Click here to switch to the map view.

The map label for this gene is hoxA [H]

Identifier: 158422233

GI number: 158422233

Start: 674775

End: 676241

Strand: Direct

Name: hoxA [H]

Synonym: AZC_0609

Alternate gene names: 158422233

Gene position: 674775-676241 (Clockwise)

Preceding gene: 158422232

Following gene: 158422234

Centisome position: 12.57

GC content: 67.21

Gene sequence:

>1467_bases
ATGACCGCGCTCGCCTCGCGTCCCGCCCTTCTCGTGGTCGATGACGAGCCGCGTTCCGTGGAGGTGATGGCGCGCGTGCT
CGGCGAGGAGTTCGACGTCTTCACCGCCGCCAGCGCCGCCGAGGCGCGGGCGGTGCTGGAGCAGGAATGGGTGCAGGCCA
TCTTCTGCGACCAGCGCATGCCGGAACTCTCGGGCGTCGCCTTCCTCACCGAGGTGCGCGAGCGCTGGCCGGAGATCGTG
CGCATCATCGTCACCGGCTATACGGAGCCGGAGGACATGATCGGCGCCATCAACGGGGCGGGCATCTATCAATATGTCAC
CAAGCCCTGGCACCCCGACCAGTTGCTGCTGGTGGCCCGCAATGCCGCGCAGCTTTTCGCGCTCCAGCGCGACCACCACC
GGCTGTCCCTGGAACTGAAGCTCGTGGCGCCCGTGGCGCAGGCGCGGGTCGTCTCCCAGCGTGAGAAGGTGGTGCGCAAC
TTCTCTTTCGACACGCTGATCCGCACGCCCCAGAGTCCACTGAACGAAACCTGCCAGCGCGCCGCACAGGCGGCGGTCTT
CGACATTCCCGTGCTCATCCAGGGCGAGACCGGCACCGGCAAGGAACTGCTCGCCCGTGCCATCCATTATTCCAGCCTGC
GGTCCGACTGCGCCTTCCATGCGGTGAACTGCGGGGCCATTCCGGACGAACTGCTGGAATCTGAACTCTTCGGCCACAAG
AAGGGGGCCTTCACTGGCGCCCATGTGACCCGCGTCGGCCTGCTCGATCAGGCGGACGGCGGCACCATCCTTCTGGACGA
GATTGGCGACGTCTCGCCGGCTTTTCAGGTGAAGCTGCTGCGCTTCCTTCAGGAAGGCGAAATCCGCCCCGTCGGCTCCA
ATGATGCCAAGCGGGTGAATGTGCGCGTGCTGGCCGCCACCCACCGCGATCTCGTGCAGGCGGTGAGTGCGGGCAAGTTC
CGCGAGGATCTCTATTACCGCCTCTCGGCCATGGTGCTGGCCATGCCGGCGCTCCGCGAGCGCAAGCAGGATCTGCGGGT
GCTCGCCGCCGCCATCCTCGACAGCCTGTGCAACCAGCACGGCAAGGCGGTGAAGGGCTTCACGGAAGAGGCGCTCGCCT
GCATCGAAGCCTATGACTGGCCGGGCAATGTGCGCGAGTTGCAGAATGAGGTGCTGCGCATGCTGGTGCTGGCGCCCGGT
CCCGAACTCGGGGCCGATCTCCTGTCGCCCCATGTGGTGCGTGCCGCCGCTGCCGACCCTATGCTCGCCGCCATCACGCT
GCCGGACAGCGGGCCGCTGAAGGACCGGATCGAGCGCATGGAAGCCTCCATCCTGCACGAAACCCTGGTGCGCTGCCGCT
GGAACAAGAGCCGGGCCGCGGAAGAACTCGGCCTCTCCCGCGTCGGCCTCAGGGCCAAGCTCGACCGCTACGGCATCGCC
CGCGACCGCACCTTCGCCCGGCATTAG

Upstream 100 bases:

>100_bases
GAGGATGTGCGCGCCGAAAAGCTGGAAGCGCTGGCCGAGGCCGCCGCCGCTCGCGCGGCGGCCCTGCGCGGTGCGGCCCG
GCGGGCGGCGGAGTAGGCCC

Downstream 100 bases:

>100_bases
GAGGACCCCATGTGTCTCGGCATTCCCGGCCGGATCGTCGCCATCGCCGATGAAGACGCGATGCTCGCCGTCGTCGATGT
GTCCGGCGTCCGCCGCACCG

Product: HoxA protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MTALASRPALLVVDDEPRSVEVMARVLGEEFDVFTAASAAEARAVLEQEWVQAIFCDQRMPELSGVAFLTEVRERWPEIV
RIIVTGYTEPEDMIGAINGAGIYQYVTKPWHPDQLLLVARNAAQLFALQRDHHRLSLELKLVAPVAQARVVSQREKVVRN
FSFDTLIRTPQSPLNETCQRAAQAAVFDIPVLIQGETGTGKELLARAIHYSSLRSDCAFHAVNCGAIPDELLESELFGHK
KGAFTGAHVTRVGLLDQADGGTILLDEIGDVSPAFQVKLLRFLQEGEIRPVGSNDAKRVNVRVLAATHRDLVQAVSAGKF
REDLYYRLSAMVLAMPALRERKQDLRVLAAAILDSLCNQHGKAVKGFTEEALACIEAYDWPGNVRELQNEVLRMLVLAPG
PELGADLLSPHVVRAAAADPMLAAITLPDSGPLKDRIERMEASILHETLVRCRWNKSRAAEELGLSRVGLRAKLDRYGIA
RDRTFARH

Sequences:

>Translated_488_residues
MTALASRPALLVVDDEPRSVEVMARVLGEEFDVFTAASAAEARAVLEQEWVQAIFCDQRMPELSGVAFLTEVRERWPEIV
RIIVTGYTEPEDMIGAINGAGIYQYVTKPWHPDQLLLVARNAAQLFALQRDHHRLSLELKLVAPVAQARVVSQREKVVRN
FSFDTLIRTPQSPLNETCQRAAQAAVFDIPVLIQGETGTGKELLARAIHYSSLRSDCAFHAVNCGAIPDELLESELFGHK
KGAFTGAHVTRVGLLDQADGGTILLDEIGDVSPAFQVKLLRFLQEGEIRPVGSNDAKRVNVRVLAATHRDLVQAVSAGKF
REDLYYRLSAMVLAMPALRERKQDLRVLAAAILDSLCNQHGKAVKGFTEEALACIEAYDWPGNVRELQNEVLRMLVLAPG
PELGADLLSPHVVRAAAADPMLAAITLPDSGPLKDRIERMEASILHETLVRCRWNKSRAAEELGLSRVGLRAKLDRYGIA
RDRTFARH
>Mature_487_residues
TALASRPALLVVDDEPRSVEVMARVLGEEFDVFTAASAAEARAVLEQEWVQAIFCDQRMPELSGVAFLTEVRERWPEIVR
IIVTGYTEPEDMIGAINGAGIYQYVTKPWHPDQLLLVARNAAQLFALQRDHHRLSLELKLVAPVAQARVVSQREKVVRNF
SFDTLIRTPQSPLNETCQRAAQAAVFDIPVLIQGETGTGKELLARAIHYSSLRSDCAFHAVNCGAIPDELLESELFGHKK
GAFTGAHVTRVGLLDQADGGTILLDEIGDVSPAFQVKLLRFLQEGEIRPVGSNDAKRVNVRVLAATHRDLVQAVSAGKFR
EDLYYRLSAMVLAMPALRERKQDLRVLAAAILDSLCNQHGKAVKGFTEEALACIEAYDWPGNVRELQNEVLRMLVLAPGP
ELGADLLSPHVVRAAAADPMLAAITLPDSGPLKDRIERMEASILHETLVRCRWNKSRAAEELGLSRVGLRAKLDRYGIAR
DRTFARH

Specific function: Probable member of the two-component regulatory system involved in the regulation of the hydrogenase activity. HoxA is probably phosphorylated by a sensory component (which could be hoxX) and then acts in conjunction with sigma-54 as a transcriptional act

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1790437, Length=468, Percent_Identity=38.2478632478632, Blast_Score=288, Evalue=4e-79,
Organism=Escherichia coli, GI1788550, Length=480, Percent_Identity=35.625, Blast_Score=288, Evalue=7e-79,
Organism=Escherichia coli, GI1788905, Length=401, Percent_Identity=39.9002493765586, Blast_Score=269, Evalue=4e-73,
Organism=Escherichia coli, GI1790299, Length=492, Percent_Identity=32.7235772357724, Blast_Score=231, Evalue=6e-62,
Organism=Escherichia coli, GI87082117, Length=361, Percent_Identity=39.8891966759003, Blast_Score=221, Evalue=1e-58,
Organism=Escherichia coli, GI1789233, Length=295, Percent_Identity=38.6440677966102, Blast_Score=208, Evalue=8e-55,
Organism=Escherichia coli, GI1789087, Length=294, Percent_Identity=41.4965986394558, Blast_Score=203, Evalue=3e-53,
Organism=Escherichia coli, GI1787583, Length=315, Percent_Identity=37.4603174603175, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI87082152, Length=224, Percent_Identity=48.2142857142857, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI87081872, Length=309, Percent_Identity=38.8349514563107, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1786524, Length=324, Percent_Identity=37.6543209876543, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1789828, Length=371, Percent_Identity=30.7277628032345, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI87081858, Length=346, Percent_Identity=30.9248554913295, Blast_Score=106, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 53921; Mature: 53789

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALASRPALLVVDDEPRSVEVMARVLGEEFDVFTAASAAEARAVLEQEWVQAIFCDQRM
CCCCCCCCEEEEECCCCCHHHHHHHHHCCHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PELSGVAFLTEVRERWPEIVRIIVTGYTEPEDMIGAINGAGIYQYVTKPWHPDQLLLVAR
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHCCCCCCCCEEEEEC
NAAQLFALQRDHHRLSLELKLVAPVAQARVVSQREKVVRNFSFDTLIRTPQSPLNETCQR
CHHHHHHHHCCCCEEEEEEEEECHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHH
AAQAAVFDIPVLIQGETGTGKELLARAIHYSSLRSDCAFHAVNCGAIPDELLESELFGHK
HHHHHHEECCEEEECCCCCCHHHHHHHHHHHHHHHCHHHEEEECCCCCHHHHHHHHHCCC
KGAFTGAHVTRVGLLDQADGGTILLDEIGDVSPAFQVKLLRFLQEGEIRPVGSNDAKRVN
CCCCCCCHHHEEECEECCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEE
VRVLAATHRDLVQAVSAGKFREDLYYRLSAMVLAMPALRERKQDLRVLAAAILDSLCNQH
EEEEEHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GKAVKGFTEEALACIEAYDWPGNVRELQNEVLRMLVLAPGPELGADLLSPHVVRAAAADP
CCHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCHHHHHHHCCCC
MLAAITLPDSGPLKDRIERMEASILHETLVRCRWNKSRAAEELGLSRVGLRAKLDRYGIA
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHCCC
RDRTFARH
CCCHHCCC
>Mature Secondary Structure 
TALASRPALLVVDDEPRSVEVMARVLGEEFDVFTAASAAEARAVLEQEWVQAIFCDQRM
CCCCCCCEEEEECCCCCHHHHHHHHHCCHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PELSGVAFLTEVRERWPEIVRIIVTGYTEPEDMIGAINGAGIYQYVTKPWHPDQLLLVAR
CHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCHHHHHCCCCCCCCEEEEEC
NAAQLFALQRDHHRLSLELKLVAPVAQARVVSQREKVVRNFSFDTLIRTPQSPLNETCQR
CHHHHHHHHCCCCEEEEEEEEECHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHH
AAQAAVFDIPVLIQGETGTGKELLARAIHYSSLRSDCAFHAVNCGAIPDELLESELFGHK
HHHHHHEECCEEEECCCCCCHHHHHHHHHHHHHHHCHHHEEEECCCCCHHHHHHHHHCCC
KGAFTGAHVTRVGLLDQADGGTILLDEIGDVSPAFQVKLLRFLQEGEIRPVGSNDAKRVN
CCCCCCCHHHEEECEECCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEE
VRVLAATHRDLVQAVSAGKFREDLYYRLSAMVLAMPALRERKQDLRVLAAAILDSLCNQH
EEEEEHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GKAVKGFTEEALACIEAYDWPGNVRELQNEVLRMLVLAPGPELGADLLSPHVVRAAAADP
CCHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHCHHHHHHHCCCC
MLAAITLPDSGPLKDRIERMEASILHETLVRCRWNKSRAAEELGLSRVGLRAKLDRYGIA
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHCCC
RDRTFARH
CCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2001989; 12948488 [H]