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The map label for this gene is argH1 [H]

Identifier: 158425497

GI number: 158425497

Start: 4423421

End: 4424935

Strand: Direct

Name: argH1 [H]

Synonym: AZC_3873

Alternate gene names: 158425497

Gene position: 4423421-4424935 (Clockwise)

Preceding gene: 158425496

Following gene: 158425498

Centisome position: 82.38

GC content: 65.48

Gene sequence:

>1515_bases
ATGATGATCGAGAGCGAAGCGCACCGGTCCAAGGTCAGCCGGCGCTTGCAGGATGAAACCGCGCAAGAGATTTGCGATTT
CATCTATCTTCCCCGCCTTGCCGACTTCGCCCGCGGCTTTCCCTATCTCACCGCCATCAATCAGGCCCACATCCTGATGC
TGGACGCCCAGGCCCTCATCCCTTCCGATGCCGCCAAGACCCTGGCGGAGGCGCTGCTGCAGATGGAGGAAAATGGGCCC
TCGGCCATCGCGCTCGATCCGCAGCGGGAGGACGCCTATTTCAATTATGAGGCGCATCTCATCGGCAAGGTGGGCCTCGA
TATCGGTGGGCGGGCCCATACGGCGCGCAGCCGGAACGACATCCTCGCCACCATGGACCGCATGCGGTGCCGCGACCTGG
TGATCGCCCTGCTGGACGCCCTGGCAGAGCTGCGGCAGACAGCAGCCGAGCAAGCCGCCCGCTATGTGGATGTGGTGATG
CCCGGCTATACCCATCTGCAGCCGGCCCAGCCCATGACCTATGGCTTCTATCTGGCCGGTGTGGCCGAGGCGCTGGAGCG
GGATGCGGAGCGGCTCGCAGGGGCCTATGGCCGCGTCGACCGGTGTCCGCTGGGGGCCGGCGCCTTCGCCGGCACACCCT
ATGGGATCGATCGGTCGGAGACGGCGCGGCTGCTGGGGTTCCCCGCGGTGGTGGACAGTACGCTGGATGCGGTGGCCTCG
CGGGACTTCATTTTCGAGGTGCTCGGCAGTCTCTCCATTCTGGCTGCCACCTGGAGCCGCATCGCGCAGGACTATTTCCT
GTGGTCCACGGACGAGTTCCGCTTCATCGAGTTCCCGGACAGCGTGGCGGGGACATCGAGCATCATGCCTCAGAAGAAAA
ATCCTATCGTGCTGGAGTTCCTGAAGGGCAAGGCGGGGCATATCATCGGCCATTATGCCGGGGCGGTGTCCATCCTGCGT
GCGACCAATTTCACCCACTCGGGCGATGCGAACCGGGAGAGCATCAGCTTCTTCTGGGGCGCGGCCGATGACTGCCTCAC
CAGCCTCAAGTTGCTGCGCCTCATCATCCGCACCGCGTCGCCGCGGCGGGAGGTCATGCTGAAGCGGGCGCGGGAGAATT
TTTCGTCCGCCACGGATCTCGCCGATGCCATCGTGATGAAGAGCGGCCTGTCCTTCCGGCAGGCCCATCACATCGTCGGC
GCCGTGGTGCGCGATGCGCTGGACCACGATCTGACGGCGGATCGCATTTCCCTCGACATGGTCCAGCGCGCCTGCCGCGA
TCAGATGGGCCGGGAAATCGCACTCTCGGAAGAGGATGTGCACGCGAGCCTTGATCCGCGGATCAGCGTAGCCAGCCGCC
GCGACGGCGGCCCGGCGGAGGAGGGCGTGCGTATGGTCCTCGGCAAGGTCCAGGCGAAGCTCGATGCGGACCGTCAGGAC
AATCGCCGCCGCCGAGAGGTGATCGACGCCGCCTGCCGTGACCGGCGCCGGCTCATGGAGGAACTCGCAGGATGA

Upstream 100 bases:

>100_bases
GCTCCGCCCTTAGCTGGCTGAGCCGCTATCTGGAGCGCCGCCTGGGCCGCAAGTCGAACCGCAAGCCATCCTTGGTCCCG
TCAGGTATGAGAGAAGCAGT

Downstream 100 bases:

>100_bases
ACGGGGCCGGGCGTGCATTGGTGCAAGTGCGAGGGTTGTACAAGGCGTTTGGGGCGGTGACCGTTCTCCACGGCATCGAC
CTCGACGTAAAGGAAGGCGA

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL 1; Arginosuccinase 1 [H]

Number of amino acids: Translated: 504; Mature: 504

Protein sequence:

>504_residues
MMIESEAHRSKVSRRLQDETAQEICDFIYLPRLADFARGFPYLTAINQAHILMLDAQALIPSDAAKTLAEALLQMEENGP
SAIALDPQREDAYFNYEAHLIGKVGLDIGGRAHTARSRNDILATMDRMRCRDLVIALLDALAELRQTAAEQAARYVDVVM
PGYTHLQPAQPMTYGFYLAGVAEALERDAERLAGAYGRVDRCPLGAGAFAGTPYGIDRSETARLLGFPAVVDSTLDAVAS
RDFIFEVLGSLSILAATWSRIAQDYFLWSTDEFRFIEFPDSVAGTSSIMPQKKNPIVLEFLKGKAGHIIGHYAGAVSILR
ATNFTHSGDANRESISFFWGAADDCLTSLKLLRLIIRTASPRREVMLKRARENFSSATDLADAIVMKSGLSFRQAHHIVG
AVVRDALDHDLTADRISLDMVQRACRDQMGREIALSEEDVHASLDPRISVASRRDGGPAEEGVRMVLGKVQAKLDADRQD
NRRRREVIDAACRDRRRLMEELAG

Sequences:

>Translated_504_residues
MMIESEAHRSKVSRRLQDETAQEICDFIYLPRLADFARGFPYLTAINQAHILMLDAQALIPSDAAKTLAEALLQMEENGP
SAIALDPQREDAYFNYEAHLIGKVGLDIGGRAHTARSRNDILATMDRMRCRDLVIALLDALAELRQTAAEQAARYVDVVM
PGYTHLQPAQPMTYGFYLAGVAEALERDAERLAGAYGRVDRCPLGAGAFAGTPYGIDRSETARLLGFPAVVDSTLDAVAS
RDFIFEVLGSLSILAATWSRIAQDYFLWSTDEFRFIEFPDSVAGTSSIMPQKKNPIVLEFLKGKAGHIIGHYAGAVSILR
ATNFTHSGDANRESISFFWGAADDCLTSLKLLRLIIRTASPRREVMLKRARENFSSATDLADAIVMKSGLSFRQAHHIVG
AVVRDALDHDLTADRISLDMVQRACRDQMGREIALSEEDVHASLDPRISVASRRDGGPAEEGVRMVLGKVQAKLDADRQD
NRRRREVIDAACRDRRRLMEELAG
>Mature_504_residues
MMIESEAHRSKVSRRLQDETAQEICDFIYLPRLADFARGFPYLTAINQAHILMLDAQALIPSDAAKTLAEALLQMEENGP
SAIALDPQREDAYFNYEAHLIGKVGLDIGGRAHTARSRNDILATMDRMRCRDLVIALLDALAELRQTAAEQAARYVDVVM
PGYTHLQPAQPMTYGFYLAGVAEALERDAERLAGAYGRVDRCPLGAGAFAGTPYGIDRSETARLLGFPAVVDSTLDAVAS
RDFIFEVLGSLSILAATWSRIAQDYFLWSTDEFRFIEFPDSVAGTSSIMPQKKNPIVLEFLKGKAGHIIGHYAGAVSILR
ATNFTHSGDANRESISFFWGAADDCLTSLKLLRLIIRTASPRREVMLKRARENFSSATDLADAIVMKSGLSFRQAHHIVG
AVVRDALDHDLTADRISLDMVQRACRDQMGREIALSEEDVHASLDPRISVASRRDGGPAEEGVRMVLGKVQAKLDADRQD
NRRRREVIDAACRDRRRLMEELAG

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=347, Percent_Identity=35.7348703170029, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI68303542, Length=347, Percent_Identity=35.7348703170029, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI68303547, Length=347, Percent_Identity=34.5821325648415, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI68303549, Length=347, Percent_Identity=32.2766570605187, Blast_Score=156, Evalue=4e-38,
Organism=Escherichia coli, GI1790398, Length=400, Percent_Identity=36.5, Blast_Score=230, Evalue=2e-61,
Organism=Escherichia coli, GI1787896, Length=212, Percent_Identity=29.2452830188679, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321806, Length=396, Percent_Identity=37.1212121212121, Blast_Score=221, Evalue=2e-58,
Organism=Drosophila melanogaster, GI221473854, Length=325, Percent_Identity=36.6153846153846, Blast_Score=195, Evalue=5e-50,
Organism=Drosophila melanogaster, GI78706858, Length=325, Percent_Identity=36.6153846153846, Blast_Score=195, Evalue=5e-50,
Organism=Drosophila melanogaster, GI24662684, Length=296, Percent_Identity=27.7027027027027, Blast_Score=76, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 55725; Mature: 55725

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMIESEAHRSKVSRRLQDETAQEICDFIYLPRLADFARGFPYLTAINQAHILMLDAQALI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEECCCCEEEEEECHHHC
PSDAAKTLAEALLQMEENGPSAIALDPQREDAYFNYEAHLIGKVGLDIGGRAHTARSRND
CCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEECCCEEEEEEECCCCCCCCCCCCCHHH
ILATMDRMRCRDLVIALLDALAELRQTAAEQAARYVDVVMPGYTHLQPAQPMTYGFYLAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
VAEALERDAERLAGAYGRVDRCPLGAGAFAGTPYGIDRSETARLLGFPAVVDSTLDAVAS
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHH
RDFIFEVLGSLSILAATWSRIAQDYFLWSTDEFRFIEFPDSVAGTSSIMPQKKNPIVLEF
HHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEECCCCCCCCHHCCCCCCCCEEEEE
LKGKAGHIIGHYAGAVSILRATNFTHSGDANRESISFFWGAADDCLTSLKLLRLIIRTAS
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCC
PRREVMLKRARENFSSATDLADAIVMKSGLSFRQAHHIVGAVVRDALDHDLTADRISLDM
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
VQRACRDQMGREIALSEEDVHASLDPRISVASRRDGGPAEEGVRMVLGKVQAKLDADRQD
HHHHHHHHHCCEEECCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHH
NRRRREVIDAACRDRRRLMEELAG
HHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MMIESEAHRSKVSRRLQDETAQEICDFIYLPRLADFARGFPYLTAINQAHILMLDAQALI
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHEECCCCEEEEEECHHHC
PSDAAKTLAEALLQMEENGPSAIALDPQREDAYFNYEAHLIGKVGLDIGGRAHTARSRND
CCHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEECCCEEEEEEECCCCCCCCCCCCCHHH
ILATMDRMRCRDLVIALLDALAELRQTAAEQAARYVDVVMPGYTHLQPAQPMTYGFYLAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
VAEALERDAERLAGAYGRVDRCPLGAGAFAGTPYGIDRSETARLLGFPAVVDSTLDAVAS
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHHHH
RDFIFEVLGSLSILAATWSRIAQDYFLWSTDEFRFIEFPDSVAGTSSIMPQKKNPIVLEF
HHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCEEEEECCCCCCCCHHCCCCCCCCEEEEE
LKGKAGHIIGHYAGAVSILRATNFTHSGDANRESISFFWGAADDCLTSLKLLRLIIRTAS
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHCCC
PRREVMLKRARENFSSATDLADAIVMKSGLSFRQAHHIVGAVVRDALDHDLTADRISLDM
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
VQRACRDQMGREIALSEEDVHASLDPRISVASRRDGGPAEEGVRMVLGKVQAKLDADRQD
HHHHHHHHHCCEEECCCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCHHH
NRRRREVIDAACRDRRRLMEELAG
HHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA