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The map label for this gene is nhaA

Identifier: 158422950

GI number: 158422950

Start: 1485304

End: 1486488

Strand: Reverse

Name: nhaA

Synonym: AZC_1326

Alternate gene names: 158422950

Gene position: 1486488-1485304 (Counterclockwise)

Preceding gene: 158422951

Following gene: 158422949

Centisome position: 27.68

GC content: 64.98

Gene sequence:

>1185_bases
ATGAGCGGGCCGTCCCGGACCCAGCGGCCGATGTCCCCGCTGCGCGCATTCTTTCATCACGAGACCTCCGCCGGACTCGT
TCTGATGGCCTGCGCATTGGCCGCCATCGCTGTCGCCAACTCGCCCTTGGCCCCCGGCTACTTCGCGACCCTGCACGCAT
ACGCCGGACCGTTGAGCGTCCAACACTGGGTGAACGACGGACTGATGGCGGTGTTCTTTCTGCTCGTCGGTCTGGAGATC
AAGCGCGAAATTCTGACCGGCCAGCTTGCCACCTGGGGGAAGCGGACACTGCCGGGCGTGGCCGCGGTGGGGGGAATGGC
CATCCCCGGCATCGTTTATGTGATGTTGAACCTGAACAACCCGGACGCCTTGCGCGGCTGGGCCATCCCCGCCGCGACCG
ATATCGCTTTCGCGCTGGGAGTGATGTCGCTCCTCGGCTCGCGCGTGCCGTCTTCTCTCAAGATCTTCCTGGCGGCCCTG
GCCATCATCGACGACTTGGGCGCCGTCATCATCATCGCGATTTTCTATACGGCCAATATCAACGTTGCCACCCTGCTGGG
CGCCGTTTTCGTCTTCGGCATTCTCAGAAGCCTGTGCGCCGCCAATTTCCAGGATCTGCGGATCTACCTCGCGCTCGGCG
CGGTGCTGTGGGTCCTGCTCCTGGTGTCCGGCGTCCACGCGACTCTCGCCGGCGTCTTGCTGGCCCTGACGATTCCCATC
ACCACGGCCTCCGCGACGCCGGATCCCTCCCGCCAGACGGCGCCTCTGCACCGCCTGGAGAGCTTGCTCCATGCGCCTGT
CGCCTTCGCCATCCTGCCGATCTTCGGCTTCGCGAATGCCGGCGTGTCCTTTGCCTCGATAACGCCTGCGATCATGACGG
ACACACTCGCCGTCGGCGTTGCGGCCGGGCTTCTGATCGGGAAGGTCGTCGGGATCTTCGGCGCGGTCGCGCTGATGGTC
CGGCTGCGGCTCGCCGAACTCCCCACACACGCGACGTGGCTTCAGGTTCTCGGAGTCGCCTTCCTCTGCGGCATCGGCTT
CACGATGAGCCTGTTCATCGGTCTGCTCGCCTTCGAGGACCCGCACATGCAGGACCGCGTCAAGTACGGCATCCTGGCGG
GCTCGCTGCTGGCCGGCGTTCTCGGATATGGCATTCTGCGGATCGCCGGAAGAAGAGCTTTGTAG

Upstream 100 bases:

>100_bases
CAGCGTTGGAGACCTGCATGTATCATCGCGCGGATACGAGCGCCGTCGCTCGTCCTTTGCTTCATAAGCGGATTTCTTCC
TCCCATGCGGGAGGACGCCC

Downstream 100 bases:

>100_bases
CCGTCGCGTCGGCCCCGTGAGCCGATCCCTGCGCCGCCAGGGCCCATCGGTTCAGGAGATCTGGATCTCGCGCGTGCCCG
TGTGTCGAGGTCCAGGGGTT

Product: Na+/H+ antiporter protein

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MSGPSRTQRPMSPLRAFFHHETSAGLVLMACALAAIAVANSPLAPGYFATLHAYAGPLSVQHWVNDGLMAVFFLLVGLEI
KREILTGQLATWGKRTLPGVAAVGGMAIPGIVYVMLNLNNPDALRGWAIPAATDIAFALGVMSLLGSRVPSSLKIFLAAL
AIIDDLGAVIIIAIFYTANINVATLLGAVFVFGILRSLCAANFQDLRIYLALGAVLWVLLLVSGVHATLAGVLLALTIPI
TTASATPDPSRQTAPLHRLESLLHAPVAFAILPIFGFANAGVSFASITPAIMTDTLAVGVAAGLLIGKVVGIFGAVALMV
RLRLAELPTHATWLQVLGVAFLCGIGFTMSLFIGLLAFEDPHMQDRVKYGILAGSLLAGVLGYGILRIAGRRAL

Sequences:

>Translated_394_residues
MSGPSRTQRPMSPLRAFFHHETSAGLVLMACALAAIAVANSPLAPGYFATLHAYAGPLSVQHWVNDGLMAVFFLLVGLEI
KREILTGQLATWGKRTLPGVAAVGGMAIPGIVYVMLNLNNPDALRGWAIPAATDIAFALGVMSLLGSRVPSSLKIFLAAL
AIIDDLGAVIIIAIFYTANINVATLLGAVFVFGILRSLCAANFQDLRIYLALGAVLWVLLLVSGVHATLAGVLLALTIPI
TTASATPDPSRQTAPLHRLESLLHAPVAFAILPIFGFANAGVSFASITPAIMTDTLAVGVAAGLLIGKVVGIFGAVALMV
RLRLAELPTHATWLQVLGVAFLCGIGFTMSLFIGLLAFEDPHMQDRVKYGILAGSLLAGVLGYGILRIAGRRAL
>Mature_393_residues
SGPSRTQRPMSPLRAFFHHETSAGLVLMACALAAIAVANSPLAPGYFATLHAYAGPLSVQHWVNDGLMAVFFLLVGLEIK
REILTGQLATWGKRTLPGVAAVGGMAIPGIVYVMLNLNNPDALRGWAIPAATDIAFALGVMSLLGSRVPSSLKIFLAALA
IIDDLGAVIIIAIFYTANINVATLLGAVFVFGILRSLCAANFQDLRIYLALGAVLWVLLLVSGVHATLAGVLLALTIPIT
TASATPDPSRQTAPLHRLESLLHAPVAFAILPIFGFANAGVSFASITPAIMTDTLAVGVAAGLLIGKVVGIFGAVALMVR
LRLAELPTHATWLQVLGVAFLCGIGFTMSLFIGLLAFEDPHMQDRVKYGILAGSLLAGVLGYGILRIAGRRAL

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family

Homologues:

Organism=Escherichia coli, GI1786201, Length=394, Percent_Identity=46.7005076142132, Blast_Score=299, Evalue=2e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NHAA_AZOC5 (A8I126)

Other databases:

- EMBL:   AP009384
- RefSeq:   YP_001524242.1
- ProteinModelPortal:   A8I126
- SMR:   A8I126
- GeneID:   5689826
- GenomeReviews:   AP009384_GR
- KEGG:   azc:AZC_1326
- HOGENOM:   HBG665619
- OMA:   YFALRDL
- BioCyc:   ACAU438753:AZC_1326-MONOMER
- HAMAP:   MF_01844
- InterPro:   IPR023171
- InterPro:   IPR004670
- TIGRFAMs:   TIGR00773

Pfam domain/function: PF06965 Na_H_antiport_1

EC number: NA

Molecular weight: Translated: 41187; Mature: 41056

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x1ec217b4)-; HASH(0x1e32566c)-; HASH(0x1de97510)-; HASH(0x1f01da38)-; HASH(0x1efda5f0)-; HASH(0x1f1ae86c)-; HASH(0x1ea6bed4)-; HASH(0x1df07674)-; HASH(0x1dba7204)-; HASH(0x1ec73ee8)-;

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGPSRTQRPMSPLRAFFHHETSAGLVLMACALAAIAVANSPLAPGYFATLHAYAGPLSV
CCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHH
QHWVNDGLMAVFFLLVGLEIKREILTGQLATWGKRTLPGVAAVGGMAIPGIVYVMLNLNN
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHEEEEEECCC
PDALRGWAIPAATDIAFALGVMSLLGSRVPSSLKIFLAALAIIDDLGAVIIIAIFYTANI
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NVATLLGAVFVFGILRSLCAANFQDLRIYLALGAVLWVLLLVSGVHATLAGVLLALTIPI
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TTASATPDPSRQTAPLHRLESLLHAPVAFAILPIFGFANAGVSFASITPAIMTDTLAVGV
EECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHH
AAGLLIGKVVGIFGAVALMVRLRLAELPTHATWLQVLGVAFLCGIGFTMSLFIGLLAFED
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PHMQDRVKYGILAGSLLAGVLGYGILRIAGRRAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
>Mature Secondary Structure 
SGPSRTQRPMSPLRAFFHHETSAGLVLMACALAAIAVANSPLAPGYFATLHAYAGPLSV
CCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHH
QHWVNDGLMAVFFLLVGLEIKREILTGQLATWGKRTLPGVAAVGGMAIPGIVYVMLNLNN
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCHHHHHHEEEEEECCC
PDALRGWAIPAATDIAFALGVMSLLGSRVPSSLKIFLAALAIIDDLGAVIIIAIFYTANI
CCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
NVATLLGAVFVFGILRSLCAANFQDLRIYLALGAVLWVLLLVSGVHATLAGVLLALTIPI
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
TTASATPDPSRQTAPLHRLESLLHAPVAFAILPIFGFANAGVSFASITPAIMTDTLAVGV
EECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHH
AAGLLIGKVVGIFGAVALMVRLRLAELPTHATWLQVLGVAFLCGIGFTMSLFIGLLAFED
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PHMQDRVKYGILAGSLLAGVLGYGILRIAGRRAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA