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The map label for this gene is ytxM [H]

Identifier: 158424065

GI number: 158424065

Start: 2777042

End: 2777920

Strand: Reverse

Name: ytxM [H]

Synonym: AZC_2441

Alternate gene names: 158424065

Gene position: 2777920-2777042 (Counterclockwise)

Preceding gene: 158424066

Following gene: 158424064

Centisome position: 51.73

GC content: 65.98

Gene sequence:

>879_bases
ATGCATGTGACCACGAAGGACGGCATCCGCCTGCATGTGGAAGAGGCGGGCGAGGGCACCCCCATCCTCTTCGTCCATGA
GTTCGGCGGCAATCACATGAGCTGGGAGCCGCAGATGCGGTTCTTCGCCCGCCGCCACCGCTGCATCACCTATGCGGCGC
GGGGCTATGCGCCGTCCGACATTCCGAGCGACATGGAGCAGTATTCGCAGGCGCTTGCCGCAGACGATGCGGTGGCGGTG
CTGGACGGCCTCGGCATCGGGAAGGCGCACATCGTCGGCCTCTCCATGGGCGGGTTTGCCACCGTCCATTTCGGCCTGCG
CACGCCCGAGCGCGCCCTCTCGCTCACCGTGGCCGGGGCCGGCTATGGCTGCGAGAAGGAGTTTGAAGAGTATTTCCGGG
GCGTCTCGCGGGAGGTGGCGGACAATTTCGAGCGCCAGGGCGCCAAGGAATTCTCCAAAATCTATGCGCTGGGCGCGAGC
CGCGTGCAGTTCCAGAACAAGGATCCGCGCGGCTGGAAAGAGTTTGCCGACCGCCTCGCCACCCATTCGGACCTCGGCGC
GGCCATGACCATGCGCGGCGTTCAGGCCCGCCGCCCCTCCTTCTGGGATCTGGAAGAGGGGCTGAAATCCATGAACGTGC
CGACCCTCATCATGGTCGGCGATGAGGACGACCATTGCCTCCAGCCGGGCATCTTCCTCAAGAAGACCATCCCGGCGAGC
GGCCTGTGCGTCTTCCCCAAGACCGGCCACACGCTGAATCTGGAAGAGCCCGCCGCCTTCAACGCGCAACTGGCGGAGTT
CATTGCGCAGGTGGAGGCGGGGCGCTGGCTGCCGCGCGATCCCCGCGCCATTCCCGGCCAGATCATGCGGACGAACTGA

Upstream 100 bases:

>100_bases
GCTGGGTGGATGCCTTCTGCGCGCAGCTTCCCGCGCTCGTCGCCACCGCCCGCACGCTCAACGACATCGGCCCCCAGTTC
TGAGCCTTGAGAGACGCACC

Downstream 100 bases:

>100_bases
CCAATGGCCTATCCTTTGATCGATGCCGGGCGGGTCTGGAACCGCCTGATGGCGCTGGCCGAGATCGGCGCGCTCTCGCA
GGGCGGCGTCAATCGTCAGG

Product: abhydrolase 1

Products: 2-oxopent-4-enoate; succinate [C]

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MHVTTKDGIRLHVEEAGEGTPILFVHEFGGNHMSWEPQMRFFARRHRCITYAARGYAPSDIPSDMEQYSQALAADDAVAV
LDGLGIGKAHIVGLSMGGFATVHFGLRTPERALSLTVAGAGYGCEKEFEEYFRGVSREVADNFERQGAKEFSKIYALGAS
RVQFQNKDPRGWKEFADRLATHSDLGAAMTMRGVQARRPSFWDLEEGLKSMNVPTLIMVGDEDDHCLQPGIFLKKTIPAS
GLCVFPKTGHTLNLEEPAAFNAQLAEFIAQVEAGRWLPRDPRAIPGQIMRTN

Sequences:

>Translated_292_residues
MHVTTKDGIRLHVEEAGEGTPILFVHEFGGNHMSWEPQMRFFARRHRCITYAARGYAPSDIPSDMEQYSQALAADDAVAV
LDGLGIGKAHIVGLSMGGFATVHFGLRTPERALSLTVAGAGYGCEKEFEEYFRGVSREVADNFERQGAKEFSKIYALGAS
RVQFQNKDPRGWKEFADRLATHSDLGAAMTMRGVQARRPSFWDLEEGLKSMNVPTLIMVGDEDDHCLQPGIFLKKTIPAS
GLCVFPKTGHTLNLEEPAAFNAQLAEFIAQVEAGRWLPRDPRAIPGQIMRTN
>Mature_292_residues
MHVTTKDGIRLHVEEAGEGTPILFVHEFGGNHMSWEPQMRFFARRHRCITYAARGYAPSDIPSDMEQYSQALAADDAVAV
LDGLGIGKAHIVGLSMGGFATVHFGLRTPERALSLTVAGAGYGCEKEFEEYFRGVSREVADNFERQGAKEFSKIYALGAS
RVQFQNKDPRGWKEFADRLATHSDLGAAMTMRGVQARRPSFWDLEEGLKSMNVPTLIMVGDEDDHCLQPGIFLKKTIPAS
GLCVFPKTGHTLNLEEPAAFNAQLAEFIAQVEAGRWLPRDPRAIPGQIMRTN

Specific function: 3-hydroxyphenylpropionate degradation. [C]

COG id: COG0596

COG function: function code R; Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lipase/esterase LIP3/BchO family [H]

Homologues:

Organism=Homo sapiens, GI218777840, Length=139, Percent_Identity=33.0935251798561, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI13376164, Length=139, Percent_Identity=33.0935251798561, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000073
- InterPro:   IPR000639
- InterPro:   IPR022485 [H]

Pfam domain/function: PF00561 Abhydrolase_1 [H]

EC number: 3.7.1.- [C]

Molecular weight: Translated: 32285; Mature: 32285

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVTTKDGIRLHVEEAGEGTPILFVHEFGGNHMSWEPQMRFFARRHRCITYAARGYAPSD
CCCCCCCCCEEEEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHEEEHCCCCCCCC
IPSDMEQYSQALAADDAVAVLDGLGIGKAHIVGLSMGGFATVHFGLRTPERALSLTVAGA
CHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEEEECCCEEEEEECCCCCCHHEEEEEECC
GYGCEKEFEEYFRGVSREVADNFERQGAKEFSKIYALGASRVQFQNKDPRGWKEFADRLA
CCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHEEECCCCCCCHHHHHHHHH
THSDLGAAMTMRGVQARRPSFWDLEEGLKSMNVPTLIMVGDEDDHCLQPGIFLKKTIPAS
HHHHCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEECCCCC
GLCVFPKTGHTLNLEEPAAFNAQLAEFIAQVEAGRWLPRDPRAIPGQIMRTN
CEEEECCCCCEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECC
>Mature Secondary Structure
MHVTTKDGIRLHVEEAGEGTPILFVHEFGGNHMSWEPQMRFFARRHRCITYAARGYAPSD
CCCCCCCCCEEEEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHEEEHCCCCCCCC
IPSDMEQYSQALAADDAVAVLDGLGIGKAHIVGLSMGGFATVHFGLRTPERALSLTVAGA
CHHHHHHHHHHHHCCCHHHHHHCCCCCCEEEEEEECCCEEEEEECCCCCCHHEEEEEECC
GYGCEKEFEEYFRGVSREVADNFERQGAKEFSKIYALGASRVQFQNKDPRGWKEFADRLA
CCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHEEECCCCCCCHHHHHHHHH
THSDLGAAMTMRGVQARRPSFWDLEEGLKSMNVPTLIMVGDEDDHCLQPGIFLKKTIPAS
HHHHCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCEEEEECCCCC
GLCVFPKTGHTLNLEEPAAFNAQLAEFIAQVEAGRWLPRDPRAIPGQIMRTN
CEEEECCCCCEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2-hydroxy-6-ketononadienedicarboxylate; H2O [C]

Specific reaction: 2-hydroxy-6-ketononadienedicarboxylate + H2O = 2-oxopent-4-enoate + succinate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8566759; 9387221; 9384377 [H]