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The map label for this gene is bisC [C]

Identifier: 158425404

GI number: 158425404

Start: 4335044

End: 4337305

Strand: Direct

Name: bisC [C]

Synonym: AZC_3780

Alternate gene names: 158425404

Gene position: 4335044-4337305 (Clockwise)

Preceding gene: 158425403

Following gene: 158425405

Centisome position: 80.73

GC content: 70.2

Gene sequence:

>2262_bases
GTGACCGCTGACGAGCGGCTGCACCTCTTCGGCAGCCACTTCGGCACCTATGAGGTGGAGGCGGGCCCCGACGGCCGCCC
CCGCCTTCTGCCCTTCCGCCATGACCCCGCGCCCTCTCCTACGGGAGCGGCCTTCCTCGATCTCGCGGACCATCCGCTGC
GGGTGCGCCATCCCATGGTCCGGCGGGGCTGGCTCACCGCCAAGGGACGGCCGCAGGGGCGCGGCGCGGAGCGCGGACGG
GACGATTTTGTCGCCGTGACATGGCCCGAGGCGGCCCGGCTGGTGGCCGGCGAGATTGCGCGCGTTTCGGGCGATTACGG
CAATGCGGCCATCTTCGGCGGCTCCTATGGCTGGGCGAGCGCCGGGCGCTTCCACCATGCCCAGAGCCAGCTGAAGCGCT
TCCTGAACCTCTGCGGCGGCTTCACCTCCTCGGTGAACACTTACAGCTATGGCGCCGCCGCAGTGCTGCTGCCCCACGTG
ATCGGCCGGGAATACCAGGGCGCGACAGACACAGCGCCGAGCTGGGACCAGATTGCCGCCCACGCGCGCCTTCTCATCTC
CTTCGGCGGCTTCCGCCTCTCCAACGCGCAGGTGGAAGCGGGCGGCACCGGGCAGCATCGCGCCGAGGCGGCGCTGGCAG
ACGTGGCGCGCGCCGGCTGCCGGATCGTCGTCTTCTCCCCCACGGGCGCGGACGCGCCCGGCCTGCCGGGCCGTGTGGAG
CACGTCCCGCTGCGGCCCGGCACGGACGCCGCCGTGCTGATCGCCATGGCGCAGGTGCTGCTGGCGGAGGGGCGGACGGA
CACGGAGGCCCTCGCGCGCCTGACCGTGGGCCATGAGGCGTTTGCCGCCTATCTGGCGGGCAGTCCCGACGGCCAGCCGA
AGACACCGGAATGGGCAGAGGGCATCTCCGGCGTGCCGGCGGCGACCATCCGGGAACTCGCGCGTGCCTATGCTCAGGTG
CCAGCGCTGGTGAACCTCTCCTGGTCATTGCAGCGCTCGCGCCATGGGGAGCAGCCTTATTGGGCGGCGATTGCCCTTGC
CGCCATGGCCGGGCAGGTGGGGCGGCCGGGATGCGGATTTGCCTTCGGACTCACCGCCGTCTCCTCCGTGGGCCAGCCGA
TCCGCCGGCTGAAGGGGCCGGCGGTGACGCAAGGGCGCAATCCGGTTTCAAGCTTCATTCCCGTCGCCCGCATCACCGAG
TTGCTGGAGAACCCCGGCGGCACGCTCGACTATGACGGGCAGAGGCTCGCCCTCCCGAACATCCGCCTCGTCCATTGGGC
GGGCGGCAACCCCTTCCACCACCATCAGGATCTGAACCGGCTCGCCGCCGCCTTCCGGCGCCCGGAAACGGTGATCGTGC
ATGAGAGCGTGTGGACCGCCACCGCCCGGCACGCGGACATCGTGCTGCCCGCGAGCCTGCCCTTCGAGCGAGACGATGTC
GCCGCCGCCTCCCGCGACAACTGGCTCATTGCCTCCCGCCGTGTGCTGGCAACGCCGCCGGACGTGCGCTCCGATCACGA
CATGCTCGCGCTTATCGCCCGCGAACTCGGCCTTGACGCCGCCTTCACCGAGGGGCGCAGCGAAGAGGATTGGCTGCGCC
ATCTCTATGCGGGCTACCGCGACGCCCATCCCGAACTGCCGGATTTCGACACCTTCTGGGCCCGCGGCTATGCTGGGCTC
GACCTCGGCGCACCCGCGCCTGCCCCCACAACGCCGCTCGCCGATTTTGCACGCGACCCGGATCTGCACCCGCTCTCTAC
TCCTTCGGGTCGCATCGAGATCGGATCTTCGACGATCGCGGCCTTCGGTTATGACGACTGCCCCGGCCATCCCGCATGGC
TGGAGCCGGAGGAATGGCTGGGGGCGCCGCTTGCCGGCACCTATCCGCTGCATCTGCTCTCTCCCCAACCAGAACACCGG
CTGCACAGCCAGCTGGAACTGGCCGGCCCCAGCCAGCAGGCGAAGGTGACCGGCTGCGAAGTTCTGCTGCTCAGCCCACA
GGATGCCGCCGCCCGCGGGCTGGCGGCGGGAGAACAGGCGACCGTCTTCAATGCGCGCGGTCGCGCTCTTGTCGCCATCG
GCATTGATAACCGGCTGTCACCGGGCGTCGCCGTTCTGCCTACGGGAGGCTGGTACGCCCCGAATGAGCAGGGCCTCGAT
CTCGGCGGCAATCCCAACACGCTGAGCTCGATCCGCCCGACCTCACGGCTCGCACAAGGCACCGCGCCCAACGCGTGTCT
GGTCGAGGTCGTCAGCCGATAA

Upstream 100 bases:

>100_bases
GCCCAACACCTATGGCACCTCCAAGCGCGTGGTGTGGCAGCCCCGTGCCGACGACTGGGTGCGCGCCTACGACCTGAAGC
CGGCGGCCAAGTGAGCCGTC

Downstream 100 bases:

>100_bases
AACAGGGCGTGAAACGCAGGGAGCGCTCGGGACGGTCCAGGCGGCGCCAAAGAACATTTCTAACAATTTATACAATCTAA
AATAGATTAAATAGCTAACT

Product: oxidoreductase

Products: Biotin. [C]

Alternate protein names: BDS reductase; BSO reductase [H]

Number of amino acids: Translated: 753; Mature: 752

Protein sequence:

>753_residues
MTADERLHLFGSHFGTYEVEAGPDGRPRLLPFRHDPAPSPTGAAFLDLADHPLRVRHPMVRRGWLTAKGRPQGRGAERGR
DDFVAVTWPEAARLVAGEIARVSGDYGNAAIFGGSYGWASAGRFHHAQSQLKRFLNLCGGFTSSVNTYSYGAAAVLLPHV
IGREYQGATDTAPSWDQIAAHARLLISFGGFRLSNAQVEAGGTGQHRAEAALADVARAGCRIVVFSPTGADAPGLPGRVE
HVPLRPGTDAAVLIAMAQVLLAEGRTDTEALARLTVGHEAFAAYLAGSPDGQPKTPEWAEGISGVPAATIRELARAYAQV
PALVNLSWSLQRSRHGEQPYWAAIALAAMAGQVGRPGCGFAFGLTAVSSVGQPIRRLKGPAVTQGRNPVSSFIPVARITE
LLENPGGTLDYDGQRLALPNIRLVHWAGGNPFHHHQDLNRLAAAFRRPETVIVHESVWTATARHADIVLPASLPFERDDV
AAASRDNWLIASRRVLATPPDVRSDHDMLALIARELGLDAAFTEGRSEEDWLRHLYAGYRDAHPELPDFDTFWARGYAGL
DLGAPAPAPTTPLADFARDPDLHPLSTPSGRIEIGSSTIAAFGYDDCPGHPAWLEPEEWLGAPLAGTYPLHLLSPQPEHR
LHSQLELAGPSQQAKVTGCEVLLLSPQDAAARGLAAGEQATVFNARGRALVAIGIDNRLSPGVAVLPTGGWYAPNEQGLD
LGGNPNTLSSIRPTSRLAQGTAPNACLVEVVSR

Sequences:

>Translated_753_residues
MTADERLHLFGSHFGTYEVEAGPDGRPRLLPFRHDPAPSPTGAAFLDLADHPLRVRHPMVRRGWLTAKGRPQGRGAERGR
DDFVAVTWPEAARLVAGEIARVSGDYGNAAIFGGSYGWASAGRFHHAQSQLKRFLNLCGGFTSSVNTYSYGAAAVLLPHV
IGREYQGATDTAPSWDQIAAHARLLISFGGFRLSNAQVEAGGTGQHRAEAALADVARAGCRIVVFSPTGADAPGLPGRVE
HVPLRPGTDAAVLIAMAQVLLAEGRTDTEALARLTVGHEAFAAYLAGSPDGQPKTPEWAEGISGVPAATIRELARAYAQV
PALVNLSWSLQRSRHGEQPYWAAIALAAMAGQVGRPGCGFAFGLTAVSSVGQPIRRLKGPAVTQGRNPVSSFIPVARITE
LLENPGGTLDYDGQRLALPNIRLVHWAGGNPFHHHQDLNRLAAAFRRPETVIVHESVWTATARHADIVLPASLPFERDDV
AAASRDNWLIASRRVLATPPDVRSDHDMLALIARELGLDAAFTEGRSEEDWLRHLYAGYRDAHPELPDFDTFWARGYAGL
DLGAPAPAPTTPLADFARDPDLHPLSTPSGRIEIGSSTIAAFGYDDCPGHPAWLEPEEWLGAPLAGTYPLHLLSPQPEHR
LHSQLELAGPSQQAKVTGCEVLLLSPQDAAARGLAAGEQATVFNARGRALVAIGIDNRLSPGVAVLPTGGWYAPNEQGLD
LGGNPNTLSSIRPTSRLAQGTAPNACLVEVVSR
>Mature_752_residues
TADERLHLFGSHFGTYEVEAGPDGRPRLLPFRHDPAPSPTGAAFLDLADHPLRVRHPMVRRGWLTAKGRPQGRGAERGRD
DFVAVTWPEAARLVAGEIARVSGDYGNAAIFGGSYGWASAGRFHHAQSQLKRFLNLCGGFTSSVNTYSYGAAAVLLPHVI
GREYQGATDTAPSWDQIAAHARLLISFGGFRLSNAQVEAGGTGQHRAEAALADVARAGCRIVVFSPTGADAPGLPGRVEH
VPLRPGTDAAVLIAMAQVLLAEGRTDTEALARLTVGHEAFAAYLAGSPDGQPKTPEWAEGISGVPAATIRELARAYAQVP
ALVNLSWSLQRSRHGEQPYWAAIALAAMAGQVGRPGCGFAFGLTAVSSVGQPIRRLKGPAVTQGRNPVSSFIPVARITEL
LENPGGTLDYDGQRLALPNIRLVHWAGGNPFHHHQDLNRLAAAFRRPETVIVHESVWTATARHADIVLPASLPFERDDVA
AASRDNWLIASRRVLATPPDVRSDHDMLALIARELGLDAAFTEGRSEEDWLRHLYAGYRDAHPELPDFDTFWARGYAGLD
LGAPAPAPTTPLADFARDPDLHPLSTPSGRIEIGSSTIAAFGYDDCPGHPAWLEPEEWLGAPLAGTYPLHLLSPQPEHRL
HSQLELAGPSQQAKVTGCEVLLLSPQDAAARGLAAGEQATVFNARGRALVAIGIDNRLSPGVAVLPTGGWYAPNEQGLDL
GGNPNTLSSIRPTSRLAQGTAPNACLVEVVSR

Specific function: This enzyme may serve as a scavenger, allowing the cell to utilize biotin sulfoxide as a biotin source. It reduces a spontaneous oxidation product of biotin, D-biotin D-sulfoxide (BSO or BDS), back to biotin [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI145693196, Length=722, Percent_Identity=38.6426592797784, Blast_Score=462, Evalue=1e-131,
Organism=Escherichia coli, GI87081994, Length=719, Percent_Identity=35.326842837274, Blast_Score=436, Evalue=1e-123,
Organism=Escherichia coli, GI1787231, Length=775, Percent_Identity=37.5483870967742, Blast_Score=435, Evalue=1e-123,
Organism=Escherichia coli, GI87081797, Length=737, Percent_Identity=29.0366350067843, Blast_Score=270, Evalue=2e-73,
Organism=Escherichia coli, GI171474008, Length=740, Percent_Identity=29.4594594594595, Blast_Score=251, Evalue=1e-67,
Organism=Escherichia coli, GI1787870, Length=743, Percent_Identity=29.07133243607, Blast_Score=244, Evalue=2e-65,
Organism=Escherichia coli, GI3868721, Length=339, Percent_Identity=25.6637168141593, Blast_Score=90, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006658
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006655 [H]

Pfam domain/function: PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.-.-.- [C]

Molecular weight: Translated: 80253; Mature: 80122

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTADERLHLFGSHFGTYEVEAGPDGRPRLLPFRHDPAPSPTGAAFLDLADHPLRVRHPMV
CCCCCEEHEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHCCCHH
RRGWLTAKGRPQGRGAERGRDDFVAVTWPEAARLVAGEIARVSGDYGNAAIFGGSYGWAS
HCCEECCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCC
AGRFHHAQSQLKRFLNLCGGFTSSVNTYSYGAAAVLLPHVIGREYQGATDTAPSWDQIAA
CCHHHHHHHHHHHHHHHHCCHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
HARLLISFGGFRLSNAQVEAGGTGQHRAEAALADVARAGCRIVVFSPTGADAPGLPGRVE
HHHHEEEECCEEECCCEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCE
HVPLRPGTDAAVLIAMAQVLLAEGRTDTEALARLTVGHEAFAAYLAGSPDGQPKTPEWAE
EECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHCCCCCCCCCCCHHHH
GISGVPAATIRELARAYAQVPALVNLSWSLQRSRHGEQPYWAAIALAAMAGQVGRPGCGF
CCCCCCHHHHHHHHHHHHHCCEEEECCCHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCH
AFGLTAVSSVGQPIRRLKGPAVTQGRNPVSSFIPVARITELLENPGGTLDYDGQRLALPN
HHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCHHHHHHHHHCCCCCCCCCCCEEECCC
IRLVHWAGGNPFHHHQDLNRLAAAFRRPETVIVHESVWTATARHADIVLPASLPFERDDV
EEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHCCCCCEEEECCCCCCCCCH
AAASRDNWLIASRRVLATPPDVRSDHDMLALIARELGLDAAFTEGRSEEDWLRHLYAGYR
HHCCCCCEEEECCEEECCCCCCCCCHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHH
DAHPELPDFDTFWARGYAGLDLGAPAPAPTTPLADFARDPDLHPLSTPSGRIEIGSSTIA
CCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCEEEECCCEEE
AFGYDDCPGHPAWLEPEEWLGAPLAGTYPLHLLSPQPEHRLHSQLELAGPSQQAKVTGCE
EECCCCCCCCCCCCCHHHHCCCCCCCCCCEEECCCCHHHHHHHHEECCCCCCCCEECCEE
VLLLSPQDAAARGLAAGEQATVFNARGRALVAIGIDNRLSPGVAVLPTGGWYAPNEQGLD
EEEECCCCHHHHCCCCCCCEEEEECCCCEEEEEECCCCCCCCEEEEECCCEECCCCCCCC
LGGNPNTLSSIRPTSRLAQGTAPNACLVEVVSR
CCCCCCCHHHCCCHHHHHCCCCCCHHHHHHHCC
>Mature Secondary Structure 
TADERLHLFGSHFGTYEVEAGPDGRPRLLPFRHDPAPSPTGAAFLDLADHPLRVRHPMV
CCCCEEHEEECCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHCCCHH
RRGWLTAKGRPQGRGAERGRDDFVAVTWPEAARLVAGEIARVSGDYGNAAIFGGSYGWAS
HCCEECCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCCEEEECCCCCCCC
AGRFHHAQSQLKRFLNLCGGFTSSVNTYSYGAAAVLLPHVIGREYQGATDTAPSWDQIAA
CCHHHHHHHHHHHHHHHHCCHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
HARLLISFGGFRLSNAQVEAGGTGQHRAEAALADVARAGCRIVVFSPTGADAPGLPGRVE
HHHHEEEECCEEECCCEEECCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCE
HVPLRPGTDAAVLIAMAQVLLAEGRTDTEALARLTVGHEAFAAYLAGSPDGQPKTPEWAE
EECCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCHHHHHHHHCCCCCCCCCCCHHHH
GISGVPAATIRELARAYAQVPALVNLSWSLQRSRHGEQPYWAAIALAAMAGQVGRPGCGF
CCCCCCHHHHHHHHHHHHHCCEEEECCCHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCH
AFGLTAVSSVGQPIRRLKGPAVTQGRNPVSSFIPVARITELLENPGGTLDYDGQRLALPN
HHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCHHHHHHHHHCCCCCCCCCCCEEECCC
IRLVHWAGGNPFHHHQDLNRLAAAFRRPETVIVHESVWTATARHADIVLPASLPFERDDV
EEEEEECCCCCCHHHHHHHHHHHHHCCCCEEEEECCHHHHHCCCCCEEEECCCCCCCCCH
AAASRDNWLIASRRVLATPPDVRSDHDMLALIARELGLDAAFTEGRSEEDWLRHLYAGYR
HHCCCCCEEEECCEEECCCCCCCCCHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHH
DAHPELPDFDTFWARGYAGLDLGAPAPAPTTPLADFARDPDLHPLSTPSGRIEIGSSTIA
CCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCEEEECCCEEE
AFGYDDCPGHPAWLEPEEWLGAPLAGTYPLHLLSPQPEHRLHSQLELAGPSQQAKVTGCE
EECCCCCCCCCCCCCHHHHCCCCCCCCCCEEECCCCHHHHHHHHEECCCCCCCCEECCEE
VLLLSPQDAAARGLAAGEQATVFNARGRALVAIGIDNRLSPGVAVLPTGGWYAPNEQGLD
EEEECCCCHHHHCCCCCCCEEEEECCCCEEEEEECCCCCCCCEEEEECCCEECCCCCCCC
LGGNPNTLSSIRPTSRLAQGTAPNACLVEVVSR
CCCCCCCHHHCCCHHHHHCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Spontaneous Oxidation Product Of Biotin, D-Biotin D-Sulfoxide (Bso Or Bds), [C]

Specific reaction: Reduces A Spontaneous Oxidation Product Of Biotin, D-Biotin D-Sulfoxide (Bso Or Bds), Back To Biotin. [C]

General reaction: Reduction [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7733660 [H]