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The map label for this gene is lysR [H]

Identifier: 158424655

GI number: 158424655

Start: 3463834

End: 3464739

Strand: Reverse

Name: lysR [H]

Synonym: AZC_3031

Alternate gene names: 158424655

Gene position: 3464739-3463834 (Counterclockwise)

Preceding gene: 158424660

Following gene: 158424654

Centisome position: 64.52

GC content: 72.52

Gene sequence:

>906_bases
ATGATCGAACTGCGGCACCTGCGCTATCTCCTGGCCGTCGCAGAGGAGGGGCACATGACCCGCGCGGCCGCCCGGCTCGG
CATCCAGCAGCCGCCGCTCAGCCAGCAGATCAAGGCGCTGGAGGGCATGGTCGGGACGCCTCTGTTCCGCCGGCTGCCCC
GGGGCGTGGAGCCCACCGCCGCCGGACTGGTGCTGGTGGAGAAGGCGCGGCTGATCCTCGCCGATGTGGACCGCGCGCTC
GATGCCGCACGCCGCACCGCGCGAGGCGAGGAGGGGCGCCTTGCGCTCGGCTTCACGTCGTCCGCCGCCTTCCACGCCCT
CGTCGCGGCGCTGGTGCGCTCCATGCGCGAGGCGGCGCCCACCCTCTCCCTTTCGCTGGAAGAGGCAAGCACGCTGGAAC
TCATCGCGGCGCTGCGGGACGGGCGTCTCGATGCCGCCTTCGTCCGTGCGCCGGTGGCGCGGCCGGACGGCCTCGTCATC
GCCCATGTGCTGGATGAAGAGATGCTCGTGGCGCTGCCCGACCATCACCGTCTCGCGGCACCCGCCCTCCGCCGTCGGGC
GCTGGAACTCGCCGCATTGGAGGAGGACACCTTCATCCTCTATCGGCGCCCCTCGGGGCCGGGCCTCTATGACAGCATCA
TCGCCGCCTGCCAGCAGGCCGGGTTCAGCCCGCGGGTGGGGCAGGAGGCGCCGCGCCTCGCTTCGACCCTGAGCCTCGTG
GCGGCGGGGCTGGGCCTCTCGATCGTGCCGGCCTCCATGGCGCGGCTGGAGACGAACGGCATCGTCTATCGCCGTCTGGC
GCCGCCGATCCGCCTGTTTGCGCCCCTGAGCCTCGCCTATCGCGACGAGGTGCCCGAAGGCCCGCTCGCCGCCCTGCTCA
GGCTGGTCGAGAGCCATCGCGCATAG

Upstream 100 bases:

>100_bases
GGGCGCCCGCTGTGCTGTGGTTCGTGGTTGGGCTCTAGTCCCGTTTCACGGCGCTGTCTAATATATGGAAGAGGCCTGCA
GCATATTTATAGGATATGGA

Downstream 100 bases:

>100_bases
GCGCCGTCATGAGGCTTGTTCCTGTTTTGTTCTTATGGCATGATTCCCTCATCGCAGTTCGCTGGAGATGAGACCCATGA
ACCTGGTGCGCGTTCCGGAG

Product: transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MIELRHLRYLLAVAEEGHMTRAAARLGIQQPPLSQQIKALEGMVGTPLFRRLPRGVEPTAAGLVLVEKARLILADVDRAL
DAARRTARGEEGRLALGFTSSAAFHALVAALVRSMREAAPTLSLSLEEASTLELIAALRDGRLDAAFVRAPVARPDGLVI
AHVLDEEMLVALPDHHRLAAPALRRRALELAALEEDTFILYRRPSGPGLYDSIIAACQQAGFSPRVGQEAPRLASTLSLV
AAGLGLSIVPASMARLETNGIVYRRLAPPIRLFAPLSLAYRDEVPEGPLAALLRLVESHRA

Sequences:

>Translated_301_residues
MIELRHLRYLLAVAEEGHMTRAAARLGIQQPPLSQQIKALEGMVGTPLFRRLPRGVEPTAAGLVLVEKARLILADVDRAL
DAARRTARGEEGRLALGFTSSAAFHALVAALVRSMREAAPTLSLSLEEASTLELIAALRDGRLDAAFVRAPVARPDGLVI
AHVLDEEMLVALPDHHRLAAPALRRRALELAALEEDTFILYRRPSGPGLYDSIIAACQQAGFSPRVGQEAPRLASTLSLV
AAGLGLSIVPASMARLETNGIVYRRLAPPIRLFAPLSLAYRDEVPEGPLAALLRLVESHRA
>Mature_301_residues
MIELRHLRYLLAVAEEGHMTRAAARLGIQQPPLSQQIKALEGMVGTPLFRRLPRGVEPTAAGLVLVEKARLILADVDRAL
DAARRTARGEEGRLALGFTSSAAFHALVAALVRSMREAAPTLSLSLEEASTLELIAALRDGRLDAAFVRAPVARPDGLVI
AHVLDEEMLVALPDHHRLAAPALRRRALELAALEEDTFILYRRPSGPGLYDSIIAACQQAGFSPRVGQEAPRLASTLSLV
AAGLGLSIVPASMARLETNGIVYRRLAPPIRLFAPLSLAYRDEVPEGPLAALLRLVESHRA

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=262, Percent_Identity=41.6030534351145, Blast_Score=171, Evalue=6e-44,
Organism=Escherichia coli, GI2367136, Length=281, Percent_Identity=34.1637010676157, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1788887, Length=271, Percent_Identity=33.210332103321, Blast_Score=120, Evalue=8e-29,
Organism=Escherichia coli, GI1790399, Length=264, Percent_Identity=30.6818181818182, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI157672245, Length=266, Percent_Identity=30.4511278195489, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI1788297, Length=278, Percent_Identity=29.4964028776978, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790262, Length=267, Percent_Identity=26.9662921348315, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1789506, Length=252, Percent_Identity=23.8095238095238, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788748, Length=268, Percent_Identity=26.1194029850746, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787601, Length=258, Percent_Identity=24.031007751938, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1787806, Length=256, Percent_Identity=27.34375, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789204, Length=268, Percent_Identity=25.7462686567164, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI87081684, Length=256, Percent_Identity=25, Blast_Score=62, Evalue=3e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32425; Mature: 32425

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELRHLRYLLAVAEEGHMTRAAARLGIQQPPLSQQIKALEGMVGTPLFRRLPRGVEPTA
CCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHCCCCCCCHH
AGLVLVEKARLILADVDRALDAARRTARGEEGRLALGFTSSAAFHALVAALVRSMREAAP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCC
TLSLSLEEASTLELIAALRDGRLDAAFVRAPVARPDGLVIAHVLDEEMLVALPDHHRLAA
CEEEEHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCEEEEEECCCCCEEECCCCCHHHH
PALRRRALELAALEEDTFILYRRPSGPGLYDSIIAACQQAGFSPRVGQEAPRLASTLSLV
HHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
AAGLGLSIVPASMARLETNGIVYRRLAPPIRLFAPLSLAYRDEVPEGPLAALLRLVESHR
HHHCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
A
C
>Mature Secondary Structure
MIELRHLRYLLAVAEEGHMTRAAARLGIQQPPLSQQIKALEGMVGTPLFRRLPRGVEPTA
CCCHHHHHHHHHHHCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHCCCCCCCHH
AGLVLVEKARLILADVDRALDAARRTARGEEGRLALGFTSSAAFHALVAALVRSMREAAP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHCC
TLSLSLEEASTLELIAALRDGRLDAAFVRAPVARPDGLVIAHVLDEEMLVALPDHHRLAA
CEEEEHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCEEEEEECCCCCEEECCCCCHHHH
PALRRRALELAALEEDTFILYRRPSGPGLYDSIIAACQQAGFSPRVGQEAPRLASTLSLV
HHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
AAGLGLSIVPASMARLETNGIVYRRLAPPIRLFAPLSLAYRDEVPEGPLAALLRLVESHR
HHHCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]