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The map label for this gene is dnaA [H]

Identifier: 158422638

GI number: 158422638

Start: 1138239

End: 1139573

Strand: Reverse

Name: dnaA [H]

Synonym: AZC_1014

Alternate gene names: 158422638

Gene position: 1139573-1138239 (Counterclockwise)

Preceding gene: 158422639

Following gene: 158422637

Centisome position: 21.22

GC content: 70.34

Gene sequence:

>1335_bases
ATGACTGGCAGCGCCGTCCAGTTGTCCGTCCCGACCCGCTTCCTCAAGGCCTGGATCCAGGACCACTATCTCGACCGCCT
GTCCGAGCTGTGGCGTGAGGAAAGCGGTACCACCCGCGTCGACCTCGTGGTCCGCACCGCCGTTGCCCGCACCGTTCCCC
TGAAGGCGGCGAATGCGCCGCGCGAGATCGTTTCCGAGCGCCCCGTTGTCGCGCCGACCGCTGCTGCTCCGGCGCGGTCC
CAGCCGGTGGCCGCTCCGACCGCGCCGGCCTCCGCCCAGCCTGCCGATGTGGCCGCCGGCTCGCCGCTGGACGCCCGCCT
CACCTTCGAGACCTTCGTGGTCGGCAAGTCCAACACCCTCGCCCATGCCGCCGCCCGGCAGGTGGCCGAGGCCGTGCCCG
GCGCCGCCCCGCTCTTCAATCCGCTCTACATGCATGCGGCCGTTGGCCTCGGTAAGACCCACCTCCTCCAGGCCGTGGCC
TGGGCCGGCGCCGCGCGCGGCCGCCGCGTGGTGTATCTGACCGCCGAGCGCTTCATGTACGGCTTCGTGGCCGCGCTGAA
GTCCCACGCCGCCATCGCCTTCAAGGATGCCCTGCGCTCCATCGACACGCTGGTGATCGACGACCTGCAGTTCCTGACCG
GCAAGAACATGCAGCAGGAGTTCTGCCACACGCTGAACGCGCTCATGGATGCCGGCCGTCAGGTGGTGGTGGCCGCCGAC
CGTCCGCCGTCCGAGCTGGACGCGCTGGACGACCGCGTGCGCTCGCGCCTCGCCGGCGGCCTCGTGGTGGAACTGGCCCC
GCTGGAAGAGGACCTGCGCGCGCAGATCCTGAAGACCCGCTCGGTGTCCCTGTCCGAGCAGCACCGCGGCTTCGCCGTTC
CCTCGGCGGTTCTGGAGTTCCTCGCCCGTCACGTGGGCACGTCCGGCCGCGACCTCGACGGCGCGCTGAACAAGCTTCTG
GCGGTGAACAAGCTCACCGGCGAGCCGGTGACGCTGGAGATGGCCGAGACCGCCGTGAAGGATCTGGTCCGCCCCTGCGA
TCCCAAGCGGGTGCGCGTGGACGACATCCTGCGCGTGGTGGCCAAGCATTATAACGTGACGCGCGCCGACCTGCTGTCGC
AACGCCGCACCGCCAACGTGGTGAAGCCGCGCCAGATCGCCATGTATCTGGCCAAGACGCTCACCCTGCGTTCGCTGCCC
GAGATCGGCCGCCGCTTCGGCGGGCGCGACCACACCACCGTCCTCCATGCGGTGCGCAAGATCGACGGCCTGATCGCCAC
CGACCGCGCGCTCGCCGACGAGATCGAGACCCTGAAGCGCCTCGTGGCTGAGTGA

Upstream 100 bases:

>100_bases
TGTCTCCTCCCTCCAATGGGACCGGGTCCGCCAGCGTCTGCGCGAAGAGATCGGCGAGGAATCCTATACGAGCTGGTTCG
CGCGCATCGAGCTCGACCGC

Downstream 100 bases:

>100_bases
GGCCCGACACGGCGCTTCTCCTCCACGCCTGAACGTCGCGGCACCGGTCCCCACCGGTGCCGTTTTCGTTTCGAGCGTTC
GGCGCGACAGACGCCCCCGC

Product: chromosomal replication initiation protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MTGSAVQLSVPTRFLKAWIQDHYLDRLSELWREESGTTRVDLVVRTAVARTVPLKAANAPREIVSERPVVAPTAAAPARS
QPVAAPTAPASAQPADVAAGSPLDARLTFETFVVGKSNTLAHAAARQVAEAVPGAAPLFNPLYMHAAVGLGKTHLLQAVA
WAGAARGRRVVYLTAERFMYGFVAALKSHAAIAFKDALRSIDTLVIDDLQFLTGKNMQQEFCHTLNALMDAGRQVVVAAD
RPPSELDALDDRVRSRLAGGLVVELAPLEEDLRAQILKTRSVSLSEQHRGFAVPSAVLEFLARHVGTSGRDLDGALNKLL
AVNKLTGEPVTLEMAETAVKDLVRPCDPKRVRVDDILRVVAKHYNVTRADLLSQRRTANVVKPRQIAMYLAKTLTLRSLP
EIGRRFGGRDHTTVLHAVRKIDGLIATDRALADEIETLKRLVAE

Sequences:

>Translated_444_residues
MTGSAVQLSVPTRFLKAWIQDHYLDRLSELWREESGTTRVDLVVRTAVARTVPLKAANAPREIVSERPVVAPTAAAPARS
QPVAAPTAPASAQPADVAAGSPLDARLTFETFVVGKSNTLAHAAARQVAEAVPGAAPLFNPLYMHAAVGLGKTHLLQAVA
WAGAARGRRVVYLTAERFMYGFVAALKSHAAIAFKDALRSIDTLVIDDLQFLTGKNMQQEFCHTLNALMDAGRQVVVAAD
RPPSELDALDDRVRSRLAGGLVVELAPLEEDLRAQILKTRSVSLSEQHRGFAVPSAVLEFLARHVGTSGRDLDGALNKLL
AVNKLTGEPVTLEMAETAVKDLVRPCDPKRVRVDDILRVVAKHYNVTRADLLSQRRTANVVKPRQIAMYLAKTLTLRSLP
EIGRRFGGRDHTTVLHAVRKIDGLIATDRALADEIETLKRLVAE
>Mature_443_residues
TGSAVQLSVPTRFLKAWIQDHYLDRLSELWREESGTTRVDLVVRTAVARTVPLKAANAPREIVSERPVVAPTAAAPARSQ
PVAAPTAPASAQPADVAAGSPLDARLTFETFVVGKSNTLAHAAARQVAEAVPGAAPLFNPLYMHAAVGLGKTHLLQAVAW
AGAARGRRVVYLTAERFMYGFVAALKSHAAIAFKDALRSIDTLVIDDLQFLTGKNMQQEFCHTLNALMDAGRQVVVAADR
PPSELDALDDRVRSRLAGGLVVELAPLEEDLRAQILKTRSVSLSEQHRGFAVPSAVLEFLARHVGTSGRDLDGALNKLLA
VNKLTGEPVTLEMAETAVKDLVRPCDPKRVRVDDILRVVAKHYNVTRADLLSQRRTANVVKPRQIAMYLAKTLTLRSLPE
IGRRFGGRDHTTVLHAVRKIDGLIATDRALADEIETLKRLVAE

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=457, Percent_Identity=38.7308533916849, Blast_Score=292, Evalue=2e-80,
Organism=Escherichia coli, GI226510964, Length=214, Percent_Identity=24.7663551401869, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 48160; Mature: 48029

Theoretical pI: Translated: 10.21; Mature: 10.21

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGSAVQLSVPTRFLKAWIQDHYLDRLSELWREESGTTRVDLVVRTAVARTVPLKAANAP
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCC
REIVSERPVVAPTAAAPARSQPVAAPTAPASAQPADVAAGSPLDARLTFETFVVGKSNTL
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCHH
AHAAARQVAEAVPGAAPLFNPLYMHAAVGLGKTHLLQAVAWAGAARGRRVVYLTAERFMY
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHH
GFVAALKSHAAIAFKDALRSIDTLVIDDLQFLTGKNMQQEFCHTLNALMDAGRQVVVAAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEECC
RPPSELDALDDRVRSRLAGGLVVELAPLEEDLRAQILKTRSVSLSEQHRGFAVPSAVLEF
CCCHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHH
LARHVGTSGRDLDGALNKLLAVNKLTGEPVTLEMAETAVKDLVRPCDPKRVRVDDILRVV
HHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
AKHYNVTRADLLSQRRTANVVKPRQIAMYLAKTLTLRSLPEIGRRFGGRDHTTVLHAVRK
HHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
IDGLIATDRALADEIETLKRLVAE
HHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TGSAVQLSVPTRFLKAWIQDHYLDRLSELWREESGTTRVDLVVRTAVARTVPLKAANAP
CCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCC
REIVSERPVVAPTAAAPARSQPVAAPTAPASAQPADVAAGSPLDARLTFETFVVGKSNTL
HHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECCCCHH
AHAAARQVAEAVPGAAPLFNPLYMHAAVGLGKTHLLQAVAWAGAARGRRVVYLTAERFMY
HHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEEEEHHHHHH
GFVAALKSHAAIAFKDALRSIDTLVIDDLQFLTGKNMQQEFCHTLNALMDAGRQVVVAAD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEEEECC
RPPSELDALDDRVRSRLAGGLVVELAPLEEDLRAQILKTRSVSLSEQHRGFAVPSAVLEF
CCCHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHCCCCHHHCCCCCCHHHHHHH
LARHVGTSGRDLDGALNKLLAVNKLTGEPVTLEMAETAVKDLVRPCDPKRVRVDDILRVV
HHHHCCCCCCCHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
AKHYNVTRADLLSQRRTANVVKPRQIAMYLAKTLTLRSLPEIGRRFGGRDHTTVLHAVRK
HHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
IDGLIATDRALADEIETLKRLVAE
HHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA