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The map label for this gene is ygeZ [C]

Identifier: 158424298

GI number: 158424298

Start: 3033339

End: 3034904

Strand: Direct

Name: ygeZ [C]

Synonym: AZC_2674

Alternate gene names: 158424298

Gene position: 3033339-3034904 (Clockwise)

Preceding gene: 158424297

Following gene: 158424299

Centisome position: 56.49

GC content: 66.09

Gene sequence:

>1566_bases
ATGCGGGGCGCTTCGGAAACGGAGCGCCCCGCAGTCTGTGGCAGTCTTCTTTGGGCGGTCCGCCGCTGCGCGGCGAGGGA
TGCATTTTGCGCACGAAGTGTATACGGTCTGGTTCTCCTAGACCGAAGACACAGCGCCATGGCTCTCTACGATACCATCA
TTTCCGGCGGCACCGTCGTCACCGCCTCGGACCGCATTCTCTGCGACGTCGCCATCAAGGACGGCAAGATCGTCGCCCTC
GGCTCCGGCCTCACCGGCGCGGATGAGGTGATCGACGCGACCGGCAAGCTCGTGCTGCCCGGCGGCGTCGACGCCCATGT
CCACATCGCCCAGCCCTCCGGCGAGGGCATCGTGATGGCGGATGACTTCGAAAGCGGCACCCGCTCGGCGGCCCTCGGCG
GCACCACCACGGTGATGCCCTTCTGCCTCCAGGAGAAGGGCCAGGGCCTGCGCGCCGCGTTGAAGGATTACCACGCCAAG
GCCGATGGCGAATGCCATGTGGACGTGAGCTTCCACCTCATCATTTCCGACCCCACCGAGCAGGTGCTGGGCCAGGAACT
GCCGGCACTGGTGGAGGACGGCTACACCTCCTTCAAGATCTTCATGACCTATGAGGGCCTTGCCCTGAAGGACCGCGAAA
TTCTCGACGTGATGTCGGTGGCTCGCGACACCGGCGCTCTCGTCATGGTCCACGCGGAAAATTACGACGCCATCCGCTTC
CTGACCGAACAGCTGGAGAAGCGCGGCCAGACGGCGCCCCGCTTCCACGCCACCTCCCGCCCCATTGCGGTCGAGCGCGA
GGCGACCCATCGCGCCATCTCGCTCGCAGAGCTGGTGGACGTGCCGGTGATGATCGTCCACGTCTCCAATCGCGAGGCCA
TGGAGCAGATCCGCTGGGCGCAGAACAAGGGCCTCACCGTGCTCGGCGAGACTTGCACGCAGTATCTGGTGCTCACCGAG
AAGGATCTCGACGGCCTCGGGATGGAAGGCGCGAAATACGTCTGCTCGCCGCCGCCGCGCGACACCGAGAGCCAGGAGGC
CTGCTGGGAAGGCCTGCGCACGGGCGTGTTCACCATCTTCTCCTCCGACCATTGCCCGTTCCGCTATGACGACCCGCAGG
GCAAGCTCACGCCCAAGGGCCGCACCTCCTTCCGCTGGGTGCCGAATGGCATTCCCGGCGTCGGCGCCCGCCTGCCGGTT
CTGTTCTCGGAAGGCGTGATGAAGGGGCGGATCGATCTGGAGCGCTTCGTCGCCGTCACCGCCACCAATCCGGCGAAGAC
CTATGGCCTCTACCCCCGCAAAGGCACCATTGCGGTGGGTGCCGACGCGGACATCGCCATCTGGGACCCGACGAAGACGC
AGACGCTGACCCACGATCTCATCCGCGACGGCGCCGATTACACGCCTTACGAGGGCATCGAGATCACCGGCTGGCCTGTG
CACACGCTGCTGCGCGGCAAGACGGTGGCGCGCGACGGAGAAGTGGTGGGGCAGAAGGGACTCGGCCAGCACCTTTCGCG
TGCCAAGTCGCCCTTCGCGGTCCAGCGCGATCCCGTAGCCTCGTGA

Upstream 100 bases:

>100_bases
CCCACGGAGCGTCCGGCGGTCGAAAGCACCGGCGCCGTTGCGGAACTGCCCCAGACCGTCTGATCGACGACCGGTTTCCT
TCCTCCCTTCCTGCCGCGGG

Downstream 100 bases:

>100_bases
CGCAGGAACGCTTGGCATGAGCGACACCGGCACAGACGAGGTTCAGGGCCGCGAGGGCGGGCGGATTGGCGGGATCAACC
TCTCGAATCTCGCCTATAAC

Product: phenylhydantoinase

Products: 3-ureidopropanoate

Alternate protein names: NA

Number of amino acids: Translated: 521; Mature: 521

Protein sequence:

>521_residues
MRGASETERPAVCGSLLWAVRRCAARDAFCARSVYGLVLLDRRHSAMALYDTIISGGTVVTASDRILCDVAIKDGKIVAL
GSGLTGADEVIDATGKLVLPGGVDAHVHIAQPSGEGIVMADDFESGTRSAALGGTTTVMPFCLQEKGQGLRAALKDYHAK
ADGECHVDVSFHLIISDPTEQVLGQELPALVEDGYTSFKIFMTYEGLALKDREILDVMSVARDTGALVMVHAENYDAIRF
LTEQLEKRGQTAPRFHATSRPIAVEREATHRAISLAELVDVPVMIVHVSNREAMEQIRWAQNKGLTVLGETCTQYLVLTE
KDLDGLGMEGAKYVCSPPPRDTESQEACWEGLRTGVFTIFSSDHCPFRYDDPQGKLTPKGRTSFRWVPNGIPGVGARLPV
LFSEGVMKGRIDLERFVAVTATNPAKTYGLYPRKGTIAVGADADIAIWDPTKTQTLTHDLIRDGADYTPYEGIEITGWPV
HTLLRGKTVARDGEVVGQKGLGQHLSRAKSPFAVQRDPVAS

Sequences:

>Translated_521_residues
MRGASETERPAVCGSLLWAVRRCAARDAFCARSVYGLVLLDRRHSAMALYDTIISGGTVVTASDRILCDVAIKDGKIVAL
GSGLTGADEVIDATGKLVLPGGVDAHVHIAQPSGEGIVMADDFESGTRSAALGGTTTVMPFCLQEKGQGLRAALKDYHAK
ADGECHVDVSFHLIISDPTEQVLGQELPALVEDGYTSFKIFMTYEGLALKDREILDVMSVARDTGALVMVHAENYDAIRF
LTEQLEKRGQTAPRFHATSRPIAVEREATHRAISLAELVDVPVMIVHVSNREAMEQIRWAQNKGLTVLGETCTQYLVLTE
KDLDGLGMEGAKYVCSPPPRDTESQEACWEGLRTGVFTIFSSDHCPFRYDDPQGKLTPKGRTSFRWVPNGIPGVGARLPV
LFSEGVMKGRIDLERFVAVTATNPAKTYGLYPRKGTIAVGADADIAIWDPTKTQTLTHDLIRDGADYTPYEGIEITGWPV
HTLLRGKTVARDGEVVGQKGLGQHLSRAKSPFAVQRDPVAS
>Mature_521_residues
MRGASETERPAVCGSLLWAVRRCAARDAFCARSVYGLVLLDRRHSAMALYDTIISGGTVVTASDRILCDVAIKDGKIVAL
GSGLTGADEVIDATGKLVLPGGVDAHVHIAQPSGEGIVMADDFESGTRSAALGGTTTVMPFCLQEKGQGLRAALKDYHAK
ADGECHVDVSFHLIISDPTEQVLGQELPALVEDGYTSFKIFMTYEGLALKDREILDVMSVARDTGALVMVHAENYDAIRF
LTEQLEKRGQTAPRFHATSRPIAVEREATHRAISLAELVDVPVMIVHVSNREAMEQIRWAQNKGLTVLGETCTQYLVLTE
KDLDGLGMEGAKYVCSPPPRDTESQEACWEGLRTGVFTIFSSDHCPFRYDDPQGKLTPKGRTSFRWVPNGIPGVGARLPV
LFSEGVMKGRIDLERFVAVTATNPAKTYGLYPRKGTIAVGADADIAIWDPTKTQTLTHDLIRDGADYTPYEGIEITGWPV
HTLLRGKTVARDGEVVGQKGLGQHLSRAKSPFAVQRDPVAS

Specific function: Catalyzes the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin. Has no activity on dihydropyrimidines [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Hydantoinase/dihydropyrimidinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503051, Length=470, Percent_Identity=34.8936170212766, Blast_Score=274, Evalue=2e-73,
Organism=Homo sapiens, GI62422571, Length=470, Percent_Identity=34.8936170212766, Blast_Score=272, Evalue=5e-73,
Organism=Homo sapiens, GI4503375, Length=476, Percent_Identity=37.6050420168067, Blast_Score=265, Evalue=8e-71,
Organism=Homo sapiens, GI4503377, Length=476, Percent_Identity=35.0840336134454, Blast_Score=262, Evalue=7e-70,
Organism=Homo sapiens, GI19923821, Length=476, Percent_Identity=35.5042016806723, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI190194363, Length=476, Percent_Identity=33.6134453781513, Blast_Score=249, Evalue=6e-66,
Organism=Homo sapiens, GI4503379, Length=472, Percent_Identity=33.0508474576271, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI18105007, Length=418, Percent_Identity=26.3157894736842, Blast_Score=98, Evalue=1e-20,
Organism=Escherichia coli, GI87082175, Length=464, Percent_Identity=40.301724137931, Blast_Score=313, Evalue=2e-86,
Organism=Escherichia coli, GI1786722, Length=456, Percent_Identity=33.5526315789474, Blast_Score=200, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17539558, Length=462, Percent_Identity=35.7142857142857, Blast_Score=253, Evalue=2e-67,
Organism=Caenorhabditis elegans, GI71989490, Length=472, Percent_Identity=36.0169491525424, Blast_Score=245, Evalue=4e-65,
Organism=Caenorhabditis elegans, GI86575075, Length=449, Percent_Identity=28.5077951002227, Blast_Score=166, Evalue=3e-41,
Organism=Caenorhabditis elegans, GI193204318, Length=410, Percent_Identity=22.9268292682927, Blast_Score=90, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6322218, Length=424, Percent_Identity=29.9528301886792, Blast_Score=143, Evalue=6e-35,
Organism=Drosophila melanogaster, GI221377917, Length=480, Percent_Identity=35.4166666666667, Blast_Score=261, Evalue=8e-70,
Organism=Drosophila melanogaster, GI17137462, Length=478, Percent_Identity=34.1004184100418, Blast_Score=252, Evalue=4e-67,
Organism=Drosophila melanogaster, GI24644287, Length=296, Percent_Identity=36.1486486486487, Blast_Score=158, Evalue=9e-39,
Organism=Drosophila melanogaster, GI24644289, Length=242, Percent_Identity=37.1900826446281, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24642586, Length=421, Percent_Identity=27.0783847980998, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI18859883, Length=454, Percent_Identity=26.431718061674, Blast_Score=96, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR011778
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: 3.5.2.2

Molecular weight: Translated: 56463; Mature: 56463

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGASETERPAVCGSLLWAVRRCAARDAFCARSVYGLVLLDRRHSAMALYDTIISGGTVV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHCCCEEE
TASDRILCDVAIKDGKIVALGSGLTGADEVIDATGKLVLPGGVDAHVHIAQPSGEGIVMA
EECCEEEEEEEECCCEEEEEECCCCCHHHHHHCCCCEEECCCCCEEEEEECCCCCEEEEE
DDFESGTRSAALGGTTTVMPFCLQEKGQGLRAALKDYHAKADGECHVDVSFHLIISDPTE
CCCCCCCCCEECCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEEEEEEEECCCHH
QVLGQELPALVEDGYTSFKIFMTYEGLALKDREILDVMSVARDTGALVMVHAENYDAIRF
HHHHHHCCHHHHCCCCEEEEEEEECCCEECCHHHHHHHHHHCCCCCEEEEECCCCHHHHH
LTEQLEKRGQTAPRFHATSRPIAVEREATHRAISLAELVDVPVMIVHVSNREAMEQIRWA
HHHHHHHCCCCCCCEECCCCCEEEECHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHH
QNKGLTVLGETCTQYLVLTEKDLDGLGMEGAKYVCSPPPRDTESQEACWEGLRTGVFTIF
HCCCCEEEECCCCEEEEEEECCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHCCEEEEE
SSDHCPFRYDDPQGKLTPKGRTSFRWVPNGIPGVGARLPVLFSEGVMKGRIDLERFVAVT
ECCCCCCEECCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEECCCCCCCCCCEEEEEEEE
ATNPAKTYGLYPRKGTIAVGADADIAIWDPTKTQTLTHDLIRDGADYTPYEGIEITGWPV
ECCCHHHCCCCCCCCCEEECCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEECCHH
HTLLRGKTVARDGEVVGQKGLGQHLSRAKSPFAVQRDPVAS
HHHHCCCEECCCCCHHCCCHHHHHHHHCCCCCEECCCCCCC
>Mature Secondary Structure
MRGASETERPAVCGSLLWAVRRCAARDAFCARSVYGLVLLDRRHSAMALYDTIISGGTVV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEECCCCHHHHHHHHHCCCEEE
TASDRILCDVAIKDGKIVALGSGLTGADEVIDATGKLVLPGGVDAHVHIAQPSGEGIVMA
EECCEEEEEEEECCCEEEEEECCCCCHHHHHHCCCCEEECCCCCEEEEEECCCCCEEEEE
DDFESGTRSAALGGTTTVMPFCLQEKGQGLRAALKDYHAKADGECHVDVSFHLIISDPTE
CCCCCCCCCEECCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCEEEEEEEEEEEECCCHH
QVLGQELPALVEDGYTSFKIFMTYEGLALKDREILDVMSVARDTGALVMVHAENYDAIRF
HHHHHHCCHHHHCCCCEEEEEEEECCCEECCHHHHHHHHHHCCCCCEEEEECCCCHHHHH
LTEQLEKRGQTAPRFHATSRPIAVEREATHRAISLAELVDVPVMIVHVSNREAMEQIRWA
HHHHHHHCCCCCCCEECCCCCEEEECHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHH
QNKGLTVLGETCTQYLVLTEKDLDGLGMEGAKYVCSPPPRDTESQEACWEGLRTGVFTIF
HCCCCEEEECCCCEEEEEEECCCCCCCCCCCCEEECCCCCCCCHHHHHHHHHHCCEEEEE
SSDHCPFRYDDPQGKLTPKGRTSFRWVPNGIPGVGARLPVLFSEGVMKGRIDLERFVAVT
ECCCCCCEECCCCCCCCCCCCCCEEECCCCCCCCCCCCCEEECCCCCCCCCCEEEEEEEE
ATNPAKTYGLYPRKGTIAVGADADIAIWDPTKTQTLTHDLIRDGADYTPYEGIEITGWPV
ECCCHHHCCCCCCCCCEEECCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCEEEECCHH
HTLLRGKTVARDGEVVGQKGLGQHLSRAKSPFAVQRDPVAS
HHHHCCCEECCCCCHHCCCHHHHHHHHCCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 5,6-dihydrouracil; H2O

Specific reaction: 5,6-dihydrouracil + H2O = 3-ureidopropanoate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7765480 [H]