Click here to switch to the map view.

The map label for this gene is pleC [H]

Identifier: 158424746

GI number: 158424746

Start: 3576934

End: 3579225

Strand: Direct

Name: pleC [H]

Synonym: AZC_3122

Alternate gene names: 158424746

Gene position: 3576934-3579225 (Clockwise)

Preceding gene: 158424745

Following gene: 158424747

Centisome position: 66.61

GC content: 67.02

Gene sequence:

>2292_bases
ATGGCACGCGCCAACGCTGCAAGCGTGGGTGCGCGCGGTGACGCCATTGGTGGTTTGGCGAGATCCGTCGCGCGTCCCGC
CTATCAGCGGCTCTTGGAAGCTGAACCCTTCCTGCGCCGCATCGTGCCCGCGCTCATCATCACCTTTCTCGTCGTGCTCG
GCATCGGCGCGCTGGTGCAGGTGCATACGCACCGGCAGTCGGTGCTCGACAATGCCAAGGACGACCTTGCCCTCCAGGCC
CTCGCTACCGCAGAGGGGCTGAACCATCGCCTCAACGGCTCGCTGGCCAATACCGGCTCCGCCCTGCTCGCGGCGCTGCC
GCCGCGCGCCACCTCCGGCGGCCGCCGCATCTATGTCACCGATCCGTCCGGCCGGGTGATCGCTGCCGCGCCCGAGAGCG
CGCCGCGCGTCACCAGCCTTGCCGACCTCATGGACCCCTCCCAGCCGCTCACCGTGTTCGCCGAGCGCGCCGGCGTGCTG
GAAATCGCGGTCGGCGACACGCAGATGCTTGCCACGGTGCGAAACCTCAATCCGCCGCTTGGCCAGATCGTCTATCTCCA
GCCCATGAACCGCGCGCTCGCGGTCTGGTCGGATTCCACCACGCTCACCATCACCCTGTTCGCCACCACCGGCGCGGTGC
TGCTCATCCTCGGCTTCTCCTTCCACTGGCAGGCGAGCCGGGCGCGCGAGGCGGACCACATCTACGACACCGTGCGCATG
CGCATCGACACCGCCCTCAACCGCGGCCGCTGCGGCATGTGGGACTGGGACATGGCCCGCGGGCGCATGTATTGGTCCGA
CACCATGTTCGAAATCCTTGGCCTCGAGCGCCGGGACGAACTTCTGTCCTTCGGCGAGATCGCCAAGCTCGTGCATCCTG
ACGATGGCAATCTCTACGAACTGGCGCAGGAACTCGCCGAGCGCCCCGGCGCCTCGGTGGACCGCGTCTTCCGCATGCGC
ACGGCGCGCGGCGACTTCGTGTGGCTGCGCATGCGCGCCGAAGTGGTGCAGCAGGCGGGCGAGGACGGCCCCCACCTCAT
CGGCATCGCCATGGACGTGACCGAGGCCCAGCGCCTCGCCGAGCGCACCGTGACCGCCGACATGCGCCTGCGCGACGCCA
TCGAGAGCATCTCCGAGGCCTTCGTGCTCTGGGACAGCCAGAACCGCCTCGTGCTCTGCAATTCCAAGTTCCAGACCCTG
CATGAACTGCCGGACGATGCCATCGTCGCCGGCACGCCCTTCGAGACCATCGCCACCGTCGGCCGCCATCCGGTGACGCG
CACGCCGCTGAAGCCGGAAGACAAGCCGGAGGAAGGCTCGCGCGCCTTCGAGGCGCAGCTCTCCAACGGCCGCTGGCTGA
AGATCGCCGAGCGTCGCACCAAGGACGGCGGCTACGTCTCGGTGGGCACCGACATTACCCCGCTCAAGCGCCATGAGGAA
CGCCTCATGGACAATGAGAAGCGCCTCATGGCGCTGGTGGCCGATCTCAGGAAGTCCCAGCAGACCCTGGAGCATCAGGC
CCAGCAGCTCGCCGAGCTGGCCGAGAAATATTCGGAAGAAAAGACCCGGGCCGAGGACGCCAACCGCGCCAAGAGCGAAT
TCCTCGCCAACATGTCCCACGAGCTGCGCACGCCGCTCAATGCCATCATCGGCTTCTCGGAGATCATGGAAAGCGGCATG
TTTGGCCCGCTCGGCTCCGACAAGTACCGGGAATACTGCTCGGACATCAAAGGCTCCGGCACCTATCTCCTCGACGTCAT
CAACGACATCCTCGACATGTCGAAGATCGAGGCGGGCCGCATGCAACTGGAGCTGGAGGACATCCGGCTCGACGAGATCA
TCGCGGATGCGATGCGCGTGACGGCCGTGAAGGGCGACGAGAAGCAGCTCGACATGACCGCGCAGGTGGGCGCCGGTCAG
GTGATGCGTGGCGACCGCCGCGCCCTCAAGCAGATCCTGCTGAACCTGCTCTCCAACGCCGTGAAGTTCACGCCCGAGGG
CGGGCATGTGGCGGTGCGAGCCAAGGTCAACGGCGGGGCGGCCGTCATCGCCATCGAGGACACCGGCATCGGCATTCCGC
GCCATGCCCTCAACAAGATCGGCCGGCCGTTCGAGCAGGTGGAGAGCCAGTTCACCAAGACCCACAAGGGATCGGGCCTC
GGCCTTGCCATTGCCAAGTCGCTGGCGGAACTGCACGGCGGTTCCATGCGCATCCGCTCCACGGAAGGCGCGGGGACGAC
AGTGGTGGTGCGCCTGCCCATCCACGGCGTGCCGCACCTCTCGCTCCATTGA

Upstream 100 bases:

>100_bases
TTCGGAGAGATGCGGCACGTCCCTCCAATCAATCGAGGGCGATAGACTTTGCGGGTGCGTGGCCGCGCCTGCGAAGCGGG
ATATCCGAAGGGGGCAGGTG

Downstream 100 bases:

>100_bases
CGTGCTTTGCGAGCGGGTTGCGCGCCAATCGGATAGCAATGCACAGGAGCCATGCGCAGTCCGCCATGGCGCCGCCATCT
TCTTGCCGTTAGAAACAGCG

Product: PAS protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 763; Mature: 762

Protein sequence:

>763_residues
MARANAASVGARGDAIGGLARSVARPAYQRLLEAEPFLRRIVPALIITFLVVLGIGALVQVHTHRQSVLDNAKDDLALQA
LATAEGLNHRLNGSLANTGSALLAALPPRATSGGRRIYVTDPSGRVIAAAPESAPRVTSLADLMDPSQPLTVFAERAGVL
EIAVGDTQMLATVRNLNPPLGQIVYLQPMNRALAVWSDSTTLTITLFATTGAVLLILGFSFHWQASRAREADHIYDTVRM
RIDTALNRGRCGMWDWDMARGRMYWSDTMFEILGLERRDELLSFGEIAKLVHPDDGNLYELAQELAERPGASVDRVFRMR
TARGDFVWLRMRAEVVQQAGEDGPHLIGIAMDVTEAQRLAERTVTADMRLRDAIESISEAFVLWDSQNRLVLCNSKFQTL
HELPDDAIVAGTPFETIATVGRHPVTRTPLKPEDKPEEGSRAFEAQLSNGRWLKIAERRTKDGGYVSVGTDITPLKRHEE
RLMDNEKRLMALVADLRKSQQTLEHQAQQLAELAEKYSEEKTRAEDANRAKSEFLANMSHELRTPLNAIIGFSEIMESGM
FGPLGSDKYREYCSDIKGSGTYLLDVINDILDMSKIEAGRMQLELEDIRLDEIIADAMRVTAVKGDEKQLDMTAQVGAGQ
VMRGDRRALKQILLNLLSNAVKFTPEGGHVAVRAKVNGGAAVIAIEDTGIGIPRHALNKIGRPFEQVESQFTKTHKGSGL
GLAIAKSLAELHGGSMRIRSTEGAGTTVVVRLPIHGVPHLSLH

Sequences:

>Translated_763_residues
MARANAASVGARGDAIGGLARSVARPAYQRLLEAEPFLRRIVPALIITFLVVLGIGALVQVHTHRQSVLDNAKDDLALQA
LATAEGLNHRLNGSLANTGSALLAALPPRATSGGRRIYVTDPSGRVIAAAPESAPRVTSLADLMDPSQPLTVFAERAGVL
EIAVGDTQMLATVRNLNPPLGQIVYLQPMNRALAVWSDSTTLTITLFATTGAVLLILGFSFHWQASRAREADHIYDTVRM
RIDTALNRGRCGMWDWDMARGRMYWSDTMFEILGLERRDELLSFGEIAKLVHPDDGNLYELAQELAERPGASVDRVFRMR
TARGDFVWLRMRAEVVQQAGEDGPHLIGIAMDVTEAQRLAERTVTADMRLRDAIESISEAFVLWDSQNRLVLCNSKFQTL
HELPDDAIVAGTPFETIATVGRHPVTRTPLKPEDKPEEGSRAFEAQLSNGRWLKIAERRTKDGGYVSVGTDITPLKRHEE
RLMDNEKRLMALVADLRKSQQTLEHQAQQLAELAEKYSEEKTRAEDANRAKSEFLANMSHELRTPLNAIIGFSEIMESGM
FGPLGSDKYREYCSDIKGSGTYLLDVINDILDMSKIEAGRMQLELEDIRLDEIIADAMRVTAVKGDEKQLDMTAQVGAGQ
VMRGDRRALKQILLNLLSNAVKFTPEGGHVAVRAKVNGGAAVIAIEDTGIGIPRHALNKIGRPFEQVESQFTKTHKGSGL
GLAIAKSLAELHGGSMRIRSTEGAGTTVVVRLPIHGVPHLSLH
>Mature_762_residues
ARANAASVGARGDAIGGLARSVARPAYQRLLEAEPFLRRIVPALIITFLVVLGIGALVQVHTHRQSVLDNAKDDLALQAL
ATAEGLNHRLNGSLANTGSALLAALPPRATSGGRRIYVTDPSGRVIAAAPESAPRVTSLADLMDPSQPLTVFAERAGVLE
IAVGDTQMLATVRNLNPPLGQIVYLQPMNRALAVWSDSTTLTITLFATTGAVLLILGFSFHWQASRAREADHIYDTVRMR
IDTALNRGRCGMWDWDMARGRMYWSDTMFEILGLERRDELLSFGEIAKLVHPDDGNLYELAQELAERPGASVDRVFRMRT
ARGDFVWLRMRAEVVQQAGEDGPHLIGIAMDVTEAQRLAERTVTADMRLRDAIESISEAFVLWDSQNRLVLCNSKFQTLH
ELPDDAIVAGTPFETIATVGRHPVTRTPLKPEDKPEEGSRAFEAQLSNGRWLKIAERRTKDGGYVSVGTDITPLKRHEER
LMDNEKRLMALVADLRKSQQTLEHQAQQLAELAEKYSEEKTRAEDANRAKSEFLANMSHELRTPLNAIIGFSEIMESGMF
GPLGSDKYREYCSDIKGSGTYLLDVINDILDMSKIEAGRMQLELEDIRLDEIIADAMRVTAVKGDEKQLDMTAQVGAGQV
MRGDRRALKQILLNLLSNAVKFTPEGGHVAVRAKVNGGAAVIAIEDTGIGIPRHALNKIGRPFEQVESQFTKTHKGSGLG
LAIAKSLAELHGGSMRIRSTEGAGTTVVVRLPIHGVPHLSLH

Specific function: Member of the two-component regulatory system involved in the regulation of polar organelle development. PleC functions as a membrane-associated protein kinase that transfers phosphate to the response regulator pleD, leading to its activation [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=263, Percent_Identity=37.6425855513308, Blast_Score=149, Evalue=8e-37,
Organism=Escherichia coli, GI145693157, Length=281, Percent_Identity=31.6725978647687, Blast_Score=139, Evalue=6e-34,
Organism=Escherichia coli, GI48994928, Length=376, Percent_Identity=31.1170212765957, Blast_Score=138, Evalue=1e-33,
Organism=Escherichia coli, GI87081816, Length=250, Percent_Identity=34.8, Blast_Score=134, Evalue=3e-32,
Organism=Escherichia coli, GI1788713, Length=361, Percent_Identity=29.0858725761773, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1786600, Length=224, Percent_Identity=30.8035714285714, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1788549, Length=241, Percent_Identity=28.6307053941909, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1786912, Length=255, Percent_Identity=27.843137254902, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI87082128, Length=223, Percent_Identity=27.8026905829596, Blast_Score=94, Evalue=5e-20,
Organism=Escherichia coli, GI1788393, Length=252, Percent_Identity=26.1904761904762, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1790436, Length=222, Percent_Identity=28.3783783783784, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1786783, Length=263, Percent_Identity=25.8555133079848, Blast_Score=87, Evalue=3e-18,
Organism=Escherichia coli, GI1790861, Length=250, Percent_Identity=26.8, Blast_Score=86, Evalue=9e-18,
Organism=Escherichia coli, GI1788279, Length=208, Percent_Identity=25.4807692307692, Blast_Score=78, Evalue=3e-15,
Organism=Escherichia coli, GI1790346, Length=255, Percent_Identity=24.3137254901961, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI1790551, Length=222, Percent_Identity=23.4234234234234, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1787894, Length=240, Percent_Identity=25, Blast_Score=63, Evalue=7e-11,
Organism=Escherichia coli, GI1789808, Length=264, Percent_Identity=24.2424242424242, Blast_Score=62, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6322044, Length=216, Percent_Identity=32.8703703703704, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 83684; Mature: 83553

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARANAASVGARGDAIGGLARSVARPAYQRLLEAEPFLRRIVPALIITFLVVLGIGALVQ
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VHTHRQSVLDNAKDDLALQALATAEGLNHRLNGSLANTGSALLAALPPRATSGGRRIYVT
HHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHEECCCCCCCCCCEEEEE
DPSGRVIAAAPESAPRVTSLADLMDPSQPLTVFAERAGVLEIAVGDTQMLATVRNLNPPL
CCCCCEEEECCCCCCHHHHHHHHCCCCCCHHHHHHCCCEEEEEECCHHHHHHHHHCCCCC
GQIVYLQPMNRALAVWSDSTTLTITLFATTGAVLLILGFSFHWQASRAREADHIYDTVRM
CCEEEEECCCCEEEEECCCCEEEEEEEHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHH
RIDTALNRGRCGMWDWDMARGRMYWSDTMFEILGLERRDELLSFGEIAKLVHPDDGNLYE
HHHHHHCCCCCCCCCHHHHCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHH
LAQELAERPGASVDRVFRMRTARGDFVWLRMRAEVVQQAGEDGPHLIGIAMDVTEAQRLA
HHHHHHHCCCCCHHHHHHHHHCCCCEEEEHHHHHHHHHCCCCCCEEEEEEECHHHHHHHH
ERTVTADMRLRDAIESISEAFVLWDSQNRLVLCNSKFQTLHELPDDAIVAGTPFETIATV
HHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEECCHHHHHHHCCCCCEECCCCHHHHHHH
GRHPVTRTPLKPEDKPEEGSRAFEAQLSNGRWLKIAERRTKDGGYVSVGTDITPLKRHEE
CCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCEEEEECCCCCCCCEEEECCCCCHHHHHHH
RLMDNEKRLMALVADLRKSQQTLEHQAQQLAELAEKYSEEKTRAEDANRAKSEFLANMSH
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELRTPLNAIIGFSEIMESGMFGPLGSDKYREYCSDIKGSGTYLLDVINDILDMSKIEAGR
HHHCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCC
MQLELEDIRLDEIIADAMRVTAVKGDEKQLDMTAQVGAGQVMRGDRRALKQILLNLLSNA
EEEEHHHHHHHHHHHHHHHHHEECCCCHHHCHHHHCCCCHHHCCHHHHHHHHHHHHHHHH
VKFTPEGGHVAVRAKVNGGAAVIAIEDTGIGIPRHALNKIGRPFEQVESQFTKTHKGSGL
EEECCCCCEEEEEEEECCCEEEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCC
GLAIAKSLAELHGGSMRIRSTEGAGTTVVVRLPIHGVPHLSLH
HHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
ARANAASVGARGDAIGGLARSVARPAYQRLLEAEPFLRRIVPALIITFLVVLGIGALVQ
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
VHTHRQSVLDNAKDDLALQALATAEGLNHRLNGSLANTGSALLAALPPRATSGGRRIYVT
HHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHEECCCCCCCCCCEEEEE
DPSGRVIAAAPESAPRVTSLADLMDPSQPLTVFAERAGVLEIAVGDTQMLATVRNLNPPL
CCCCCEEEECCCCCCHHHHHHHHCCCCCCHHHHHHCCCEEEEEECCHHHHHHHHHCCCCC
GQIVYLQPMNRALAVWSDSTTLTITLFATTGAVLLILGFSFHWQASRAREADHIYDTVRM
CCEEEEECCCCEEEEECCCCEEEEEEEHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHH
RIDTALNRGRCGMWDWDMARGRMYWSDTMFEILGLERRDELLSFGEIAKLVHPDDGNLYE
HHHHHHCCCCCCCCCHHHHCCEEEHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHH
LAQELAERPGASVDRVFRMRTARGDFVWLRMRAEVVQQAGEDGPHLIGIAMDVTEAQRLA
HHHHHHHCCCCCHHHHHHHHHCCCCEEEEHHHHHHHHHCCCCCCEEEEEEECHHHHHHHH
ERTVTADMRLRDAIESISEAFVLWDSQNRLVLCNSKFQTLHELPDDAIVAGTPFETIATV
HHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEECCHHHHHHHCCCCCEECCCCHHHHHHH
GRHPVTRTPLKPEDKPEEGSRAFEAQLSNGRWLKIAERRTKDGGYVSVGTDITPLKRHEE
CCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCEEEEECCCCCCCCEEEECCCCCHHHHHHH
RLMDNEKRLMALVADLRKSQQTLEHQAQQLAELAEKYSEEKTRAEDANRAKSEFLANMSH
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELRTPLNAIIGFSEIMESGMFGPLGSDKYREYCSDIKGSGTYLLDVINDILDMSKIEAGR
HHHCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCC
MQLELEDIRLDEIIADAMRVTAVKGDEKQLDMTAQVGAGQVMRGDRRALKQILLNLLSNA
EEEEHHHHHHHHHHHHHHHHHEECCCCHHHCHHHHCCCCHHHCCHHHHHHHHHHHHHHHH
VKFTPEGGHVAVRAKVNGGAAVIAIEDTGIGIPRHALNKIGRPFEQVESQFTKTHKGSGL
EEECCCCCEEEEEEEECCCEEEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCC
GLAIAKSLAELHGGSMRIRSTEGAGTTVVVRLPIHGVPHLSLH
HHHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8421698; 11259647 [H]