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The map label for this gene is degP [H]

Identifier: 158424196

GI number: 158424196

Start: 2896479

End: 2898050

Strand: Direct

Name: degP [H]

Synonym: AZC_2572

Alternate gene names: 158424196

Gene position: 2896479-2898050 (Clockwise)

Preceding gene: 158424195

Following gene: 158424197

Centisome position: 53.94

GC content: 66.48

Gene sequence:

>1572_bases
TTGAAGTCTCATTGCCCTTCTCGGGGGATGGTGCTTCCGTGCCAGTTCGTCATCGAAAGTCCGGGTCCGCGAGGAGATCC
CATGTTCCGTATCGATCGTTTGCGCGCTGCGATGGCCGCCCCTGCGCTGGCGCTTGCCCTGGCCGTATCCGGCCCCGTGC
ATGCCGCTGCCAGCAAGGGGCCGGACACGGTCGCGGATGTCGCTGAGAAGGTGATGGATGCGGTGGTGAACATCTCCACC
TCGCAGAACGTCGCCCCGTCCCGCAGCGTCCCCGCCCCGCAGCTCCCGCCCGGCTCGCCCTTCGAGGATTTCTTCGACGA
GTTCTTCAAGCGCCGGCAACAGCAGGATGACGGCGACCAGGAACAGTCGAACCGCCGCCCCCGCCGCGTCTCGTCCCTCG
GCTCGGGCTTCGTCATCGATCCGACCGGCTACATCGTGACCAACAATCACGTCATCGCCGACGCGGATGAGATCTACGCC
AATTTCAACGACGGCACGAAGCTCAAGGCCGAACTCGTCGGCCGCGACACCAAGACCGACCTCGCCCTGCTGAAGGTGAA
GCCGGAGAAGCCGCTGGTGTCCGTGAAGTTCGGCGACAGCGACAAGATGCGGGTCGGCGACTGGGTGATGGCCATCGGCA
ATCCGTTCGGCCTCGGCGGCACGCTCACGGTGGGCGTCATCTCCGCCCGCAACCGCGACATCAATTCCGGCCCCTACGAC
AACTTCCTGCAGACGGACGCGGCCATCAACCGGGGCAATTCCGGCGGCCCGCTGTTCAACATGGAAGGCGACGTGATCGG
CGTGAACACCGCCATCATCTCCCCCTCGGGCGGCTCCATCGGCATCGGCTTCGCCGTGCCCTCCTCCACCGCCGGCCCGG
TGATCGCCCAGCTCCAGCAGTTCAAGGAAGTGCGGCGCGGCTGGATCGGCGTGCGCATCCAGAACGTCTCCGACGAGATC
GCCGAGAGCCTGGGCATCGGCAAGGCGCGCGGCGCGCTGGTGGGCGGCCTCAATGACGACAACAGCCCGGCGGCCAAGGC
CGGCGTGAAGGCCGGCGACGTGATCGTCAAGTTCGACGGCAAGGACGTGAAGGATGTCCGCGACCTGCCCCGCATCGTGG
CCGACACGCCGGTGGGCAAGGAAGTGGACATCGTCGTCCTGCGCAAGGGCAAGGAAGAGACCCTGAAGATCACGGTCGCC
CGCGCCCCCGAGGAGGAGAAGACCGCCGCCGACAAGTCCAAGCCCCAGAGCGCGGACGCCGACAAGCCGGTGGTGAAGAA
GGTGCTCGGCCTCGAAGTCGCCAGCATCACCGACGACCTGCGCCGCCGCTTCAAGATCAAGGACACGGTGAAGGGCGTGG
TCATCACCTCCGTGGACCGCAATTCCGCCGCCGCCGACAAGGGCCTCAAGGCCGGTCAGGTGATCGTGGAAGTGGGCCAG
GAGCCGGTCTCCGCCCCGGCCGACCTCCAGAAGCGGGTGGATGCGCTGAAGAAGGACAACAAGAAGTCGGCCCTGCTGCT
GATTTCCGACGGCGAAGGCCAGGTCCAGTTCGCGGCCGTGCCGCTCAACTGA

Upstream 100 bases:

>100_bases
GCCCGCTTGCGTCCGCCGAGCCGGGACCGCGCCCCGTTACGGCGCAGCGCGGAGGATTGACGTTCCGTTCACCCGAGCGT
GACTCTCGTCCAACGCGTTT

Downstream 100 bases:

>100_bases
CGGCGGCGTCCGGTTCGAACGCCAGCACCCCTGAAATGCGATCCGCGGCGCGCCATTGGCGCGCCGCTTTGCGTTTGGCC
GGACGAATCGAAGGCCGCGG

Product: serine protease DO-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 523; Mature: 523

Protein sequence:

>523_residues
MKSHCPSRGMVLPCQFVIESPGPRGDPMFRIDRLRAAMAAPALALALAVSGPVHAAASKGPDTVADVAEKVMDAVVNIST
SQNVAPSRSVPAPQLPPGSPFEDFFDEFFKRRQQQDDGDQEQSNRRPRRVSSLGSGFVIDPTGYIVTNNHVIADADEIYA
NFNDGTKLKAELVGRDTKTDLALLKVKPEKPLVSVKFGDSDKMRVGDWVMAIGNPFGLGGTLTVGVISARNRDINSGPYD
NFLQTDAAINRGNSGGPLFNMEGDVIGVNTAIISPSGGSIGIGFAVPSSTAGPVIAQLQQFKEVRRGWIGVRIQNVSDEI
AESLGIGKARGALVGGLNDDNSPAAKAGVKAGDVIVKFDGKDVKDVRDLPRIVADTPVGKEVDIVVLRKGKEETLKITVA
RAPEEEKTAADKSKPQSADADKPVVKKVLGLEVASITDDLRRRFKIKDTVKGVVITSVDRNSAAADKGLKAGQVIVEVGQ
EPVSAPADLQKRVDALKKDNKKSALLLISDGEGQVQFAAVPLN

Sequences:

>Translated_523_residues
MKSHCPSRGMVLPCQFVIESPGPRGDPMFRIDRLRAAMAAPALALALAVSGPVHAAASKGPDTVADVAEKVMDAVVNIST
SQNVAPSRSVPAPQLPPGSPFEDFFDEFFKRRQQQDDGDQEQSNRRPRRVSSLGSGFVIDPTGYIVTNNHVIADADEIYA
NFNDGTKLKAELVGRDTKTDLALLKVKPEKPLVSVKFGDSDKMRVGDWVMAIGNPFGLGGTLTVGVISARNRDINSGPYD
NFLQTDAAINRGNSGGPLFNMEGDVIGVNTAIISPSGGSIGIGFAVPSSTAGPVIAQLQQFKEVRRGWIGVRIQNVSDEI
AESLGIGKARGALVGGLNDDNSPAAKAGVKAGDVIVKFDGKDVKDVRDLPRIVADTPVGKEVDIVVLRKGKEETLKITVA
RAPEEEKTAADKSKPQSADADKPVVKKVLGLEVASITDDLRRRFKIKDTVKGVVITSVDRNSAAADKGLKAGQVIVEVGQ
EPVSAPADLQKRVDALKKDNKKSALLLISDGEGQVQFAAVPLN
>Mature_523_residues
MKSHCPSRGMVLPCQFVIESPGPRGDPMFRIDRLRAAMAAPALALALAVSGPVHAAASKGPDTVADVAEKVMDAVVNIST
SQNVAPSRSVPAPQLPPGSPFEDFFDEFFKRRQQQDDGDQEQSNRRPRRVSSLGSGFVIDPTGYIVTNNHVIADADEIYA
NFNDGTKLKAELVGRDTKTDLALLKVKPEKPLVSVKFGDSDKMRVGDWVMAIGNPFGLGGTLTVGVISARNRDINSGPYD
NFLQTDAAINRGNSGGPLFNMEGDVIGVNTAIISPSGGSIGIGFAVPSSTAGPVIAQLQQFKEVRRGWIGVRIQNVSDEI
AESLGIGKARGALVGGLNDDNSPAAKAGVKAGDVIVKFDGKDVKDVRDLPRIVADTPVGKEVDIVVLRKGKEETLKITVA
RAPEEEKTAADKSKPQSADADKPVVKKVLGLEVASITDDLRRRFKIKDTVKGVVITSVDRNSAAADKGLKAGQVIVEVGQ
EPVSAPADLQKRVDALKKDNKKSALLLISDGEGQVQFAAVPLN

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=283, Percent_Identity=32.5088339222615, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI4506141, Length=296, Percent_Identity=32.4324324324324, Blast_Score=137, Evalue=3e-32,
Organism=Homo sapiens, GI24308541, Length=251, Percent_Identity=30.6772908366534, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI7019477, Length=290, Percent_Identity=33.448275862069, Blast_Score=121, Evalue=2e-27,
Organism=Escherichia coli, GI1786356, Length=449, Percent_Identity=37.8619153674833, Blast_Score=272, Evalue=5e-74,
Organism=Escherichia coli, GI1789629, Length=470, Percent_Identity=36.5957446808511, Blast_Score=255, Evalue=6e-69,
Organism=Escherichia coli, GI1789630, Length=278, Percent_Identity=39.568345323741, Blast_Score=178, Evalue=1e-45,
Organism=Drosophila melanogaster, GI24646839, Length=297, Percent_Identity=31.986531986532, Blast_Score=134, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 55432; Mature: 55432

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSHCPSRGMVLPCQFVIESPGPRGDPMFRIDRLRAAMAAPALALALAVSGPVHAAASKG
CCCCCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCC
PDTVADVAEKVMDAVVNISTSQNVAPSRSVPAPQLPPGSPFEDFFDEFFKRRQQQDDGDQ
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCH
EQSNRRPRRVSSLGSGFVIDPTGYIVTNNHVIADADEIYANFNDGTKLKAELVGRDTKTD
HHHCCCCHHHHHCCCCEEECCCCEEEECCEEEECHHHHEEECCCCCEEEEEECCCCCCCC
LALLKVKPEKPLVSVKFGDSDKMRVGDWVMAIGNPFGLGGTLTVGVISARNRDINSGPYD
EEEEEECCCCCEEEEEECCCCCEEECCEEEEECCCCCCCCEEEEEEEEECCCCCCCCCCC
NFLQTDAAINRGNSGGPLFNMEGDVIGVNTAIISPSGGSIGIGFAVPSSTAGPVIAQLQQ
CHHHHHHHHCCCCCCCCEEECCCCEEEEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHH
FKEVRRGWIGVRIQNVSDEIAESLGIGKARGALVGGLNDDNSPAAKAGVKAGDVIVKFDG
HHHHHCCEEEEEEECCHHHHHHHHCCCCCCCEEEECCCCCCCCHHHCCCCCCCEEEEECC
KDVKDVRDLPRIVADTPVGKEVDIVVLRKGKEETLKITVARAPEEEKTAADKSKPQSADA
CCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEEEECCCHHHHHCCCCCCCCCCC
DKPVVKKVLGLEVASITDDLRRRFKIKDTVKGVVITSVDRNSAAADKGLKAGQVIVEVGQ
CHHHHHHHHCCHHHHHHHHHHHHCCHHHHHCEEEEEEECCCCHHHHCCCCCCHHHEEECC
EPVSAPADLQKRVDALKKDNKKSALLLISDGEGQVQFAAVPLN
CCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEECCC
>Mature Secondary Structure
MKSHCPSRGMVLPCQFVIESPGPRGDPMFRIDRLRAAMAAPALALALAVSGPVHAAASKG
CCCCCCCCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCC
PDTVADVAEKVMDAVVNISTSQNVAPSRSVPAPQLPPGSPFEDFFDEFFKRRQQQDDGDQ
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCH
EQSNRRPRRVSSLGSGFVIDPTGYIVTNNHVIADADEIYANFNDGTKLKAELVGRDTKTD
HHHCCCCHHHHHCCCCEEECCCCEEEECCEEEECHHHHEEECCCCCEEEEEECCCCCCCC
LALLKVKPEKPLVSVKFGDSDKMRVGDWVMAIGNPFGLGGTLTVGVISARNRDINSGPYD
EEEEEECCCCCEEEEEECCCCCEEECCEEEEECCCCCCCCEEEEEEEEECCCCCCCCCCC
NFLQTDAAINRGNSGGPLFNMEGDVIGVNTAIISPSGGSIGIGFAVPSSTAGPVIAQLQQ
CHHHHHHHHCCCCCCCCEEECCCCEEEEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHH
FKEVRRGWIGVRIQNVSDEIAESLGIGKARGALVGGLNDDNSPAAKAGVKAGDVIVKFDG
HHHHHCCEEEEEEECCHHHHHHHHCCCCCCCEEEECCCCCCCCHHHCCCCCCCEEEEECC
KDVKDVRDLPRIVADTPVGKEVDIVVLRKGKEETLKITVARAPEEEKTAADKSKPQSADA
CCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEEEECCCHHHHHCCCCCCCCCCC
DKPVVKKVLGLEVASITDDLRRRFKIKDTVKGVVITSVDRNSAAADKGLKAGQVIVEVGQ
CHHHHHHHHCCHHHHHHHHHHHHCCHHHHHCEEEEEEECCCCHHHHCCCCCCHHHEEECC
EPVSAPADLQKRVDALKKDNKKSALLLISDGEGQVQFAAVPLN
CCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]