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The map label for this gene is groL1

Identifier: 158422048

GI number: 158422048

Start: 478741

End: 480384

Strand: Reverse

Name: groL1

Synonym: AZC_0424

Alternate gene names: 158422048

Gene position: 480384-478741 (Counterclockwise)

Preceding gene: 158422049

Following gene: 158422045

Centisome position: 8.95

GC content: 66.3

Gene sequence:

>1644_bases
ATGGCTGCCAAAGAAGTCAAGTTCGCCGGCGAAGCCCGCGAGAAGATGCTGCGCGGCGTGGACATCCTCGCCAACGCGGT
GAAGGTCACCCTCGGCCCCAAGGGCCGCAACGTGGTGATCGAGAAGTCCTTCGGCGCCCCGCGCATCACCAAGGACGGCG
TGTCCGTCGCCAAGGAAATCGAGCTCGAGGACAAGTTCGAGAACCTCGGCGCCCAGCTGGTGCGCGAAGTCGCCTCCAAG
ACCAATGACCTCGCCGGCGACGGCACCACCACCGCCACGGTGCTGGCCCAGGCCATCGTCAAGGAAGGCGCCAAGGCGGT
TGCCGCCGGCATGAACCCGATGGACCTGAAGCGCGGCATCGACCTCGCCACCGCCGCTGCGGTGAAGGACATCCAGGCCC
GCGCCAAGAAGGTCTCCTCCTCCGCCGAGGTGGCCCAGGTCGGCACCATTTCCGCCAATGGCGACAGCTCCATCGGCGAG
ATGATCGCCGGCGCGATGCAGAAGGTCGGCAACGAGGGTGTCATCACCGTCGAGGAAGCCAAGACCGCCGAGACCGAGCT
CGAAGTGGTCGAGGGCATGCAGTTCGACCGCGGCTATCTCTCTCCCTATTTCATCACGAATGCGGAGAAGATGATCGCCG
ACCTCGAAGATCCCTTCCTGCTGATCTTCGAGAAGAAGCTCTCCGGCCTCCAGCCGATCCTCCCGGTCCTTGAGGCCGTG
GTGCAGTCCGGCAAGCCGCTCGTCATCGTGGCCGAGGACGTCGAGGGCGAGGCTCTGGCCACCCTCGTGGTCAACAAGCT
GCGCGGCGGCCTCAAGGTCGCGGCCGTGAAGGCTCCCGGCTTCGGTGACCGTCGCAAGGCCATGCTCGAGGATATCGCCA
TCCTCACCGGCGGTCAGGTGATCTCCGAAGATCTCGGCATCAAGCTCGAGAACGTGACGCTGGCCCAGCTCGGCCGCGCC
AAGAAGGTCATCCTCGAGAAGGAAAAGACCACGATCGTCGACGGCGTCGGCGAGAAGGCGGAGATCGAGGCCCGCGTGGC
GCAGATCAAGGCGCAGATCGAGGAGACCTCCTCGGACTACGACCGTGAGAAGCTCCAGGAGCGTCTGGCCAAGCTCGCGG
GCGGCGTTGCGGTCATCCGCGTCGGCGGCTCCACGGAAGTGGAAGTCAAGGAGAAGAAGGACCGCGTGGACGACGCGCTG
AACGCCACCCGCGCTGCGGTGGAAGAAGGCATCGTCCCTGGTGGCGGCGTGGCCCTGCTGCGCGCCAAGAAGGCCGTGGA
AGCCCTCTCCTCCGAGAACCCCGACATCGCCGCCGGCATCAAGATCGTGCTGCGCGCCCTTGAGGCCCCGATCCGCCAGA
TCGCCGAGAACTCCGGCGTGGAAGGCTCCATCGTGGTGGGCAAGGTGCTCGAAAGCGAAGGCAATTTCGGCTTCAACGCC
CAGACCGAGCAGTATGTGGACCTCGTCGCCGAAGGCGTCGTCGACCCGGCCAAGGTCGTGCGCACCGCCCTCCAGGACGC
CTCTTCCGTGGCCAGCCTGCTGGTGACCACCGAGGCGCTCATCGCCGAGCTGCCGAAGAAGGACGCCGGCATGCCCGCGA
TGCCGGGCGGCGGCATGGGCGGCATGGGCGGCATGGACTTCTGA

Upstream 100 bases:

>100_bases
CAGGACCTGCTGATCATGAAGGAAAGCGACATCCTCGGCGTGATCGGCTGATCCGCGCCCGCCTGTCCCTTCCTCCCGTT
TCCCTTTCAGGAGAGCCAAC

Downstream 100 bases:

>100_bases
GGAAGTCCATGCCGACCAACAGTTCAGGTATTCCGAAGCTGGCGAAGGCCAGCTTCGGTGGCGGCATGGACTTCTGAGGA
AGTCGAAGCCGACCAACGGC

Product: chaperonin

Products: NA

Alternate protein names: GroEL protein 1; Protein Cpn60 1

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MAAKEVKFAGEAREKMLRGVDILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVSVAKEIELEDKFENLGAQLVREVASK
TNDLAGDGTTTATVLAQAIVKEGAKAVAAGMNPMDLKRGIDLATAAAVKDIQARAKKVSSSAEVAQVGTISANGDSSIGE
MIAGAMQKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFITNAEKMIADLEDPFLLIFEKKLSGLQPILPVLEAV
VQSGKPLVIVAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGQVISEDLGIKLENVTLAQLGRA
KKVILEKEKTTIVDGVGEKAEIEARVAQIKAQIEETSSDYDREKLQERLAKLAGGVAVIRVGGSTEVEVKEKKDRVDDAL
NATRAAVEEGIVPGGGVALLRAKKAVEALSSENPDIAAGIKIVLRALEAPIRQIAENSGVEGSIVVGKVLESEGNFGFNA
QTEQYVDLVAEGVVDPAKVVRTALQDASSVASLLVTTEALIAELPKKDAGMPAMPGGGMGGMGGMDF

Sequences:

>Translated_547_residues
MAAKEVKFAGEAREKMLRGVDILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVSVAKEIELEDKFENLGAQLVREVASK
TNDLAGDGTTTATVLAQAIVKEGAKAVAAGMNPMDLKRGIDLATAAAVKDIQARAKKVSSSAEVAQVGTISANGDSSIGE
MIAGAMQKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFITNAEKMIADLEDPFLLIFEKKLSGLQPILPVLEAV
VQSGKPLVIVAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGQVISEDLGIKLENVTLAQLGRA
KKVILEKEKTTIVDGVGEKAEIEARVAQIKAQIEETSSDYDREKLQERLAKLAGGVAVIRVGGSTEVEVKEKKDRVDDAL
NATRAAVEEGIVPGGGVALLRAKKAVEALSSENPDIAAGIKIVLRALEAPIRQIAENSGVEGSIVVGKVLESEGNFGFNA
QTEQYVDLVAEGVVDPAKVVRTALQDASSVASLLVTTEALIAELPKKDAGMPAMPGGGMGGMGGMDF
>Mature_546_residues
AAKEVKFAGEAREKMLRGVDILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVSVAKEIELEDKFENLGAQLVREVASKT
NDLAGDGTTTATVLAQAIVKEGAKAVAAGMNPMDLKRGIDLATAAAVKDIQARAKKVSSSAEVAQVGTISANGDSSIGEM
IAGAMQKVGNEGVITVEEAKTAETELEVVEGMQFDRGYLSPYFITNAEKMIADLEDPFLLIFEKKLSGLQPILPVLEAVV
QSGKPLVIVAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGQVISEDLGIKLENVTLAQLGRAK
KVILEKEKTTIVDGVGEKAEIEARVAQIKAQIEETSSDYDREKLQERLAKLAGGVAVIRVGGSTEVEVKEKKDRVDDALN
ATRAAVEEGIVPGGGVALLRAKKAVEALSSENPDIAAGIKIVLRALEAPIRQIAENSGVEGSIVVGKVLESEGNFGFNAQ
TEQYVDLVAEGVVDPAKVVRTALQDASSVASLLVTTEALIAELPKKDAGMPAMPGGGMGGMGGMDF

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=527, Percent_Identity=54.0796963946869, Blast_Score=572, Evalue=1e-163,
Organism=Homo sapiens, GI31542947, Length=527, Percent_Identity=54.0796963946869, Blast_Score=572, Evalue=1e-163,
Organism=Homo sapiens, GI5453607, Length=553, Percent_Identity=22.2423146473779, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=66.7296786389414, Blast_Score=702, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=53.3081285444234, Blast_Score=555, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI193210679, Length=220, Percent_Identity=52.2727272727273, Blast_Score=218, Evalue=7e-57,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=56.2737642585551, Blast_Score=583, Evalue=1e-167,
Organism=Saccharomyces cerevisiae, GI6322524, Length=520, Percent_Identity=22.6923076923077, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24641193, Length=527, Percent_Identity=56.3567362428843, Blast_Score=592, Evalue=1e-169,
Organism=Drosophila melanogaster, GI24641191, Length=527, Percent_Identity=56.3567362428843, Blast_Score=592, Evalue=1e-169,
Organism=Drosophila melanogaster, GI45550936, Length=524, Percent_Identity=53.2442748091603, Blast_Score=557, Evalue=1e-159,
Organism=Drosophila melanogaster, GI45550132, Length=524, Percent_Identity=53.2442748091603, Blast_Score=557, Evalue=1e-159,
Organism=Drosophila melanogaster, GI45550935, Length=524, Percent_Identity=53.2442748091603, Blast_Score=557, Evalue=1e-159,
Organism=Drosophila melanogaster, GI17864606, Length=548, Percent_Identity=45.0729927007299, Blast_Score=481, Evalue=1e-136,
Organism=Drosophila melanogaster, GI24584129, Length=536, Percent_Identity=36.3805970149254, Blast_Score=348, Evalue=8e-96,
Organism=Drosophila melanogaster, GI19921262, Length=536, Percent_Identity=36.3805970149254, Blast_Score=348, Evalue=8e-96,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH601_AZOC5 (A8ILV4)

Other databases:

- EMBL:   AP009384
- RefSeq:   YP_001523340.1
- ProteinModelPortal:   A8ILV4
- SMR:   A8ILV4
- GeneID:   5691255
- GenomeReviews:   AP009384_GR
- KEGG:   azc:AZC_0424
- HOGENOM:   HBG625289
- OMA:   AGSENNI
- ProtClustDB:   CLSK2516664
- BioCyc:   ACAU438753:AZC_0424-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298
- TIGRFAMs:   TIGR02348

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 57255; Mature: 57123

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKEVKFAGEAREKMLRGVDILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVSVAKEI
CCCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHH
ELEDKFENLGAQLVREVASKTNDLAGDGTTTATVLAQAIVKEGAKAVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCHHHHHCCCCHHHHHHCC
DLATAAAVKDIQARAKKVSSSAEVAQVGTISANGDSSIGEMIAGAMQKVGNEGVITVEEA
CHHHHHHHHHHHHHHHHHCCCCHHHHEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEECC
KTAETELEVVEGMQFDRGYLSPYFITNAEKMIADLEDPFLLIFEKKLSGLQPILPVLEAV
CCHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHHH
VQSGKPLVIVAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGQV
HHCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHH
ISEDLGIKLENVTLAQLGRAKKVILEKEKTTIVDGVGEKAEIEARVAQIKAQIEETSSDY
HHHHHCEEEECCHHHHHCCHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCC
DREKLQERLAKLAGGVAVIRVGGSTEVEVKEKKDRVDDALNATRAAVEEGIVPGGGVALL
CHHHHHHHHHHHHCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAKKAVEALSSENPDIAAGIKIVLRALEAPIRQIAENSGVEGSIVVGKVLESEGNFGFNA
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHCCCCCCCCC
QTEQYVDLVAEGVVDPAKVVRTALQDASSVASLLVTTEALIAELPKKDAGMPAMPGGGMG
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GMGGMDF
CCCCCCC
>Mature Secondary Structure 
AAKEVKFAGEAREKMLRGVDILANAVKVTLGPKGRNVVIEKSFGAPRITKDGVSVAKEI
CCCCCHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHH
ELEDKFENLGAQLVREVASKTNDLAGDGTTTATVLAQAIVKEGAKAVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCHHHHHCCCCHHHHHHCC
DLATAAAVKDIQARAKKVSSSAEVAQVGTISANGDSSIGEMIAGAMQKVGNEGVITVEEA
CHHHHHHHHHHHHHHHHHCCCCHHHHEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEECC
KTAETELEVVEGMQFDRGYLSPYFITNAEKMIADLEDPFLLIFEKKLSGLQPILPVLEAV
CCHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHCCCCEEEEEEHHHCCCCHHHHHHHHH
VQSGKPLVIVAEDVEGEALATLVVNKLRGGLKVAAVKAPGFGDRRKAMLEDIAILTGGQV
HHCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHH
ISEDLGIKLENVTLAQLGRAKKVILEKEKTTIVDGVGEKAEIEARVAQIKAQIEETSSDY
HHHHHCEEEECCHHHHHCCHHHHHHHCCCHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCC
DREKLQERLAKLAGGVAVIRVGGSTEVEVKEKKDRVDDALNATRAAVEEGIVPGGGVALL
CHHHHHHHHHHHHCCEEEEEECCCCCEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
RAKKAVEALSSENPDIAAGIKIVLRALEAPIRQIAENSGVEGSIVVGKVLESEGNFGFNA
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHCCCCCCCCC
QTEQYVDLVAEGVVDPAKVVRTALQDASSVASLLVTTEALIAELPKKDAGMPAMPGGGMG
CHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCC
GMGGMDF
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA