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The map label for this gene is trpE [H]

Identifier: 158423832

GI number: 158423832

Start: 2522011

End: 2523525

Strand: Reverse

Name: trpE [H]

Synonym: AZC_2208

Alternate gene names: 158423832

Gene position: 2523525-2522011 (Counterclockwise)

Preceding gene: 158423833

Following gene: 158423831

Centisome position: 47.0

GC content: 68.32

Gene sequence:

>1515_bases
ATGAGCGCACCGACCTCGTTCGACGGCTTCGCCGCCCGCTACGCGCGGGGCGAGGCCCAGGTAGTCAGCACCACGCTGGT
CGCCGACCTCGAAACGCCCGTCTCGGCCTTCCTCAAGATCGCCGGTGACAAGGCCAATGCCTTCCTGCTGGAATCGGTGG
AAGGCGGCGAGACCCGCGGGCGCTATTCGATGATCGGCCTCGAGCCGGACGTGATCTGGCGCAGCAATCGTGCGAAGGCC
GAGATCAACCGCCACGCGCTCACCGACACCGAGACCTTCGAGCCCTGCCCCGAAGCTCCGCTGGCCGCGCTGCGCAGCCT
TTTGGCCGAATCGCGCATCGAGCTGCCTGAGGGCGCCCCCCCCATGGCGGCCGGGGTGTTCGGCTATCTCGGCTACGACA
TGGTGCGGCAGATGGAGCTGAAACTCGGCCCCGCCAAGGCCGACCCCATCGGCGTGCCGGAAGCTTTGCTCATCCGCCCG
ACCATCATGGTGGTGTTCGATGCGGTGAAGGACGAGATCACCGCCGTCACCCCCGTGCGGCCGAAGCCCGGCGTTTCCGC
GACTGCCGCCTTCGAGGCCGCGCTCGCCCGCCTCGACCGGGTGACGCTGGCGCTGGAACAGCCCATCGCCCATCCGGCGC
CCGAGCCCTTCCATGGTGCGGTGGAGGCCACCTCCAACACCACGGAAGCCGACTTCTGCGCCATGGTGGAAAAGGCCAAG
GACTACATCCGGGCCGGCGACATCTTCCAGGTGGTGCTCTCGCAGCGCTTCGAGAGTCCCTTCACCCTGCCGCCCTTCGC
GCTCTACCGCGCGCTGCGACGGATCAATCCCGCGCCCTTCCTTGTCTATCTGAACTTCGCCGACTTCTCGGTGGTCTGCT
CCAGCCCCGAGATCCTCGTGCGGCTGCGCGACGGCAAGGTCACCATCCGCCCCATCGCCGGCACCCGCCGCCGGGGCGCA
AGCCCGACCGAGGACGAGGCGCTCGCGACCGAGCTTCTGGCCGATCCGAAGGAGCGGGCCGAGCATCTCATGCTGCTCGA
CCTCGGCCGCAACGACACCGGCCGCGTCTCGAAGATCGGGACCGTGAAGGTGACGGACAGCTTCTTCATCGAGCGCTACA
GCCAGGTCATGCACATCGTCTCCAATGTGGAGGGCGAGGTGGACCCGCGCTTCGACGCGCTGGACGCGCTGGCGGCGGGC
TTCCCGGCCGGGACGGTCTCGGGCGCGCCCAAGGTGCGGGCCATGGAGATCATCGACGAGCTGGAGCGCGACAAGCGCGG
CATCTACGCCGGCGCCATCGGCTATTTCGGCGCCAATGGCGAGATGGACACCTGCATCGTCCTGCGCACCGCCATCGTGA
AGGACGGGCGCATGTATGTGCAGGCCGGTGCCGGCCTCGTCTATGACAGCGTGCCTTTGAGCGAGCATCAGGAGTGCGTC
AACAAGGCCAAGGCCCTGTTCCGCGCCGGAGAGGAAGCGGTGCGCTTTGCGGCGCGGGCGGGGCGCGGCCAATGA

Upstream 100 bases:

>100_bases
AGTATCTGACAGCCCTGCAGGGCCAGATCGGCCTCACCATCAACCAGCGCGCGGTGCAGCAGGCGGTCGGCGCCAATCAG
GTCAACTGAGGGAGCGTGGC

Downstream 100 bases:

>100_bases
GGCGCGCCGGGCTCCCCACACCGGAAGGGCGATGGCGCGGCGCTTGACCCTATGAACGCCGCCACGCTTTAACCCTTGTC
CGGAGCGCCAGGCCTCGCCC

Product: anthranilate synthase component I

Products: NA

Alternate protein names: Anthranilate synthase component I [H]

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MSAPTSFDGFAARYARGEAQVVSTTLVADLETPVSAFLKIAGDKANAFLLESVEGGETRGRYSMIGLEPDVIWRSNRAKA
EINRHALTDTETFEPCPEAPLAALRSLLAESRIELPEGAPPMAAGVFGYLGYDMVRQMELKLGPAKADPIGVPEALLIRP
TIMVVFDAVKDEITAVTPVRPKPGVSATAAFEAALARLDRVTLALEQPIAHPAPEPFHGAVEATSNTTEADFCAMVEKAK
DYIRAGDIFQVVLSQRFESPFTLPPFALYRALRRINPAPFLVYLNFADFSVVCSSPEILVRLRDGKVTIRPIAGTRRRGA
SPTEDEALATELLADPKERAEHLMLLDLGRNDTGRVSKIGTVKVTDSFFIERYSQVMHIVSNVEGEVDPRFDALDALAAG
FPAGTVSGAPKVRAMEIIDELERDKRGIYAGAIGYFGANGEMDTCIVLRTAIVKDGRMYVQAGAGLVYDSVPLSEHQECV
NKAKALFRAGEEAVRFAARAGRGQ

Sequences:

>Translated_504_residues
MSAPTSFDGFAARYARGEAQVVSTTLVADLETPVSAFLKIAGDKANAFLLESVEGGETRGRYSMIGLEPDVIWRSNRAKA
EINRHALTDTETFEPCPEAPLAALRSLLAESRIELPEGAPPMAAGVFGYLGYDMVRQMELKLGPAKADPIGVPEALLIRP
TIMVVFDAVKDEITAVTPVRPKPGVSATAAFEAALARLDRVTLALEQPIAHPAPEPFHGAVEATSNTTEADFCAMVEKAK
DYIRAGDIFQVVLSQRFESPFTLPPFALYRALRRINPAPFLVYLNFADFSVVCSSPEILVRLRDGKVTIRPIAGTRRRGA
SPTEDEALATELLADPKERAEHLMLLDLGRNDTGRVSKIGTVKVTDSFFIERYSQVMHIVSNVEGEVDPRFDALDALAAG
FPAGTVSGAPKVRAMEIIDELERDKRGIYAGAIGYFGANGEMDTCIVLRTAIVKDGRMYVQAGAGLVYDSVPLSEHQECV
NKAKALFRAGEEAVRFAARAGRGQ
>Mature_503_residues
SAPTSFDGFAARYARGEAQVVSTTLVADLETPVSAFLKIAGDKANAFLLESVEGGETRGRYSMIGLEPDVIWRSNRAKAE
INRHALTDTETFEPCPEAPLAALRSLLAESRIELPEGAPPMAAGVFGYLGYDMVRQMELKLGPAKADPIGVPEALLIRPT
IMVVFDAVKDEITAVTPVRPKPGVSATAAFEAALARLDRVTLALEQPIAHPAPEPFHGAVEATSNTTEADFCAMVEKAKD
YIRAGDIFQVVLSQRFESPFTLPPFALYRALRRINPAPFLVYLNFADFSVVCSSPEILVRLRDGKVTIRPIAGTRRRGAS
PTEDEALATELLADPKERAEHLMLLDLGRNDTGRVSKIGTVKVTDSFFIERYSQVMHIVSNVEGEVDPRFDALDALAAGF
PAGTVSGAPKVRAMEIIDELERDKRGIYAGAIGYFGANGEMDTCIVLRTAIVKDGRMYVQAGAGLVYDSVPLSEHQECVN
KAKALFRAGEEAVRFAARAGRGQ

Specific function: Tryptophan biosynthesis; first step. [C]

COG id: COG0147

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate synthase component I family [H]

Homologues:

Organism=Escherichia coli, GI1787518, Length=302, Percent_Identity=44.3708609271523, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI1788114, Length=447, Percent_Identity=30.8724832214765, Blast_Score=208, Evalue=5e-55,
Organism=Escherichia coli, GI1786809, Length=261, Percent_Identity=26.4367816091954, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI87082077, Length=259, Percent_Identity=27.027027027027, Blast_Score=75, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6320935, Length=464, Percent_Identity=38.1465517241379, Blast_Score=292, Evalue=9e-80,
Organism=Saccharomyces cerevisiae, GI6324361, Length=374, Percent_Identity=25.668449197861, Blast_Score=122, Evalue=1e-28,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005801
- InterPro:   IPR019999
- InterPro:   IPR006805
- InterPro:   IPR005256
- InterPro:   IPR015890 [H]

Pfam domain/function: PF04715 Anth_synt_I_N; PF00425 Chorismate_bind [H]

EC number: =4.1.3.27 [H]

Molecular weight: Translated: 54558; Mature: 54427

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPTSFDGFAARYARGEAQVVSTTLVADLETPVSAFLKIAGDKANAFLLESVEGGETRG
CCCCCCCCHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCC
RYSMIGLEPDVIWRSNRAKAEINRHALTDTETFEPCPEAPLAALRSLLAESRIELPEGAP
CEEEEECCCCEEECCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
PMAAGVFGYLGYDMVRQMELKLGPAKADPIGVPEALLIRPTIMVVFDAVKDEITAVTPVR
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCC
PKPGVSATAAFEAALARLDRVTLALEQPIAHPAPEPFHGAVEATSNTTEADFCAMVEKAK
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHH
DYIRAGDIFQVVLSQRFESPFTLPPFALYRALRRINPAPFLVYLNFADFSVVCSSPEILV
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCEEEE
RLRDGKVTIRPIAGTRRRGASPTEDEALATELLADPKERAEHLMLLDLGRNDTGRVSKIG
EEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHCEEEEEECCCCCCCCEEEEE
TVKVTDSFFIERYSQVMHIVSNVEGEVDPRFDALDALAAGFPAGTVSGAPKVRAMEIIDE
EEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
LERDKRGIYAGAIGYFGANGEMDTCIVLRTAIVKDGRMYVQAGAGLVYDSVPLSEHQECV
HHHHCCCEEEEEHEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCEEEECCCCHHHHHHH
NKAKALFRAGEEAVRFAARAGRGQ
HHHHHHHHCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
SAPTSFDGFAARYARGEAQVVSTTLVADLETPVSAFLKIAGDKANAFLLESVEGGETRG
CCCCCCCHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCC
RYSMIGLEPDVIWRSNRAKAEINRHALTDTETFEPCPEAPLAALRSLLAESRIELPEGAP
CEEEEECCCCEEECCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCC
PMAAGVFGYLGYDMVRQMELKLGPAKADPIGVPEALLIRPTIMVVFDAVKDEITAVTPVR
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCC
PKPGVSATAAFEAALARLDRVTLALEQPIAHPAPEPFHGAVEATSNTTEADFCAMVEKAK
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEECCCCCCHHHHHHHHHHHH
DYIRAGDIFQVVLSQRFESPFTLPPFALYRALRRINPAPFLVYLNFADFSVVCSSPEILV
HHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCEEEEECCCEEEE
RLRDGKVTIRPIAGTRRRGASPTEDEALATELLADPKERAEHLMLLDLGRNDTGRVSKIG
EEECCEEEEEECCCCCCCCCCCCHHHHHHHHHHCCHHHHHCEEEEEECCCCCCCCEEEEE
TVKVTDSFFIERYSQVMHIVSNVEGEVDPRFDALDALAAGFPAGTVSGAPKVRAMEIIDE
EEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHH
LERDKRGIYAGAIGYFGANGEMDTCIVLRTAIVKDGRMYVQAGAGLVYDSVPLSEHQECV
HHHHCCCEEEEEHEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCEEEECCCCHHHHHHH
NKAKALFRAGEEAVRFAARAGRGQ
HHHHHHHHCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA