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The map label for this gene is mntH [H]

Identifier: 158424919

GI number: 158424919

Start: 3806174

End: 3807514

Strand: Direct

Name: mntH [H]

Synonym: AZC_3295

Alternate gene names: 158424919

Gene position: 3806174-3807514 (Clockwise)

Preceding gene: 158424918

Following gene: 158424921

Centisome position: 70.88

GC content: 66.52

Gene sequence:

>1341_bases
ATGCTGGATCAGGCGACGAAGGGAATGAATGGCTGGCGGCGGGAGCGCGGCGAAGCGGCGCTGTCGGATGTGCATGGCAC
CATCGCCGTCAGCCACCGCAGCCGGCTGGGGCGCCTGTTCGCCTTCATCGGGCCCGGCTATCTCGTCGCCACCGGCTATA
TGGACCCCGGCAACTGGGCGACGTCGCTCGCCGGCGGCTCGCGCTTCGGTTATGCGCTGCTGTTCGTGGCTCTCCTGTCG
AACATGATCGCCATCCTGCTGCAGGCGCTGTGCTCGCGCCTCGGCGTCGCCACCGGACGCGACCTCGCCCAGGCGTGCCG
CGACAGCTTTCCAAAGCCCGTGGCCTTCGTGCTCTGGCTGCTGGCGGAACTCGCCATCTGCGCCACCGATCTGGCCGAAG
TAATCGGCACGGCCATCGGCCTCAATCTCCTCTTCGGCATTCCGCTGGAGCTCGGCGTCATCGTCACCGCGCTCGACGTG
TTCTTGATCCTCTGGCTCCAGAAGCTCGGCTTCCGCTTCGTGGAAGCCTTCATCGTGGCGTTGCTGGGCATCATCGGGGC
CTGCTTCTTCATCCAGATCGCCATGGCCGACCCGGACTGGGGCGCCGTGATCCGCGGCTTTGCACCGACCACCGAGATCG
TGACGAACCCGGACATGCTCTATCTCGCGCTCGGCATTCTCGGCGCGACGGTGATGCCCCATAACCTCTATCTGCACTCG
GCCATCGTGCAGACCCGCAAGCATGCGCCGACACCCGATGGCGTGCGCGAAGCCATCCGCTTCGCCACGTGGGATTCCAC
CTTCGCTTTGATGTTCGCCCTCACCATCAATGCCTCGATCCTCATTCTCGCCGCCGCCGCCTTCCATGGCACCGGCACCG
GCGAGGTGGCGGACCTCGGCAAGGCGCACGAACTGCTGAACCCGCTGCTCGGCTCGGCGCTGGCGCCCACGCTCTTTGCC
GTGGCGCTGCTCTGCTGCGGGCTCAACTCCACGGTCACGGCCACCATCGCCGGACAGGCGGTGATGGAGGGCTTCATCGA
GATGAAGATCCAGCCGTGGCTGCGGCGCCTCATCACCCGCGCCATCGCCATCGTGCCGGCGGCGGCTGTGACCATCGCTT
ATGGGGAAAAAGGCGCCTCCACGCTGCTCATCCTCAGCCAGGTGGTGCTGTCCCTCCAGTTGCCCTTCGCCATCGTGCCG
CTGGTGCTGTTCACCGCGGACCGCCGGAAGATGGGCGAGCATGTGGCGCCCCGCTGGCAGACGGTTCTGGCCGCCGCCGC
GAGCCTCCTCATCATCGCGCTCAATGTGAAGCTGCTGGTGGATACCGCGCTGGGCAGCTAA

Upstream 100 bases:

>100_bases
GCGCTTCGCCGGGCGTTCTTGCAAATCGTTCGCATTTGCATTGACAGGCCGGCTTCTTCTGCCATTCTCGCGAAACAACG
GGATTGGCTAGGCTTGCATC

Downstream 100 bases:

>100_bases
CGCGCCTCAGCCGGCACGCGCGACGGCCTCGGTCTCGTCCTGAAGCGCCGCGATGAGGTTCAGGAAGCGCTCGCCCTGCA
CCAACACATGGGCCCGCAGC

Product: manganese transporter MntH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MLDQATKGMNGWRRERGEAALSDVHGTIAVSHRSRLGRLFAFIGPGYLVATGYMDPGNWATSLAGGSRFGYALLFVALLS
NMIAILLQALCSRLGVATGRDLAQACRDSFPKPVAFVLWLLAELAICATDLAEVIGTAIGLNLLFGIPLELGVIVTALDV
FLILWLQKLGFRFVEAFIVALLGIIGACFFIQIAMADPDWGAVIRGFAPTTEIVTNPDMLYLALGILGATVMPHNLYLHS
AIVQTRKHAPTPDGVREAIRFATWDSTFALMFALTINASILILAAAAFHGTGTGEVADLGKAHELLNPLLGSALAPTLFA
VALLCCGLNSTVTATIAGQAVMEGFIEMKIQPWLRRLITRAIAIVPAAAVTIAYGEKGASTLLILSQVVLSLQLPFAIVP
LVLFTADRRKMGEHVAPRWQTVLAAAASLLIIALNVKLLVDTALGS

Sequences:

>Translated_446_residues
MLDQATKGMNGWRRERGEAALSDVHGTIAVSHRSRLGRLFAFIGPGYLVATGYMDPGNWATSLAGGSRFGYALLFVALLS
NMIAILLQALCSRLGVATGRDLAQACRDSFPKPVAFVLWLLAELAICATDLAEVIGTAIGLNLLFGIPLELGVIVTALDV
FLILWLQKLGFRFVEAFIVALLGIIGACFFIQIAMADPDWGAVIRGFAPTTEIVTNPDMLYLALGILGATVMPHNLYLHS
AIVQTRKHAPTPDGVREAIRFATWDSTFALMFALTINASILILAAAAFHGTGTGEVADLGKAHELLNPLLGSALAPTLFA
VALLCCGLNSTVTATIAGQAVMEGFIEMKIQPWLRRLITRAIAIVPAAAVTIAYGEKGASTLLILSQVVLSLQLPFAIVP
LVLFTADRRKMGEHVAPRWQTVLAAAASLLIIALNVKLLVDTALGS
>Mature_446_residues
MLDQATKGMNGWRRERGEAALSDVHGTIAVSHRSRLGRLFAFIGPGYLVATGYMDPGNWATSLAGGSRFGYALLFVALLS
NMIAILLQALCSRLGVATGRDLAQACRDSFPKPVAFVLWLLAELAICATDLAEVIGTAIGLNLLFGIPLELGVIVTALDV
FLILWLQKLGFRFVEAFIVALLGIIGACFFIQIAMADPDWGAVIRGFAPTTEIVTNPDMLYLALGILGATVMPHNLYLHS
AIVQTRKHAPTPDGVREAIRFATWDSTFALMFALTINASILILAAAAFHGTGTGEVADLGKAHELLNPLLGSALAPTLFA
VALLCCGLNSTVTATIAGQAVMEGFIEMKIQPWLRRLITRAIAIVPAAAVTIAYGEKGASTLLILSQVVLSLQLPFAIVP
LVLFTADRRKMGEHVAPRWQTVLAAAASLLIIALNVKLLVDTALGS

Specific function: H(+)-stimulated, highly selective, manganese uptake system [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI109255241, Length=434, Percent_Identity=36.6359447004608, Blast_Score=232, Evalue=6e-61,
Organism=Homo sapiens, GI295293167, Length=429, Percent_Identity=35.6643356643357, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI295293178, Length=429, Percent_Identity=35.6643356643357, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI295293175, Length=429, Percent_Identity=35.6643356643357, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI295293173, Length=429, Percent_Identity=35.6643356643357, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI10835169, Length=429, Percent_Identity=35.6643356643357, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI295293171, Length=429, Percent_Identity=35.6643356643357, Blast_Score=218, Evalue=6e-57,
Organism=Homo sapiens, GI295293169, Length=429, Percent_Identity=35.6643356643357, Blast_Score=218, Evalue=6e-57,
Organism=Escherichia coli, GI1788736, Length=420, Percent_Identity=40, Blast_Score=276, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI71999499, Length=434, Percent_Identity=34.5622119815668, Blast_Score=221, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI193210616, Length=475, Percent_Identity=31.1578947368421, Blast_Score=217, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI17569473, Length=367, Percent_Identity=34.6049046321526, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI71993856, Length=245, Percent_Identity=34.6938775510204, Blast_Score=148, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6323062, Length=405, Percent_Identity=44.4444444444444, Blast_Score=291, Evalue=1e-79,
Organism=Saccharomyces cerevisiae, GI6324450, Length=434, Percent_Identity=38.4792626728111, Blast_Score=276, Evalue=4e-75,
Organism=Saccharomyces cerevisiae, GI6321841, Length=450, Percent_Identity=38.8888888888889, Blast_Score=271, Evalue=2e-73,
Organism=Drosophila melanogaster, GI24648607, Length=459, Percent_Identity=32.244008714597, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI281362176, Length=459, Percent_Identity=32.244008714597, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI24648609, Length=459, Percent_Identity=32.244008714597, Blast_Score=226, Evalue=3e-59,
Organism=Drosophila melanogaster, GI45553443, Length=434, Percent_Identity=33.4101382488479, Blast_Score=222, Evalue=4e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 47408; Mature: 47408

Theoretical pI: Translated: 7.87; Mature: 7.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDQATKGMNGWRRERGEAALSDVHGTIAVSHRSRLGRLFAFIGPGYLVATGYMDPGNWA
CCCCHHCCCCHHHHHHHHHHHHHCCHHEEEHHHHHHHHHHHHHCCCEEEEECCCCCCCHH
TSLAGGSRFGYALLFVALLSNMIAILLQALCSRLGVATGRDLAQACRDSFPKPVAFVLWL
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHH
LAELAICATDLAEVIGTAIGLNLLFGIPLELGVIVTALDVFLILWLQKLGFRFVEAFIVA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLGIIGACFFIQIAMADPDWGAVIRGFAPTTEIVTNPDMLYLALGILGATVMPHNLYLHS
HHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHHCCCHHHHHH
AIVQTRKHAPTPDGVREAIRFATWDSTFALMFALTINASILILAAAAFHGTGTGEVADLG
HHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCCHHHHHH
KAHELLNPLLGSALAPTLFAVALLCCGLNSTVTATIAGQAVMEGFIEMKIQPWLRRLITR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIAIVPAAAVTIAYGEKGASTLLILSQVVLSLQLPFAIVPLVLFTADRRKMGEHVAPRWQ
HHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHH
TVLAAAASLLIIALNVKLLVDTALGS
HHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLDQATKGMNGWRRERGEAALSDVHGTIAVSHRSRLGRLFAFIGPGYLVATGYMDPGNWA
CCCCHHCCCCHHHHHHHHHHHHHCCHHEEEHHHHHHHHHHHHHCCCEEEEECCCCCCCHH
TSLAGGSRFGYALLFVALLSNMIAILLQALCSRLGVATGRDLAQACRDSFPKPVAFVLWL
HHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHH
LAELAICATDLAEVIGTAIGLNLLFGIPLELGVIVTALDVFLILWLQKLGFRFVEAFIVA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLGIIGACFFIQIAMADPDWGAVIRGFAPTTEIVTNPDMLYLALGILGATVMPHNLYLHS
HHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHCCCHHHHHHHHHHHHHHCCCHHHHHH
AIVQTRKHAPTPDGVREAIRFATWDSTFALMFALTINASILILAAAAFHGTGTGEVADLG
HHHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHCCCCCCHHHHHH
KAHELLNPLLGSALAPTLFAVALLCCGLNSTVTATIAGQAVMEGFIEMKIQPWLRRLITR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
AIAIVPAAAVTIAYGEKGASTLLILSQVVLSLQLPFAIVPLVLFTADRRKMGEHVAPRWQ
HHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHH
TVLAAAASLLIIALNVKLLVDTALGS
HHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]