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The map label for this gene is lysR [H]

Identifier: 158422204

GI number: 158422204

Start: 644747

End: 645766

Strand: Reverse

Name: lysR [H]

Synonym: AZC_0580

Alternate gene names: 158422204

Gene position: 645766-644747 (Counterclockwise)

Preceding gene: 158422211

Following gene: 158422203

Centisome position: 12.03

GC content: 67.25

Gene sequence:

>1020_bases
TTGCCACCCGCATCGGCATGGGGTGCGGTAGGCCGTTCACCCTGCACAGAGTGTCCCATGAGCCGATCCAAGGCTGATGC
CCGGGCTGCGAGCCGAGCCCCCGAGATCCCGTTGCGCATGAGCGCCTTGCATCTCGACGTGTTCAACGCCGTCGTGGTGA
CGGGCGGCGTGACCGCGGCCAGCCGCCAGCTTCACCTCTCGCAGCCCGCGGTCAGCCGCCGCCTTGCCGACCTTGAGCGG
GTGCTCGGCTTCGATCTCTTCCTCCGGGACGGCAAACGGCTCATCATCACGCCGGAGGGGAAGGCTTTTCACGAAGAATT
GTCCATCTCCTATCTGGGGCTCGAGCACCTCACCAAGGTGGCGCTCGACATCCGCGAACTGCGGCGGGGCCATCTGCGGT
TCGTGTGCATGCCGGCCATGAGCTTCGGACCGGTGCCGAAGGGACTCGCCGCGTTTTCCGCAAGGCACCCTGACATTCAC
ATCACCCACGAGACCCACTCGGCGGCGCGGATCGAGGATGCGCTGACCTCCAATCTCTTCGACGTGGGGATCGGCATGGC
GCCCCGCGACATGGCGGGGCTGGTGAGCGAAGGCCGCTTCGCGTTCTCGTGCGTCTGCGTCATGCGCCCGGACCATCCCC
TCGCCACGCAAGAGACGGTCACGGCGACCGATATCTGCCGCGAAGCGGTTGTGGGCATCAATCCGGACACCGAGATCGGG
TCGCAGTTGCGGCGGCTTTTCGAGAGCCTGCCTCATTCCGTCAGCCTGCGCATCGAGACCCAGACGTCCATCGCCGCCTG
CGGTCTGGTGGAGGCGGGCGCGGGCGTTGCGGTGGTCGACCCCTTCACGGCCGCGCATCTCGGCCGTGGCGGCGGCCTCG
TCTCACGGCGGTTTTCGCCGATCATTCCCTTCGACATCCACATCCTGCGGCCGGAGCGGCGGGTTCCCTCCCGCGCGGCG
CAGGCGCTCATCGCGGAACTGGCCGCAGCGATGACCTCCGAGGAAGAAGCCAGCTCATGA

Upstream 100 bases:

>100_bases
TGGTTTGATCTGGAGCAACCTATGTTGCGTCCGACGGGTCCGCCGCAGGCGAGCCGATCATAAGCTCAGCATAAGTATTT
GATTTTCGTTCCTTTTCCTG

Downstream 100 bases:

>100_bases
CTGGGTCACATGCAGTCAATGCCTTTATGCCGTCCACGCATAAACAGCACACAAAAGAGCATTGGAGCGGCACCCCTAGG
TTGTGTTGTTTAGCCGCAGG

Product: regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MPPASAWGAVGRSPCTECPMSRSKADARAASRAPEIPLRMSALHLDVFNAVVVTGGVTAASRQLHLSQPAVSRRLADLER
VLGFDLFLRDGKRLIITPEGKAFHEELSISYLGLEHLTKVALDIRELRRGHLRFVCMPAMSFGPVPKGLAAFSARHPDIH
ITHETHSAARIEDALTSNLFDVGIGMAPRDMAGLVSEGRFAFSCVCVMRPDHPLATQETVTATDICREAVVGINPDTEIG
SQLRRLFESLPHSVSLRIETQTSIAACGLVEAGAGVAVVDPFTAAHLGRGGGLVSRRFSPIIPFDIHILRPERRVPSRAA
QALIAELAAAMTSEEEASS

Sequences:

>Translated_339_residues
MPPASAWGAVGRSPCTECPMSRSKADARAASRAPEIPLRMSALHLDVFNAVVVTGGVTAASRQLHLSQPAVSRRLADLER
VLGFDLFLRDGKRLIITPEGKAFHEELSISYLGLEHLTKVALDIRELRRGHLRFVCMPAMSFGPVPKGLAAFSARHPDIH
ITHETHSAARIEDALTSNLFDVGIGMAPRDMAGLVSEGRFAFSCVCVMRPDHPLATQETVTATDICREAVVGINPDTEIG
SQLRRLFESLPHSVSLRIETQTSIAACGLVEAGAGVAVVDPFTAAHLGRGGGLVSRRFSPIIPFDIHILRPERRVPSRAA
QALIAELAAAMTSEEEASS
>Mature_338_residues
PPASAWGAVGRSPCTECPMSRSKADARAASRAPEIPLRMSALHLDVFNAVVVTGGVTAASRQLHLSQPAVSRRLADLERV
LGFDLFLRDGKRLIITPEGKAFHEELSISYLGLEHLTKVALDIRELRRGHLRFVCMPAMSFGPVPKGLAAFSARHPDIHI
THETHSAARIEDALTSNLFDVGIGMAPRDMAGLVSEGRFAFSCVCVMRPDHPLATQETVTATDICREAVVGINPDTEIGS
QLRRLFESLPHSVSLRIETQTSIAACGLVEAGAGVAVVDPFTAAHLGRGGGLVSRRFSPIIPFDIHILRPERRVPSRAAQ
ALIAELAAAMTSEEEASS

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=290, Percent_Identity=34.4827586206897, Blast_Score=168, Evalue=5e-43,
Organism=Escherichia coli, GI157672245, Length=204, Percent_Identity=30.8823529411765, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI145693105, Length=300, Percent_Identity=22.6666666666667, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87081904, Length=201, Percent_Identity=30.8457711442786, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1790262, Length=254, Percent_Identity=24.4094488188976, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788887, Length=201, Percent_Identity=29.3532338308458, Blast_Score=69, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 36427; Mature: 36296

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPASAWGAVGRSPCTECPMSRSKADARAASRAPEIPLRMSALHLDVFNAVVVTGGVTAA
CCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHCCCCHHH
SRQLHLSQPAVSRRLADLERVLGFDLFLRDGKRLIITPEGKAFHEELSISYLGLEHLTKV
CCEEECCCHHHHHHHHHHHHHHHHHHEEECCCEEEECCCCCHHHHHHHHHHCCHHHHHHH
ALDIRELRRGHLRFVCMPAMSFGPVPKGLAAFSARHPDIHITHETHSAARIEDALTSNLF
HHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHH
DVGIGMAPRDMAGLVSEGRFAFSCVCVMRPDHPLATQETVTATDICREAVVGINPDTEIG
HHCCCCCCHHHHHHHHCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHH
SQLRRLFESLPHSVSLRIETQTSIAACGLVEAGAGVAVVDPFTAAHLGRGGGLVSRRFSP
HHHHHHHHHCCCEEEEEEECCCCHHHHHHHHCCCCEEEECCHHHHHCCCCCCCHHHCCCC
IIPFDIHILRPERRVPSRAAQALIAELAAAMTSEEEASS
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHCCC
>Mature Secondary Structure 
PPASAWGAVGRSPCTECPMSRSKADARAASRAPEIPLRMSALHLDVFNAVVVTGGVTAA
CCCCHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEHHHHHHHHHHHHHHCCCCHHH
SRQLHLSQPAVSRRLADLERVLGFDLFLRDGKRLIITPEGKAFHEELSISYLGLEHLTKV
CCEEECCCHHHHHHHHHHHHHHHHHHEEECCCEEEECCCCCHHHHHHHHHHCCHHHHHHH
ALDIRELRRGHLRFVCMPAMSFGPVPKGLAAFSARHPDIHITHETHSAARIEDALTSNLF
HHHHHHHHCCCEEEEEECCCCCCCCCCHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHH
DVGIGMAPRDMAGLVSEGRFAFSCVCVMRPDHPLATQETVTATDICREAVVGINPDTEIG
HHCCCCCCHHHHHHHHCCCEEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHH
SQLRRLFESLPHSVSLRIETQTSIAACGLVEAGAGVAVVDPFTAAHLGRGGGLVSRRFSP
HHHHHHHHHCCCEEEEEEECCCCHHHHHHHHCCCCEEEECCHHHHHCCCCCCCHHHCCCC
IIPFDIHILRPERRVPSRAAQALIAELAAAMTSEEEASS
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]