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The map label for this gene is lpxB [H]

Identifier: 158423330

GI number: 158423330

Start: 1953498

End: 1954670

Strand: Direct

Name: lpxB [H]

Synonym: AZC_1706

Alternate gene names: 158423330

Gene position: 1953498-1954670 (Clockwise)

Preceding gene: 158423329

Following gene: 158423332

Centisome position: 36.38

GC content: 70.16

Gene sequence:

>1173_bases
ATGAGTGCGCCCGGCAAGCCGCTCGACATCTTCGTCGTCGCCGGCGAGGAATCGGGCGATGTGCTGGGCGGTGCGCTGCT
GGCGGCTTTGAAGGTGCAGGCGCCGCAGGGCGTCACCTTCCGCGGCATTGGCGGCACGCGCATGGCGGGGCAGGGGCTCA
AGAGCCTCTTCCCCATGGACGATCTCACCGCCATCGGCTTCGGTGCCGTGCTCTCCAAGCTGCGCACCATCCTGAAGCGG
CTGAAGGAGACGGTGGAGGCCATCTGCGCCGCACCGCCGGACGTGCTGGTGCTGATCGACGCGCCGGATTTCACCCATCG
CGTCGCAGCCAAGGTGCGCAAGCGCCGGCCGGACATTCCCATCGTCAAATATGTCTCGCCCACGGTCTGGGCGTGGCGCT
CCGGCCGTGCGAAGGCCATGCGGCCCTATACGGACCGCTTGCTGGCGCTGCTGCCCTTCGAACCGGAGGTGCATGAGCGC
CTCGGCGGGCCCGTGACCGACTATGTGGGGCATCCGCTGCTGGAGCATCTGGAGGACCTGCGCCCCTCCGCCGAGGAGGT
GGTCCGCCGCGCTTCCGATCCGCCGCTGGTGCTCGCCTTGCCGGGCAGCCGGCGGGCCGAACTGGAGCGGCTCGGTGCCA
TCTTCGGGGAGGCGCTGGGCCGTGTGGCCGTTGAGCGGCCCATCGAGGTGGTGCTGCCCACCTTGCCGCGTCTGGTGCCC
AAGGTTCTGGCCATGGTCGCGAGTTGGCCGGTGCCGGTGCGCATCGTCACCGATGCGGGCGAGAAGCATGCCGTCTTCCG
GCAGGCGCGCGCGGCGCTTGCCGCCTCGGGCACCGTGACGCTGGAACTCGGCCTTGCGGGCGTGCCCACCGTTGCGGCCT
ACAAGCTGTCCGAATGGGAGGCCAAGATCGCCCCCCACGTGCTGCACCTCACCACGGTGATCCTCGCCAATCTGGTGATC
GGCGAGAACGTGGTGCCCGAATTCCTCCAGAAGGACTGCACGCCGGAGAAGCTGTCGGCGGCGCTCCTCGAGACGCTGGC
CGAGGGCCCCGCTCGCACCCGCCAGCTCGAGGGCTTCGCGAAGCTCGACACCATCATGGGTGCCGACGACGCCCCGCCCT
CCCAGCGGGCGGCGGCTGTAGTGCTCGAGGCAGCGGCTGCGCGCCGGCACTGA

Upstream 100 bases:

>100_bases
TCGAGGCGGGCGGGGCCATCGTGCCGGATGCCGAGCATCTGGTGGCGGAGGCCGACAAGGCCGGTCTCTTCGTGGTCGGC
GTGCGCCCGCAGGTGGCATC

Downstream 100 bases:

>100_bases
GCTTCACTCGTCCAGTTTCAGCCGGTTGAAGGTGGCGGCGAGGTGGTCGATGAGCGCGCGCACGGCGGGCGTCAGGCCCC
GGCGCGTTGTAAAGACGATG

Product: lipid-A-disaccharide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MSAPGKPLDIFVVAGEESGDVLGGALLAALKVQAPQGVTFRGIGGTRMAGQGLKSLFPMDDLTAIGFGAVLSKLRTILKR
LKETVEAICAAPPDVLVLIDAPDFTHRVAAKVRKRRPDIPIVKYVSPTVWAWRSGRAKAMRPYTDRLLALLPFEPEVHER
LGGPVTDYVGHPLLEHLEDLRPSAEEVVRRASDPPLVLALPGSRRAELERLGAIFGEALGRVAVERPIEVVLPTLPRLVP
KVLAMVASWPVPVRIVTDAGEKHAVFRQARAALAASGTVTLELGLAGVPTVAAYKLSEWEAKIAPHVLHLTTVILANLVI
GENVVPEFLQKDCTPEKLSAALLETLAEGPARTRQLEGFAKLDTIMGADDAPPSQRAAAVVLEAAAARRH

Sequences:

>Translated_390_residues
MSAPGKPLDIFVVAGEESGDVLGGALLAALKVQAPQGVTFRGIGGTRMAGQGLKSLFPMDDLTAIGFGAVLSKLRTILKR
LKETVEAICAAPPDVLVLIDAPDFTHRVAAKVRKRRPDIPIVKYVSPTVWAWRSGRAKAMRPYTDRLLALLPFEPEVHER
LGGPVTDYVGHPLLEHLEDLRPSAEEVVRRASDPPLVLALPGSRRAELERLGAIFGEALGRVAVERPIEVVLPTLPRLVP
KVLAMVASWPVPVRIVTDAGEKHAVFRQARAALAASGTVTLELGLAGVPTVAAYKLSEWEAKIAPHVLHLTTVILANLVI
GENVVPEFLQKDCTPEKLSAALLETLAEGPARTRQLEGFAKLDTIMGADDAPPSQRAAAVVLEAAAARRH
>Mature_389_residues
SAPGKPLDIFVVAGEESGDVLGGALLAALKVQAPQGVTFRGIGGTRMAGQGLKSLFPMDDLTAIGFGAVLSKLRTILKRL
KETVEAICAAPPDVLVLIDAPDFTHRVAAKVRKRRPDIPIVKYVSPTVWAWRSGRAKAMRPYTDRLLALLPFEPEVHERL
GGPVTDYVGHPLLEHLEDLRPSAEEVVRRASDPPLVLALPGSRRAELERLGAIFGEALGRVAVERPIEVVLPTLPRLVPK
VLAMVASWPVPVRIVTDAGEKHAVFRQARAALAASGTVTLELGLAGVPTVAAYKLSEWEAKIAPHVLHLTTVILANLVIG
ENVVPEFLQKDCTPEKLSAALLETLAEGPARTRQLEGFAKLDTIMGADDAPPSQRAAAVVLEAAAARRH

Specific function: Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0763

COG function: function code M; Lipid A disaccharide synthetase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxB family [H]

Homologues:

Organism=Escherichia coli, GI1786379, Length=387, Percent_Identity=34.1085271317829, Blast_Score=169, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003835 [H]

Pfam domain/function: PF02684 LpxB [H]

EC number: =2.4.1.182 [H]

Molecular weight: Translated: 41743; Mature: 41612

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAPGKPLDIFVVAGEESGDVLGGALLAALKVQAPQGVTFRGIGGTRMAGQGLKSLFPMD
CCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHCCCH
DLTAIGFGAVLSKLRTILKRLKETVEAICAAPPDVLVLIDAPDFTHRVAAKVRKRRPDIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCCCC
IVKYVSPTVWAWRSGRAKAMRPYTDRLLALLPFEPEVHERLGGPVTDYVGHPLLEHLEDL
EEEECCCCCEEECCCCCCCCCCHHHHHHHHCCCCHHHHHHCCCCHHHHHCCHHHHHHHHH
RPSAEEVVRRASDPPLVLALPGSRRAELERLGAIFGEALGRVAVERPIEVVLPTLPRLVP
CCCHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
KVLAMVASWPVPVRIVTDAGEKHAVFRQARAALAASGTVTLELGLAGVPTVAAYKLSEWE
HHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHH
AKIAPHVLHLTTVILANLVIGENVVPEFLQKDCTPEKLSAALLETLAEGPARTRQLEGFA
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHH
KLDTIMGADDAPPSQRAAAVVLEAAAARRH
HHHHHHCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SAPGKPLDIFVVAGEESGDVLGGALLAALKVQAPQGVTFRGIGGTRMAGQGLKSLFPMD
CCCCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHCCCH
DLTAIGFGAVLSKLRTILKRLKETVEAICAAPPDVLVLIDAPDFTHRVAAKVRKRRPDIP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCCCC
IVKYVSPTVWAWRSGRAKAMRPYTDRLLALLPFEPEVHERLGGPVTDYVGHPLLEHLEDL
EEEECCCCCEEECCCCCCCCCCHHHHHHHHCCCCHHHHHHCCCCHHHHHCCHHHHHHHHH
RPSAEEVVRRASDPPLVLALPGSRRAELERLGAIFGEALGRVAVERPIEVVLPTLPRLVP
CCCHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
KVLAMVASWPVPVRIVTDAGEKHAVFRQARAALAASGTVTLELGLAGVPTVAAYKLSEWE
HHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHH
AKIAPHVLHLTTVILANLVIGENVVPEFLQKDCTPEKLSAALLETLAEGPARTRQLEGFA
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHHHHH
KLDTIMGADDAPPSQRAAAVVLEAAAARRH
HHHHHHCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA