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The map label for this gene is lysR [H]

Identifier: 158421895

GI number: 158421895

Start: 314202

End: 315176

Strand: Direct

Name: lysR [H]

Synonym: AZC_0271

Alternate gene names: 158421895

Gene position: 314202-315176 (Clockwise)

Preceding gene: 158421891

Following gene: 158421896

Centisome position: 5.85

GC content: 69.64

Gene sequence:

>975_bases
ATGGATATCGATCTCAACCATATCCGCCGCTTTGACGGGGCGCTGCTGCTGGTCTTCCGGGAGCTGATGGCGACGGGCCA
GACCACCGCCGCCGCGCGCCGCCTTGGCCTCACGCAATCCACGGTCAGCCATGCGCTGCGCCGCCTGCGCGACCTCACCG
GCGATCCGCTGTTCCAGCGCCGGCCGGACGGCCTGACCCCGACGCCCCGCGCCCACGAGCTGCTGCCCATCGTGGTGGAG
ATGCTGCGGCTCTCTCAGGCGCTGAAGGGAGAGCCGGGCGAATTCGATCCTGCCGCCTCCACGCGGCACTTCCGCATCGC
AGGTCCGGACATCGTCTCCACCGTGCTGGCCGGGCCGCTGGCGCACCGCTTTGCCCAGCACGCGCCGAACGCCCGCCTCT
CCTTCGGCTTCATCGTGGGGGCTGCGGCTCTTGAGGCGCTGCGGCGAGGCGAGATCGACATGGCCATCGGCCATTTCCCC
AGCGTACCGCGCGGATTTGCCGCTTCCACCCTCTGGGAGGAGGAATTCGTCGCCATCGCCCGCAAGGGACATCCGCGCTT
CCCGCCGCTGGACCTTGCCGGCTATCTCGCCGCCGACCACGTGCTCGTCTCCTTCTCCGGTCGCTTCACCGGCGTGGTGG
ACCGGGTGCTGCAGCCGCTTGGCCTTGCCCGCCGGGTCGTTGCCTCCTTCCCTCTGTTCCTCTCCGTGTTCGATGCCGTG
GCGCAGAGTGATGCGGTGGCGGCCGTGCCCTATTCACTCTGCGAACGGCATGCCGAGACCTTTGGCCTCGCCCGCCTGCC
CATGCCCATCGCGGTGCCCGGTTTTCCCATCGTGAGCGTGCGCCGCGCGGGCGTCCCCGACGGCGGCTATGAGTGGCTGG
AGGCTCTGATCCGGCGCATGGTTGCCGAATATGCCGACGAGATCGAGGCGCGGGGCGAATGGCCGCCGCGCCAGCCGGTA
CCGGCCGCCGTTTAA

Upstream 100 bases:

>100_bases
AGAATGGCGATGTCCATGATGCCCCACCGCGCCCGTTGCGATCCGTCGCGGCGGACTATGGCCAAGCCCCGATATGTGGG
CTAATGAAATTACTCGTTGA

Downstream 100 bases:

>100_bases
GGGAGCGCCCTTCTATCGGCGTCCGGCGTGCTAGCGTCGGGCCGTCGTGACAGGGAGATTCGATCGGTGAACGGCAAGCT
GCATCTCTTCCTGCGCGGCC

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MDIDLNHIRRFDGALLLVFRELMATGQTTAAARRLGLTQSTVSHALRRLRDLTGDPLFQRRPDGLTPTPRAHELLPIVVE
MLRLSQALKGEPGEFDPAASTRHFRIAGPDIVSTVLAGPLAHRFAQHAPNARLSFGFIVGAAALEALRRGEIDMAIGHFP
SVPRGFAASTLWEEEFVAIARKGHPRFPPLDLAGYLAADHVLVSFSGRFTGVVDRVLQPLGLARRVVASFPLFLSVFDAV
AQSDAVAAVPYSLCERHAETFGLARLPMPIAVPGFPIVSVRRAGVPDGGYEWLEALIRRMVAEYADEIEARGEWPPRQPV
PAAV

Sequences:

>Translated_324_residues
MDIDLNHIRRFDGALLLVFRELMATGQTTAAARRLGLTQSTVSHALRRLRDLTGDPLFQRRPDGLTPTPRAHELLPIVVE
MLRLSQALKGEPGEFDPAASTRHFRIAGPDIVSTVLAGPLAHRFAQHAPNARLSFGFIVGAAALEALRRGEIDMAIGHFP
SVPRGFAASTLWEEEFVAIARKGHPRFPPLDLAGYLAADHVLVSFSGRFTGVVDRVLQPLGLARRVVASFPLFLSVFDAV
AQSDAVAAVPYSLCERHAETFGLARLPMPIAVPGFPIVSVRRAGVPDGGYEWLEALIRRMVAEYADEIEARGEWPPRQPV
PAAV
>Mature_324_residues
MDIDLNHIRRFDGALLLVFRELMATGQTTAAARRLGLTQSTVSHALRRLRDLTGDPLFQRRPDGLTPTPRAHELLPIVVE
MLRLSQALKGEPGEFDPAASTRHFRIAGPDIVSTVLAGPLAHRFAQHAPNARLSFGFIVGAAALEALRRGEIDMAIGHFP
SVPRGFAASTLWEEEFVAIARKGHPRFPPLDLAGYLAADHVLVSFSGRFTGVVDRVLQPLGLARRVVASFPLFLSVFDAV
AQSDAVAAVPYSLCERHAETFGLARLPMPIAVPGFPIVSVRRAGVPDGGYEWLEALIRRMVAEYADEIEARGEWPPRQPV
PAAV

Specific function: Regulates the expression of the naphthalene (nahA-F) and salicylate (nahG-M) metabolism genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87081684, Length=295, Percent_Identity=30.5084745762712, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1790147, Length=305, Percent_Identity=25.9016393442623, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI87081766, Length=269, Percent_Identity=27.8810408921933, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1789506, Length=244, Percent_Identity=23.7704918032787, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: 825 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35319; Mature: 35319

Theoretical pI: Translated: 8.53; Mature: 8.53

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIDLNHIRRFDGALLLVFRELMATGQTTAAARRLGLTQSTVSHALRRLRDLTGDPLFQR
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHC
RPDGLTPTPRAHELLPIVVEMLRLSQALKGEPGEFDPAASTRHFRIAGPDIVSTVLAGPL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHH
AHRFAQHAPNARLSFGFIVGAAALEALRRGEIDMAIGHFPSVPRGFAASTLWEEEFVAIA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCHHHHHHHHHHHHHHH
RKGHPRFPPLDLAGYLAADHVLVSFSGRFTGVVDRVLQPLGLARRVVASFPLFLSVFDAV
HCCCCCCCCHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQSDAVAAVPYSLCERHAETFGLARLPMPIAVPGFPIVSVRRAGVPDGGYEWLEALIRRM
HHCCCHHHHHHHHHHHHHHHHCHHHCCCCEECCCCCHHHHHHCCCCCCHHHHHHHHHHHH
VAEYADEIEARGEWPPRQPVPAAV
HHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure
MDIDLNHIRRFDGALLLVFRELMATGQTTAAARRLGLTQSTVSHALRRLRDLTGDPLFQR
CCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCHHC
RPDGLTPTPRAHELLPIVVEMLRLSQALKGEPGEFDPAASTRHFRIAGPDIVSTVLAGPL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHH
AHRFAQHAPNARLSFGFIVGAAALEALRRGEIDMAIGHFPSVPRGFAASTLWEEEFVAIA
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCHHHHHHHHHHHHHHH
RKGHPRFPPLDLAGYLAADHVLVSFSGRFTGVVDRVLQPLGLARRVVASFPLFLSVFDAV
HCCCCCCCCHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQSDAVAAVPYSLCERHAETFGLARLPMPIAVPGFPIVSVRRAGVPDGGYEWLEALIRRM
HHCCCHHHHHHHHHHHHHHHHCHHHCCCCEECCCCCHHHHHHCCCCCCHHHHHHHHHHHH
VAEYADEIEARGEWPPRQPVPAAV
HHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2703465; 2848005 [H]