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The map label for this gene is mmgB [H]

Identifier: 158424836

GI number: 158424836

Start: 3676551

End: 3677648

Strand: Reverse

Name: mmgB [H]

Synonym: AZC_3212

Alternate gene names: 158424836

Gene position: 3677648-3676551 (Counterclockwise)

Preceding gene: 158424838

Following gene: 158424835

Centisome position: 68.49

GC content: 67.3

Gene sequence:

>1098_bases
TTGGCTTGGACGTCCCAAATGCTGGACGAGAACAGTCCGCGGCGGGCATTGATATTGCCGGTCCGGCCTTTGAAAACGCT
GCAAAATCGCACTGATGCGGTCGTGGCACGCGGATTGCTGAACATCGTCACAACGGGCGTCCCGCCCGGCAGCGCCAGCC
GGCGTCGCCAGGCGACGAGAACGCCCCGACCTGGGGTGGACATGCAGCCGACGAGGATCGCCGTCATCGGTGCCGGCCTG
ATGGGCCATGGCATCGCGCAAGCCTTCGCAATGGCCGGCTACGCGGTCGGCATCTATGAGCCAGACCCGGAACGGCGTGG
CGCGATCCGCGATCAGGTCCGGGCCAATCTGCGCCTTGTTGGAGCGGATGAGTGCGTCGCGGATCGCATCGCGGTCCATG
GGGGGCTGGCCGACGCCGTCGCCCACGCTTCGGTGGTGATCGAAGCGGTGCCGGAAGACCTCGACCTCAAGCGCCGGCTG
TTCGTCGAGATCGAAGCGGCGGCGCCCCGTTCCGCCTTGCTGGCCAGCAATACGTCCGCCATCCCCATCACCAGCATCAT
GTCGGTGCTGAAGGACCGCCGCCGGGCGATGGGCACCCACTGGTGGAACCCGCCTCACCTCGTTCCTCTGGTCGAGGTCG
TGCAAGGCGAGGAGACGGGGGCAGAAGAGATCGCGGCCATGATGGCCCTGCTGTGCTCCATCGGAAAGACGCCGGTTCAC
GTGCGCAAGGATGTGCCCGGCTTCATCGGAAACCGTCTCCAGCACGCCATGTGGCGTGAGGCCATTGCGCTGGTGCAGAG
CGGTGTCTGCGACGCCGAGACCGTGGACACGGTGGTGAAGGCGAGCTTCGGCCGGCGTCTGGCGGTCCTCGGGCCGTTGG
AGAATGCGGACCTCGTGGGAACGGATCTCACGCTCCAGGTCCACCGGACCATCCTGCCCGACCTCGACGGCACGCCCGGT
CCTTTGCCCCTGCTGGAGGACCTCGTCCGCGCCGGCCACCTCGGCATGAAGAGCGGCCGCGGCTTTCGTGAATGGAATGC
CGAGAGCGCCCGGACGGTGCGCGAGGCCCTCGCGCGGCATCTCGCGCAGACGTTCTGA

Upstream 100 bases:

>100_bases
TCCTTCGGGAGTGTCCGGAATATGGACGGAGCTGTCAGAATCTAGAACGTCTCGTGTTCAACGGGAAGGCGTTGGAAATG
AACGCGCGGAGGCGTCGGCT

Downstream 100 bases:

>100_bases
CCGTCCATACAGGGAAGACACGCATGAAGGGACGCAACGCCGTCGTCACCGGGTCCACGTCCGGCATCGGGCTCGCGATT
GCAAGGTCACTTGCCGCCGA

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 365; Mature: 364

Protein sequence:

>365_residues
MAWTSQMLDENSPRRALILPVRPLKTLQNRTDAVVARGLLNIVTTGVPPGSASRRRQATRTPRPGVDMQPTRIAVIGAGL
MGHGIAQAFAMAGYAVGIYEPDPERRGAIRDQVRANLRLVGADECVADRIAVHGGLADAVAHASVVIEAVPEDLDLKRRL
FVEIEAAAPRSALLASNTSAIPITSIMSVLKDRRRAMGTHWWNPPHLVPLVEVVQGEETGAEEIAAMMALLCSIGKTPVH
VRKDVPGFIGNRLQHAMWREAIALVQSGVCDAETVDTVVKASFGRRLAVLGPLENADLVGTDLTLQVHRTILPDLDGTPG
PLPLLEDLVRAGHLGMKSGRGFREWNAESARTVREALARHLAQTF

Sequences:

>Translated_365_residues
MAWTSQMLDENSPRRALILPVRPLKTLQNRTDAVVARGLLNIVTTGVPPGSASRRRQATRTPRPGVDMQPTRIAVIGAGL
MGHGIAQAFAMAGYAVGIYEPDPERRGAIRDQVRANLRLVGADECVADRIAVHGGLADAVAHASVVIEAVPEDLDLKRRL
FVEIEAAAPRSALLASNTSAIPITSIMSVLKDRRRAMGTHWWNPPHLVPLVEVVQGEETGAEEIAAMMALLCSIGKTPVH
VRKDVPGFIGNRLQHAMWREAIALVQSGVCDAETVDTVVKASFGRRLAVLGPLENADLVGTDLTLQVHRTILPDLDGTPG
PLPLLEDLVRAGHLGMKSGRGFREWNAESARTVREALARHLAQTF
>Mature_364_residues
AWTSQMLDENSPRRALILPVRPLKTLQNRTDAVVARGLLNIVTTGVPPGSASRRRQATRTPRPGVDMQPTRIAVIGAGLM
GHGIAQAFAMAGYAVGIYEPDPERRGAIRDQVRANLRLVGADECVADRIAVHGGLADAVAHASVVIEAVPEDLDLKRRLF
VEIEAAAPRSALLASNTSAIPITSIMSVLKDRRRAMGTHWWNPPHLVPLVEVVQGEETGAEEIAAMMALLCSIGKTPVHV
RKDVPGFIGNRLQHAMWREAIALVQSGVCDAETVDTVVKASFGRRLAVLGPLENADLVGTDLTLQVHRTILPDLDGTPGP
LPLLEDLVRAGHLGMKSGRGFREWNAESARTVREALARHLAQTF

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=294, Percent_Identity=32.312925170068, Blast_Score=129, Evalue=5e-30,
Organism=Homo sapiens, GI115430219, Length=235, Percent_Identity=30.2127659574468, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI296179427, Length=311, Percent_Identity=30.5466237942122, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI20127408, Length=284, Percent_Identity=32.3943661971831, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI68989263, Length=307, Percent_Identity=28.9902280130293, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI261878539, Length=307, Percent_Identity=28.9902280130293, Blast_Score=106, Evalue=3e-23,
Organism=Escherichia coli, GI1787661, Length=293, Percent_Identity=34.8122866894198, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1790281, Length=211, Percent_Identity=31.7535545023697, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI1788682, Length=235, Percent_Identity=30.6382978723404, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17563036, Length=292, Percent_Identity=33.2191780821918, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17549919, Length=292, Percent_Identity=34.5890410958904, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17553560, Length=300, Percent_Identity=31.6666666666667, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI71985930, Length=307, Percent_Identity=25.0814332247557, Blast_Score=115, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI71985923, Length=300, Percent_Identity=24.3333333333333, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI25144276, Length=299, Percent_Identity=32.7759197324415, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17508953, Length=295, Percent_Identity=33.2203389830508, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17508951, Length=299, Percent_Identity=32.7759197324415, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17558304, Length=327, Percent_Identity=30.2752293577982, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI193203623, Length=185, Percent_Identity=32.4324324324324, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI115533614, Length=185, Percent_Identity=32.4324324324324, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45549573, Length=266, Percent_Identity=30.8270676691729, Blast_Score=131, Evalue=6e-31,
Organism=Drosophila melanogaster, GI20129993, Length=248, Percent_Identity=31.0483870967742, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI19921000, Length=327, Percent_Identity=31.1926605504587, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24583077, Length=327, Percent_Identity=31.1926605504587, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24583079, Length=327, Percent_Identity=31.1926605504587, Blast_Score=112, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 39374; Mature: 39243

Theoretical pI: Translated: 8.90; Mature: 8.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAWTSQMLDENSPRRALILPVRPLKTLQNRTDAVVARGLLNIVTTGVPPGSASRRRQATR
CCCCHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCC
TPRPGVDMQPTRIAVIGAGLMGHGIAQAFAMAGYAVGIYEPDPERRGAIRDQVRANLRLV
CCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHHCCEEEE
GADECVADRIAVHGGLADAVAHASVVIEAVPEDLDLKRRLFVEIEAAAPRSALLASNTSA
ECHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCHHHHHCCCCC
IPITSIMSVLKDRRRAMGTHWWNPPHLVPLVEVVQGEETGAEEIAAMMALLCSIGKTPVH
CCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEE
VRKDVPGFIGNRLQHAMWREAIALVQSGVCDAETVDTVVKASFGRRLAVLGPLENADLVG
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCEEEEECCCCCCCEEC
TDLTLQVHRTILPDLDGTPGPLPLLEDLVRAGHLGMKSGRGFREWNAESARTVREALARH
CCEEEEEHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHCCCHHHHHHHHHHHHH
LAQTF
HHHCC
>Mature Secondary Structure 
AWTSQMLDENSPRRALILPVRPLKTLQNRTDAVVARGLLNIVTTGVPPGSASRRRQATR
CCCHHHHCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCC
TPRPGVDMQPTRIAVIGAGLMGHGIAQAFAMAGYAVGIYEPDPERRGAIRDQVRANLRLV
CCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHCEEEEEECCCHHHHHHHHHHHHCCEEEE
GADECVADRIAVHGGLADAVAHASVVIEAVPEDLDLKRRLFVEIEAAAPRSALLASNTSA
ECHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEEEEECCCCCHHHHHCCCCC
IPITSIMSVLKDRRRAMGTHWWNPPHLVPLVEVVQGEETGAEEIAAMMALLCSIGKTPVH
CCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEE
VRKDVPGFIGNRLQHAMWREAIALVQSGVCDAETVDTVVKASFGRRLAVLGPLENADLVG
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCEEEEECCCCCCCEEC
TDLTLQVHRTILPDLDGTPGPLPLLEDLVRAGHLGMKSGRGFREWNAESARTVREALARH
CCEEEEEHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHCCCHHHHHHHHHHHHH
LAQTF
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]