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The map label for this gene is sdhA [H]

Identifier: 158425369

GI number: 158425369

Start: 4296565

End: 4298397

Strand: Direct

Name: sdhA [H]

Synonym: AZC_3745

Alternate gene names: 158425369

Gene position: 4296565-4298397 (Clockwise)

Preceding gene: 158425368

Following gene: 158425370

Centisome position: 80.01

GC content: 67.59

Gene sequence:

>1833_bases
ATGGCTGAATCCACCAACGGCGCCGCCGCCCCCGGCATCAACGGCCGCGCCTATCAGGTCACGGACCATACCTATGACGT
GCTCGTCGTCGGCGCCGGCGGCGCGGGCCTGCGCGCTGTCGTCGGCTGCTCCGAGGCGGGACTTCGCACCGCCTGCGTGA
CCAAGGTCTTCCCCACCCGCTCCCACACGGTGGCCGCCCAGGGCGGCGTCGCCGCTTCCCTCGCCAACATGGGCGAGGAC
AAGTGGGAATGGCACATGTACGACACCGTGAAGGGGTCGGACTGGCTGGGTGACCAGGACGCCATCGAATATCTGGTGCG
CAATGCGCCGGCCGCCGTCTACGAGCTCGAGCACTGGGGCGTGCCCTTCTCGCGCACGGAGGACGGCAAGATCTACCAGC
GCCCCTTCGGCGGCATGACCACGCACTTCGGCAAGGGCACCGCCCAGCGCACCTGCGCCGCCGCCGACCGCACCGGCCAT
GCCATGCTGCACACGCTCTATGGCGCGGCGCTGAAGCACAAGGCCGAGTTCTTCATCGAATACTTCGCTATCGACCTCAT
CATGGACGAGGACGGCCGTTGCTGCGGCATCGTCGCCCTGAAGATGGACGACGGCACGCTGCACCGCTTCCGCGCCAACC
TCACCATCCTGGCGACGGGCGGCTATGGCCGCGCCTATTTCTCCGCCACCTCCGCCCACACCTGCACGGGTGACGGCGGC
GGCATGGTGCTGCGCGCCGGCCTGCCGCTCCAGGACATGGAGTTCGTGCAGTTCCACCCGACCGGCATCTACGGCTCGGG
CTGCCTCATCACCGAAGGCTCGCGCGGCGAAGGCGGCTACCTGACCAATTCCGAGGGCGAGCGCTTCATGGAGCGCTATG
CCCCCTCGGCCAAGGACCTCGCCTCGCGCGACGTGGTGTCCCGCTCCATGACCATGGAGATCCGCGAGGGACGCGGCGTC
GGCAAGAACAAGGACCACATCTTCCTGCATCTGGATCACCTCGATCCGGCGATCCTGCACGAGCGCCTGCCGGGCATCTC
GGAAAGCGCCCGTATCTTCGCCGGCGTGGACGTGACCCGCGAGCCGATCCCGGTGATCCCCACCGTCCACTACAACATGG
GCGGCATCCCGACGAACTATCACGGCGAGGTGCTGAACAAGGTGGGCGGTGACCCGGACAAGGTGGTGCCGGGCCTCATG
GCCATCGGCGAAGCTGCCTGCGTGTCGGTGCACGGCGCTAACCGCCTCGGCTCCAACTCGCTCATCGATCTCGTGGTGTT
CGGCCGCGCGGCGGCGCTCCGGGCCGCCGAGTTGGTGCGCCCCGGCGAGAAGCAGCGCGAGCTGCCGGCGGATGGCGGCG
AACTGGCCCTCTCGCGCCTCGACCGCTTCCGCAACGCCTCCGGCGATACGCCGACGGCCGAGCTGCGCGGCAACATGCAG
CGCGTGATGCAGAACAACTGCGCCGTGTTCCGCACCGGCGAGGTGCTGGAGGAAGGGCACACGCTCATCCATGACGTGTT
CAAGGCCTCCAGCAACATCCGGGTCTCCGACCGCTCGCTGGTCTGGAACTCGGACCTCATCGAGACGCTGGAATACGACA
ATCTCATCGCCCAGGCCGTCGTGACCATGGACAGCGCGCTGAACCGCAAGGAAAGCCGCGGCGCCCATGCCCGCGAGGAC
TTCCCGGACCGCGACGACGTGAACTGGATGAAGCACACGCTGGCTTACATCGACACGGCGAGCGGCGAGGTGAAGCTCGA
GGACCGGCCGGTCCACACCTACACGCTGTCGAACGACATCCAGTACATCGAGCCCAAGAAGCGCGTGTACTGA

Upstream 100 bases:

>100_bases
GGACTGAAGGTGGCGCTGATCATCGCCAACACCTTCTTCACCACGGTGGTCGGCCTGGCCGGCGCCTTCGCTGTTCTCAA
GATCAGCCTGGGAGGCTGAC

Downstream 100 bases:

>100_bases
GCCCCGCGTGACACTATCGGGCCGGCCCAGCGGGGCCGGCTCTCTCGCACGACCGGCGCAGCCGACGATTGGGACGCACC
ATGGCTGAGTTCACCCTCCC

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 610; Mature: 609

Protein sequence:

>610_residues
MAESTNGAAAPGINGRAYQVTDHTYDVLVVGAGGAGLRAVVGCSEAGLRTACVTKVFPTRSHTVAAQGGVAASLANMGED
KWEWHMYDTVKGSDWLGDQDAIEYLVRNAPAAVYELEHWGVPFSRTEDGKIYQRPFGGMTTHFGKGTAQRTCAAADRTGH
AMLHTLYGAALKHKAEFFIEYFAIDLIMDEDGRCCGIVALKMDDGTLHRFRANLTILATGGYGRAYFSATSAHTCTGDGG
GMVLRAGLPLQDMEFVQFHPTGIYGSGCLITEGSRGEGGYLTNSEGERFMERYAPSAKDLASRDVVSRSMTMEIREGRGV
GKNKDHIFLHLDHLDPAILHERLPGISESARIFAGVDVTREPIPVIPTVHYNMGGIPTNYHGEVLNKVGGDPDKVVPGLM
AIGEAACVSVHGANRLGSNSLIDLVVFGRAAALRAAELVRPGEKQRELPADGGELALSRLDRFRNASGDTPTAELRGNMQ
RVMQNNCAVFRTGEVLEEGHTLIHDVFKASSNIRVSDRSLVWNSDLIETLEYDNLIAQAVVTMDSALNRKESRGAHARED
FPDRDDVNWMKHTLAYIDTASGEVKLEDRPVHTYTLSNDIQYIEPKKRVY

Sequences:

>Translated_610_residues
MAESTNGAAAPGINGRAYQVTDHTYDVLVVGAGGAGLRAVVGCSEAGLRTACVTKVFPTRSHTVAAQGGVAASLANMGED
KWEWHMYDTVKGSDWLGDQDAIEYLVRNAPAAVYELEHWGVPFSRTEDGKIYQRPFGGMTTHFGKGTAQRTCAAADRTGH
AMLHTLYGAALKHKAEFFIEYFAIDLIMDEDGRCCGIVALKMDDGTLHRFRANLTILATGGYGRAYFSATSAHTCTGDGG
GMVLRAGLPLQDMEFVQFHPTGIYGSGCLITEGSRGEGGYLTNSEGERFMERYAPSAKDLASRDVVSRSMTMEIREGRGV
GKNKDHIFLHLDHLDPAILHERLPGISESARIFAGVDVTREPIPVIPTVHYNMGGIPTNYHGEVLNKVGGDPDKVVPGLM
AIGEAACVSVHGANRLGSNSLIDLVVFGRAAALRAAELVRPGEKQRELPADGGELALSRLDRFRNASGDTPTAELRGNMQ
RVMQNNCAVFRTGEVLEEGHTLIHDVFKASSNIRVSDRSLVWNSDLIETLEYDNLIAQAVVTMDSALNRKESRGAHARED
FPDRDDVNWMKHTLAYIDTASGEVKLEDRPVHTYTLSNDIQYIEPKKRVY
>Mature_609_residues
AESTNGAAAPGINGRAYQVTDHTYDVLVVGAGGAGLRAVVGCSEAGLRTACVTKVFPTRSHTVAAQGGVAASLANMGEDK
WEWHMYDTVKGSDWLGDQDAIEYLVRNAPAAVYELEHWGVPFSRTEDGKIYQRPFGGMTTHFGKGTAQRTCAAADRTGHA
MLHTLYGAALKHKAEFFIEYFAIDLIMDEDGRCCGIVALKMDDGTLHRFRANLTILATGGYGRAYFSATSAHTCTGDGGG
MVLRAGLPLQDMEFVQFHPTGIYGSGCLITEGSRGEGGYLTNSEGERFMERYAPSAKDLASRDVVSRSMTMEIREGRGVG
KNKDHIFLHLDHLDPAILHERLPGISESARIFAGVDVTREPIPVIPTVHYNMGGIPTNYHGEVLNKVGGDPDKVVPGLMA
IGEAACVSVHGANRLGSNSLIDLVVFGRAAALRAAELVRPGEKQRELPADGGELALSRLDRFRNASGDTPTAELRGNMQR
VMQNNCAVFRTGEVLEEGHTLIHDVFKASSNIRVSDRSLVWNSDLIETLEYDNLIAQAVVTMDSALNRKESRGAHAREDF
PDRDDVNWMKHTLAYIDTASGEVKLEDRPVHTYTLSNDIQYIEPKKRVY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=612, Percent_Identity=62.4183006535948, Blast_Score=744, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=559, Percent_Identity=54.9194991055456, Blast_Score=559, Evalue=1e-160,
Organism=Escherichia coli, GI1790597, Length=581, Percent_Identity=43.0292598967298, Blast_Score=416, Evalue=1e-117,
Organism=Escherichia coli, GI1788928, Length=564, Percent_Identity=30.3191489361702, Blast_Score=206, Evalue=5e-54,
Organism=Caenorhabditis elegans, GI17550100, Length=612, Percent_Identity=61.1111111111111, Blast_Score=743, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=613, Percent_Identity=60.1957585644372, Blast_Score=719, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322701, Length=611, Percent_Identity=63.9934533551555, Blast_Score=793, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=597, Percent_Identity=64.8241206030151, Blast_Score=773, Evalue=0.0,
Organism=Drosophila melanogaster, GI17137288, Length=621, Percent_Identity=61.5136876006441, Blast_Score=760, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=621, Percent_Identity=61.5136876006441, Blast_Score=760, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=621, Percent_Identity=61.5136876006441, Blast_Score=760, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=613, Percent_Identity=54.8123980424144, Blast_Score=665, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 66419; Mature: 66287

