCAATTCCGTGGACCTGAGCCTTGAG
GCGGGAGAGATCCACTGCCT

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 351; Mature: 350

Protein sequence:

>351_residues
MAFGILTRLEGPQTLGRGPAFWGGFLLVLAAACAYPLFADGYTVGNTVYFFTWVFMALGLSVIWGYCGALSFGQTAFFGI
AGYGYGILTINFGSAYGFTLIALVIAVALACLFAALLGYFLFYGRIAGVFLGIVTLSVTLVLERFMAQTAGPEWRIGAAR
LNGFNGMSNMPQLTIPWPGGDVVLFPDVELYYVVLGLMVLVYLALRILLNSRFGNVIVAIRENPERAEMLGYDVRRYQLV
AFVIGAALAGLSGVLYTTWGQYITPSSMGMTAAALPIVWVAVGGRSDITTTLVGTLAVLSGFQTLTIYGSQYALVVMGLL
LVVTVLAAPRGLVMALADVLARPFRRKGEGA

Sequences:

>Translated_351_residues
MAFGILTRLEGPQTLGRGPAFWGGFLLVLAAACAYPLFADGYTVGNTVYFFTWVFMALGLSVIWGYCGALSFGQTAFFGI
AGYGYGILTINFGSAYGFTLIALVIAVALACLFAALLGYFLFYGRIAGVFLGIVTLSVTLVLERFMAQTAGPEWRIGAAR
LNGFNGMSNMPQLTIPWPGGDVVLFPDVELYYVVLGLMVLVYLALRILLNSRFGNVIVAIRENPERAEMLGYDVRRYQLV
AFVIGAALAGLSGVLYTTWGQYITPSSMGMTAAALPIVWVAVGGRSDITTTLVGTLAVLSGFQTLTIYGSQYALVVMGLL
LVVTVLAAPRGLVMALADVLARPFRRKGEGA
>Mature_350_residues
AFGILTRLEGPQTLGRGPAFWGGFLLVLAAACAYPLFADGYTVGNTVYFFTWVFMALGLSVIWGYCGALSFGQTAFFGIA
GYGYGILTINFGSAYGFTLIALVIAVALACLFAALLGYFLFYGRIAGVFLGIVTLSVTLVLERFMAQTAGPEWRIGAARL
NGFNGMSNMPQLTIPWPGGDVVLFPDVELYYVVLGLMVLVYLALRILLNSRFGNVIVAIRENPERAEMLGYDVRRYQLVA
FVIGAALAGLSGVLYTTWGQYITPSSMGMTAAALPIVWVAVGGRSDITTTLVGTLAVLSGFQTLTIYGSQYALVVMGLLL
VVTVLAAPRGLVMALADVLARPFRRKGEGA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=339, Percent_Identity=26.5486725663717, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 37517; Mature: 37386

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFGILTRLEGPQTLGRGPAFWGGFLLVLAAACAYPLFADGYTVGNTVYFFTWVFMALGL
CCCCHHHHCCCCHHCCCCCHHHHHHHHHHHHHHCCCHHCCCEEECCHHHHHHHHHHHHHH
SVIWGYCGALSFGQTAFFGIAGYGYGILTINFGSAYGFTLIALVIAVALACLFAALLGYF
HHHHHHHHCCCCCCHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LFYGRIAGVFLGIVTLSVTLVLERFMAQTAGPEWRIGAARLNGFNGMSNMPQLTIPWPGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHCCCCCCCCCCCEEEEECCCC
DVVLFPDVELYYVVLGLMVLVYLALRILLNSRFGNVIVAIRENPERAEMLGYDVRRYQLV
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
AFVIGAALAGLSGVLYTTWGQYITPSSMGMTAAALPIVWVAVGGRSDITTTLVGTLAVLS
HHHHHHHHHHHCHHHHHHCCCCCCCCCCCCHHHHHHHHEEEECCCCCHHHHHHHHHHHHC
GFQTLTIYGSQYALVVMGLLLVVTVLAAPRGLVMALADVLARPFRRKGEGA
CCCEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AFGILTRLEGPQTLGRGPAFWGGFLLVLAAACAYPLFADGYTVGNTVYFFTWVFMALGL
CCCHHHHCCCCHHCCCCCHHHHHHHHHHHHHHCCCHHCCCEEECCHHHHHHHHHHHHHH
SVIWGYCGALSFGQTAFFGIAGYGYGILTINFGSAYGFTLIALVIAVALACLFAALLGYF
HHHHHHHHCCCCCCHHHHHHHCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LFYGRIAGVFLGIVTLSVTLVLERFMAQTAGPEWRIGAARLNGFNGMSNMPQLTIPWPGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHCCCCCCCCCCCEEEEECCCC
DVVLFPDVELYYVVLGLMVLVYLALRILLNSRFGNVIVAIRENPERAEMLGYDVRRYQLV
CEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
AFVIGAALAGLSGVLYTTWGQYITPSSMGMTAAALPIVWVAVGGRSDITTTLVGTLAVLS
HHHHHHHHHHHCHHHHHHCCCCCCCCCCCCHHHHHHHHEEEECCCCCHHHHHHHHHHHHC
GFQTLTIYGSQYALVVMGLLLVVTVLAAPRGLVMALADVLARPFRRKGEGA
CCCEEEEECCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]