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The map label for this gene is flhA [H]

Identifier: 158422278

GI number: 158422278

Start: 723859

End: 725940

Strand: Direct

Name: flhA [H]

Synonym: AZC_0654

Alternate gene names: 158422278

Gene position: 723859-725940 (Clockwise)

Preceding gene: 158422277

Following gene: 158422279

Centisome position: 13.48

GC content: 65.8

Gene sequence:

>2082_bases
ATGGCCGACGTTTCGCTTACCGCCGGAGACCAGCGCTCACGCCGCGACATAGGCTTTGCCGTTGGCATCGTCGCGATTCT
CGCGGTGCTCTTCCTGCCGATCCCGCCGCTGCTCATCGATATCGGGCTTGCGCTGTCGATCGCGCTCTCGGTTCTGATCC
TGATGGTGTCGCTCTGGATCCAGAAGCCGCTCGAATTCTCGTCCTTCCCGACCATCCTTCTGCTCGCCACCATGCTGCGC
CTCGCGCTCGGCGTCGCAACCACGCGCCTCATTCTCGCGCACGGTGCGGACGGCGTGCACGCCGCCGGTGCCATCATCGC
GGGCTTTTCCAAGCTCGTCATGAGCGGCGATTTCGTGATCGGTATCGTGGTATTCGCGATCCTCGTCACGGTGAACTTCC
TCGTCATCACCAAGGGCGCCACGCGTATCGCGGAAGTGGGCGCCCGCTTCACCCTCGACGCCATCCCCGGCAAGCAGATG
GCCATCGACGCCGATCTCAACGCCGGCCTCATCGACGACAAGGAAGCCCAGCGCCGGCGCAGTGAGCTCGAAGAGGAAAG
CTCCTTCTTCGGCTCCATGGACGGTGCCTCCAAGTTCGTGCGCGGCGAGGCCGTGGCGAGCTTGATCACCATCGCCATCA
ACATCTTCGGCGGCATCATCATCGGCGTCACCCGCCATGGCCTGCCGATCGGCGATGCTGCGGACATCTACACCCGCCTG
TCGGTGGGCGACGGCCTGGTCTCGCAGATTCCCGCGCTCATCGTGTCGCTGTCCGCCGGCCTGCTGGTGTCCAAGGGCGG
CACCAAGGGCTCGGCGGAAAAGGCGGTGCTCGGCCAGCTCGGCGCCTATCCGCGCGCGCTGTTCGTCTCCGCCGGCCTCC
TGTTCGCGCTGGCTCTGGTTCCCGGGCTGCCGCTCATCCCCTTCGCCGCCCTCGGCGGTCTGATGGCCTTTGTCGGCTAT
GCGGTGCCCAAGCAGCTCGCCAAGGAGAAGGCCGAGAAGGAAGCCAAGGAAAAGGCGGTCAAGGAGCAGCAGGCGCTCGA
AGTGCGCGAGTCGGTGAAGGAGCAGCTGAAGACCGCCGAGATCGAGGTGGTGTTCGACAAGCAGCTCGCCGGCGTGATGA
CCCGCGCCTCCACCGAGTTCGGCCAGCGCATCGCCAAGATGCGGCGCAAGTTCGCCCAGCGCTACGGCTTCGTGGTTCCG
GACGTGAAGATCTCCGAGAGCCTGAACGTCCCGGCCAAGACCTACCAGATCAAGATCCACGGCACCGTGGTGACCTCGCA
GGAGATGCGCATCGGCGAGCTGCTGGTGGTGACCGGCGACGGCGCCAAGCCGGACGTGCCGGGCGACGAGGTGCGTGAAC
CCGCATTCGGCATGAAGGCCATGTGGGTGGCGGAGGCCTATCAGGCCGAGGTGCGGCGCGAGGGCTTCACGGCGGTGGAC
AATTCCACCGTGATCCTGACCCACCTCAGCGAAGTGATCGCCAACAACCTGCCGCAGCTCCTGTCCTATAAGGACATGCG
CACGCTGCTGGACCGGCTCGATCCCGAGTACAAGCGCCTGATCGAGGACATCTGCCCCTCGCAGATTTCCTACTCCGGCC
TCCAGGCGGTGCTGAAGCTGCTGCTCTCCGAGCGAGTCTCCATCCGCAACCTGCACCTCATCCTCGAAGCCATCGCCGAG
ATCGTGCCCCATGCCCGCCGCTCCGAGCAGGTGGCCGAGCACGTGCGCATGCGCATGGCCCAGCAAATCTGCGGCGACCT
TGCCGATGGCGGTGTGCTGCGGGTGCTGCGCCTCGGCAGCAAGTGGGACCTCACCTTCCACCAGAGCCTCAAGCGCGACG
CCAAGGGCGACGTGGTGGAGTTCGACATCGATCCGCGCCTCGTGGAGCAGTTCGGCACCGATGCCTCCGTCGTGGTGCGC
GAGCAGATGAAGGAGGGGCAACCCTTCGTGCTGGTCAGTGCGCCCGACGCGCGGCCCTACGTGCGCATGATCATCGAGCG
CATGTTCCCCTCGCTGCCCGTGCTCTCGCACGTGGAGATCGCCCGCGGCGTCGAGATCAAGTCCCTCGGGACCATCTCGT
GA

Upstream 100 bases:

>100_bases
GGTCGAGGCCCGGAGTTGCGAGCCCAGACGTCATGAGGACGTCGCGCGCAGAGACAGGACACCGGCCCCGCGTGGCCGTG
GCGTCCGGGAATGAGATGAG

Downstream 100 bases:

>100_bases
TCCCTCTGGACGTCTCGATCCTGAGCGCCTTCCTGGTGTTCTGCAGGATCGGGAGCTGCATCATGATGATGCCGGGCCTG
TCGGGCTATCGCCTGCCCGT

Product: flagellar biosynthesis protein FlhA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 693; Mature: 692

Protein sequence:

>693_residues
MADVSLTAGDQRSRRDIGFAVGIVAILAVLFLPIPPLLIDIGLALSIALSVLILMVSLWIQKPLEFSSFPTILLLATMLR
LALGVATTRLILAHGADGVHAAGAIIAGFSKLVMSGDFVIGIVVFAILVTVNFLVITKGATRIAEVGARFTLDAIPGKQM
AIDADLNAGLIDDKEAQRRRSELEEESSFFGSMDGASKFVRGEAVASLITIAINIFGGIIIGVTRHGLPIGDAADIYTRL
SVGDGLVSQIPALIVSLSAGLLVSKGGTKGSAEKAVLGQLGAYPRALFVSAGLLFALALVPGLPLIPFAALGGLMAFVGY
AVPKQLAKEKAEKEAKEKAVKEQQALEVRESVKEQLKTAEIEVVFDKQLAGVMTRASTEFGQRIAKMRRKFAQRYGFVVP
DVKISESLNVPAKTYQIKIHGTVVTSQEMRIGELLVVTGDGAKPDVPGDEVREPAFGMKAMWVAEAYQAEVRREGFTAVD
NSTVILTHLSEVIANNLPQLLSYKDMRTLLDRLDPEYKRLIEDICPSQISYSGLQAVLKLLLSERVSIRNLHLILEAIAE
IVPHARRSEQVAEHVRMRMAQQICGDLADGGVLRVLRLGSKWDLTFHQSLKRDAKGDVVEFDIDPRLVEQFGTDASVVVR
EQMKEGQPFVLVSAPDARPYVRMIIERMFPSLPVLSHVEIARGVEIKSLGTIS

Sequences:

>Translated_693_residues
MADVSLTAGDQRSRRDIGFAVGIVAILAVLFLPIPPLLIDIGLALSIALSVLILMVSLWIQKPLEFSSFPTILLLATMLR
LALGVATTRLILAHGADGVHAAGAIIAGFSKLVMSGDFVIGIVVFAILVTVNFLVITKGATRIAEVGARFTLDAIPGKQM
AIDADLNAGLIDDKEAQRRRSELEEESSFFGSMDGASKFVRGEAVASLITIAINIFGGIIIGVTRHGLPIGDAADIYTRL
SVGDGLVSQIPALIVSLSAGLLVSKGGTKGSAEKAVLGQLGAYPRALFVSAGLLFALALVPGLPLIPFAALGGLMAFVGY
AVPKQLAKEKAEKEAKEKAVKEQQALEVRESVKEQLKTAEIEVVFDKQLAGVMTRASTEFGQRIAKMRRKFAQRYGFVVP
DVKISESLNVPAKTYQIKIHGTVVTSQEMRIGELLVVTGDGAKPDVPGDEVREPAFGMKAMWVAEAYQAEVRREGFTAVD
NSTVILTHLSEVIANNLPQLLSYKDMRTLLDRLDPEYKRLIEDICPSQISYSGLQAVLKLLLSERVSIRNLHLILEAIAE
IVPHARRSEQVAEHVRMRMAQQICGDLADGGVLRVLRLGSKWDLTFHQSLKRDAKGDVVEFDIDPRLVEQFGTDASVVVR
EQMKEGQPFVLVSAPDARPYVRMIIERMFPSLPVLSHVEIARGVEIKSLGTIS
>Mature_692_residues
ADVSLTAGDQRSRRDIGFAVGIVAILAVLFLPIPPLLIDIGLALSIALSVLILMVSLWIQKPLEFSSFPTILLLATMLRL
ALGVATTRLILAHGADGVHAAGAIIAGFSKLVMSGDFVIGIVVFAILVTVNFLVITKGATRIAEVGARFTLDAIPGKQMA
IDADLNAGLIDDKEAQRRRSELEEESSFFGSMDGASKFVRGEAVASLITIAINIFGGIIIGVTRHGLPIGDAADIYTRLS
VGDGLVSQIPALIVSLSAGLLVSKGGTKGSAEKAVLGQLGAYPRALFVSAGLLFALALVPGLPLIPFAALGGLMAFVGYA
VPKQLAKEKAEKEAKEKAVKEQQALEVRESVKEQLKTAEIEVVFDKQLAGVMTRASTEFGQRIAKMRRKFAQRYGFVVPD
VKISESLNVPAKTYQIKIHGTVVTSQEMRIGELLVVTGDGAKPDVPGDEVREPAFGMKAMWVAEAYQAEVRREGFTAVDN
STVILTHLSEVIANNLPQLLSYKDMRTLLDRLDPEYKRLIEDICPSQISYSGLQAVLKLLLSERVSIRNLHLILEAIAEI
VPHARRSEQVAEHVRMRMAQQICGDLADGGVLRVLRLGSKWDLTFHQSLKRDAKGDVVEFDIDPRLVEQFGTDASVVVRE
QMKEGQPFVLVSAPDARPYVRMIIERMFPSLPVLSHVEIARGVEIKSLGTIS

Specific function: Required for formation of the rod structure of the flagellar apparatus. May constitute the export apparatus of flagellin. The flagellum is required to cause a persistent disease in a murine model of infection [H]

COG id: COG1298

COG function: function code NU; Flagellar biosynthesis pathway, component FlhA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family [H]

Homologues:

Organism=Escherichia coli, GI1788187, Length=677, Percent_Identity=38.9955686853767, Blast_Score=430, Evalue=1e-121,

Paralogues:

None

Copy number: 10-20 (rich media) [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006301
- InterPro:   IPR001712 [H]

Pfam domain/function: PF00771 FHIPEP [H]

EC number: NA

Molecular weight: Translated: 74947; Mature: 74816

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADVSLTAGDQRSRRDIGFAVGIVAILAVLFLPIPPLLIDIGLALSIALSVLILMVSLWI
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QKPLEFSSFPTILLLATMLRLALGVATTRLILAHGADGVHAAGAIIAGFSKLVMSGDFVI
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHH
GIVVFAILVTVNFLVITKGATRIAEVGARFTLDAIPGKQMAIDADLNAGLIDDKEAQRRR
HHHHHHHHHHHHHHHEECCHHHHHHCCCCEEEECCCCCCEEEECCCCCCCCCCHHHHHHH
SELEEESSFFGSMDGASKFVRGEAVASLITIAINIFGGIIIGVTRHGLPIGDAADIYTRL
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHCCCCCCCHHHHHHHH
SVGDGLVSQIPALIVSLSAGLLVSKGGTKGSAEKAVLGQLGAYPRALFVSAGLLFALALV
CCCCCHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
PGLPLIPFAALGGLMAFVGYAVPKQLAKEKAEKEAKEKAVKEQQALEVRESVKEQLKTAE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEVVFDKQLAGVMTRASTEFGQRIAKMRRKFAQRYGFVVPDVKISESLNVPAKTYQIKIH
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCEEEEEEEE
GTVVTSQEMRIGELLVVTGDGAKPDVPGDEVREPAFGMKAMWVAEAYQAEVRREGFTAVD
EEEEECCCCCCCEEEEEECCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
NSTVILTHLSEVIANNLPQLLSYKDMRTLLDRLDPEYKRLIEDICPSQISYSGLQAVLKL
CCEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHH
LLSERVSIRNLHLILEAIAEIVPHARRSEQVAEHVRMRMAQQICGDLADGGVLRVLRLGS
HHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCC
KWDLTFHQSLKRDAKGDVVEFDIDPRLVEQFGTDASVVVREQMKEGQPFVLVSAPDARPY
CCCHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCHH
VRMIIERMFPSLPVLSHVEIARGVEIKSLGTIS
HHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
ADVSLTAGDQRSRRDIGFAVGIVAILAVLFLPIPPLLIDIGLALSIALSVLILMVSLWI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
QKPLEFSSFPTILLLATMLRLALGVATTRLILAHGADGVHAAGAIIAGFSKLVMSGDFVI
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHH
GIVVFAILVTVNFLVITKGATRIAEVGARFTLDAIPGKQMAIDADLNAGLIDDKEAQRRR
HHHHHHHHHHHHHHHEECCHHHHHHCCCCEEEECCCCCCEEEECCCCCCCCCCHHHHHHH
SELEEESSFFGSMDGASKFVRGEAVASLITIAINIFGGIIIGVTRHGLPIGDAADIYTRL
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHCCCCCCCHHHHHHHH
SVGDGLVSQIPALIVSLSAGLLVSKGGTKGSAEKAVLGQLGAYPRALFVSAGLLFALALV
CCCCCHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
PGLPLIPFAALGGLMAFVGYAVPKQLAKEKAEKEAKEKAVKEQQALEVRESVKEQLKTAE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IEVVFDKQLAGVMTRASTEFGQRIAKMRRKFAQRYGFVVPDVKISESLNVPAKTYQIKIH
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCEEEEEEEE
GTVVTSQEMRIGELLVVTGDGAKPDVPGDEVREPAFGMKAMWVAEAYQAEVRREGFTAVD
EEEEECCCCCCCEEEEEECCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
NSTVILTHLSEVIANNLPQLLSYKDMRTLLDRLDPEYKRLIEDICPSQISYSGLQAVLKL
CCEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHH
LLSERVSIRNLHLILEAIAEIVPHARRSEQVAEHVRMRMAQQICGDLADGGVLRVLRLGS
HHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCC
KWDLTFHQSLKRDAKGDVVEFDIDPRLVEQFGTDASVVVREQMKEGQPFVLVSAPDARPY
CCCHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCHH
VRMIIERMFPSLPVLSHVEIARGVEIKSLGTIS
HHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11756688 [H]