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The map label for this gene is lysR [H]

Identifier: 158424355

GI number: 158424355

Start: 3101039

End: 3101950

Strand: Reverse

Name: lysR [H]

Synonym: AZC_2731

Alternate gene names: 158424355

Gene position: 3101950-3101039 (Counterclockwise)

Preceding gene: 158424362

Following gene: 158424354

Centisome position: 57.77

GC content: 69.3

Gene sequence:

>912_bases
ATGAACCTGCGCCAGCTGGAGATCTTTCGCGCCGTGATGCGGTGCCAGACCACCATGGGGGCCGCCACTGCCCTCTCCAT
GTCCCAGCCGGCGGTGAGCAATGCCCTGAAGCAGATGGAGAGCCAGATCGGCTTCCTGCTGTTCGACCGCATCAACAACC
GCCTCTTTCCCACCGAGGCGGCGCGCATGATCTACGAGGATTCCGAGCCCCTCTTCGCCATGCATGCCGCGCTGGAAACA
CGGGTGCGCGACCTGCGGGACGACAAGGTGGCGCGCTTGCGCATCCTCTCCACCCCGCCGCTCGGCCATGGGGTGATCGC
GCAGACCCTGGTGCGCTTTGCCGCCGCCAATCCCAAAGTGCGGGTGGGGTTCGACGTGCGCCATCTGGACGAGGTGATCG
AGGGGGTGGAGACGGGCGCGGCCGACCTCGGCTTCGGTCTTGCGCTGGGCGACACGCCGTCGCTGAAGGTGCAGGCGCTG
CATGCGGGCGCCATGGTGTGCGTTTGCCGGGAGGACCATCCGCTGGCGCGGGAAGAGGTGGTGACGCCGGATCTCCTGAG
GGGCCGCAGCTTCGTGGGGCTGGAGGGCGAAACGCGCATGGGCCAGTCCGTCCGCACGGCGTTCGAGACGTCTGGCGTGC
CTTATGAGGCGAGCGTGATGGTGCGCTATTGCGGCACCGCCTGCGTCCTCGCGGCGGCTGGACTCGGGGCGGCGGTGGTG
GACGCCTTCTCCCCGGCGTCATCTGGGCAGGCAGGGCTCGTAGTGCGGCCTTTCGCGCCCCGCGTGCCTTGCGTCGCCTC
CGCCTTCTGGTCGGGTCTGCGGCGTCCACCGGTGGCGGCCGGGCGCTTTCTCGATGCGCTGCGGGTCACGCTGTCCGTGA
CGGTGCCCCATCTGGTGGGGCAGGGTGGCTGA

Upstream 100 bases:

>100_bases
AATTTTCGTCACGTCAGAGCCTCGCACACTCTTTGCGCATTTCAACGTTGTTGATTATAAAAACGCAGCCTTCGCCATTT
GCATTCCGAATAGGTGCGCG

Downstream 100 bases:

>100_bases
GACCTATTCGCGCCGGGAATACAGGGGGCGGCAATTTCATAGCGGTGAGGATTGAACACGTCGCGCATCGGCGCGCGCAT
CTTTCATAATCGAGGCATGA

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MNLRQLEIFRAVMRCQTTMGAATALSMSQPAVSNALKQMESQIGFLLFDRINNRLFPTEAARMIYEDSEPLFAMHAALET
RVRDLRDDKVARLRILSTPPLGHGVIAQTLVRFAAANPKVRVGFDVRHLDEVIEGVETGAADLGFGLALGDTPSLKVQAL
HAGAMVCVCREDHPLAREEVVTPDLLRGRSFVGLEGETRMGQSVRTAFETSGVPYEASVMVRYCGTACVLAAAGLGAAVV
DAFSPASSGQAGLVVRPFAPRVPCVASAFWSGLRRPPVAAGRFLDALRVTLSVTVPHLVGQGG

Sequences:

>Translated_303_residues
MNLRQLEIFRAVMRCQTTMGAATALSMSQPAVSNALKQMESQIGFLLFDRINNRLFPTEAARMIYEDSEPLFAMHAALET
RVRDLRDDKVARLRILSTPPLGHGVIAQTLVRFAAANPKVRVGFDVRHLDEVIEGVETGAADLGFGLALGDTPSLKVQAL
HAGAMVCVCREDHPLAREEVVTPDLLRGRSFVGLEGETRMGQSVRTAFETSGVPYEASVMVRYCGTACVLAAAGLGAAVV
DAFSPASSGQAGLVVRPFAPRVPCVASAFWSGLRRPPVAAGRFLDALRVTLSVTVPHLVGQGG
>Mature_303_residues
MNLRQLEIFRAVMRCQTTMGAATALSMSQPAVSNALKQMESQIGFLLFDRINNRLFPTEAARMIYEDSEPLFAMHAALET
RVRDLRDDKVARLRILSTPPLGHGVIAQTLVRFAAANPKVRVGFDVRHLDEVIEGVETGAADLGFGLALGDTPSLKVQAL
HAGAMVCVCREDHPLAREEVVTPDLLRGRSFVGLEGETRMGQSVRTAFETSGVPYEASVMVRYCGTACVLAAAGLGAAVV
DAFSPASSGQAGLVVRPFAPRVPCVASAFWSGLRRPPVAAGRFLDALRVTLSVTVPHLVGQGG

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=279, Percent_Identity=29.3906810035842, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788481, Length=145, Percent_Identity=31.0344827586207, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI145693105, Length=240, Percent_Identity=21.25, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI157672245, Length=210, Percent_Identity=25.2380952380952, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788748, Length=264, Percent_Identity=21.969696969697, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32412; Mature: 32412

Theoretical pI: Translated: 8.14; Mature: 8.14

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLRQLEIFRAVMRCQTTMGAATALSMSQPAVSNALKQMESQIGFLLFDRINNRLFPTEA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
ARMIYEDSEPLFAMHAALETRVRDLRDDKVARLRILSTPPLGHGVIAQTLVRFAAANPKV
HHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCE
RVGFDVRHLDEVIEGVETGAADLGFGLALGDTPSLKVQALHAGAMVCVCREDHPLAREEV
EECCCHHHHHHHHHHHHCCCHHHCCEEEECCCCCCEEEEEECCEEEEEECCCCCCCHHHC
VTPDLLRGRSFVGLEGETRMGQSVRTAFETSGVPYEASVMVRYCGTACVLAAAGLGAAVV
CCHHHHCCCCEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHH
DAFSPASSGQAGLVVRPFAPRVPCVASAFWSGLRRPPVAAGRFLDALRVTLSVTVPHLVG
HHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEEHHHHHC
QGG
CCC
>Mature Secondary Structure
MNLRQLEIFRAVMRCQTTMGAATALSMSQPAVSNALKQMESQIGFLLFDRINNRLFPTEA
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
ARMIYEDSEPLFAMHAALETRVRDLRDDKVARLRILSTPPLGHGVIAQTLVRFAAANPKV
HHHHHCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCE
RVGFDVRHLDEVIEGVETGAADLGFGLALGDTPSLKVQALHAGAMVCVCREDHPLAREEV
EECCCHHHHHHHHHHHHCCCHHHCCEEEECCCCCCEEEEEECCEEEEEECCCCCCCHHHC
VTPDLLRGRSFVGLEGETRMGQSVRTAFETSGVPYEASVMVRYCGTACVLAAAGLGAAVV
CCHHHHCCCCEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHH
DAFSPASSGQAGLVVRPFAPRVPCVASAFWSGLRRPPVAAGRFLDALRVTLSVTVPHLVG
HHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEEHHHHHC
QGG
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]