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAESTNGAAAPGINGRAYQVTDHTYDVLVVGAGGAGLRAVVGCSEAGLRTACVTKVFPTR
CCCCCCCCCCCCCCCCEEEEECCCEEEEEEECCCCCCEEEEECCCCCCHHHHHHHCCCCC
SHTVAAQGGVAASLANMGEDKWEWHMYDTVKGSDWLGDQDAIEYLVRNAPAAVYELEHWG
CCEEEECCCHHHHHHHCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEHHHCC
VPFSRTEDGKIYQRPFGGMTTHFGKGTAQRTCAAADRTGHAMLHTLYGAALKHKAEFFIE
CCCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHE
YFAIDLIMDEDGRCCGIVALKMDDGTLHRFRANLTILATGGYGRAYFSATSAHTCTGDGG
EEEEEEEECCCCCEEEEEEEEECCCCEEEEEEEEEEEEECCCCEEEEECCCCCEEECCCC
GMVLRAGLPLQDMEFVQFHPTGIYGSGCLITEGSRGEGGYLTNSEGERFMERYAPSAKDL
CEEEECCCCCCCCCEEEEECCCEECCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHH
ASRDVVSRSMTMEIREGRGVGKNKDHIFLHLDHLDPAILHERLPGISESARIFAGVDVTR
HHHHHHHHHHEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCEEEEECCCCC
EPIPVIPTVHYNMGGIPTNYHGEVLNKVGGDPDKVVPGLMAIGEAACVSVHGANRLGSNS
CCCCCCEEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCEEEEEEECCCCCCCCC
LIDLVVFGRAAALRAAELVRPGEKQRELPADGGELALSRLDRFRNASGDTPTAELRGNMQ
EEEEEECCHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHH
RVMQNNCAVFRTGEVLEEGHTLIHDVFKASSNIRVSDRSLVWNSDLIETLEYDNLIAQAV
HHHHCCCEEEECCHHHHHHHHHHHHHHHCCCCCEEECCEEEECHHHHHHHHHHHHHHHHH
VTMDSALNRKESRGAHAREDFPDRDDVNWMKHTLAYIDTASGEVKLEDRPVHTYTLSNDI
HHHHHHHCHHHHCCCCCCCCCCCCCCHHHHHHHHHHEECCCCEEEECCCCEEEEEECCCC
QYIEPKKRVY
EEECCHHCCC
>Mature Secondary Structure 
AESTNGAAAPGINGRAYQVTDHTYDVLVVGAGGAGLRAVVGCSEAGLRTACVTKVFPTR
CCCCCCCCCCCCCCCEEEEECCCEEEEEEECCCCCCEEEEECCCCCCHHHHHHHCCCCC
SHTVAAQGGVAASLANMGEDKWEWHMYDTVKGSDWLGDQDAIEYLVRNAPAAVYELEHWG
CCEEEECCCHHHHHHHCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEEHHHCC
VPFSRTEDGKIYQRPFGGMTTHFGKGTAQRTCAAADRTGHAMLHTLYGAALKHKAEFFIE
CCCCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHE
YFAIDLIMDEDGRCCGIVALKMDDGTLHRFRANLTILATGGYGRAYFSATSAHTCTGDGG
EEEEEEEECCCCCEEEEEEEEECCCCEEEEEEEEEEEEECCCCEEEEECCCCCEEECCCC
GMVLRAGLPLQDMEFVQFHPTGIYGSGCLITEGSRGEGGYLTNSEGERFMERYAPSAKDL
CEEEECCCCCCCCCEEEEECCCEECCCEEEECCCCCCCCEEECCCHHHHHHHHCCCHHHH
ASRDVVSRSMTMEIREGRGVGKNKDHIFLHLDHLDPAILHERLPGISESARIFAGVDVTR
HHHHHHHHHHEEEEECCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCEEEEECCCCC
EPIPVIPTVHYNMGGIPTNYHGEVLNKVGGDPDKVVPGLMAIGEAACVSVHGANRLGSNS
CCCCCCEEEEECCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHCCEEEEEEECCCCCCCCC
LIDLVVFGRAAALRAAELVRPGEKQRELPADGGELALSRLDRFRNASGDTPTAELRGNMQ
EEEEEECCHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHH
RVMQNNCAVFRTGEVLEEGHTLIHDVFKASSNIRVSDRSLVWNSDLIETLEYDNLIAQAV
HHHHCCCEEEECCHHHHHHHHHHHHHHHCCCCCEEECCEEEECHHHHHHHHHHHHHHHHH
VTMDSALNRKESRGAHAREDFPDRDDVNWMKHTLAYIDTASGEVKLEDRPVHTYTLSNDI
HHHHHHHCHHHHCCCCCCCCCCCCCCHHHHHHHHHHEECCCCEEEECCCCEEEEEECCCC
QYIEPKKRVY
EEECCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA