Click here to switch to the map view.

The map label for this gene is glsA

Identifier: 158425162

GI number: 158425162

Start: 4062718

End: 4063647

Strand: Direct

Name: glsA

Synonym: AZC_3538

Alternate gene names: 158425162

Gene position: 4062718-4063647 (Clockwise)

Preceding gene: 158425161

Following gene: 158425163

Centisome position: 75.66

GC content: 67.96

Gene sequence:

>930_bases
TTGCCGAAGCTCAATGACGTCGTCGCGGAGATCGCCGCCGACCTCGCCAAGGCGACCGAGCGCGGCGCCGTGGCCACTTA
CATCCCCATGCTGGCGGAAGTGCCGATCAACCAGTTCGGCATGGCGGTGGTGACCGCCGATGGCGAGACCATCCTGGCGG
GGGACGCGGACACCGTCTTTTCCATCCAGAGCATTTCGAAGGTCTTCACCCTGACCCTCGCCCTCGGCCAGATCGGCGAC
GCGCTGTGGACGCGGGTGGGCAAGGAGCCCTCGGGCAACGCCTTCAACTCCATCGTGCAGCTGGAGTATGAGCACGGCAT
CCCGCGCAACCCCTTCATCAATGCAGGGGCCATCGTGGTGGCGGACGCCATGCTCTCCGGCCACCAGCCGCGCGAGGCGC
TGGGCGCCATCCTGCGCTTCGTGCGTTTCGTCGCCGCCGACGAGAGCATCACCATCGACGAGGCTGTGGCGCGATCGGAG
AAGGAAACCGGTTTCCGCAACACGGCGCTCGCAAACTACATGCGCTCCTTCGGCGTGCTCCGCCATCCGGTGGACCATGC
GCTCGGCGTCTATTTCCACCAGTGCGCCATCGCCATGAGCTGCCGGCACCTGGCCCGCGCCGGCCGCTATCTCGCCTTCT
CCGGCCGCCTGACGCCCGAGGGGCCGAGTGTGGTGGCGTCCGAGCGCGCCCGTCGCATCGCCGCGCTGATGCTGACGTGC
GGCCATTATGACGGCTCGGGCGACTTCGCCTTCCGCGTGGGCCTTCCGGGCAAGAGCGGCGTGGGTGGAGGCATTCTGGC
GATCGCGCCCGGCAAGGCCTCCATCGCGGTCTGGTCTCCGGGTCTTGATCCGCACGGCAATTCGCTACTCGGCTCCATCG
CGCTGGAGCGCCTCGCCAAAGCCATGCGCTGGTCGGTCTTCGCCGGCTGA

Upstream 100 bases:

>100_bases
GCCTGAGGCAGCCCCGCTTCGCAAGCGGCACGGGGCGGCTATAGTCACGCCGCACGGCCCGCGCTATGCCGGGTGCGCCA
TGGCCTGACCGGGGGAAGCG

Downstream 100 bases:

>100_bases
TCCGCGGGGTGCCCCGGAACCTCCTGCCGGACGCGGGCGCAACCGCTGCGGATCCATCCTGGACCTCGCACCTGACGCAA
GGTCCGCACAAGCTGCGCCT

Product: glutaminase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 308

Protein sequence:

>309_residues
MPKLNDVVAEIAADLAKATERGAVATYIPMLAEVPINQFGMAVVTADGETILAGDADTVFSIQSISKVFTLTLALGQIGD
ALWTRVGKEPSGNAFNSIVQLEYEHGIPRNPFINAGAIVVADAMLSGHQPREALGAILRFVRFVAADESITIDEAVARSE
KETGFRNTALANYMRSFGVLRHPVDHALGVYFHQCAIAMSCRHLARAGRYLAFSGRLTPEGPSVVASERARRIAALMLTC
GHYDGSGDFAFRVGLPGKSGVGGGILAIAPGKASIAVWSPGLDPHGNSLLGSIALERLAKAMRWSVFAG

Sequences:

>Translated_309_residues
MPKLNDVVAEIAADLAKATERGAVATYIPMLAEVPINQFGMAVVTADGETILAGDADTVFSIQSISKVFTLTLALGQIGD
ALWTRVGKEPSGNAFNSIVQLEYEHGIPRNPFINAGAIVVADAMLSGHQPREALGAILRFVRFVAADESITIDEAVARSE
KETGFRNTALANYMRSFGVLRHPVDHALGVYFHQCAIAMSCRHLARAGRYLAFSGRLTPEGPSVVASERARRIAALMLTC
GHYDGSGDFAFRVGLPGKSGVGGGILAIAPGKASIAVWSPGLDPHGNSLLGSIALERLAKAMRWSVFAG
>Mature_308_residues
PKLNDVVAEIAADLAKATERGAVATYIPMLAEVPINQFGMAVVTADGETILAGDADTVFSIQSISKVFTLTLALGQIGDA
LWTRVGKEPSGNAFNSIVQLEYEHGIPRNPFINAGAIVVADAMLSGHQPREALGAILRFVRFVAADESITIDEAVARSEK
ETGFRNTALANYMRSFGVLRHPVDHALGVYFHQCAIAMSCRHLARAGRYLAFSGRLTPEGPSVVASERARRIAALMLTCG
HYDGSGDFAFRVGLPGKSGVGGGILAIAPGKASIAVWSPGLDPHGNSLLGSIALERLAKAMRWSVFAG

Specific function: Unknown

COG id: COG2066

COG function: function code E; Glutaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutaminase family

Homologues:

Organism=Homo sapiens, GI156104878, Length=279, Percent_Identity=37.6344086021505, Blast_Score=177, Evalue=8e-45,
Organism=Homo sapiens, GI20336214, Length=303, Percent_Identity=35.3135313531353, Blast_Score=171, Evalue=9e-43,
Organism=Escherichia coli, GI1787804, Length=306, Percent_Identity=49.6732026143791, Blast_Score=267, Evalue=6e-73,
Organism=Escherichia coli, GI1786693, Length=289, Percent_Identity=40.1384083044983, Blast_Score=189, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17507019, Length=304, Percent_Identity=38.4868421052632, Blast_Score=181, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI193204073, Length=290, Percent_Identity=36.2068965517241, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17532727, Length=293, Percent_Identity=34.8122866894198, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI193204075, Length=292, Percent_Identity=35.6164383561644, Blast_Score=170, Evalue=9e-43,
Organism=Drosophila melanogaster, GI281363241, Length=316, Percent_Identity=33.5443037974684, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24653162, Length=316, Percent_Identity=33.5443037974684, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24653164, Length=316, Percent_Identity=33.5443037974684, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI281363239, Length=316, Percent_Identity=33.5443037974684, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24653156, Length=316, Percent_Identity=33.5443037974684, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI116008307, Length=307, Percent_Identity=34.5276872964169, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24653158, Length=316, Percent_Identity=33.5443037974684, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24653166, Length=307, Percent_Identity=34.5276872964169, Blast_Score=169, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLSA_AZOC5 (A8IEU9)

Other databases:

- EMBL:   AP009384
- RefSeq:   YP_001526454.1
- ProteinModelPortal:   A8IEU9
- SMR:   A8IEU9
- GeneID:   5690350
- GenomeReviews:   AP009384_GR
- KEGG:   azc:AZC_3538
- HOGENOM:   HBG512335
- OMA:   SERESCH
- ProtClustDB:   PRK00971
- BioCyc:   ACAU438753:AZC_3538-MONOMER
- HAMAP:   MF_00313
- InterPro:   IPR012338
- InterPro:   IPR015868
- Gene3D:   G3DSA:3.40.710.20
- PANTHER:   PTHR12544
- TIGRFAMs:   TIGR03814

Pfam domain/function: PF04960 Glutaminase; SSF56601 PBP_transp_fold

EC number: =3.5.1.2

Molecular weight: Translated: 32659; Mature: 32528

Theoretical pI: Translated: 7.67; Mature: 7.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKLNDVVAEIAADLAKATERGAVATYIPMLAEVPINQFGMAVVTADGETILAGDADTVF
CCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEECCCEEEECCCCHHH
SIQSISKVFTLTLALGQIGDALWTRVGKEPSGNAFNSIVQLEYEHGIPRNPFINAGAIVV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHEEEEECCCCCCCCCCCCCHHHH
ADAMLSGHQPREALGAILRFVRFVAADESITIDEAVARSEKETGFRNTALANYMRSFGVL
HHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RHPVDHALGVYFHQCAIAMSCRHLARAGRYLAFSGRLTPEGPSVVASERARRIAALMLTC
HCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
GHYDGSGDFAFRVGLPGKSGVGGGILAIAPGKASIAVWSPGLDPHGNSLLGSIALERLAK
CCCCCCCCEEEEEECCCCCCCCCCEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHH
AMRWSVFAG
HHHHHHCCC
>Mature Secondary Structure 
PKLNDVVAEIAADLAKATERGAVATYIPMLAEVPINQFGMAVVTADGETILAGDADTVF
CCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCEEEEEECCCEEEECCCCHHH
SIQSISKVFTLTLALGQIGDALWTRVGKEPSGNAFNSIVQLEYEHGIPRNPFINAGAIVV
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHEEEEECCCCCCCCCCCCCHHHH
ADAMLSGHQPREALGAILRFVRFVAADESITIDEAVARSEKETGFRNTALANYMRSFGVL
HHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RHPVDHALGVYFHQCAIAMSCRHLARAGRYLAFSGRLTPEGPSVVASERARRIAALMLTC
HCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHH
GHYDGSGDFAFRVGLPGKSGVGGGILAIAPGKASIAVWSPGLDPHGNSLLGSIALERLAK
CCCCCCCCEEEEEECCCCCCCCCCEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHH
AMRWSVFAG
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA