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The map label for this gene is lysR [H]

Identifier: 158424263

GI number: 158424263

Start: 2988999

End: 2989901

Strand: Reverse

Name: lysR [H]

Synonym: AZC_2639

Alternate gene names: 158424263

Gene position: 2989901-2988999 (Counterclockwise)

Preceding gene: 158424264

Following gene: 158424262

Centisome position: 55.68

GC content: 69.44

Gene sequence:

>903_bases
ATGTTCGATCTCAACCAGATCCGCTGCTTTGTCGCGGTGGCGGAGGAACTTCACTTCGGTCGCGCCGCCGAGCGCCTGAA
CATGACGCAGCCGCCCCTGAGCCGTCAGGTACAGATTCTGGAGCGCATCCTCGATGTGGCGCTGTTCGAGCGCACCAGCC
GTTCCGTGCAGCTCACGCCCGCCGGCCGCAGCTTCCTGCCCGAGGCGCGCCATCTGCTGAAGCTCGCCGGCAACGCGGCG
CTGGTCGCCAAGCGCGTGGCCGCCGGCAAGGCCGGCTCCATCCGCATCGGCTTCACTGCAGCCTCGGCCTATTCCTTCCT
GCCTGATCTCGTTGCCGCCTGCCGCACCCAACTGCCGGATGTCGATCTGGCGCTGAAGGAGATGGTGAGCGGCGAACAGC
TTGAGGCGCTGGGGGCGGGCGAGATCGACGCCGCGCTGCTGCGCCCGCCGGTGCCGGCGGCGGGCATGGGCTTCTTCCGC
GTGGCCTCCGAGCAGCTGCTGGCGGCGGTGCCGGAGGCCCATCCGCTGGCCGCGAAGGACACCCTGACGCTCGATGATTT
CATCGAGGTGCCGCTGATCATGTACGATCCCTATCAGGCCCGCTATTTCCACGATCTGGTGGCGGAGCTGTTCTCCGGCG
CCGGCTTCCTGCCGCGCCCCGTGCAGCATCTGACGCAGGTGCATTCCATCCTCGCCCTCGTCCGCTCGGGGCTGGGGCTC
GCGCTTGTGCCGGAGGCGGCGCGGAACCTCCATGCGACAGGCGTGATGCTGCGCCCCGTTGCGGCGCGCGCCCCGCGACC
GGTGGAGCTTTTCCTGGGCTGGCGGCGCGACAATGCCAATCCGCTCCTGCCCATCCTGCGCGACATCGCCCGCGGCCTGC
CGGAGAGTGGCGCGCGGTCGTAA

Upstream 100 bases:

>100_bases
CCGGTCAGGGCCTTGAGATGCCGCGCCGCTGGGCCCGCCAGCCGCGCGGCATCGTCATGTCCTCAGACCGCCAGCGAGAA
CCGGCCGGGACAGGAGCGTC

Downstream 100 bases:

>100_bases
CTGATCCCAAAAACGCATCGATCCATGCCGTATTTGGTCTGACTTGGCATCGATCCGGCAGTACCACTGATGCTGGTTTC
AGCGGCCCGAGACAAGCGCC

Product: transcriptional regulator

Products: NA

Alternate protein names: Als operon regulatory protein [H]

Number of amino acids: Translated: 300; Mature: 300

Protein sequence:

>300_residues
MFDLNQIRCFVAVAEELHFGRAAERLNMTQPPLSRQVQILERILDVALFERTSRSVQLTPAGRSFLPEARHLLKLAGNAA
LVAKRVAAGKAGSIRIGFTAASAYSFLPDLVAACRTQLPDVDLALKEMVSGEQLEALGAGEIDAALLRPPVPAAGMGFFR
VASEQLLAAVPEAHPLAAKDTLTLDDFIEVPLIMYDPYQARYFHDLVAELFSGAGFLPRPVQHLTQVHSILALVRSGLGL
ALVPEAARNLHATGVMLRPVAARAPRPVELFLGWRRDNANPLLPILRDIARGLPESGARS

Sequences:

>Translated_300_residues
MFDLNQIRCFVAVAEELHFGRAAERLNMTQPPLSRQVQILERILDVALFERTSRSVQLTPAGRSFLPEARHLLKLAGNAA
LVAKRVAAGKAGSIRIGFTAASAYSFLPDLVAACRTQLPDVDLALKEMVSGEQLEALGAGEIDAALLRPPVPAAGMGFFR
VASEQLLAAVPEAHPLAAKDTLTLDDFIEVPLIMYDPYQARYFHDLVAELFSGAGFLPRPVQHLTQVHSILALVRSGLGL
ALVPEAARNLHATGVMLRPVAARAPRPVELFLGWRRDNANPLLPILRDIARGLPESGARS
>Mature_300_residues
MFDLNQIRCFVAVAEELHFGRAAERLNMTQPPLSRQVQILERILDVALFERTSRSVQLTPAGRSFLPEARHLLKLAGNAA
LVAKRVAAGKAGSIRIGFTAASAYSFLPDLVAACRTQLPDVDLALKEMVSGEQLEALGAGEIDAALLRPPVPAAGMGFFR
VASEQLLAAVPEAHPLAAKDTLTLDDFIEVPLIMYDPYQARYFHDLVAELFSGAGFLPRPVQHLTQVHSILALVRSGLGL
ALVPEAARNLHATGVMLRPVAARAPRPVELFLGWRRDNANPLLPILRDIARGLPESGARS

Specific function: Regulates the expression of the alsSD operon for acetoin biosynthesis [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=274, Percent_Identity=36.1313868613139, Blast_Score=175, Evalue=4e-45,
Organism=Escherichia coli, GI1788887, Length=282, Percent_Identity=32.2695035460993, Blast_Score=151, Evalue=6e-38,
Organism=Escherichia coli, GI2367136, Length=280, Percent_Identity=32.1428571428571, Blast_Score=149, Evalue=3e-37,
Organism=Escherichia coli, GI145693105, Length=258, Percent_Identity=26.3565891472868, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI157672245, Length=247, Percent_Identity=29.9595141700405, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1790399, Length=243, Percent_Identity=26.3374485596708, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87081904, Length=193, Percent_Identity=31.0880829015544, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1790208, Length=250, Percent_Identity=27.6, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1788748, Length=243, Percent_Identity=23.8683127572016, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788297, Length=253, Percent_Identity=28.8537549407115, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1787530, Length=248, Percent_Identity=27.8225806451613, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1787601, Length=284, Percent_Identity=26.4084507042254, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1787806, Length=282, Percent_Identity=25.886524822695, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789204, Length=297, Percent_Identity=26.2626262626263, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1786713, Length=75, Percent_Identity=48, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1790262, Length=245, Percent_Identity=23.6734693877551, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32495; Mature: 32495

Theoretical pI: Translated: 8.26; Mature: 8.26

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDLNQIRCFVAVAEELHFGRAAERLNMTQPPLSRQVQILERILDVALFERTSRSVQLTP
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECC
AGRSFLPEARHLLKLAGNAALVAKRVAAGKAGSIRIGFTAASAYSFLPDLVAACRTQLPD
CCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCC
VDLALKEMVSGEQLEALGAGEIDAALLRPPVPAAGMGFFRVASEQLLAAVPEAHPLAAKD
HHHHHHHHHCCCHHHHCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
TLTLDDFIEVPLIMYDPYQARYFHDLVAELFSGAGFLPRPVQHLTQVHSILALVRSGLGL
CCCHHHHHCCCEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCE
ALVPEAARNLHATGVMLRPVAARAPRPVELFLGWRRDNANPLLPILRDIARGLPESGARS
EECCHHHHHHHHCCCEECHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MFDLNQIRCFVAVAEELHFGRAAERLNMTQPPLSRQVQILERILDVALFERTSRSVQLTP
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECC
AGRSFLPEARHLLKLAGNAALVAKRVAAGKAGSIRIGFTAASAYSFLPDLVAACRTQLPD
CCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCC
VDLALKEMVSGEQLEALGAGEIDAALLRPPVPAAGMGFFRVASEQLLAAVPEAHPLAAKD
HHHHHHHHHCCCHHHHCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCC
TLTLDDFIEVPLIMYDPYQARYFHDLVAELFSGAGFLPRPVQHLTQVHSILALVRSGLGL
CCCHHHHHCCCEEEECCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCE
ALVPEAARNLHATGVMLRPVAARAPRPVELFLGWRRDNANPLLPILRDIARGLPESGARS
EECCHHHHHHHHCCCEECHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7685336; 9353933; 9384377 [H]