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The map label for this gene is pyrC [H]

Identifier: 158424474

GI number: 158424474

Start: 3243999

End: 3245294

Strand: Reverse

Name: pyrC [H]

Synonym: AZC_2850

Alternate gene names: 158424474

Gene position: 3245294-3243999 (Counterclockwise)

Preceding gene: 158424475

Following gene: 158424473

Centisome position: 60.44

GC content: 70.29

Gene sequence:

>1296_bases
GTGACTGAGCCGCATCCGCTTCTTCTCGCCAACGCCCGCGTCATCGATCCCTCGCGCGGCGCCGATTTCCGCGGCGACGT
GTTGCTCGCCAGCGGCGTCATCAAGGACGCCGCCTTCGGCATCGCCGCCGCCGGCGTGCCGGATGGCGCCGAGGTCGTGG
ACTGCAAGGGCGCTGTGGTCGCGCCCGGCCTCGTGGACATGCGTGCCTTCATCGGCGAGCCCGGTGCCGAGCATCGCGAG
ACGCTGGCCTCCGCCAGCCACGCGGCGGCAGCGGGCGGCGTGACCACCATCGTCTGCCAGCCGGACACCGATCCGGTGGT
GGACGATCCGGCGATCGTGGACTTCATCCTGCGCCGCGCCCGCGATACAGCCGTGGTGCGCATCCACCCCATGGCGGCCC
TCACCAAGGGCCTCAAGGGCGAGGAGATGACCGAGATCGGCCTGCTGCAGGCCGCCGGCGCCGTCGCCTTCACCGATGGC
GCGCGCTCCATTGCGTCCGCGCAGGGGCTGCGCCGCATGCTCACCTATGCGCGCGACTTCGACGCCCTCATTGTCCACCA
CACCGAGGACGCCACCATGTCGGGCGGCGCCATGAACGAGGGGCTGTTCGCCTCCCGTCTCGGCCTGCCGGGCATTCCGA
AGGCGGCGGAGACCATCGTCCTGGAGCGCGACCTGCGCCTCGTGGATGGGGTGCGGGGGCGCTATCACGCCGCCTCCATC
ACCTGCCGCGAATCGCTGGAGGTTCTGGCGCGGGCGAAGGAGGCGGGTCTCGCCGTCACCGGCTCGGTGTCCATCAACCA
CCTCTCCTTCAACGAACTGGACGTCGGCCAGTACCGCACCTTCTTCAAGGTGTCGCCGCCGCTCCGGGCGGAGGACGACC
GGGTGGCGCTCATCCAGGCGCTGTCCTCCGGCCTCATCGACGTGGTGGTGTCCGACCACAATCCGCAGGACGTGGAGATG
AAGCGCCTGCCGTTCTCGGAGGCCGAGCCCGGCGCCATCGGTCTCGAAACCCTGCTGAGCGCCGCCCTGCGGCTGGTGCA
TGCGGGCGATGTGGACCTCGTGAACGTGCTGCGCGCGCTCTCCACCCGGCCGGCGGAATTGCTCGGCCTGAAGGGCGGCA
CGCTGAAGGCAGGCAGCCCGGCGGACGTGATCGTGCTCGATCCGGAGATGCCCTGGGTGCTCGATCCGGCGAACCTCAAG
TCGCGCTCGCGCAACACGCCGTTCGACGGCGCGCGGCTTCAGGGGCGGGTGCTGCGCACCATCGTTGCCGGCCGCACGGT
GTACGAATACGTTTGA

Upstream 100 bases:

>100_bases
CAGTCGCTGATCCGCGAGCAGGTGGAAATGGGCGTCGCCGTGCGCATGGCGGTGCTGGACGCTCTGGCGCGCAAGCTGCC
CAACGCGACGGGAGCCGAAC

Downstream 100 bases:

>100_bases
CCTCGCGGCGGCGGGCGGTCTCGAGCCGGCCCGCCGCCCCGACATGATCGGGACCTGAATGCCAGCCTCCGTGCCGTTCC
TCGCCGAAATCCCGCTGACG

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MTEPHPLLLANARVIDPSRGADFRGDVLLASGVIKDAAFGIAAAGVPDGAEVVDCKGAVVAPGLVDMRAFIGEPGAEHRE
TLASASHAAAAGGVTTIVCQPDTDPVVDDPAIVDFILRRARDTAVVRIHPMAALTKGLKGEEMTEIGLLQAAGAVAFTDG
ARSIASAQGLRRMLTYARDFDALIVHHTEDATMSGGAMNEGLFASRLGLPGIPKAAETIVLERDLRLVDGVRGRYHAASI
TCRESLEVLARAKEAGLAVTGSVSINHLSFNELDVGQYRTFFKVSPPLRAEDDRVALIQALSSGLIDVVVSDHNPQDVEM
KRLPFSEAEPGAIGLETLLSAALRLVHAGDVDLVNVLRALSTRPAELLGLKGGTLKAGSPADVIVLDPEMPWVLDPANLK
SRSRNTPFDGARLQGRVLRTIVAGRTVYEYV

Sequences:

>Translated_431_residues
MTEPHPLLLANARVIDPSRGADFRGDVLLASGVIKDAAFGIAAAGVPDGAEVVDCKGAVVAPGLVDMRAFIGEPGAEHRE
TLASASHAAAAGGVTTIVCQPDTDPVVDDPAIVDFILRRARDTAVVRIHPMAALTKGLKGEEMTEIGLLQAAGAVAFTDG
ARSIASAQGLRRMLTYARDFDALIVHHTEDATMSGGAMNEGLFASRLGLPGIPKAAETIVLERDLRLVDGVRGRYHAASI
TCRESLEVLARAKEAGLAVTGSVSINHLSFNELDVGQYRTFFKVSPPLRAEDDRVALIQALSSGLIDVVVSDHNPQDVEM
KRLPFSEAEPGAIGLETLLSAALRLVHAGDVDLVNVLRALSTRPAELLGLKGGTLKAGSPADVIVLDPEMPWVLDPANLK
SRSRNTPFDGARLQGRVLRTIVAGRTVYEYV
>Mature_430_residues
TEPHPLLLANARVIDPSRGADFRGDVLLASGVIKDAAFGIAAAGVPDGAEVVDCKGAVVAPGLVDMRAFIGEPGAEHRET
LASASHAAAAGGVTTIVCQPDTDPVVDDPAIVDFILRRARDTAVVRIHPMAALTKGLKGEEMTEIGLLQAAGAVAFTDGA
RSIASAQGLRRMLTYARDFDALIVHHTEDATMSGGAMNEGLFASRLGLPGIPKAAETIVLERDLRLVDGVRGRYHAASIT
CRESLEVLARAKEAGLAVTGSVSINHLSFNELDVGQYRTFFKVSPPLRAEDDRVALIQALSSGLIDVVVSDHNPQDVEMK
RLPFSEAEPGAIGLETLLSAALRLVHAGDVDLVNVLRALSTRPAELLGLKGGTLKAGSPADVIVLDPEMPWVLDPANLKS
RSRNTPFDGARLQGRVLRTIVAGRTVYEYV

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=388, Percent_Identity=27.319587628866, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI19923821, Length=454, Percent_Identity=23.568281938326, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1786722, Length=413, Percent_Identity=26.3922518159806, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI87082175, Length=464, Percent_Identity=23.9224137931034, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI86575075, Length=444, Percent_Identity=24.7747747747748, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6322218, Length=397, Percent_Identity=24.9370277078086, Blast_Score=100, Evalue=6e-22,
Organism=Drosophila melanogaster, GI24642586, Length=394, Percent_Identity=25.6345177664975, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI18859883, Length=420, Percent_Identity=25.7142857142857, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004722
- InterPro:   IPR002195
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 45498; Mature: 45366

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPHPLLLANARVIDPSRGADFRGDVLLASGVIKDAAFGIAAAGVPDGAEVVDCKGAVV
CCCCCCEEEECCEEECCCCCCCCCCCEEEECCHHHHHHHCEEECCCCCCCCEEECCCCEE
APGLVDMRAFIGEPGAEHRETLASASHAAAAGGVTTIVCQPDTDPVVDDPAIVDFILRRA
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHC
RDTAVVRIHPMAALTKGLKGEEMTEIGLLQAAGAVAFTDGARSIASAQGLRRMLTYARDF
CCCEEEEEECHHHHHCCCCCCCHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHCCC
DALIVHHTEDATMSGGAMNEGLFASRLGLPGIPKAAETIVLERDLRLVDGVRGRYHAASI
CEEEEEECCCCCCCCCCCCCCCHHHHCCCCCCCHHHHEEEECCCHHHHHCCCCCEEEEEE
TCRESLEVLARAKEAGLAVTGSVSINHLSFNELDVGQYRTFFKVSPPLRAEDDRVALIQA
EHHHHHHHHHHHHHCCEEEECCEEEEEEECCCCCCCCCEEEEEECCCCCCCCCHHHHHHH
LSSGLIDVVVSDHNPQDVEMKRLPFSEAEPGAIGLETLLSAALRLVHAGDVDLVNVLRAL
HHCCCEEEEECCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHH
STRPAELLGLKGGTLKAGSPADVIVLDPEMPWVLDPANLKSRSRNTPFDGARLQGRVLRT
CCCCHHHEECCCCCCCCCCCCCEEEECCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHH
IVAGRTVYEYV
HHHCCHHHHCC
>Mature Secondary Structure 
TEPHPLLLANARVIDPSRGADFRGDVLLASGVIKDAAFGIAAAGVPDGAEVVDCKGAVV
CCCCCEEEECCEEECCCCCCCCCCCEEEECCHHHHHHHCEEECCCCCCCCEEECCCCEE
APGLVDMRAFIGEPGAEHRETLASASHAAAAGGVTTIVCQPDTDPVVDDPAIVDFILRRA
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHC
RDTAVVRIHPMAALTKGLKGEEMTEIGLLQAAGAVAFTDGARSIASAQGLRRMLTYARDF
CCCEEEEEECHHHHHCCCCCCCHHHHHHHHHCCCEEECCCHHHHHHHHHHHHHHHHHCCC
DALIVHHTEDATMSGGAMNEGLFASRLGLPGIPKAAETIVLERDLRLVDGVRGRYHAASI
CEEEEEECCCCCCCCCCCCCCCHHHHCCCCCCCHHHHEEEECCCHHHHHCCCCCEEEEEE
TCRESLEVLARAKEAGLAVTGSVSINHLSFNELDVGQYRTFFKVSPPLRAEDDRVALIQA
EHHHHHHHHHHHHHCCEEEECCEEEEEEECCCCCCCCCEEEEEECCCCCCCCCHHHHHHH
LSSGLIDVVVSDHNPQDVEMKRLPFSEAEPGAIGLETLLSAALRLVHAGDVDLVNVLRAL
HHCCCEEEEECCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHH
STRPAELLGLKGGTLKAGSPADVIVLDPEMPWVLDPANLKSRSRNTPFDGARLQGRVLRT
CCCCHHHEECCCCCCCCCCCCCEEEECCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHH
IVAGRTVYEYV
HHHCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA