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The map label for this gene is ilvD

Identifier: 158425154

GI number: 158425154

Start: 4054273

End: 4056126

Strand: Reverse

Name: ilvD

Synonym: AZC_3530

Alternate gene names: 158425154

Gene position: 4056126-4054273 (Counterclockwise)

Preceding gene: 158425158

Following gene: 158425152

Centisome position: 75.54

GC content: 67.75

Gene sequence:

>1854_bases
ATGCCCGCTTATCGTTCCCGCACCAGCACCCATGGCCGCAACATGGCCGGAGCCCGTGGCCTCTGGCGCGCCACCGGCAT
GAAGGACGGGGATTTCGGCAAGCCGATCATCGCGGTGGTGAACTCCTTCACCCAGTTCGTGCCCGGCCATGTGCACCTGA
AGGATCTCGGCCAGCTCGTGGCCCGCGAGATCGAGAAGGCCGGCGGCGTCGCCAAGGAGTTCAACACCATCGCGGTGGAT
GACGGCATCGCCATGGGCCATGACGGCATGCTCTATTCGCTGCCGTCCCGCGAGATCATCGCCGACAGCGTGGAGTACAT
GGTGAACGCGCACTGCGCCGACGCCATGGTCTGCATTTCCAATTGCGACAAGATCACCCCCGGCATGCTGATGGCCGCCA
TGCGCCTCAACATCCCGGCCGTCTTCGTCTCCGGTGGCCCCATGGAGGCCGGCAAGGTGCTCCTCTCCACCGGCGAGAAG
AAGGTGGACCTGATCGACGCCATGATCGCCGCCGCCGACGATCGCGTGTCGGACGAGGACGTGAAGGTGATGGAGCGCTC
CGCGTGCCCCACCTGCGGCTCCTGCTCGGGCATGTTCACCGCCAATTCCATGAACTGCCTCACCGAGGCCCTCGGCCTCG
CCCTGCCGGGCAACGGCTCCGTGCTCGCCACCCATGCGGACCGCGAGCGCCTGTTCGTGGAGGCTGGCCACCTCGTGGTG
GACCTCGCCCGCCGCTATTACGAGCAGGACGATGCGGGCGTGCTGCCGCGCACCATCGCCAGCTTCAAGGCGTTCGAGAA
TGCCATGACGCTCGACATCTCCATGGGCGGCTCCACCAACACGGTGCTGCATCTGCTCGCCGCCGCCAATGAGGGCGAGG
TGCCCTTCACCATGGCGGACATCGACCGCCTGTCGCGCAAGGTGCCGGTGCTCTGCAAGGTGGCGCCCGCGGTCGCCAAC
ATCCACATGGAAGACGTGCACCGCGCGGGCGGCATCATGGGCATCCTCGGCGAACTCGACCGCGCCGGCCTGATCCACAC
CGACCTGCCCACGGTCCACGCGCCGTCCATGAAGGATGCGCTGGAGCGCTGGGACGTGACGCGCACGAAGGCCGAGAGCG
TCACCACCTTCTATCGCGCAGCGCCCGGCGGCGTGCCGACCCAGGTGGCCTTCAGCCAGTCCCGTCGCTGGGACGATCTG
GACACGGACCGCGCCAGCGGCGTCATCCGCGATTTCGAGCACGCTTATTCCAAGGACGGCGGCCTCGCCGTGCTGTTCGG
CAACATTGCCGAGGATGGCTGCATCGTGAAGACGGCGGGCGTGGACGCTTCCATCCTGAAGTTCACGGGCCCGGCCCGCA
TCTTCGAGAGCCAGGATGCGGCGGTGGAGGCGATCCTCGCCAACGGCAAGATCAAGGCCGGTGACATCGTGCTCATCCGC
TACGAGGGACCGCGCGGCGGTCCCGGCATGCAGGAGATGCTCTACCCGACCTCCTATCTGAAGTCGAAGGGCCTCGGCAA
AGCCTGCGCTCTGGTGACGGACGGGCGCTTCTCGGGCGGTTCCTCGGGCCTGTCCATCGGCCACGTGTCGCCGGAAGCTG
CCGAGGGCGGCGCCATCGGCCTCGTGGAAGAGGGCGACACCATCGAGATCGACATCCCCAACCGCCGCATCCACCTCGCC
ATCTCGGACGAGGAAATGGCCCGCCGCCGTGCGGCCATGGAGGCCAAGGGCGACGCAGCCTGGAAGCCGAAAGACCGCCA
GCGCGTGGTCTCGCAGGCGTTGCAGGCCTATGCCGCCCTCACCACCTCCGCCGCCCGCGGCGCGGTGCGCGACGTGAAGT
CCCTGCGGCGCTGA

Upstream 100 bases:

>100_bases
GCACGCGAAAAAGATTTCTCTGTTGCCTGAATTCGCTCTAAGACAGCCGTTATAAAATTGCGCAGAGCGCCCCCGAACAG
GACATAAAGGTACCGAGGAC

Downstream 100 bases:

>100_bases
TTGCAAATGCAAACGGCTCCCGAAAGGGAGCCGTCCAGGATGGTGTTTAAACCCGCCGGAACGCATGTTCCGGCGGTTTT
TTTGTCAGCGGTTGCAGACC

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 617; Mature: 616

Protein sequence:

>617_residues
MPAYRSRTSTHGRNMAGARGLWRATGMKDGDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEKAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPAVFVSGGPMEAGKVLLSTGEK
KVDLIDAMIAAADDRVSDEDVKVMERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSVLATHADRERLFVEAGHLVV
DLARRYYEQDDAGVLPRTIASFKAFENAMTLDISMGGSTNTVLHLLAAANEGEVPFTMADIDRLSRKVPVLCKVAPAVAN
IHMEDVHRAGGIMGILGELDRAGLIHTDLPTVHAPSMKDALERWDVTRTKAESVTTFYRAAPGGVPTQVAFSQSRRWDDL
DTDRASGVIRDFEHAYSKDGGLAVLFGNIAEDGCIVKTAGVDASILKFTGPARIFESQDAAVEAILANGKIKAGDIVLIR
YEGPRGGPGMQEMLYPTSYLKSKGLGKACALVTDGRFSGGSSGLSIGHVSPEAAEGGAIGLVEEGDTIEIDIPNRRIHLA
ISDEEMARRRAAMEAKGDAAWKPKDRQRVVSQALQAYAALTTSAARGAVRDVKSLRR

Sequences:

>Translated_617_residues
MPAYRSRTSTHGRNMAGARGLWRATGMKDGDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEKAGGVAKEFNTIAVD
DGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPAVFVSGGPMEAGKVLLSTGEK
KVDLIDAMIAAADDRVSDEDVKVMERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSVLATHADRERLFVEAGHLVV
DLARRYYEQDDAGVLPRTIASFKAFENAMTLDISMGGSTNTVLHLLAAANEGEVPFTMADIDRLSRKVPVLCKVAPAVAN
IHMEDVHRAGGIMGILGELDRAGLIHTDLPTVHAPSMKDALERWDVTRTKAESVTTFYRAAPGGVPTQVAFSQSRRWDDL
DTDRASGVIRDFEHAYSKDGGLAVLFGNIAEDGCIVKTAGVDASILKFTGPARIFESQDAAVEAILANGKIKAGDIVLIR
YEGPRGGPGMQEMLYPTSYLKSKGLGKACALVTDGRFSGGSSGLSIGHVSPEAAEGGAIGLVEEGDTIEIDIPNRRIHLA
ISDEEMARRRAAMEAKGDAAWKPKDRQRVVSQALQAYAALTTSAARGAVRDVKSLRR
>Mature_616_residues
PAYRSRTSTHGRNMAGARGLWRATGMKDGDFGKPIIAVVNSFTQFVPGHVHLKDLGQLVAREIEKAGGVAKEFNTIAVDD
GIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAMVCISNCDKITPGMLMAAMRLNIPAVFVSGGPMEAGKVLLSTGEKK
VDLIDAMIAAADDRVSDEDVKVMERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSVLATHADRERLFVEAGHLVVD
LARRYYEQDDAGVLPRTIASFKAFENAMTLDISMGGSTNTVLHLLAAANEGEVPFTMADIDRLSRKVPVLCKVAPAVANI
HMEDVHRAGGIMGILGELDRAGLIHTDLPTVHAPSMKDALERWDVTRTKAESVTTFYRAAPGGVPTQVAFSQSRRWDDLD
TDRASGVIRDFEHAYSKDGGLAVLFGNIAEDGCIVKTAGVDASILKFTGPARIFESQDAAVEAILANGKIKAGDIVLIRY
EGPRGGPGMQEMLYPTSYLKSKGLGKACALVTDGRFSGGSSGLSIGHVSPEAAEGGAIGLVEEGDTIEIDIPNRRIHLAI
SDEEMARRRAAMEAKGDAAWKPKDRQRVVSQALQAYAALTTSAARGAVRDVKSLRR

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=615, Percent_Identity=73.9837398373984, Blast_Score=951, Evalue=0.0,
Organism=Escherichia coli, GI2367371, Length=572, Percent_Identity=32.1678321678322, Blast_Score=189, Evalue=5e-49,
Organism=Escherichia coli, GI1786464, Length=545, Percent_Identity=32.8440366972477, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1788157, Length=541, Percent_Identity=28.8354898336414, Blast_Score=179, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6322476, Length=610, Percent_Identity=37.2131147540984, Blast_Score=349, Evalue=6e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_AZOC5 (A8IES7)

Other databases:

- EMBL:   AP009384
- RefSeq:   YP_001526446.1
- GeneID:   5689396
- GenomeReviews:   AP009384_GR
- KEGG:   azc:AZC_3530
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- ProtClustDB:   PRK12448
- BioCyc:   ACAU438753:AZC_3530-MONOMER
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 65733; Mature: 65602

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPAYRSRTSTHGRNMAGARGLWRATGMKDGDFGKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEKAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAMVCIS
HHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAAMRLNIPAVFVSGGPMEAGKVLLSTGEKKVDLIDAMIAAADDRVSDED
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCHH
VKVMERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSVLATHADRERLFVEAGHLVV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCEECCCCCCEEEEECCCCEEEHHHHHHHH
DLARRYYEQDDAGVLPRTIASFKAFENAMTLDISMGGSTNTVLHLLAAANEGEVPFTMAD
HHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHEEECCCCCCCCEEHHH
IDRLSRKVPVLCKVAPAVANIHMEDVHRAGGIMGILGELDRAGLIHTDLPTVHAPSMKDA
HHHHHCCCCEEEEECHHHHHCCHHHHHHHCCHHHHHHHHCCCCEEECCCCCCCCCCHHHH
LERWDVTRTKAESVTTFYRAAPGGVPTQVAFSQSRRWDDLDTDRASGVIRDFEHAYSKDG
HHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCC
GLAVLFGNIAEDGCIVKTAGVDASILKFTGPARIFESQDAAVEAILANGKIKAGDIVLIR
CEEEEECCCCCCCEEEEECCCCCEEEEECCCHHHHCCCHHHHHHHHCCCCEEECCEEEEE
YEGPRGGPGMQEMLYPTSYLKSKGLGKACALVTDGRFSGGSSGLSIGHVSPEAAEGGAIG
ECCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCCEEE
LVEEGDTIEIDIPNRRIHLAISDEEMARRRAAMEAKGDAAWKPKDRQRVVSQALQAYAAL
EEECCCEEEEECCCCEEEEEECHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
TTSAARGAVRDVKSLRR
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PAYRSRTSTHGRNMAGARGLWRATGMKDGDFGKPIIAVVNSFTQFVPGHVHLKDLGQLV
CCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHCCCCEEHHHHHHHH
AREIEKAGGVAKEFNTIAVDDGIAMGHDGMLYSLPSREIIADSVEYMVNAHCADAMVCIS
HHHHHHHCCCHHHCCEEEECCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHH
NCDKITPGMLMAAMRLNIPAVFVSGGPMEAGKVLLSTGEKKVDLIDAMIAAADDRVSDED
CCCCCCHHHHHHHHHCCCCEEEEECCCCCCCEEEEECCCCHHHHHHHHHHHCCCCCCCHH
VKVMERSACPTCGSCSGMFTANSMNCLTEALGLALPGNGSVLATHADRERLFVEAGHLVV
HHHHHHHCCCCCCCCCCCEECCHHHHHHHHHCEECCCCCCEEEEECCCCEEEHHHHHHHH
DLARRYYEQDDAGVLPRTIASFKAFENAMTLDISMGGSTNTVLHLLAAANEGEVPFTMAD
HHHHHHHCCCCCCCCHHHHHHHHHHCCCEEEEEECCCCHHHHHHEEECCCCCCCCEEHHH
IDRLSRKVPVLCKVAPAVANIHMEDVHRAGGIMGILGELDRAGLIHTDLPTVHAPSMKDA
HHHHHCCCCEEEEECHHHHHCCHHHHHHHCCHHHHHHHHCCCCEEECCCCCCCCCCHHHH
LERWDVTRTKAESVTTFYRAAPGGVPTQVAFSQSRRWDDLDTDRASGVIRDFEHAYSKDG
HHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCC
GLAVLFGNIAEDGCIVKTAGVDASILKFTGPARIFESQDAAVEAILANGKIKAGDIVLIR
CEEEEECCCCCCCEEEEECCCCCEEEEECCCHHHHCCCHHHHHHHHCCCCEEECCEEEEE
YEGPRGGPGMQEMLYPTSYLKSKGLGKACALVTDGRFSGGSSGLSIGHVSPEAAEGGAIG
ECCCCCCCCHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCCEEE
LVEEGDTIEIDIPNRRIHLAISDEEMARRRAAMEAKGDAAWKPKDRQRVVSQALQAYAAL
EEECCCEEEEECCCCEEEEEECHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
TTSAARGAVRDVKSLRR
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA