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The map label for this gene is lpxD

Identifier: 158423326

GI number: 158423326

Start: 1950252

End: 1951325

Strand: Direct

Name: lpxD

Synonym: AZC_1702

Alternate gene names: 158423326

Gene position: 1950252-1951325 (Clockwise)

Preceding gene: 158423325

Following gene: 158423327

Centisome position: 36.32

GC content: 70.76

Gene sequence:

>1074_bases
ATGAGCGAACCCGCATTCTTCCCCCTTCCGACGCCGCTGACGCTGGATGAGGTGGCTGCGCTGAGCGGCGCGCGCCTCGC
CCGTCCCGGCGCGCAGGACGCCCTGCGCCTGACGGGTGTCGGAACCCTGGCGGACGCCGGCCCGAGCGAACTCGCCTTCC
TCGACCAGTCCCGCTATCTGGCGACGCTGGGCACCGCCCGCGCCGGCGCCATCATCACCAGCGAGAAGTTCGCAGGCGAA
GTGCCCGAGGCCATCGCGGTCCTGGTATCGCCGCGCCCCGCCAGCGCCTTCGTGGCCGTGACCCGGCAGCTTTTCCCCCA
GGCCCTGCGGCCGCAGCCGGTGTTCGGCCACACCGGCATCGCCCCCGGCGCCTTCATCCATCCCACCGCCAGCCTTGAGG
CAGGGGTGACCGTCGATCCCGGCGCGGTGATCGGCCCCGGTGCCGAGGTCGGTGCCGGTTCGGTCATCTGTGCCAATGCC
GTGGTGGGTGCGGGCGTGCGGATCGGCCGGGACAGCACCATCGGGGCCGGCGTCAGCCTTTCCCATGCGCTGGTCGGCAA
TCGCGTCATCGTCCATGCCGGCGCCCGCATCGGGCAGGACGGCTTCGGCTATCAGCCCGGCCCCGGCGGCCACCTGAAGG
TGCCGCAGATCGGCCGCGTGGTCCTTCAGGACGACGTGGAAGTCGGCGCCGGCTCCACCATCGACCGCGGCGCGCTGCGC
GACACGGTGATCGGGGAGGGGACCAAGATCGACAATCTGGTCCAGATCGCCCACAACGTGGTCATCGGTCGCCACTGCAT
CATCGTCTCCCAGACCGGGATCTCCGGCAGCACCACACTGGGCGATTTCGTGATGCTTGGCGGGCAGGTGGGCGTGGTCG
GCCACTGCACCATCGGCGATGGCGCCCAGATCGCCGCCTCCAGCAATGTGAAGGGCGATGTGCCCCCCGGCGTGCGCTGG
GGCGGGTCTCCGGCCAAGCCGGTGCGCGAGTGGTTCCGCGAAATGACCACCTTGAAGAAGCTGGCTGAGTCGAGGGCGCG
TTCCGGCGCCGCGACGCCGGGGGAAGAAGAATGA

Upstream 100 bases:

>100_bases
TTCCGCTTCTCCGGCGGCACCAAGTTCTGATCGTCGTTACATCGGTCCATCACGGGCGTCGCCGGCTGAGGCCGGCGGCG
CCCGAACCACATTTTAGGTC

Downstream 100 bases:

>100_bases
GCGAAGAAACCAAGGCGGACGAGACGAAGGTTCTGGACAGCATCGACATCCTGCGCATCCTGGCGCTCCTGCCGCATCGC
TATCCGTTCCTGATGGTGGA

Product: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 356

Protein sequence:

>357_residues
MSEPAFFPLPTPLTLDEVAALSGARLARPGAQDALRLTGVGTLADAGPSELAFLDQSRYLATLGTARAGAIITSEKFAGE
VPEAIAVLVSPRPASAFVAVTRQLFPQALRPQPVFGHTGIAPGAFIHPTASLEAGVTVDPGAVIGPGAEVGAGSVICANA
VVGAGVRIGRDSTIGAGVSLSHALVGNRVIVHAGARIGQDGFGYQPGPGGHLKVPQIGRVVLQDDVEVGAGSTIDRGALR
DTVIGEGTKIDNLVQIAHNVVIGRHCIIVSQTGISGSTTLGDFVMLGGQVGVVGHCTIGDGAQIAASSNVKGDVPPGVRW
GGSPAKPVREWFREMTTLKKLAESRARSGAATPGEEE

Sequences:

>Translated_357_residues
MSEPAFFPLPTPLTLDEVAALSGARLARPGAQDALRLTGVGTLADAGPSELAFLDQSRYLATLGTARAGAIITSEKFAGE
VPEAIAVLVSPRPASAFVAVTRQLFPQALRPQPVFGHTGIAPGAFIHPTASLEAGVTVDPGAVIGPGAEVGAGSVICANA
VVGAGVRIGRDSTIGAGVSLSHALVGNRVIVHAGARIGQDGFGYQPGPGGHLKVPQIGRVVLQDDVEVGAGSTIDRGALR
DTVIGEGTKIDNLVQIAHNVVIGRHCIIVSQTGISGSTTLGDFVMLGGQVGVVGHCTIGDGAQIAASSNVKGDVPPGVRW
GGSPAKPVREWFREMTTLKKLAESRARSGAATPGEEE
>Mature_356_residues
SEPAFFPLPTPLTLDEVAALSGARLARPGAQDALRLTGVGTLADAGPSELAFLDQSRYLATLGTARAGAIITSEKFAGEV
PEAIAVLVSPRPASAFVAVTRQLFPQALRPQPVFGHTGIAPGAFIHPTASLEAGVTVDPGAVIGPGAEVGAGSVICANAV
VGAGVRIGRDSTIGAGVSLSHALVGNRVIVHAGARIGQDGFGYQPGPGGHLKVPQIGRVVLQDDVEVGAGSTIDRGALRD
TVIGEGTKIDNLVQIAHNVVIGRHCIIVSQTGISGSTTLGDFVMLGGQVGVVGHCTIGDGAQIAASSNVKGDVPPGVRWG
GSPAKPVREWFREMTTLKKLAESRARSGAATPGEEE

Specific function: Lipid A biosynthesis; third step. [C]

COG id: COG1044

COG function: function code M; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transferase hexapeptide repeat family. LpxD subfamily

Homologues:

Organism=Escherichia coli, GI1786376, Length=314, Percent_Identity=34.7133757961783, Blast_Score=168, Evalue=5e-43,
Organism=Escherichia coli, GI1786378, Length=253, Percent_Identity=30.0395256916996, Blast_Score=84, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXD_AZOC5 (A8I485)

Other databases:

- EMBL:   AP009384
- RefSeq:   YP_001524618.1
- ProteinModelPortal:   A8I485
- SMR:   A8I485
- GeneID:   5689710
- GenomeReviews:   AP009384_GR
- KEGG:   azc:AZC_1702
- HOGENOM:   HBG469615
- OMA:   IAQAFYP
- ProtClustDB:   PRK00892
- BioCyc:   ACAU438753:AZC_1702-MONOMER
- HAMAP:   MF_00523
- InterPro:   IPR018357
- InterPro:   IPR011004
- InterPro:   IPR007691
- InterPro:   IPR020573
- TIGRFAMs:   TIGR01853

Pfam domain/function: PF04613 LpxD; SSF51161 Trimer_LpxA_like

EC number: 2.3.1.-

Molecular weight: Translated: 36161; Mature: 36029

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPAFFPLPTPLTLDEVAALSGARLARPGAQDALRLTGVGTLADAGPSELAFLDQSRYL
CCCCCCCCCCCCCCHHHHHHHCCCHHCCCCCHHCEEEECCCHHCCCCCCCEEEECCCCCE
ATLGTARAGAIITSEKFAGEVPEAIAVLVSPRPASAFVAVTRQLFPQALRPQPVFGHTGI
EECCCCCCCEEEECHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
APGAFIHPTASLEAGVTVDPGAVIGPGAEVGAGSVICANAVVGAGVRIGRDSTIGAGVSL
CCCCEECCCCCCCCCCEECCCCEECCCCCCCCCCEEEHHHHHHCCEEECCCCCCCCCCCH
SHALVGNRVIVHAGARIGQDGFGYQPGPGGHLKVPQIGRVVLQDDVEVGAGSTIDRGALR
HHHHHCCEEEEEECCEECCCCCCCCCCCCCEEECCCCCEEEEECCCCCCCCCCCCCCCHH
DTVIGEGTKIDNLVQIAHNVVIGRHCIIVSQTGISGSTTLGDFVMLGGQVGVVGHCTIGD
HHHCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHEECCCEEEEEEEECCC
GAQIAASSNVKGDVPPGVRWGGSPAKPVREWFREMTTLKKLAESRARSGAATPGEEE
CCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SEPAFFPLPTPLTLDEVAALSGARLARPGAQDALRLTGVGTLADAGPSELAFLDQSRYL
CCCCCCCCCCCCCHHHHHHHCCCHHCCCCCHHCEEEECCCHHCCCCCCCEEEECCCCCE
ATLGTARAGAIITSEKFAGEVPEAIAVLVSPRPASAFVAVTRQLFPQALRPQPVFGHTGI
EECCCCCCCEEEECHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
APGAFIHPTASLEAGVTVDPGAVIGPGAEVGAGSVICANAVVGAGVRIGRDSTIGAGVSL
CCCCEECCCCCCCCCCEECCCCEECCCCCCCCCCEEEHHHHHHCCEEECCCCCCCCCCCH
SHALVGNRVIVHAGARIGQDGFGYQPGPGGHLKVPQIGRVVLQDDVEVGAGSTIDRGALR
HHHHHCCEEEEEECCEECCCCCCCCCCCCCEEECCCCCEEEEECCCCCCCCCCCCCCCHH
DTVIGEGTKIDNLVQIAHNVVIGRHCIIVSQTGISGSTTLGDFVMLGGQVGVVGHCTIGD
HHHCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHEECCCEEEEEEEECCC
GAQIAASSNVKGDVPPGVRWGGSPAKPVREWFREMTTLKKLAESRARSGAATPGEEE
CCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Acyltransferases; Transferring groups other than amino-acyl groups [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA