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The map label for this gene is dxs

Identifier: 158424735

GI number: 158424735

Start: 3562144

End: 3564069

Strand: Reverse

Name: dxs

Synonym: AZC_3111

Alternate gene names: 158424735

Gene position: 3564069-3562144 (Counterclockwise)

Preceding gene: 158424736

Following gene: 158424732

Centisome position: 66.37

GC content: 67.86

Gene sequence:

>1926_bases
GTGACGGTAACCAAGACACCGCTTCTCGATACGGTGCGCGACGCCTCAGACGTCAGGCGCCTGCCGGAAGAGAAGCTTTC
CCAGCTGGCGGATGAACTGCGTGCGGAGACGATCAGCGCCGTCTCCGTGACCGGCGGTCACCTCGGCGCGGGCCTCGGCG
TGGTGGAACTCACCGTCGCCCTGCACCACGTGTTCAATACGCCCCACGACCGCCTGATCTGGGACGTGGGCCACCAGTGC
TATCCGCACAAGATCCTGACCGGCCGCCGCGACCGCATCCGCACCCTGCGCCAGGGCGGCGGGCTGTCCGGCTTCACGCG
CCGGTCCGAGAGCGAATACGATCCTTTCGGCGCTGCCCATTCCTCGACATCCATCTCCGCCGGTCTCGGCATGGCGGTGG
CGCGCGACCTCTCCGGCGGCGACCGCAATGTGATCGCTGTGATCGGCGACGGCGCCATGTCGGCGGGCATGGCCTATGAA
GCCATGAACAATGCCGGCGCCATGGACAGCCGGCTGATCGTCATCCTCAACGACAATGACATGTCCATTGCCCCGCCGAC
CGGGGCCATGTCAGCCTATCTCGCCCGGCTCATTTCCGGGCGCACCTATCTCTCCCTGCGCGAGATCGGCAAGCAGCTCG
CCGGACACCTGCCCAAGTTCGTGAAGGATGGCGCCGCCAAGGCGGAGGAGTTCGCGCGCGGCTTCTGGACCGGCGGCACG
CTGTTCGAGGAGATGGGCTTCTATTATGTGGGCCCCATCGACGGCCACAATCTGGAGCACCTGCTGCCGGTGCTGAAGAA
TGTGCGCGATGCCAAGACCGGCCCCATCCTGGTCCATGTGGTGACGCAGAAGGGCAAGGGCTATCCGCCCGCCGAAGCCT
CGGCCGACAAGTATCATGGCGTCGTGAAGTTCGACGTGGTGACGGGCGCGCAGGTGAAGGCCAAGTCCAACGCCCCCAGC
TACACCCGCGTCTTCGCCGAGACGCTGATCGATGAAGCCCGCCGCGACGACAAGGTGGTGGCCATCACTGCCGCCATGCC
CTCGGGCACCGGGCTCGACCTGTTCGGACAGGCCTTCCCCCAGCGGACCTTCGACGTAGGGATTGCCGAGCAGCATGCCG
TGACCTTCGCCGCAGGCCTTGCGGCGGAAGGCTACCGGCCGTTTTGCGCGCTTTATTCCACCTTCCTTCAGCGCGGCTAT
GATCAGGTGGTGCACGACGTGGCCCTTCAGGGCCTGCCGGTGCGCTTCGCCATCGATCGCGCCGGCCTTGTGGGCGCGGA
TGGCGCGACCCACGCGGGTGCCTTCGATCTCGCCATGCTTACCTGCCTGCCGGGCTTCACGGTGATGGCCCCCGCCGACG
AGGCGGAACTCACGCACATGATCGCCACGGCCGTGGGGCATGACGCCGGCCCCATCGCCTTCCGCTTCCCGCGCGGGGAA
GGGGTGGGCGTGGAGCGGCCGGAGAAGGGCGAGCGCCTGCCCATCGGCAAGGGCCGCGTGGTGCGCGAGGGGCAGGATAT
CGCCTTCCTGTCGCTGGGCACCCGGCTTGCCGCCTGCCTCGATGTGGCCGAGCGCCTCTCCAGCCTCGGCATTTCGGCGA
CCGTCGCGGATGCGCGCTTCGCCAAGCCCATCGACCGGGAACTGATCGCGCACCTTGCCCGCACCCATGCGGCACTTGTG
GTGGTGGAGGAGGGCTCCGTCGGCGGCTTCGGCAGCCAGGTGCTCCAGTTCCTCAGCGATGAGGGGCTCATGGACGGCGG
CCTGAAGGTGCGTGCGCTGACCCTGCCGGACACCTATATCGACCACGATACGCCTGCCGCCCAGCTGGCGGAGGCGGGGC
TTGATGCCGATGGCATCTACAAGCGCGCGCTGGCGCTGGTTCAGCCCGCGGAGCGCCGGGGGGCGGTCGCAACAAAACGC
GCCTGA

Upstream 100 bases:

>100_bases
CGCCCGGCGGCGGGTCACAAGGCGGTGCTTGCGCGTTGCGTTGCGGGGGCGGACTGTGTAACCCGTCCTTTCCCGGTGAG
AGGCCGGAGCGGAGTGTGCG

Downstream 100 bases:

>100_bases
AGCCGGCAGGCAACAGGCGCGCAAGGTGCTCCCACTTGAATGAACGCGGCCCGGAGGTCAGCCGGCCGCGTCGGGATTTC
AGCCTTTGCAGGCGGTCTCG

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 641; Mature: 640

Protein sequence:

>641_residues
MTVTKTPLLDTVRDASDVRRLPEEKLSQLADELRAETISAVSVTGGHLGAGLGVVELTVALHHVFNTPHDRLIWDVGHQC
YPHKILTGRRDRIRTLRQGGGLSGFTRRSESEYDPFGAAHSSTSISAGLGMAVARDLSGGDRNVIAVIGDGAMSAGMAYE
AMNNAGAMDSRLIVILNDNDMSIAPPTGAMSAYLARLISGRTYLSLREIGKQLAGHLPKFVKDGAAKAEEFARGFWTGGT
LFEEMGFYYVGPIDGHNLEHLLPVLKNVRDAKTGPILVHVVTQKGKGYPPAEASADKYHGVVKFDVVTGAQVKAKSNAPS
YTRVFAETLIDEARRDDKVVAITAAMPSGTGLDLFGQAFPQRTFDVGIAEQHAVTFAAGLAAEGYRPFCALYSTFLQRGY
DQVVHDVALQGLPVRFAIDRAGLVGADGATHAGAFDLAMLTCLPGFTVMAPADEAELTHMIATAVGHDAGPIAFRFPRGE
GVGVERPEKGERLPIGKGRVVREGQDIAFLSLGTRLAACLDVAERLSSLGISATVADARFAKPIDRELIAHLARTHAALV
VVEEGSVGGFGSQVLQFLSDEGLMDGGLKVRALTLPDTYIDHDTPAAQLAEAGLDADGIYKRALALVQPAERRGAVATKR
A

Sequences:

>Translated_641_residues
MTVTKTPLLDTVRDASDVRRLPEEKLSQLADELRAETISAVSVTGGHLGAGLGVVELTVALHHVFNTPHDRLIWDVGHQC
YPHKILTGRRDRIRTLRQGGGLSGFTRRSESEYDPFGAAHSSTSISAGLGMAVARDLSGGDRNVIAVIGDGAMSAGMAYE
AMNNAGAMDSRLIVILNDNDMSIAPPTGAMSAYLARLISGRTYLSLREIGKQLAGHLPKFVKDGAAKAEEFARGFWTGGT
LFEEMGFYYVGPIDGHNLEHLLPVLKNVRDAKTGPILVHVVTQKGKGYPPAEASADKYHGVVKFDVVTGAQVKAKSNAPS
YTRVFAETLIDEARRDDKVVAITAAMPSGTGLDLFGQAFPQRTFDVGIAEQHAVTFAAGLAAEGYRPFCALYSTFLQRGY
DQVVHDVALQGLPVRFAIDRAGLVGADGATHAGAFDLAMLTCLPGFTVMAPADEAELTHMIATAVGHDAGPIAFRFPRGE
GVGVERPEKGERLPIGKGRVVREGQDIAFLSLGTRLAACLDVAERLSSLGISATVADARFAKPIDRELIAHLARTHAALV
VVEEGSVGGFGSQVLQFLSDEGLMDGGLKVRALTLPDTYIDHDTPAAQLAEAGLDADGIYKRALALVQPAERRGAVATKR
A
>Mature_640_residues
TVTKTPLLDTVRDASDVRRLPEEKLSQLADELRAETISAVSVTGGHLGAGLGVVELTVALHHVFNTPHDRLIWDVGHQCY
PHKILTGRRDRIRTLRQGGGLSGFTRRSESEYDPFGAAHSSTSISAGLGMAVARDLSGGDRNVIAVIGDGAMSAGMAYEA
MNNAGAMDSRLIVILNDNDMSIAPPTGAMSAYLARLISGRTYLSLREIGKQLAGHLPKFVKDGAAKAEEFARGFWTGGTL
FEEMGFYYVGPIDGHNLEHLLPVLKNVRDAKTGPILVHVVTQKGKGYPPAEASADKYHGVVKFDVVTGAQVKAKSNAPSY
TRVFAETLIDEARRDDKVVAITAAMPSGTGLDLFGQAFPQRTFDVGIAEQHAVTFAAGLAAEGYRPFCALYSTFLQRGYD
QVVHDVALQGLPVRFAIDRAGLVGADGATHAGAFDLAMLTCLPGFTVMAPADEAELTHMIATAVGHDAGPIAFRFPRGEG
VGVERPEKGERLPIGKGRVVREGQDIAFLSLGTRLAACLDVAERLSSLGISATVADARFAKPIDRELIAHLARTHAALVV
VEEGSVGGFGSQVLQFLSDEGLMDGGLKVRALTLPDTYIDHDTPAAQLAEAGLDADGIYKRALALVQPAERRGAVATKRA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=660, Percent_Identity=23.4848484848485, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI4507521, Length=660, Percent_Identity=23.4848484848485, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI133778974, Length=371, Percent_Identity=24.2587601078167, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI225637461, Length=419, Percent_Identity=24.582338902148, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI225637459, Length=421, Percent_Identity=24.4655581947743, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI225637463, Length=421, Percent_Identity=24.4655581947743, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI156564403, Length=253, Percent_Identity=26.4822134387352, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI291084858, Length=245, Percent_Identity=25.3061224489796, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1786622, Length=620, Percent_Identity=51.9354838709677, Blast_Score=613, Evalue=1e-177,
Organism=Caenorhabditis elegans, GI17539652, Length=435, Percent_Identity=25.9770114942529, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17538422, Length=311, Percent_Identity=25.08038585209, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI45551847, Length=636, Percent_Identity=24.5283018867925, Blast_Score=102, Evalue=1e-21,
Organism=Drosophila melanogaster, GI45550715, Length=636, Percent_Identity=24.5283018867925, Blast_Score=102, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24645119, Length=507, Percent_Identity=25.2465483234714, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24666278, Length=645, Percent_Identity=25.1162790697674, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21358145, Length=320, Percent_Identity=24.6875, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24650940, Length=320, Percent_Identity=24.6875, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_AZOC5 (A8IBS1)

Other databases:

- EMBL:   AP009384
- RefSeq:   YP_001526027.1
- ProteinModelPortal:   A8IBS1
- SMR:   A8IBS1
- GeneID:   5690373
- GenomeReviews:   AP009384_GR
- KEGG:   azc:AZC_3111
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- ProtClustDB:   PRK05444
- BioCyc:   ACAU438753:AZC_3111-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 68121; Mature: 67990

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTKTPLLDTVRDASDVRRLPEEKLSQLADELRAETISAVSVTGGHLGAGLGVVELTVA
CCCCCCCHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHH
LHHVFNTPHDRLIWDVGHQCYPHKILTGRRDRIRTLRQGGGLSGFTRRSESEYDPFGAAH
HHHHHCCCCHHHHHHCCCCCCCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
SSTSISAGLGMAVARDLSGGDRNVIAVIGDGAMSAGMAYEAMNNAGAMDSRLIVILNDND
CCCCHHHCCCHHHHHCCCCCCCEEEEEEECCCHHCCHHHHHHCCCCCCCCEEEEEECCCC
MSIAPPTGAMSAYLARLISGRTYLSLREIGKQLAGHLPKFVKDGAAKAEEFARGFWTGGT
CEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCH
LFEEMGFYYVGPIDGHNLEHLLPVLKNVRDAKTGPILVHVVTQKGKGYPPAEASADKYHG
HHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCHHHCC
VVKFDVVTGAQVKAKSNAPSYTRVFAETLIDEARRDDKVVAITAAMPSGTGLDLFGQAFP
EEEEEEECCCEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHCC
QRTFDVGIAEQHAVTFAAGLAAEGYRPFCALYSTFLQRGYDQVVHDVALQGLPVRFAIDR
CCHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
AGLVGADGATHAGAFDLAMLTCLPGFTVMAPADEAELTHMIATAVGHDAGPIAFRFPRGE
CCEECCCCCCCCCHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHCCCCCCEEEECCCCC
GVGVERPEKGERLPIGKGRVVREGQDIAFLSLGTRLAACLDVAERLSSLGISATVADARF
CCCCCCCCCCCCCCCCCCCEEECCCCEEEEHHHHHHHHHHHHHHHHHHCCCEEEECHHHH
AKPIDRELIAHLARTHAALVVVEEGSVGGFGSQVLQFLSDEGLMDGGLKVRALTLPDTYI
CCHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCHHC
DHDTPAAQLAEAGLDADGIYKRALALVQPAERRGAVATKRA
CCCCCHHHHHHCCCCHHHHHHHHHHHHCCHHHCCCCCCCCC
>Mature Secondary Structure 
TVTKTPLLDTVRDASDVRRLPEEKLSQLADELRAETISAVSVTGGHLGAGLGVVELTVA
CCCCCCHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHHEEEECCCCCCCCHHHHHHHHH
LHHVFNTPHDRLIWDVGHQCYPHKILTGRRDRIRTLRQGGGLSGFTRRSESEYDPFGAAH
HHHHHCCCCHHHHHHCCCCCCCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
SSTSISAGLGMAVARDLSGGDRNVIAVIGDGAMSAGMAYEAMNNAGAMDSRLIVILNDND
CCCCHHHCCCHHHHHCCCCCCCEEEEEEECCCHHCCHHHHHHCCCCCCCCEEEEEECCCC
MSIAPPTGAMSAYLARLISGRTYLSLREIGKQLAGHLPKFVKDGAAKAEEFARGFWTGGT
CEECCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCH
LFEEMGFYYVGPIDGHNLEHLLPVLKNVRDAKTGPILVHVVTQKGKGYPPAEASADKYHG
HHHHCCCEEECCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCCCHHHCC
VVKFDVVTGAQVKAKSNAPSYTRVFAETLIDEARRDDKVVAITAAMPSGTGLDLFGQAFP
EEEEEEECCCEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHCC
QRTFDVGIAEQHAVTFAAGLAAEGYRPFCALYSTFLQRGYDQVVHDVALQGLPVRFAIDR
CCHHCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
AGLVGADGATHAGAFDLAMLTCLPGFTVMAPADEAELTHMIATAVGHDAGPIAFRFPRGE
CCEECCCCCCCCCHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHCCCCCCEEEECCCCC
GVGVERPEKGERLPIGKGRVVREGQDIAFLSLGTRLAACLDVAERLSSLGISATVADARF
CCCCCCCCCCCCCCCCCCCEEECCCCEEEEHHHHHHHHHHHHHHHHHHCCCEEEECHHHH
AKPIDRELIAHLARTHAALVVVEEGSVGGFGSQVLQFLSDEGLMDGGLKVRALTLPDTYI
CCHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCHHC
DHDTPAAQLAEAGLDADGIYKRALALVQPAERRGAVATKRA
CCCCCHHHHHHCCCCHHHHHHHHHHHHCCHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA