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The map label for this gene is lhgO [H]

Identifier: 158422720

GI number: 158422720

Start: 1222858

End: 1224015

Strand: Direct

Name: lhgO [H]

Synonym: AZC_1096

Alternate gene names: 158422720

Gene position: 1222858-1224015 (Clockwise)

Preceding gene: 158422719

Following gene: 158422724

Centisome position: 22.77

GC content: 69.69

Gene sequence:

>1158_bases
TTGGATTCCCGGTGTGCCATGGACGTCATTGAACTCGATCATGTGGTTGTCGGCGCCGGTGTCGTCGGCTTGGCCAGCGC
TGCGGCGCTGGCGCGGGCAGGGCGCGAGGTGTTCGTGCTGGAAGCCGGGCCGACCATCGGCAGCGGCATCTCCTCGCGCA
ACAGCGAGGTGATCCACTCCGGCGTCTATTACACCACCGGCACCCTGCGCCATCTCCTCTGCGTCGAGGGCCGTCGGCGG
CTCTATGCCTATTGCGAGCGCCACGGCATCGCCCACAACAAGTGCGGCAAGCTCATCGTCGCCACCAACGAGGCCGAGGC
CGAGAAGATCGCCGGCATTGCGGTGCGGGCGAAGGAGAACGGCGTCGAGAACACCGATCTCATCACCGGCGCCGCCGCCA
TGGCGCTGGAACCGGCGCTGAAGGCGGTGGCGGCGCTTCATGTGGCCGAGACCGGCATCATCGATACGCATGGCTACATG
CTGGCGCTCCAGGGCGAGGTGGAGGCGGCGGGCGGCGCCGTGCTGCTGCGCCACAGCGTGCGGCGGGGCACCGCTGCGCC
GGGCCGCTTCACGCTGGACGTGGACACGCCGGACGGTCCCTTCACGCTCACCTGCCGCTCGCTGGTGATCGCCGCCGGCC
CTTGGACGCACAAGGTGGCGGGCCGCATCGAGGGCTATGACATCTCGGCCATCCACCCCCTCGTGCTGGCCAAGGGCTCC
TATTTCTCCTATGCCGGCAAGCCGGTGTTCTCGCGCCTCATCTATCCGGCGCCCATCGACGGCGGCCTCGGCACCCATGT
GACGCTCGATCTCGCCGGGCGCATGCGCTTCGGCCCCGACGTGGAATGGCTGAACACGGGCGATCCGGATGCGGTGGACT
TCTCCGTGGATCCCGCGCGGGCGGAAAGCTTCTACGCCAATGTGCGCCGCTTCTGGCCGCACCTGCCGGACGGCTCGCTC
GTGCCGGACTATTCCGGCGTGCGGCCCAAGCTTGCGCCGCGCGGCACGCAGGAGGACTTCCTGCTGCATGGCCCTGCCCA
GCACGGCGTCGAGGGGCTGGTCGGCCTGTTCGGCCTCGAAAGCCCCGGCCTCACCTCGTCTCTCGCCATCGGCGAGCGCG
TGCGCGGCCTCGTGGAGCCCACCGCGCTCGCCGCCTGA

Upstream 100 bases:

>100_bases
CCGCAGCTTCCTTGATCTCGCAAAAGCTTGAGATTTCCGCCGCCCTGACGCTGCGGTGCAGCTTTCCCTTTGGCATCCCA
CGGCTTAGCCTGTCGCCGAT

Downstream 100 bases:

>100_bases
GCGGGCGCGCGAAGATGGGCTGAAGGTTGCACCAGATTGGACCTACACCCAAGAACAAGCTTCGCGAAACCTTCCGGTCG
GATCGACGTTCTCAGGTCAT

Product: FAD dependent oxidoreductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MDSRCAMDVIELDHVVVGAGVVGLASAAALARAGREVFVLEAGPTIGSGISSRNSEVIHSGVYYTTGTLRHLLCVEGRRR
LYAYCERHGIAHNKCGKLIVATNEAEAEKIAGIAVRAKENGVENTDLITGAAAMALEPALKAVAALHVAETGIIDTHGYM
LALQGEVEAAGGAVLLRHSVRRGTAAPGRFTLDVDTPDGPFTLTCRSLVIAAGPWTHKVAGRIEGYDISAIHPLVLAKGS
YFSYAGKPVFSRLIYPAPIDGGLGTHVTLDLAGRMRFGPDVEWLNTGDPDAVDFSVDPARAESFYANVRRFWPHLPDGSL
VPDYSGVRPKLAPRGTQEDFLLHGPAQHGVEGLVGLFGLESPGLTSSLAIGERVRGLVEPTALAA

Sequences:

>Translated_385_residues
MDSRCAMDVIELDHVVVGAGVVGLASAAALARAGREVFVLEAGPTIGSGISSRNSEVIHSGVYYTTGTLRHLLCVEGRRR
LYAYCERHGIAHNKCGKLIVATNEAEAEKIAGIAVRAKENGVENTDLITGAAAMALEPALKAVAALHVAETGIIDTHGYM
LALQGEVEAAGGAVLLRHSVRRGTAAPGRFTLDVDTPDGPFTLTCRSLVIAAGPWTHKVAGRIEGYDISAIHPLVLAKGS
YFSYAGKPVFSRLIYPAPIDGGLGTHVTLDLAGRMRFGPDVEWLNTGDPDAVDFSVDPARAESFYANVRRFWPHLPDGSL
VPDYSGVRPKLAPRGTQEDFLLHGPAQHGVEGLVGLFGLESPGLTSSLAIGERVRGLVEPTALAA
>Mature_385_residues
MDSRCAMDVIELDHVVVGAGVVGLASAAALARAGREVFVLEAGPTIGSGISSRNSEVIHSGVYYTTGTLRHLLCVEGRRR
LYAYCERHGIAHNKCGKLIVATNEAEAEKIAGIAVRAKENGVENTDLITGAAAMALEPALKAVAALHVAETGIIDTHGYM
LALQGEVEAAGGAVLLRHSVRRGTAAPGRFTLDVDTPDGPFTLTCRSLVIAAGPWTHKVAGRIEGYDISAIHPLVLAKGS
YFSYAGKPVFSRLIYPAPIDGGLGTHVTLDLAGRMRFGPDVEWLNTGDPDAVDFSVDPARAESFYANVRRFWPHLPDGSL
VPDYSGVRPKLAPRGTQEDFLLHGPAQHGVEGLVGLFGLESPGLTSSLAIGERVRGLVEPTALAA

Specific function: Oxidizes L-2-hydroxyglutarate, probably to recover alpha-ketoglutarate mistakenly reduced by other enzymes or formed during growth on propionate [H]

COG id: COG0579

COG function: function code R; Predicted dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the L2HGDH family [H]

Homologues:

Organism=Homo sapiens, GI13376331, Length=276, Percent_Identity=29.7101449275362, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI87082148, Length=237, Percent_Identity=27.0042194092827, Blast_Score=86, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17565764, Length=288, Percent_Identity=30.2083333333333, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24585081, Length=168, Percent_Identity=35.1190476190476, Blast_Score=96, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015657
- InterPro:   IPR006076 [H]

Pfam domain/function: PF01266 DAO [H]

EC number: =1.1.3.15 [H]

Molecular weight: Translated: 40582; Mature: 40582

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSRCAMDVIELDHVVVGAGVVGLASAAALARAGREVFVLEAGPTIGSGISSRNSEVIHS
CCCCHHHHHHHHCCEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEEEC
GVYYTTGTLRHLLCVEGRRRLYAYCERHGIAHNKCGKLIVATNEAEAEKIAGIAVRAKEN
CEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHEEEEEECCC
GVENTDLITGAAAMALEPALKAVAALHVAETGIIDTHGYMLALQGEVEAAGGAVLLRHSV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCEEEEEECCCCCCCCEEEEEHHH
RRGTAAPGRFTLDVDTPDGPFTLTCRSLVIAAGPWTHKVAGRIEGYDISAIHPLVLAKGS
HCCCCCCCEEEEEECCCCCCEEEEEEEEEEECCCCHHHHHCCCCCCEECCCCCEEEECCC
YFSYAGKPVFSRLIYPAPIDGGLGTHVTLDLAGRMRFGPDVEWLNTGDPDAVDFSVDPAR
CCCCCCCHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEECCCHHH
AESFYANVRRFWPHLPDGSLVPDYSGVRPKLAPRGTQEDFLLHGPAQHGVEGLVGLFGLE
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCC
SPGLTSSLAIGERVRGLVEPTALAA
CCCCCHHHHHHHHHHHHCCCHHHCC
>Mature Secondary Structure
MDSRCAMDVIELDHVVVGAGVVGLASAAALARAGREVFVLEAGPTIGSGISSRNSEVIHS
CCCCHHHHHHHHCCEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCCEEEC
GVYYTTGTLRHLLCVEGRRRLYAYCERHGIAHNKCGKLIVATNEAEAEKIAGIAVRAKEN
CEEEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHEEEEEECCC
GVENTDLITGAAAMALEPALKAVAALHVAETGIIDTHGYMLALQGEVEAAGGAVLLRHSV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCEEEEEECCCCCCCCEEEEEHHH
RRGTAAPGRFTLDVDTPDGPFTLTCRSLVIAAGPWTHKVAGRIEGYDISAIHPLVLAKGS
HCCCCCCCEEEEEECCCCCCEEEEEEEEEEECCCCHHHHHCCCCCCEECCCCCEEEECCC
YFSYAGKPVFSRLIYPAPIDGGLGTHVTLDLAGRMRFGPDVEWLNTGDPDAVDFSVDPAR
CCCCCCCHHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEECCCHHH
AESFYANVRRFWPHLPDGSLVPDYSGVRPKLAPRGTQEDFLLHGPAQHGVEGLVGLFGLE
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHCCC
SPGLTSSLAIGERVRGLVEPTALAA
CCCCCHHHHHHHHHHHHCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 8297211; 7984428 [H]