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The map label for this gene is rkpK [H]

Identifier: 158423884

GI number: 158423884

Start: 2583528

End: 2584874

Strand: Direct

Name: rkpK [H]

Synonym: AZC_2260

Alternate gene names: 158423884

Gene position: 2583528-2584874 (Clockwise)

Preceding gene: 158423882

Following gene: 158423885

Centisome position: 48.11

GC content: 66.74

Gene sequence:

>1347_bases
ATGCGCGTCGCGATGATTGGCACGGGGTACGTGGGTCTGGTGTCCGGCGCCTGTTTTGCGGACTTCGGGCATCACGTCAC
CTGCGTGGACAAGGACGCGCAGAAGATCGAGCGTTTGGAGCGGGGCGAAATCCCCATCTTCGAGCCCGGCCTTGATGCCC
TGGTGGCGCGCAACCGCGCCGCGGGACGGCTCGATTTCGCGGTGGACCTGACGCAGGCTGTGCGCGAGGCGGACGCGGTG
TTCATCGCGGTGGGGACGCCCTCCCGGCGCGGCGACGGCCATGCCGACCTCTCCTATGTCTATGCGGCCGCGCGCGAGAT
CGCCCAGGCGGCGGAGGGCTATACGGTCGTGGTCACCAAGTCGACTGTGCCCGTGGGCACCGGCGACGAGGTGGAGCGGG
TGATCCGCGAGACCCGTCCCGATGCGGACATCTCCGTGGTGTCTAACCCCGAATTCCTGCGCGAAGGCGCGGCCATCGAG
GATTTCAAGCGGCCGGACCGCATCGTCGTCGGCACGGACGAGCCGCGCGCCCGCGAGGTGATGGCGCAGCTCTATCGCCC
GCTGGCGCTGAACAGCCTGCCGCTGGTCTATACGAGCCGCCGCACCTCCGAACTCATCAAATATGCCGGCAACGCCTTCC
TCGCAGTGAAGATCACCTTCATCAACGAGATCGCCGACCTGTGCGAGCAGGTCGGCGCGAACGTCCAGGACGTGGCACGC
GGCATCGGCCTCGACAACCGCATCGGCTCGAAATTCCTGCATGCCGGCCCCGGCTATGGTGGCTCCTGCTTCCCGAAGGA
CACGCTCGCCCTCACCCGCACGGCGCAGGAAGCCGGAACGCCCTTGCGCATCGTCGAGACGGTGGTCGGCGTGAATGACG
TGCGCAAGCTTGCCATGGCCAAGAAGGTGGTGAACGTCCTTGGCGGCGATGTGCGCGGCAAGACCGCGGCGGTTCTGGGC
CTCACCTTCAAGCCGAATACCGACGACATGCGCGAGAGCCCGGCCATTTCCATCATCCATGCGCTTCTGGACCGTGGAAT
GAAGATCCGCGCTTTCGATCCCGAAGGCATGGAGGAAGCCAAGAAGGTGCTGCCCGCCGACGTTGCCTATGCGAGCGGCC
CCTATGAGGCCGCAGACGGCGCCGACTGCCTCGTCATCGTCACCGAATGGGACGCCTTCCGGGCGCTCGATTTCGAGCGC
ATGCGCAAGCTGCTGAAGCAGCCGGTTCTCGTGGACCTGCGCAACATCTACCGGCCCGATGAGATGGCGGCGCTCGGCTT
CACCTATGAGAGCGTCGGCCGCGGCACGCCCGGCGCGCCGGATACGCTGACGCTCGCGGCGCAGTGA

Upstream 100 bases:

>100_bases
GGGAACGGGACGTCCTGTAATGTCTGTCACGGGAAGTGTCTTCATTTTCTCATGCCGAAGTGCGAGAAGCGCGCTCGGTT
GAATGCAGCAAGGAACCGTC

Downstream 100 bases:

>100_bases
CGGCTACCATTTTGCCGTCACACTCCTGTGGTCCGACGCGCTTGAGCGAGAGCTTGGCCTTGATGCTGCGGATCCATCAG
GGCGGGGCAGGGCGCTTCGG

Product: UDP-glucose 6-dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MRVAMIGTGYVGLVSGACFADFGHHVTCVDKDAQKIERLERGEIPIFEPGLDALVARNRAAGRLDFAVDLTQAVREADAV
FIAVGTPSRRGDGHADLSYVYAAAREIAQAAEGYTVVVTKSTVPVGTGDEVERVIRETRPDADISVVSNPEFLREGAAIE
DFKRPDRIVVGTDEPRAREVMAQLYRPLALNSLPLVYTSRRTSELIKYAGNAFLAVKITFINEIADLCEQVGANVQDVAR
GIGLDNRIGSKFLHAGPGYGGSCFPKDTLALTRTAQEAGTPLRIVETVVGVNDVRKLAMAKKVVNVLGGDVRGKTAAVLG
LTFKPNTDDMRESPAISIIHALLDRGMKIRAFDPEGMEEAKKVLPADVAYASGPYEAADGADCLVIVTEWDAFRALDFER
MRKLLKQPVLVDLRNIYRPDEMAALGFTYESVGRGTPGAPDTLTLAAQ

Sequences:

>Translated_448_residues
MRVAMIGTGYVGLVSGACFADFGHHVTCVDKDAQKIERLERGEIPIFEPGLDALVARNRAAGRLDFAVDLTQAVREADAV
FIAVGTPSRRGDGHADLSYVYAAAREIAQAAEGYTVVVTKSTVPVGTGDEVERVIRETRPDADISVVSNPEFLREGAAIE
DFKRPDRIVVGTDEPRAREVMAQLYRPLALNSLPLVYTSRRTSELIKYAGNAFLAVKITFINEIADLCEQVGANVQDVAR
GIGLDNRIGSKFLHAGPGYGGSCFPKDTLALTRTAQEAGTPLRIVETVVGVNDVRKLAMAKKVVNVLGGDVRGKTAAVLG
LTFKPNTDDMRESPAISIIHALLDRGMKIRAFDPEGMEEAKKVLPADVAYASGPYEAADGADCLVIVTEWDAFRALDFER
MRKLLKQPVLVDLRNIYRPDEMAALGFTYESVGRGTPGAPDTLTLAAQ
>Mature_448_residues
MRVAMIGTGYVGLVSGACFADFGHHVTCVDKDAQKIERLERGEIPIFEPGLDALVARNRAAGRLDFAVDLTQAVREADAV
FIAVGTPSRRGDGHADLSYVYAAAREIAQAAEGYTVVVTKSTVPVGTGDEVERVIRETRPDADISVVSNPEFLREGAAIE
DFKRPDRIVVGTDEPRAREVMAQLYRPLALNSLPLVYTSRRTSELIKYAGNAFLAVKITFINEIADLCEQVGANVQDVAR
GIGLDNRIGSKFLHAGPGYGGSCFPKDTLALTRTAQEAGTPLRIVETVVGVNDVRKLAMAKKVVNVLGGDVRGKTAAVLG
LTFKPNTDDMRESPAISIIHALLDRGMKIRAFDPEGMEEAKKVLPADVAYASGPYEAADGADCLVIVTEWDAFRALDFER
MRKLLKQPVLVDLRNIYRPDEMAALGFTYESVGRGTPGAPDTLTLAAQ

Specific function: Catalyzes The Oxidation Of Udp-Mannac To Udp-N- Acetylmannosaminuronic Acid (Udp-Mannaca). [C]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=462, Percent_Identity=38.5281385281385, Blast_Score=300, Evalue=1e-81,
Organism=Homo sapiens, GI296040438, Length=363, Percent_Identity=39.6694214876033, Blast_Score=255, Evalue=6e-68,
Organism=Homo sapiens, GI296040443, Length=313, Percent_Identity=39.9361022364217, Blast_Score=217, Evalue=2e-56,
Organism=Escherichia coli, GI48994968, Length=435, Percent_Identity=30.3448275862069, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1788340, Length=360, Percent_Identity=28.0555555555556, Blast_Score=154, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17560350, Length=460, Percent_Identity=37.1739130434783, Blast_Score=278, Evalue=5e-75,
Organism=Drosophila melanogaster, GI17136908, Length=463, Percent_Identity=36.9330453563715, Blast_Score=290, Evalue=1e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 48379; Mature: 48379

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVAMIGTGYVGLVSGACFADFGHHVTCVDKDAQKIERLERGEIPIFEPGLDALVARNRA
CEEEEEECCHHHHHCCHHHHHCCCEEEEECCHHHHHHHHHCCCCCEECCCHHHHHHCCCC
AGRLDFAVDLTQAVREADAVFIAVGTPSRRGDGHADLSYVYAAAREIAQAAEGYTVVVTK
CCCEEHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEE
STVPVGTGDEVERVIRETRPDADISVVSNPEFLREGAAIEDFKRPDRIVVGTDEPRAREV
CCCCCCCCHHHHHHHHHCCCCCCEEEECCHHHHHCCCCHHHHCCCCEEEEECCCHHHHHH
MAQLYRPLALNSLPLVYTSRRTSELIKYAGNAFLAVKITFINEIADLCEQVGANVQDVAR
HHHHHHHHHCCCCCEEEECHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHCCCHHHHHH
GIGLDNRIGSKFLHAGPGYGGSCFPKDTLALTRTAQEAGTPLRIVETVVGVNDVRKLAMA
HCCCCCHHCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHH
KKVVNVLGGDVRGKTAAVLGLTFKPNTDDMRESPAISIIHALLDRGMKIRAFDPEGMEEA
HHHHHHHCCCCCCCEEEEEEEEECCCCCHHHCCHHHHHHHHHHHCCCEEEEECCCCHHHH
KKVLPADVAYASGPYEAADGADCLVIVTEWDAFRALDFERMRKLLKQPVLVDLRNIYRPD
HHHCCCHHHCCCCCCCCCCCCCEEEEEECCCCHHHCCHHHHHHHHHCCHHHHHHHHCCCC
EMAALGFTYESVGRGTPGAPDTLTLAAQ
HHHEECCCHHHHCCCCCCCCCCEEEECC
>Mature Secondary Structure
MRVAMIGTGYVGLVSGACFADFGHHVTCVDKDAQKIERLERGEIPIFEPGLDALVARNRA
CEEEEEECCHHHHHCCHHHHHCCCEEEEECCHHHHHHHHHCCCCCEECCCHHHHHHCCCC
AGRLDFAVDLTQAVREADAVFIAVGTPSRRGDGHADLSYVYAAAREIAQAAEGYTVVVTK
CCCEEHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCEEEEEEE
STVPVGTGDEVERVIRETRPDADISVVSNPEFLREGAAIEDFKRPDRIVVGTDEPRAREV
CCCCCCCCHHHHHHHHHCCCCCCEEEECCHHHHHCCCCHHHHCCCCEEEEECCCHHHHHH
MAQLYRPLALNSLPLVYTSRRTSELIKYAGNAFLAVKITFINEIADLCEQVGANVQDVAR
HHHHHHHHHCCCCCEEEECHHHHHHHHHCCCEEEEEEEHHHHHHHHHHHHHCCCHHHHHH
GIGLDNRIGSKFLHAGPGYGGSCFPKDTLALTRTAQEAGTPLRIVETVVGVNDVRKLAMA
HCCCCCHHCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHH
KKVVNVLGGDVRGKTAAVLGLTFKPNTDDMRESPAISIIHALLDRGMKIRAFDPEGMEEA
HHHHHHHCCCCCCCEEEEEEEEECCCCCHHHCCHHHHHHHHHHHCCCEEEEECCCCHHHH
KKVLPADVAYASGPYEAADGADCLVIVTEWDAFRALDFERMRKLLKQPVLVDLRNIYRPD
HHHCCCHHHCCCCCCCCCCCCCEEEEEECCCCHHHCCHHHHHHHHHCCHHHHHHHHCCCC
EMAALGFTYESVGRGTPGAPDTLTLAAQ
HHHEECCCHHHHCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9765575; 11481430 [H]