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The map label for this gene is nuoL [H]

Identifier: 158422933

GI number: 158422933

Start: 1464724

End: 1466295

Strand: Direct

Name: nuoL [H]

Synonym: AZC_1309

Alternate gene names: 158422933

Gene position: 1464724-1466295 (Clockwise)

Preceding gene: 158422929

Following gene: 158422934

Centisome position: 27.28

GC content: 67.68

Gene sequence:

>1572_bases
TTGTCACCTTACCTGCTTCCACTTTGCGCACCGCTCCTGCTGCTGGGGGCGGCCGCGTTCGGCTTCATGCGGAAGGGGCG
GCGCCCACCCCTGGTGCCCGTCTGCGCAGAAGCGGCCGCGCTTGGCGGACTGCTGGTCGCCCTGGCATCGCTGGCGGTTC
TGATCCTTCGCGGTCCCGGCGCCAGCGGGCTGATCGGATGGGCGGGCATCGGCCTGTCGGTGAGGCTCGATGCGGTCAGC
GTAACGATGCTCCTCCTCGTCACGTTCATCGGCTGGATCGTGGTGAGATACGCCCGCACCTATCTCGATGGCGAGGCGCG
GCAGGGTTATTTCATCGGCTGGCTTTGCACGGCGCTCGCGGCAGTCCTTCTCCTCGTCCAGGCGGGCAACGTCGTCCAAT
TGGTCGCGGCGTGGGTCGCAACCAGCGCGGCGCTACATCGCCTGTTGCTGTTCTATCCCGATCGTCGGGCGGCGCAGCGG
GCCGCCCGCAAGAAGCGTCTGTTCTCGTCGATCAGCGCCGCCGCACTCCTCACGGCCATCGGTCTCATCTGGGTGAGCTT
CGGGACGACCGATATCGCGACGATCAATGCACAAGCCCGCACGGGCGAGGGCTCCTGGCTCATCGTAACGGCCGCCGCCA
TGCTCGCGCTCGCCGCCATCCTGAAATCGGCGCAGTTCCCGACCCATGGCTGGCTCACCGAGGTGATGGAGGCGCCGACG
CCGGTCTCGGCCCTGCTTCATGCCGGCGTGATCAATGCCGGCGGCTTCCTGCTGATCCGTTTCGCCGATCTGATGGTTTC
AGCCCCCGGCGTGCTCGCCGTGCTGGCGATGCTCGGCGGGTTCACTGCGTTGTTCGGCGCGCTCGTGATGTTGACGCAGC
CTGCGGTCAAGACCTCGCTCGCCTGGTCGACGGTCGCGCAAATGGGGTTCATGACGCTCCAGTGTGGTCTGGCGCTGTTT
CCGCTGGCGCTGCTCCACATCGTCGCTCACTCGCTCTACAAGGCGCACGCGTTCCTCGCCTCGGGCGGGGCCGTGGAGCA
GGTCGCGTCCATTCGCCGGCCTGGGCCTGTCGCGGTTCCGAACGGGTTGGCGGTAGTCCGCGCCTTCCTGATCGCACTCG
CGATCTACGCGGGGATTGGCGCAGCCTTCGGGTTCACCTTCGGTTTCGAACATAAATCACCGCAAGCGCTCGCGCTCGGC
ACCATCCTGATCTTCGGTGTCGCCTACCTGTTGGCCCAGGGCCTTGCCGATGCGGCGCCCCATCCCCTGACACGCAGGAC
GGCGATCTACGCCAGCGCCGCTGCGATCGGCTACTTCGCGCTCCAGACCGCAGCCGAATGGCTGACCGCAGGGGTTCTCC
CCGCGACGCCGGCACCGGGACGGCTGGAGTGGACGCTGATGGCGCTGGCGGTGCTGAGCTTCGGGGCCGCCGCAGTGGCG
CAGGCGCTGTTCCCGCTCTGGGCATCGCACCCCGCCGCCGCCGGACTTCGCGTCCATCTCTCCAACGGCCTTTACGTCAA
CGCCACGATCGATCGCGTCCTCGGCGGCTGGTCTGTCCCCAAGGCGTCGTGA

Upstream 100 bases:

>100_bases
CGATATTAGCGAACGATTTTGCGCCGACAATGAATTTTAATTCGCTTCCTGCGATCGATATCCAAGGCTTCCCGACTGTC
ACGACTACAGGGGAACCGCC

Downstream 100 bases:

>100_bases
ACCCACAGGAATAAGGACAAGACCCATGTTGATGACCACTCCCGGATCGCCGCTGCCGTCTCCCGATGTGCTTCTCGAGG
CGGCCAATCGGGCGGCGCGC

Product: NADH dehydrogenase

Products: NA

Alternate protein names: NADH dehydrogenase I subunit L; NDH-1 subunit L [H]

Number of amino acids: Translated: 523; Mature: 522

Protein sequence:

>523_residues
MSPYLLPLCAPLLLLGAAAFGFMRKGRRPPLVPVCAEAAALGGLLVALASLAVLILRGPGASGLIGWAGIGLSVRLDAVS
VTMLLLVTFIGWIVVRYARTYLDGEARQGYFIGWLCTALAAVLLLVQAGNVVQLVAAWVATSAALHRLLLFYPDRRAAQR
AARKKRLFSSISAAALLTAIGLIWVSFGTTDIATINAQARTGEGSWLIVTAAAMLALAAILKSAQFPTHGWLTEVMEAPT
PVSALLHAGVINAGGFLLIRFADLMVSAPGVLAVLAMLGGFTALFGALVMLTQPAVKTSLAWSTVAQMGFMTLQCGLALF
PLALLHIVAHSLYKAHAFLASGGAVEQVASIRRPGPVAVPNGLAVVRAFLIALAIYAGIGAAFGFTFGFEHKSPQALALG
TILIFGVAYLLAQGLADAAPHPLTRRTAIYASAAAIGYFALQTAAEWLTAGVLPATPAPGRLEWTLMALAVLSFGAAAVA
QALFPLWASHPAAAGLRVHLSNGLYVNATIDRVLGGWSVPKAS

Sequences:

>Translated_523_residues
MSPYLLPLCAPLLLLGAAAFGFMRKGRRPPLVPVCAEAAALGGLLVALASLAVLILRGPGASGLIGWAGIGLSVRLDAVS
VTMLLLVTFIGWIVVRYARTYLDGEARQGYFIGWLCTALAAVLLLVQAGNVVQLVAAWVATSAALHRLLLFYPDRRAAQR
AARKKRLFSSISAAALLTAIGLIWVSFGTTDIATINAQARTGEGSWLIVTAAAMLALAAILKSAQFPTHGWLTEVMEAPT
PVSALLHAGVINAGGFLLIRFADLMVSAPGVLAVLAMLGGFTALFGALVMLTQPAVKTSLAWSTVAQMGFMTLQCGLALF
PLALLHIVAHSLYKAHAFLASGGAVEQVASIRRPGPVAVPNGLAVVRAFLIALAIYAGIGAAFGFTFGFEHKSPQALALG
TILIFGVAYLLAQGLADAAPHPLTRRTAIYASAAAIGYFALQTAAEWLTAGVLPATPAPGRLEWTLMALAVLSFGAAAVA
QALFPLWASHPAAAGLRVHLSNGLYVNATIDRVLGGWSVPKAS
>Mature_522_residues
SPYLLPLCAPLLLLGAAAFGFMRKGRRPPLVPVCAEAAALGGLLVALASLAVLILRGPGASGLIGWAGIGLSVRLDAVSV
TMLLLVTFIGWIVVRYARTYLDGEARQGYFIGWLCTALAAVLLLVQAGNVVQLVAAWVATSAALHRLLLFYPDRRAAQRA
ARKKRLFSSISAAALLTAIGLIWVSFGTTDIATINAQARTGEGSWLIVTAAAMLALAAILKSAQFPTHGWLTEVMEAPTP
VSALLHAGVINAGGFLLIRFADLMVSAPGVLAVLAMLGGFTALFGALVMLTQPAVKTSLAWSTVAQMGFMTLQCGLALFP
LALLHIVAHSLYKAHAFLASGGAVEQVASIRRPGPVAVPNGLAVVRAFLIALAIYAGIGAAFGFTFGFEHKSPQALALGT
ILIFGVAYLLAQGLADAAPHPLTRRTAIYASAAAIGYFALQTAAEWLTAGVLPATPAPGRLEWTLMALAVLSFGAAAVAQ
ALFPLWASHPAAAGLRVHLSNGLYVNATIDRVLGGWSVPKAS

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1009

COG function: function code CP; NADH:ubiquinone oxidoreductase subunit 5 (chain L)/Multisubunit Na+/H+ antiporter, MnhA subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 5 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=295, Percent_Identity=32.5423728813559, Blast_Score=131, Evalue=2e-30,
Organism=Escherichia coli, GI1788614, Length=284, Percent_Identity=32.0422535211268, Blast_Score=135, Evalue=6e-33,
Organism=Escherichia coli, GI1788829, Length=287, Percent_Identity=31.7073170731707, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI1788831, Length=303, Percent_Identity=28.3828382838284, Blast_Score=77, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001750
- InterPro:   IPR001516
- InterPro:   IPR003945
- InterPro:   IPR018393 [H]

Pfam domain/function: PF00361 Oxidored_q1; PF00662 Oxidored_q1_N [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 54262; Mature: 54131

Theoretical pI: Translated: 10.53; Mature: 10.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPYLLPLCAPLLLLGAAAFGFMRKGRRPPLVPVCAEAAALGGLLVALASLAVLILRGPG
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ASGLIGWAGIGLSVRLDAVSVTMLLLVTFIGWIVVRYARTYLDGEARQGYFIGWLCTALA
CCCCHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
AVLLLVQAGNVVQLVAAWVATSAALHRLLLFYPDRRAAQRAARKKRLFSSISAAALLTAI
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GLIWVSFGTTDIATINAQARTGEGSWLIVTAAAMLALAAILKSAQFPTHGWLTEVMEAPT
HHHHHHCCCCCEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCC
PVSALLHAGVINAGGFLLIRFADLMVSAPGVLAVLAMLGGFTALFGALVMLTQPAVKTSL
HHHHHHHHCHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
AWSTVAQMGFMTLQCGLALFPLALLHIVAHSLYKAHAFLASGGAVEQVASIRRPGPVAVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCC
NGLAVVRAFLIALAIYAGIGAAFGFTFGFEHKSPQALALGTILIFGVAYLLAQGLADAAP
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
HPLTRRTAIYASAAAIGYFALQTAAEWLTAGVLPATPAPGRLEWTLMALAVLSFGAAAVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
QALFPLWASHPAAAGLRVHLSNGLYVNATIDRVLGGWSVPKAS
HHHHHHHHCCCCCCCEEEEECCCEEEEEEHHHHHCCCCCCCCC
>Mature Secondary Structure 
SPYLLPLCAPLLLLGAAAFGFMRKGRRPPLVPVCAEAAALGGLLVALASLAVLILRGPG
CCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
ASGLIGWAGIGLSVRLDAVSVTMLLLVTFIGWIVVRYARTYLDGEARQGYFIGWLCTALA
CCCCHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
AVLLLVQAGNVVQLVAAWVATSAALHRLLLFYPDRRAAQRAARKKRLFSSISAAALLTAI
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GLIWVSFGTTDIATINAQARTGEGSWLIVTAAAMLALAAILKSAQFPTHGWLTEVMEAPT
HHHHHHCCCCCEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCC
PVSALLHAGVINAGGFLLIRFADLMVSAPGVLAVLAMLGGFTALFGALVMLTQPAVKTSL
HHHHHHHHCHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
AWSTVAQMGFMTLQCGLALFPLALLHIVAHSLYKAHAFLASGGAVEQVASIRRPGPVAVP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCC
NGLAVVRAFLIALAIYAGIGAAFGFTFGFEHKSPQALALGTILIFGVAYLLAQGLADAAP
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
HPLTRRTAIYASAAAIGYFALQTAAEWLTAGVLPATPAPGRLEWTLMALAVLSFGAAAVA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
QALFPLWASHPAAAGLRVHLSNGLYVNATIDRVLGGWSVPKAS
HHHHHHHHCCCCCCCEEEEECCCEEEEEEHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]