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The map label for this gene is iclR [H]

Identifier: 158423897

GI number: 158423897

Start: 2598458

End: 2599285

Strand: Direct

Name: iclR [H]

Synonym: AZC_2273

Alternate gene names: 158423897

Gene position: 2598458-2599285 (Clockwise)

Preceding gene: 158423890

Following gene: 158423898

Centisome position: 48.39

GC content: 70.05

Gene sequence:

>828_bases
GTGTCAATGTCCGTTGCTAGCGTTGGAAACGGTCCGGACGAGAGCGGCCCCGAAAGCAAGGCGGCGGGTCCCGCCGGCAG
CCAGGCCGTGATGCGCGCGCTTGACGTGCTTGAGGCCGCCGCGTCCGACCCCATCGATCTCGGCACCCTCGCCTCAAGCC
TCGGTCTCACCCGCAGCACGGCGCACCGCCTTGCCAGCGGTCTGGCTGCGCGCGGCTATCTGCGGCTTGCGCCCGGCGAG
GGCTATTCGCTCGGCCCGAAGGTCATGGAACTCGGGGCACGGGCGCGGGCCCAGCGCCCCCTCGCCCGCATCGCCCGTCC
GCATCTGGAAGCGCTGGCGTCCGAGACCGAGGACACGGTTCATCTCGGCGTGCTGGAAGGGGACTGGGCGCTCTATCTCG
ACAAGCTGCCTGGACGTCGGCGTTTCGAGATTTCCTCCCGCGTGGGTGAGCGCCACCCGGTCTGGTCCACGGGCCTTGGC
AAGGCGCTGATTCTCGACGGGGATGCGGCGACCTGGGAGCGCTTCTTCGAGATCGGCTCCGCACGCGGCCCGAACCGCGA
GCAGGCGCGCACCGCCTGGCTCGGGCGCATGAGCAATTATGCCGACTGGGGCTACGCCTTCGACCTGGAGGAAAACGAGC
CGCGCGTGCGCTGCGTGGCGGCGCCGATCCGCGATGCCTCGGGCCTCACGGTCGGCGCCATCAGCGTCTCCAGCGCCTCC
CATTACATGGACGATGCCCGGATGAAGGCGCTGTCGCAGATGGTGACCGGAACGGCGGACCGGATCAGCGGCGAGCTTGG
CTGGCGGCGCAGGCCGTCGGGCCAATAG

Upstream 100 bases:

>100_bases
ATGGCGTTTCCTCAGGGACTGAAGTTGGGGGAGTGGTGCATCCCATATTGTGGGACGTCATCTTATTATGTAGGATGATG
ATTAGGAGAGGTTTCGGAGG

Downstream 100 bases:

>100_bases
GAAAGCATCGCTGAGCGGGGCTGCGGCATAAGGACCGGCGTCGCGCCGCTCACCTCGCCGCGAGCGGGCTTGATCCGCCC
ATAATTTAATCTATCTGTGC

Product: transcriptional regulator

Products: NA

Alternate protein names: YiaKLMNOPQRS operon repressor; YiaK-S operon repressor [H]

Number of amino acids: Translated: 275; Mature: 274

Protein sequence:

>275_residues
MSMSVASVGNGPDESGPESKAAGPAGSQAVMRALDVLEAAASDPIDLGTLASSLGLTRSTAHRLASGLAARGYLRLAPGE
GYSLGPKVMELGARARAQRPLARIARPHLEALASETEDTVHLGVLEGDWALYLDKLPGRRRFEISSRVGERHPVWSTGLG
KALILDGDAATWERFFEIGSARGPNREQARTAWLGRMSNYADWGYAFDLEENEPRVRCVAAPIRDASGLTVGAISVSSAS
HYMDDARMKALSQMVTGTADRISGELGWRRRPSGQ

Sequences:

>Translated_275_residues
MSMSVASVGNGPDESGPESKAAGPAGSQAVMRALDVLEAAASDPIDLGTLASSLGLTRSTAHRLASGLAARGYLRLAPGE
GYSLGPKVMELGARARAQRPLARIARPHLEALASETEDTVHLGVLEGDWALYLDKLPGRRRFEISSRVGERHPVWSTGLG
KALILDGDAATWERFFEIGSARGPNREQARTAWLGRMSNYADWGYAFDLEENEPRVRCVAAPIRDASGLTVGAISVSSAS
HYMDDARMKALSQMVTGTADRISGELGWRRRPSGQ
>Mature_274_residues
SMSVASVGNGPDESGPESKAAGPAGSQAVMRALDVLEAAASDPIDLGTLASSLGLTRSTAHRLASGLAARGYLRLAPGEG
YSLGPKVMELGARARAQRPLARIARPHLEALASETEDTVHLGVLEGDWALYLDKLPGRRRFEISSRVGERHPVWSTGLGK
ALILDGDAATWERFFEIGSARGPNREQARTAWLGRMSNYADWGYAFDLEENEPRVRCVAAPIRDASGLTVGAISVSSASH
YMDDARMKALSQMVTGTADRISGELGWRRRPSGQ

Specific function: Negatively controls the transcription of the yiaKLMNOPQRS operon, which may be involved in the utilization of 2,3-diketo-L-gulonate [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI1788131, Length=253, Percent_Identity=28.8537549407115, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1789999, Length=256, Percent_Identity=31.640625, Blast_Score=115, Evalue=3e-27,
Organism=Escherichia coli, GI1786468, Length=246, Percent_Identity=30.8943089430894, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI1788581, Length=244, Percent_Identity=27.4590163934426, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1786715, Length=263, Percent_Identity=24.7148288973384, Blast_Score=70, Evalue=1e-13,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 29384; Mature: 29253

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMSVASVGNGPDESGPESKAAGPAGSQAVMRALDVLEAAASDPIDLGTLASSLGLTRST
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHH
AHRLASGLAARGYLRLAPGEGYSLGPKVMELGARARAQRPLARIARPHLEALASETEDTV
HHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCEE
HLGVLEGDWALYLDKLPGRRRFEISSRVGERHPVWSTGLGKALILDGDAATWERFFEIGS
EEEEECCCCEEEEECCCCCCEEEHHHHCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHC
ARGPNREQARTAWLGRMSNYADWGYAFDLEENEPRVRCVAAPIRDASGLTVGAISVSSAS
CCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEEEECCCCCCCCEEEEEEECCHH
HYMDDARMKALSQMVTGTADRISGELGWRRRPSGQ
HHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
SMSVASVGNGPDESGPESKAAGPAGSQAVMRALDVLEAAASDPIDLGTLASSLGLTRST
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHH
AHRLASGLAARGYLRLAPGEGYSLGPKVMELGARARAQRPLARIARPHLEALASETEDTV
HHHHHHHHHHCCEEEECCCCCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCEE
HLGVLEGDWALYLDKLPGRRRFEISSRVGERHPVWSTGLGKALILDGDAATWERFFEIGS
EEEEECCCCEEEEECCCCCCEEEHHHHCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHHC
ARGPNREQARTAWLGRMSNYADWGYAFDLEENEPRVRCVAAPIRDASGLTVGAISVSSAS
CCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCCEEEEEECCCCCCCCEEEEEEECCHH
HYMDDARMKALSQMVTGTADRISGELGWRRRPSGQ
HHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503 [H]