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The map label for this gene is fabG [H]

Identifier: 158422557

GI number: 158422557

Start: 1045794

End: 1046555

Strand: Direct

Name: fabG [H]

Synonym: AZC_0933

Alternate gene names: 158422557

Gene position: 1045794-1046555 (Clockwise)

Preceding gene: 158422556

Following gene: 158422558

Centisome position: 19.48

GC content: 72.83

Gene sequence:

>762_bases
ATGGATGTGAAGGGACATGCCGCCGTCGTCACCGGCGCGGCGTCGGGGCTCGGCGCGGTCACGGCGCGGGCGCTGGCCGC
GGCAGGGGCGAAGGTGGCGCTGCTCGACCGGGAGGTGGAGGGCGCGGCGCGGGTGGCAGCAGAAATCGGCGGGCAGGCCT
TCGCCTGCGACGTTGTGGATGCGGCGAGCGCAGAAGCCGCGGTGGCCGCGGCGGCCGCGGCGCACGGGCCGGCGCGCATC
CTCGTGAATTGCGCGGGCGTCGCTCCGGCGGGCCGCATCGTCGGCCGCAAGGGGCCGCAACCGCTGGAGGATTTCCGCCG
GGTGGTGGAGATCAACCTCATCGGCACGTTCAACCTGCTGCGCCTCGTGGCGGCCGGCGCCGTGGGGCTGGAGCCGCTGG
CGCGGGGCGAGCGGGGCGTGCTCATCAACACCGCCTCCATTGCCGCCTATGACGGGCAGGTCGGCCAGCCGGCCTATGCG
GCCTCCAAGGCGGGCGTCGCGGGCCTGACCCTGCCGGCGGCGCGCGAATTCGCGGGCGTCGGCATTCGCGTGGTGACCAT
CGCGCCCGGCATCTTTGCCACGCCCATGATGCTCAACATGCCGCAGGAGGTGCAGGACAGCATCGGCGCCACCGTGCCCT
TTCCGCCGGGGCTGGGCGATCCGGAGGATTATGCCCGTCTGGTGCTCCACATCATCGGCAACACCATGCTGAACGGGGAG
GTGATCCGCCTCGACGGGGCGTTGCGCATGGCGCCGAAGTGA

Upstream 100 bases:

>100_bases
CGAGGGTGTCGCTGCCTTCGTCGCCAAGCGCCTGCCCCGCTTCGAGGGGCACTGACCCGGCGCACGCCGGGCGAACCATA
AGAACAGCGGGGAGAAGGCC

Downstream 100 bases:

>100_bases
GAATTAAACGGATGTATCGCGTGAATATACCCAATTCCGCTCGCTATTGACTTAAACCACTAATCCGGTAGATTGAGATG
AGAATATTCCGTGCCGGAGA

Product: 3-hydroxyacyl-CoA dehydrogenase type II

Products: NA

Alternate protein names: 3-ketoacyl-acyl carrier protein reductase [H]

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MDVKGHAAVVTGAASGLGAVTARALAAAGAKVALLDREVEGAARVAAEIGGQAFACDVVDAASAEAAVAAAAAAHGPARI
LVNCAGVAPAGRIVGRKGPQPLEDFRRVVEINLIGTFNLLRLVAAGAVGLEPLARGERGVLINTASIAAYDGQVGQPAYA
ASKAGVAGLTLPAAREFAGVGIRVVTIAPGIFATPMMLNMPQEVQDSIGATVPFPPGLGDPEDYARLVLHIIGNTMLNGE
VIRLDGALRMAPK

Sequences:

>Translated_253_residues
MDVKGHAAVVTGAASGLGAVTARALAAAGAKVALLDREVEGAARVAAEIGGQAFACDVVDAASAEAAVAAAAAAHGPARI
LVNCAGVAPAGRIVGRKGPQPLEDFRRVVEINLIGTFNLLRLVAAGAVGLEPLARGERGVLINTASIAAYDGQVGQPAYA
ASKAGVAGLTLPAAREFAGVGIRVVTIAPGIFATPMMLNMPQEVQDSIGATVPFPPGLGDPEDYARLVLHIIGNTMLNGE
VIRLDGALRMAPK
>Mature_253_residues
MDVKGHAAVVTGAASGLGAVTARALAAAGAKVALLDREVEGAARVAAEIGGQAFACDVVDAASAEAAVAAAAAAHGPARI
LVNCAGVAPAGRIVGRKGPQPLEDFRRVVEINLIGTFNLLRLVAAGAVGLEPLARGERGVLINTASIAAYDGQVGQPAYA
ASKAGVAGLTLPAAREFAGVGIRVVTIAPGIFATPMMLNMPQEVQDSIGATVPFPPGLGDPEDYARLVLHIIGNTMLNGE
VIRLDGALRMAPK

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=255, Percent_Identity=50.9803921568627, Blast_Score=235, Evalue=3e-62,
Organism=Homo sapiens, GI83715985, Length=254, Percent_Identity=48.0314960629921, Blast_Score=212, Evalue=3e-55,
Organism=Homo sapiens, GI15277342, Length=258, Percent_Identity=36.4341085271318, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI40254992, Length=243, Percent_Identity=29.2181069958848, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI31542939, Length=264, Percent_Identity=29.9242424242424, Blast_Score=96, Evalue=4e-20,
Organism=Homo sapiens, GI224922801, Length=184, Percent_Identity=32.0652173913043, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI32483357, Length=244, Percent_Identity=31.5573770491803, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI59889578, Length=176, Percent_Identity=29.5454545454545, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI5031737, Length=205, Percent_Identity=33.1707317073171, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI33667109, Length=203, Percent_Identity=33.4975369458128, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1787335, Length=254, Percent_Identity=31.1023622047244, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI87082100, Length=199, Percent_Identity=35.1758793969849, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI87082160, Length=261, Percent_Identity=30.2681992337165, Blast_Score=81, Evalue=5e-17,
Organism=Escherichia coli, GI1787905, Length=256, Percent_Identity=30.859375, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1786812, Length=201, Percent_Identity=31.3432835820896, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789208, Length=254, Percent_Identity=29.9212598425197, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1789057, Length=243, Percent_Identity=29.2181069958848, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1790717, Length=258, Percent_Identity=27.906976744186, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI2367175, Length=251, Percent_Identity=30.2788844621514, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=250, Percent_Identity=48.4, Blast_Score=216, Evalue=6e-57,
Organism=Caenorhabditis elegans, GI25147288, Length=254, Percent_Identity=32.6771653543307, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17555706, Length=248, Percent_Identity=31.4516129032258, Blast_Score=103, Evalue=8e-23,
Organism=Caenorhabditis elegans, GI17563726, Length=244, Percent_Identity=25.8196721311475, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17538480, Length=243, Percent_Identity=27.9835390946502, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17559104, Length=238, Percent_Identity=26.890756302521, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17551412, Length=241, Percent_Identity=28.6307053941909, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI72000259, Length=245, Percent_Identity=26.530612244898, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17562906, Length=244, Percent_Identity=28.6885245901639, Blast_Score=64, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17560150, Length=244, Percent_Identity=24.5901639344262, Blast_Score=64, Evalue=1e-10,
Organism=Saccharomyces cerevisiae, GI6322861, Length=205, Percent_Identity=32.1951219512195, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17737361, Length=255, Percent_Identity=47.843137254902, Blast_Score=221, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24639444, Length=251, Percent_Identity=36.6533864541833, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24644339, Length=202, Percent_Identity=30.6930693069307, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21357041, Length=199, Percent_Identity=32.1608040201005, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24665243, Length=211, Percent_Identity=30.3317535545024, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI221331218, Length=211, Percent_Identity=30.3317535545024, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24665247, Length=212, Percent_Identity=30.6603773584906, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI221331216, Length=212, Percent_Identity=30.6603773584906, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28571526, Length=228, Percent_Identity=29.3859649122807, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI23397609, Length=201, Percent_Identity=30.3482587064677, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21355319, Length=247, Percent_Identity=27.5303643724696, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011284
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.100 [H]

Molecular weight: Translated: 25363; Mature: 25363

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDVKGHAAVVTGAASGLGAVTARALAAAGAKVALLDREVEGAARVAAEIGGQAFACDVVD
CCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCCEEEEEHHH
AASAEAAVAAAAAAHGPARILVNCAGVAPAGRIVGRKGPQPLEDFRRVVEINLIGTFNLL
CCCHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHCCCCCCCHHHHHHHEEEEEECHHHHH
RLVAAGAVGLEPLARGERGVLINTASIAAYDGQVGQPAYAASKAGVAGLTLPAAREFAGV
HHHHHCCCCCCHHHCCCCCEEEEECEEEEECCCCCCCCHHHHCCCCCEEECHHHHHHHCC
GIRVVTIAPGIFATPMMLNMPQEVQDSIGATVPFPPGLGDPEDYARLVLHIIGNTMLNGE
CEEEEEECCCHHHCCHHHCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCHHCCCE
VIRLDGALRMAPK
EEEECCCEECCCC
>Mature Secondary Structure
MDVKGHAAVVTGAASGLGAVTARALAAAGAKVALLDREVEGAARVAAEIGGQAFACDVVD
CCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCCEEEEEHHH
AASAEAAVAAAAAAHGPARILVNCAGVAPAGRIVGRKGPQPLEDFRRVVEINLIGTFNLL
CCCHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHCCCCCCCHHHHHHHEEEEEECHHHHH
RLVAAGAVGLEPLARGERGVLINTASIAAYDGQVGQPAYAASKAGVAGLTLPAAREFAGV
HHHHHCCCCCCHHHCCCCCEEEEECEEEEECCCCCCCCHHHHCCCCCEEECHHHHHHHCC
GIRVVTIAPGIFATPMMLNMPQEVQDSIGATVPFPPGLGDPEDYARLVLHIIGNTMLNGE
CEEEEEECCCHHHCCHHHCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCHHCCCE
VIRLDGALRMAPK
EEEECCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]