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The map label for this gene is mmlH [H]

Identifier: 158424848

GI number: 158424848

Start: 3695062

End: 3696348

Strand: Direct

Name: mmlH [H]

Synonym: AZC_3224

Alternate gene names: 158424848

Gene position: 3695062-3696348 (Clockwise)

Preceding gene: 158424847

Following gene: 158424849

Centisome position: 68.81

GC content: 65.89

Gene sequence:

>1287_bases
ATGTCATCGACCACCAATGCGGCCGCAACAGCCGCGGATACCAGCCTGACCGGCTTCTACAGGGACATGACCCTGCCGGA
ACGCCGCACCTTCTGGGCCTGCGCCACCGGCTGGGCGCTCGATGGCATGGACTTCATGATCTATCCGCTGGTGATTGGCA
CAATCATCAAGCTGTGGAACGTGGATGCAGGCGCCGCCGGCCTCGCCGGCACTGTGACCCTGCTGGCCTCGGCGCTCGGT
GGCTGGGGCGCCGGCTATCTGGCGGACCGCATCGGCCGTGTGCGCACGCTTCAGTTCACCATCCTCTGGTTCTCTTTCTT
TTCTCTGCTTTGCGCCTTCGCGCAGAATTTTGAGCAGCTCCTGATCTGTCGCGCCCTGCTCGGCATCGGCTTTGGCGGCG
AATGGGCGGCCGGAGCGGTGCTGATGGGCGAGACCATCCGGGCGCAGTATCGCGGCCGTGCCGTGGGATCGGTGCAGTCT
GGCTGGGCCATCGGCTGGGGCGCCGCCGTGCTGGCGCAGGCGGCCCTGTTCTCGCTCATGCCGGCAGAGGAGGCGTGGCG
CTGGATGTTCGGCATCGGCGCGCTGCCGGCGCTGCTGGTCCTCTACCTGCGCAGCTATGTGAAGGAGCCCGAGGTCTCGG
CCCAGACCATCAAGCGCGGGCAAACCTCCGGCGACCGGCCCTCCATCCTCGAGATATTCCGGGGCCCGATCCTGAAGGTG
ACCATCCTCGCCTCGCTGGTGGCTACCGGCTGCCAGGGCGGCTATTACGCCATCACCTTCTGGGTGCCGCGCTTCCTCAC
CACCGAACGGCATCTGTCCATCGTCAGCTCCACTGGTTATCTGGCGGCCCTGATCGTCGGCTCGTTCGCGGGCTATCTGG
TGGGCGCCTGGTTCTCGGACCGCTTCGGCCGCCGCAGCCTGTTCCTCGTGTTCTCGCTCGGCGCCATGGCCGTGGTGCTC
GCCTATACCCAGCTGCCGCTGTCGAACGAAATACTATGGGTGCTGGGCTTCCCGCTGGGCTTCTTCGCCTCCGGCTATTT
CTCCGGCATGGGCGCGTTCCTGACCGAGCTCTATCCCACCCGGCTGCGCGGCTCGGGTCAGGGCTTCTGCTACAACTTCG
GCCGCGGCATCGGAGCGCTGTTCCCGTTCCTGGTCGGCTATCTCTCGCAGACCACCTCGCTGGCCAACGCCATTTGCATC
TTCGCGATGGTGGCCTATGTGGTGTTTTTCCTGGCCGCCTATGGCCTGCCCGAGACGCGCGGCAAGGTGTTGCACGCCGA
TGCATGA

Upstream 100 bases:

>100_bases
AGCAGGGCCCATGCGGCCTGTTTTCCGGAAGACGCCGCCGCCGAGATCATCCCACTCTCCCGCCAAACGCCGCGCTGAAC
GGCGATCAAGGGAGGCACAG

Downstream 100 bases:

>100_bases
CATGACGCCGGAAACCAGCGCCGCCCCGGTCTGTCCGGGGCCGGCGCCCGATCCCCACGGCCCCACCCGATACGCGGTGC
CGCCGGGAGCCGTGGATTGC

Product: 4-methylmuconolactone transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 427

Protein sequence:

>428_residues
MSSTTNAAATAADTSLTGFYRDMTLPERRTFWACATGWALDGMDFMIYPLVIGTIIKLWNVDAGAAGLAGTVTLLASALG
GWGAGYLADRIGRVRTLQFTILWFSFFSLLCAFAQNFEQLLICRALLGIGFGGEWAAGAVLMGETIRAQYRGRAVGSVQS
GWAIGWGAAVLAQAALFSLMPAEEAWRWMFGIGALPALLVLYLRSYVKEPEVSAQTIKRGQTSGDRPSILEIFRGPILKV
TILASLVATGCQGGYYAITFWVPRFLTTERHLSIVSSTGYLAALIVGSFAGYLVGAWFSDRFGRRSLFLVFSLGAMAVVL
AYTQLPLSNEILWVLGFPLGFFASGYFSGMGAFLTELYPTRLRGSGQGFCYNFGRGIGALFPFLVGYLSQTTSLANAICI
FAMVAYVVFFLAAYGLPETRGKVLHADA

Sequences:

>Translated_428_residues
MSSTTNAAATAADTSLTGFYRDMTLPERRTFWACATGWALDGMDFMIYPLVIGTIIKLWNVDAGAAGLAGTVTLLASALG
GWGAGYLADRIGRVRTLQFTILWFSFFSLLCAFAQNFEQLLICRALLGIGFGGEWAAGAVLMGETIRAQYRGRAVGSVQS
GWAIGWGAAVLAQAALFSLMPAEEAWRWMFGIGALPALLVLYLRSYVKEPEVSAQTIKRGQTSGDRPSILEIFRGPILKV
TILASLVATGCQGGYYAITFWVPRFLTTERHLSIVSSTGYLAALIVGSFAGYLVGAWFSDRFGRRSLFLVFSLGAMAVVL
AYTQLPLSNEILWVLGFPLGFFASGYFSGMGAFLTELYPTRLRGSGQGFCYNFGRGIGALFPFLVGYLSQTTSLANAICI
FAMVAYVVFFLAAYGLPETRGKVLHADA
>Mature_427_residues
SSTTNAAATAADTSLTGFYRDMTLPERRTFWACATGWALDGMDFMIYPLVIGTIIKLWNVDAGAAGLAGTVTLLASALGG
WGAGYLADRIGRVRTLQFTILWFSFFSLLCAFAQNFEQLLICRALLGIGFGGEWAAGAVLMGETIRAQYRGRAVGSVQSG
WAIGWGAAVLAQAALFSLMPAEEAWRWMFGIGALPALLVLYLRSYVKEPEVSAQTIKRGQTSGDRPSILEIFRGPILKVT
ILASLVATGCQGGYYAITFWVPRFLTTERHLSIVSSTGYLAALIVGSFAGYLVGAWFSDRFGRRSLFLVFSLGAMAVVLA
YTQLPLSNEILWVLGFPLGFFASGYFSGMGAFLTELYPTRLRGSGQGFCYNFGRGIGALFPFLVGYLSQTTSLANAICIF
AMVAYVVFFLAAYGLPETRGKVLHADA

Specific function: Probable uptake of 4-methylmuconolactone [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family [H]

Homologues:

Organism=Homo sapiens, GI24308167, Length=447, Percent_Identity=23.9373601789709, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI213021148, Length=443, Percent_Identity=22.1218961625282, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI87082404, Length=376, Percent_Identity=27.1276595744681, Blast_Score=124, Evalue=9e-30,
Organism=Escherichia coli, GI1790550, Length=445, Percent_Identity=24.9438202247191, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87082231, Length=270, Percent_Identity=28.8888888888889, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87081723, Length=322, Percent_Identity=29.5031055900621, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1786229, Length=430, Percent_Identity=24.4186046511628, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI87082159, Length=123, Percent_Identity=35.7723577235772, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788068, Length=381, Percent_Identity=24.6719160104987, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788292, Length=394, Percent_Identity=24.1116751269036, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 46192; Mature: 46061

Theoretical pI: Translated: 9.07; Mature: 9.07

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1 ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSTTNAAATAADTSLTGFYRDMTLPERRTFWACATGWALDGMDFMIYPLVIGTIIKLWN
CCCCCCCHHHHCCCHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHC
VDAGAAGLAGTVTLLASALGGWGAGYLADRIGRVRTLQFTILWFSFFSLLCAFAQNFEQL
CCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LICRALLGIGFGGEWAAGAVLMGETIRAQYRGRAVGSVQSGWAIGWGAAVLAQAALFSLM
HHHHHHHHCCCCCCHHHCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
PAEEAWRWMFGIGALPALLVLYLRSYVKEPEVSAQTIKRGQTSGDRPSILEIFRGPILKV
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCHHHHHHCCCHHHH
TILASLVATGCQGGYYAITFWVPRFLTTERHLSIVSSTGYLAALIVGSFAGYLVGAWFSD
HHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
RFGRRSLFLVFSLGAMAVVLAYTQLPLSNEILWVLGFPLGFFASGYFSGMGAFLTELYPT
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
RLRGSGQGFCYNFGRGIGALFPFLVGYLSQTTSLANAICIFAMVAYVVFFLAAYGLPETR
HHCCCCCCEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GKVLHADA
CCEEECCC
>Mature Secondary Structure 
SSTTNAAATAADTSLTGFYRDMTLPERRTFWACATGWALDGMDFMIYPLVIGTIIKLWN
CCCCCCHHHHCCCHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHC
VDAGAAGLAGTVTLLASALGGWGAGYLADRIGRVRTLQFTILWFSFFSLLCAFAQNFEQL
CCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LICRALLGIGFGGEWAAGAVLMGETIRAQYRGRAVGSVQSGWAIGWGAAVLAQAALFSLM
HHHHHHHHCCCCCCHHHCHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHC
PAEEAWRWMFGIGALPALLVLYLRSYVKEPEVSAQTIKRGQTSGDRPSILEIFRGPILKV
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCHHHHHHCCCHHHH
TILASLVATGCQGGYYAITFWVPRFLTTERHLSIVSSTGYLAALIVGSFAGYLVGAWFSD
HHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
RFGRRSLFLVFSLGAMAVVLAYTQLPLSNEILWVLGFPLGFFASGYFSGMGAFLTELYPT
CCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
RLRGSGQGFCYNFGRGIGALFPFLVGYLSQTTSLANAICIFAMVAYVVFFLAAYGLPETR
HHCCCCCCEEEHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GKVLHADA
CCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9461415 [H]