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The map label for this gene is cpg2 [H]

Identifier: 158423698

GI number: 158423698

Start: 2386643

End: 2387776

Strand: Reverse

Name: cpg2 [H]

Synonym: AZC_2074

Alternate gene names: 158423698

Gene position: 2387776-2386643 (Counterclockwise)

Preceding gene: 158423699

Following gene: 158423696

Centisome position: 44.47

GC content: 68.78

Gene sequence:

>1134_bases
ATGGACCTCTCTGCCCTGCCGTTCGACACGACATCCATGCTGGCGCGCCTGCGCCCCTGGATCGAGTGCGAGAGCCCTAC
CTATGACCCGGCGGCCGTCTCGCGCGCCGTGGCGCTGGCCGCGCGCGACGCGGCGGCGGCAGGCGGACAGGTCGACCATA
TCCCCGGGCCGGACGGGCTCGGGGACTGCGCCCGCATACGCTTTCCGCACAGGGATGCCGGCACGCCCGGCATCCTTGTG
ATGGGCCATTTCGACACCGTGCATCCCATCGGCACGCTGGAAAAGCTCGCCTTCCGGCAGGAGGGCAACCTGTGCTGGGG
GCCGGGCCTGCTGGACATGAAGGGCGGCACCTTCACCGCGCTGGAGGCGCTGATCCAGCTCACGCGAGCCGGCATCGAGA
CGCCGCTGCCCATCACCTTCCTCTTCACCAGCGACGAGGAGATCGGCAGCCCCGGCACCCGCACCCTCATCGAAGAGGAA
GCGAAGACGCACAAATATGTGCTGGTGCCCGAGCCCGGCCTTGCCGACAAGGGCGTGACCACGGGACGCTATGCCATCGC
CCGCTACAAGCTCACCGCTTACGGCCGGGCGAGCCATGCCGGCGCAACGCTGAAGGAAGGGCGTTCCGCCATACGGGAGA
TGGCGCGACGCATTCCCGAAATCGAGGATATGACCTCGGACGACTGCACCTTTTCGGTCGGCGTCGTCCATGGCGGGCAG
TGGGTGAACTGCGTTGCCACGACCTGCAGCGGCGAAGCGCTGAGCATGGCCAAGCGGCAGGAGGACCTCGACCGCGGCAC
CACCCGCATCCTGGCCCTCAACGAGCGGCGGGAGGACGGCACCGGCTTTGAGGTGAAGACCAGCGTGGTGCGCCCCGTGT
GGGAGCCGAACGCGGGCTCCATGGCGCTCCACGCCCTCGCGAAATCCATCGCCGGAGAACTCGGCTTCGATCTGCCCCAC
CGCTCCTCGCCCGGCGGCTCGGACGGCAATTTCACGGGAGCGCTCGGCATCCCGACGCTGGACAGCCTCGGGCCCTGCGG
CGGCGACTATCACACGCTCAACGAGCACATCCGCATCGACACCTTGGCCGAGCGGGGCCGCCTCATCGCCGGCCTGATGG
CCCGACTGTCCTGA

Upstream 100 bases:

>100_bases
ACAATCCTGGCTTCGTCCTGGACGAGGCCATCCTGCCCATCGGCTCCAGCCTGCTGGCGACGGTCGCCACCGACCGCCTC
GCGGCGGCCTGAGGCACGCC

Downstream 100 bases:

>100_bases
GCGGGCGCCGCCGGCCTCACCACACCGGCGGCGTGGTGATCCAGAGCACGCGGGTGACGCCCTCCGAGAGGTTGCGGAAC
TTGTGCGGCAGGGCGCTCTC

Product: carboxypeptidase

Products: NA

Alternate protein names: CPDG2; Folate hydrolase G2; Glutamate carboxypeptidase; Pteroylmonoglutamic acid hydrolase G2; Glucarpidase [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MDLSALPFDTTSMLARLRPWIECESPTYDPAAVSRAVALAARDAAAAGGQVDHIPGPDGLGDCARIRFPHRDAGTPGILV
MGHFDTVHPIGTLEKLAFRQEGNLCWGPGLLDMKGGTFTALEALIQLTRAGIETPLPITFLFTSDEEIGSPGTRTLIEEE
AKTHKYVLVPEPGLADKGVTTGRYAIARYKLTAYGRASHAGATLKEGRSAIREMARRIPEIEDMTSDDCTFSVGVVHGGQ
WVNCVATTCSGEALSMAKRQEDLDRGTTRILALNERREDGTGFEVKTSVVRPVWEPNAGSMALHALAKSIAGELGFDLPH
RSSPGGSDGNFTGALGIPTLDSLGPCGGDYHTLNEHIRIDTLAERGRLIAGLMARLS

Sequences:

>Translated_377_residues
MDLSALPFDTTSMLARLRPWIECESPTYDPAAVSRAVALAARDAAAAGGQVDHIPGPDGLGDCARIRFPHRDAGTPGILV
MGHFDTVHPIGTLEKLAFRQEGNLCWGPGLLDMKGGTFTALEALIQLTRAGIETPLPITFLFTSDEEIGSPGTRTLIEEE
AKTHKYVLVPEPGLADKGVTTGRYAIARYKLTAYGRASHAGATLKEGRSAIREMARRIPEIEDMTSDDCTFSVGVVHGGQ
WVNCVATTCSGEALSMAKRQEDLDRGTTRILALNERREDGTGFEVKTSVVRPVWEPNAGSMALHALAKSIAGELGFDLPH
RSSPGGSDGNFTGALGIPTLDSLGPCGGDYHTLNEHIRIDTLAERGRLIAGLMARLS
>Mature_377_residues
MDLSALPFDTTSMLARLRPWIECESPTYDPAAVSRAVALAARDAAAAGGQVDHIPGPDGLGDCARIRFPHRDAGTPGILV
MGHFDTVHPIGTLEKLAFRQEGNLCWGPGLLDMKGGTFTALEALIQLTRAGIETPLPITFLFTSDEEIGSPGTRTLIEEE
AKTHKYVLVPEPGLADKGVTTGRYAIARYKLTAYGRASHAGATLKEGRSAIREMARRIPEIEDMTSDDCTFSVGVVHGGQ
WVNCVATTCSGEALSMAKRQEDLDRGTTRILALNERREDGTGFEVKTSVVRPVWEPNAGSMALHALAKSIAGELGFDLPH
RSSPGGSDGNFTGALGIPTLDSLGPCGGDYHTLNEHIRIDTLAERGRLIAGLMARLS

Specific function: Catalyzes the hydrolysis of reduced and non-reduced folates to pteroates and L-glutamate. This enzyme has a broad specificity [H]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001261
- InterPro:   IPR017150
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.17.11 [H]

Molecular weight: Translated: 40256; Mature: 40256

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00758 ARGE_DAPE_CPG2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLSALPFDTTSMLARLRPWIECESPTYDPAAVSRAVALAARDAAAAGGQVDHIPGPDGL
CCCCCCCCCHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GDCARIRFPHRDAGTPGILVMGHFDTVHPIGTLEKLAFRQEGNLCWGPGLLDMKGGTFTA
CCHHEEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCEEECCCEEECCCCHHHH
LEALIQLTRAGIETPLPITFLFTSDEEIGSPGTRTLIEEEAKTHKYVLVPEPGLADKGVT
HHHHHHHHHHCCCCCCCEEEEEECCHHHCCCCCHHHHHHHHCCCEEEEECCCCCCCCCCC
TGRYAIARYKLTAYGRASHAGATLKEGRSAIREMARRIPEIEDMTSDDCTFSVGVVHGGQ
CCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHCCCCCCCEEEEEEEECCC
WVNCVATTCSGEALSMAKRQEDLDRGTTRILALNERREDGTGFEVKTSVVRPVWEPNAGS
EEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEEHHHCCCCCCCCCCH
MALHALAKSIAGELGFDLPHRSSPGGSDGNFTGALGIPTLDSLGPCGGDYHTLNEHIRID
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHCCCCEEEE
TLAERGRLIAGLMARLS
EHHHCCHHHHHHHHHCC
>Mature Secondary Structure
MDLSALPFDTTSMLARLRPWIECESPTYDPAAVSRAVALAARDAAAAGGQVDHIPGPDGL
CCCCCCCCCHHHHHHHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
GDCARIRFPHRDAGTPGILVMGHFDTVHPIGTLEKLAFRQEGNLCWGPGLLDMKGGTFTA
CCHHEEECCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCEEECCCEEECCCCHHHH
LEALIQLTRAGIETPLPITFLFTSDEEIGSPGTRTLIEEEAKTHKYVLVPEPGLADKGVT
HHHHHHHHHHCCCCCCCEEEEEECCHHHCCCCCHHHHHHHHCCCEEEEECCCCCCCCCCC
TGRYAIARYKLTAYGRASHAGATLKEGRSAIREMARRIPEIEDMTSDDCTFSVGVVHGGQ
CCCEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCHHCCCCCCCEEEEEEEECCC
WVNCVATTCSGEALSMAKRQEDLDRGTTRILALNERREDGTGFEVKTSVVRPVWEPNAGS
EEEEEEECCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEEHHHCCCCCCCCCCH
MALHALAKSIAGELGFDLPHRSSPGGSDGNFTGALGIPTLDSLGPCGGDYHTLNEHIRID
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEECCCCHHHCCCCCCCCHHCCCCEEEE
TLAERGRLIAGLMARLS
EHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6396165; 3838935; 9083113 [H]