Click here to switch to the map view.

The map label for this gene is acoA [H]

Identifier: 158423533

GI number: 158423533

Start: 2187380

End: 2188363

Strand: Reverse

Name: acoA [H]

Synonym: AZC_1909

Alternate gene names: 158423533

Gene position: 2188363-2187380 (Counterclockwise)

Preceding gene: 158423534

Following gene: 158423532

Centisome position: 40.75

GC content: 66.16

Gene sequence:

>984_bases
ATGACCAATTCGCCTTTCCCCCTGAGCAAGGAGGAGTTGCTCGCCGCCTACCGCACCATGCGGACGATCCGCGATTTCGA
GGAGCGGCTGCATGTGGAATTCGCCAAGGGCGACATTCCCGGCTTCGTCCATCTCTATGCCGGCGAGGAAGCCTGTGCCG
CCGGCATCATGACCCACCTGACCGACATTGACCGCATCGCCTCCACCCATCGCGGTCACGGCCATTGCATCGCCAAGGGC
GTGGATGTGCACGAGATGATGGCGGAGATTTACGGCAAGGCCACCGGAGCCTGCCGCGGCAAGGGCGGTTCCATGCACAT
TGCCGATCTCGCCAAGGGCATGATGGGCGCCAACGGCATTCTCGGCGCCGGCGCCCCGCTCATCTGCGGCGCGGCGCTGG
CGGCAAAGTTCCGAGGCGATGGCGGGGTCGGCATCACCTTCTTCGGCGACGGCGCCTCCAACCAGGGCACGGTTCTGGAG
AGCATGAACCTCGCCGCCATCTGGAACCTGCCGGTGATCTTCGTGGTGGAGAACAACGGCTATGCGGAATCCACCTCCGT
GAATTATGCGACCGCCGTGGATTCCTATGTGGATCGCGCCGCCGGCTTCGGCCTGCCGGGCGTGACCGTGGACGGCACGG
ATTTCTTCGCCGTGCATGAGGCGGCCGGCGAGATCATCCGGCGAGCACGGACCGGCGGGGGACCCGCCCTGCTGGAATGC
AAGATGGTGCGCTTCTTCGGCCATTTCGAGGGCGACGCCCAGACGTACAAGGCCAAGGGCGAGAACGACTACAACCGCGC
CAACCGCGACTGCCTCACCCTCTTCGCCGGCCGCGTGACCTCCGCCGGCGTGATCTCGGACGCCGAACTCGCCCTCATCG
ACCGCGAGGTGGCGACGCTCATCGACGATGCGGTGGCCTCCGCCAAGGCGGCCCCCCTGCCCGCTGCGCGCGAGCTGCTC
ACCGATGTTTACGTCGCCTACTGA

Upstream 100 bases:

>100_bases
CGCACCGTCGATGTCGCCGCGGTCATGCGCACGGCCGGCACGCGCGGCCTGCTGCGCTCCGTCCCGTCTCACGCTTACGC
CTAGCAATGGAGAGTGCCTG

Downstream 100 bases:

>100_bases
TCACACAAGAAACAGGGAGGACGGCCATGGGCCGAAAGATCAGCTACAAGCAGGCCATCAACGAGGCGCTGGATCTGGAA
ATGCGCCGTGACCCCACGGT

Product: acetoin dehydrogenase complex E1 component subunit alpha

Products: [dihydrolipoyllysine-residue acetyltransferase] ; $S-acetyldihydrolipoyllysine; CO2

Alternate protein names: Acetoin:DCPIP oxidoreductase-alpha; Ao:DCPIP OR [H]

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MTNSPFPLSKEELLAAYRTMRTIRDFEERLHVEFAKGDIPGFVHLYAGEEACAAGIMTHLTDIDRIASTHRGHGHCIAKG
VDVHEMMAEIYGKATGACRGKGGSMHIADLAKGMMGANGILGAGAPLICGAALAAKFRGDGGVGITFFGDGASNQGTVLE
SMNLAAIWNLPVIFVVENNGYAESTSVNYATAVDSYVDRAAGFGLPGVTVDGTDFFAVHEAAGEIIRRARTGGGPALLEC
KMVRFFGHFEGDAQTYKAKGENDYNRANRDCLTLFAGRVTSAGVISDAELALIDREVATLIDDAVASAKAAPLPAARELL
TDVYVAY

Sequences:

>Translated_327_residues
MTNSPFPLSKEELLAAYRTMRTIRDFEERLHVEFAKGDIPGFVHLYAGEEACAAGIMTHLTDIDRIASTHRGHGHCIAKG
VDVHEMMAEIYGKATGACRGKGGSMHIADLAKGMMGANGILGAGAPLICGAALAAKFRGDGGVGITFFGDGASNQGTVLE
SMNLAAIWNLPVIFVVENNGYAESTSVNYATAVDSYVDRAAGFGLPGVTVDGTDFFAVHEAAGEIIRRARTGGGPALLEC
KMVRFFGHFEGDAQTYKAKGENDYNRANRDCLTLFAGRVTSAGVISDAELALIDREVATLIDDAVASAKAAPLPAARELL
TDVYVAY
>Mature_326_residues
TNSPFPLSKEELLAAYRTMRTIRDFEERLHVEFAKGDIPGFVHLYAGEEACAAGIMTHLTDIDRIASTHRGHGHCIAKGV
DVHEMMAEIYGKATGACRGKGGSMHIADLAKGMMGANGILGAGAPLICGAALAAKFRGDGGVGITFFGDGASNQGTVLES
MNLAAIWNLPVIFVVENNGYAESTSVNYATAVDSYVDRAAGFGLPGVTVDGTDFFAVHEAAGEIIRRARTGGGPALLECK
MVRFFGHFEGDAQTYKAKGENDYNRANRDCLTLFAGRVTSAGVISDAELALIDREVATLIDDAVASAKAAPLPAARELLT
DVYVAY

Specific function: Catalyzes the 2,6-dichlorophenolindophenol-dependent cleavage of acetoin into acetate and acetaldehyde, in vitro. The alpha subunit is probably the catalytic subunit of the enzyme [H]

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=318, Percent_Identity=37.4213836477987, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI291084742, Length=318, Percent_Identity=39.3081761006289, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI4505685, Length=318, Percent_Identity=39.3081761006289, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI291084744, Length=325, Percent_Identity=38.4615384615385, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI291084757, Length=318, Percent_Identity=34.5911949685535, Blast_Score=162, Evalue=3e-40,
Organism=Homo sapiens, GI11386135, Length=318, Percent_Identity=27.3584905660377, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI258645172, Length=318, Percent_Identity=27.3584905660377, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI32564172, Length=323, Percent_Identity=37.7708978328173, Blast_Score=224, Evalue=6e-59,
Organism=Caenorhabditis elegans, GI17536047, Length=323, Percent_Identity=37.7708978328173, Blast_Score=224, Evalue=7e-59,
Organism=Caenorhabditis elegans, GI86563355, Length=313, Percent_Identity=26.8370607028754, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI86563357, Length=313, Percent_Identity=26.8370607028754, Blast_Score=108, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6321026, Length=323, Percent_Identity=37.1517027863777, Blast_Score=212, Evalue=6e-56,
Organism=Drosophila melanogaster, GI24639744, Length=318, Percent_Identity=40.5660377358491, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI28571106, Length=318, Percent_Identity=40.5660377358491, Blast_Score=218, Evalue=6e-57,
Organism=Drosophila melanogaster, GI24639740, Length=318, Percent_Identity=40.5660377358491, Blast_Score=217, Evalue=8e-57,
Organism=Drosophila melanogaster, GI24639746, Length=306, Percent_Identity=40.8496732026144, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24639748, Length=318, Percent_Identity=37.1069182389937, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI21355903, Length=320, Percent_Identity=24.0625, Blast_Score=85, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: 1.2.4.1

Molecular weight: Translated: 34515; Mature: 34384

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNSPFPLSKEELLAAYRTMRTIRDFEERLHVEFAKGDIPGFVHLYAGEEACAAGIMTHL
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEEECCCHHHHHHHHHHH
TDIDRIASTHRGHGHCIAKGVDVHEMMAEIYGKATGACRGKGGSMHIADLAKGMMGANGI
HHHHHHHHHCCCCCEEEECCCCHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHCCCCCC
LGAGAPLICGAALAAKFRGDGGVGITFFGDGASNQGTVLESMNLAAIWNLPVIFVVENNG
CCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEECCCCEEEEECCCEEEEECCCC
YAESTSVNYATAVDSYVDRAAGFGLPGVTVDGTDFFAVHEAAGEIIRRARTGGGPALLEC
CCCCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
KMVRFFGHFEGDAQTYKAKGENDYNRANRDCLTLFAGRVTSAGVISDAELALIDREVATL
HHHHHHHCCCCCCCEEECCCCCCCHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
IDDAVASAKAAPLPAARELLTDVYVAY
HHHHHHHCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TNSPFPLSKEELLAAYRTMRTIRDFEERLHVEFAKGDIPGFVHLYAGEEACAAGIMTHL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCEEEEECCCHHHHHHHHHHH
TDIDRIASTHRGHGHCIAKGVDVHEMMAEIYGKATGACRGKGGSMHIADLAKGMMGANGI
HHHHHHHHHCCCCCEEEECCCCHHHHHHHHHCCCCCCCCCCCCCEEHHHHHHHHCCCCCC
LGAGAPLICGAALAAKFRGDGGVGITFFGDGASNQGTVLESMNLAAIWNLPVIFVVENNG
CCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEECCCCEEEEECCCEEEEECCCC
YAESTSVNYATAVDSYVDRAAGFGLPGVTVDGTDFFAVHEAAGEIIRRARTGGGPALLEC
CCCCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
KMVRFFGHFEGDAQTYKAKGENDYNRANRDCLTLFAGRVTSAGVISDAELALIDREVATL
HHHHHHHCCCCCCCEEECCCCCCCHHCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
IDDAVASAKAAPLPAARELLTDVYVAY
HHHHHHHCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: pyruvate; [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine

Specific reaction: pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S- $acetyldihydrolipoyllysine + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2061286 [H]