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The map label for this gene is acoB [H]

Identifier: 158423532

GI number: 158423532

Start: 2186331

End: 2187353

Strand: Reverse

Name: acoB [H]

Synonym: AZC_1908

Alternate gene names: 158423532

Gene position: 2187353-2186331 (Counterclockwise)

Preceding gene: 158423533

Following gene: 158423531

Centisome position: 40.73

GC content: 67.35

Gene sequence:

>1023_bases
ATGGGCCGAAAGATCAGCTACAAGCAGGCCATCAACGAGGCGCTGGATCTGGAAATGCGCCGTGACCCCACGGTGATCGT
GCTGGGCGAGGACATCGTCGGCGGTGCCGGCGCGCCCGGCGAGGCGGACGCCTGGGGCGGCGTGCTCGGCGTCACCAAGG
GGCTGCATGCCAAACATGGCGACCGCCTGATGGATACGCCCCTGTCCGAGAGCGCCTATATCGGCGCGGCCATCGGCGCC
GCCGCCTGCGGCATGCGCCCTGTGGCGGAACTGATGTTCCTCGACTTCATGGGGGTGTGCTTCGACCAGATCCTGAACCA
GGCGGCGAAGTTCAAATACATGTTCGGCGGCAAGGCCAAGACGCCGGTGGTGATCCGCGCCATGGTCGGCGCCGGTTTCC
GCGCCGCCGCCCAGCATTCCCAGATGCTCACCCCCCTCTTCACCCATGTTCCGGGGCTGAAGGTCGTCTGTCCTTCCAAT
GCCTATGACGCCAAGGGGCTGCTCATCCAGGCGATCCGCGACGACGACCCGGTGATCTTCTGCGAGCACAAGGCCCTCTA
TGGCCACGAATGCGATGTGCCGGAAGAGGCCTATGCCATCCCCTTCGCCGAAGCGAACGTGGCCCGCGAGGGCAAGGACG
TGACCATCGTCGGCTACGGCCTCACGGTGCACCGCGCCCTGGCGGCCGCGGAAGACCTTGCGCGCCGGGGAGGCATCGAG
GCGGAGGTGATCGACCTGCGCACCCTCTCGCCCATGGACTGGGACACGGTGATCGAGAGCGTGGAGGCGACCGGTCGGCT
GGTGGTGGTCGACGAGGCCAATCCGCGCTGCTCCATCGCCAGCGATGTCGCCGCTTACGTAACCCAGCATGCCTTCGGTG
CCCTTAAGGCGGCCCCGCAAATGGTGACGGCCCCGCATACGCCCGTGCCGTTCTCCCCTGTGCTGGAGGATCTCTACATC
CCCTCCGCCGACGCCGTCTCGGCGGCGGTGTCCCGCATCACCGCGAAGGCGCTCGCGGCCTGA

Upstream 100 bases:

>100_bases
CGGTGGCCTCCGCCAAGGCGGCCCCCCTGCCCGCTGCGCGCGAGCTGCTCACCGATGTTTACGTCGCCTACTGATCACAC
AAGAAACAGGGAGGACGGCC

Downstream 100 bases:

>100_bases
GGCGCGCCCCGCAAGGCCGGGACGCCTCAGGGCGGTCCCGGCCACCATCCAGAGCTTCAGCTTCAAACCGGCACCGGCCG
CACAGACACGCGGGCCCGGC

Product: acetoin dehydrogenase complex E1 component subunit beta

Products: [dihydrolipoyllysine-residue acetyltransferase] ; $S-acetyldihydrolipoyllysine; CO2

Alternate protein names: Acetoin:DCPIP oxidoreductase-beta; Ao:DCPIP OR; TPP-dependent acetoin dehydrogenase E1 subunit beta [H]

Number of amino acids: Translated: 340; Mature: 339

Protein sequence:

>340_residues
MGRKISYKQAINEALDLEMRRDPTVIVLGEDIVGGAGAPGEADAWGGVLGVTKGLHAKHGDRLMDTPLSESAYIGAAIGA
AACGMRPVAELMFLDFMGVCFDQILNQAAKFKYMFGGKAKTPVVIRAMVGAGFRAAAQHSQMLTPLFTHVPGLKVVCPSN
AYDAKGLLIQAIRDDDPVIFCEHKALYGHECDVPEEAYAIPFAEANVAREGKDVTIVGYGLTVHRALAAAEDLARRGGIE
AEVIDLRTLSPMDWDTVIESVEATGRLVVVDEANPRCSIASDVAAYVTQHAFGALKAAPQMVTAPHTPVPFSPVLEDLYI
PSADAVSAAVSRITAKALAA

Sequences:

>Translated_340_residues
MGRKISYKQAINEALDLEMRRDPTVIVLGEDIVGGAGAPGEADAWGGVLGVTKGLHAKHGDRLMDTPLSESAYIGAAIGA
AACGMRPVAELMFLDFMGVCFDQILNQAAKFKYMFGGKAKTPVVIRAMVGAGFRAAAQHSQMLTPLFTHVPGLKVVCPSN
AYDAKGLLIQAIRDDDPVIFCEHKALYGHECDVPEEAYAIPFAEANVAREGKDVTIVGYGLTVHRALAAAEDLARRGGIE
AEVIDLRTLSPMDWDTVIESVEATGRLVVVDEANPRCSIASDVAAYVTQHAFGALKAAPQMVTAPHTPVPFSPVLEDLYI
PSADAVSAAVSRITAKALAA
>Mature_339_residues
GRKISYKQAINEALDLEMRRDPTVIVLGEDIVGGAGAPGEADAWGGVLGVTKGLHAKHGDRLMDTPLSESAYIGAAIGAA
ACGMRPVAELMFLDFMGVCFDQILNQAAKFKYMFGGKAKTPVVIRAMVGAGFRAAAQHSQMLTPLFTHVPGLKVVCPSNA
YDAKGLLIQAIRDDDPVIFCEHKALYGHECDVPEEAYAIPFAEANVAREGKDVTIVGYGLTVHRALAAAEDLARRGGIEA
EVIDLRTLSPMDWDTVIESVEATGRLVVVDEANPRCSIASDVAAYVTQHAFGALKAAPQMVTAPHTPVPFSPVLEDLYIP
SADAVSAAVSRITAKALAA

Specific function: Catalyzes the 2,6-dichlorophenolindophenol-dependent cleavage of acetoin into acetate and acetaldehyde, in vitro. The beta subunit is probably not the catalytic subunit of the enzyme [H]

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI156564403, Length=335, Percent_Identity=37.910447761194, Blast_Score=231, Evalue=9e-61,
Organism=Homo sapiens, GI4557353, Length=322, Percent_Identity=39.1304347826087, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI34101272, Length=322, Percent_Identity=39.1304347826087, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI291084858, Length=335, Percent_Identity=36.1194029850746, Blast_Score=213, Evalue=3e-55,
Organism=Homo sapiens, GI225637463, Length=251, Percent_Identity=27.0916334661355, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI225637459, Length=251, Percent_Identity=27.0916334661355, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI225637461, Length=251, Percent_Identity=27.0916334661355, Blast_Score=72, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17538422, Length=334, Percent_Identity=40.4191616766467, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI17506935, Length=332, Percent_Identity=38.2530120481928, Blast_Score=193, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6319698, Length=337, Percent_Identity=36.4985163204748, Blast_Score=231, Evalue=1e-61,
Organism=Drosophila melanogaster, GI21358145, Length=325, Percent_Identity=38.1538461538462, Blast_Score=221, Evalue=7e-58,
Organism=Drosophila melanogaster, GI24650940, Length=325, Percent_Identity=38.1538461538462, Blast_Score=221, Evalue=7e-58,
Organism=Drosophila melanogaster, GI160714832, Length=335, Percent_Identity=35.5223880597015, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI160714828, Length=335, Percent_Identity=35.5223880597015, Blast_Score=193, Evalue=1e-49,
Organism=Drosophila melanogaster, GI24650943, Length=102, Percent_Identity=36.2745098039216, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24650945, Length=102, Percent_Identity=36.2745098039216, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: 1.2.4.1

Molecular weight: Translated: 35971; Mature: 35840

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGRKISYKQAINEALDLEMRRDPTVIVLGEDIVGGAGAPGEADAWGGVLGVTKGLHAKHG
CCCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCC
DRLMDTPLSESAYIGAAIGAAACGMRPVAELMFLDFMGVCFDQILNQAAKFKYMFGGKAK
CCHHCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCC
TPVVIRAMVGAGFRAAAQHSQMLTPLFTHVPGLKVVCPSNAYDAKGLLIQAIRDDDPVIF
CCEEEEEHHCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEECCCCCEEE
CEHKALYGHECDVPEEAYAIPFAEANVAREGKDVTIVGYGLTVHRALAAAEDLARRGGIE
EECCCCCCCCCCCCCHHEECCCHHCHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCC
AEVIDLRTLSPMDWDTVIESVEATGRLVVVDEANPRCSIASDVAAYVTQHAFGALKAAPQ
EEEEEEECCCCCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCC
MVTAPHTPVPFSPVLEDLYIPSADAVSAAVSRITAKALAA
CCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GRKISYKQAINEALDLEMRRDPTVIVLGEDIVGGAGAPGEADAWGGVLGVTKGLHAKHG
CCCCCHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCC
DRLMDTPLSESAYIGAAIGAAACGMRPVAELMFLDFMGVCFDQILNQAAKFKYMFGGKAK
CCHHCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCC
TPVVIRAMVGAGFRAAAQHSQMLTPLFTHVPGLKVVCPSNAYDAKGLLIQAIRDDDPVIF
CCEEEEEHHCCCHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEECCCCCEEE
CEHKALYGHECDVPEEAYAIPFAEANVAREGKDVTIVGYGLTVHRALAAAEDLARRGGIE
EECCCCCCCCCCCCCHHEECCCHHCHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHCCCC
AEVIDLRTLSPMDWDTVIESVEATGRLVVVDEANPRCSIASDVAAYVTQHAFGALKAAPQ
EEEEEEECCCCCCHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCC
MVTAPHTPVPFSPVLEDLYIPSADAVSAAVSRITAKALAA
CCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: pyruvate; [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine

Specific reaction: pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S- $acetyldihydrolipoyllysine + CO2

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2061286 [H]