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The map label for this gene is cbh [H]

Identifier: 158421835

GI number: 158421835

Start: 251571

End: 252689

Strand: Reverse

Name: cbh [H]

Synonym: AZC_0211

Alternate gene names: 158421835

Gene position: 252689-251571 (Counterclockwise)

Preceding gene: 158421845

Following gene: 158421831

Centisome position: 4.71

GC content: 66.04

Gene sequence:

>1119_bases
TTGCGGACGCGGAGGAACCCCATGTTGCGCACCCTCACCACCGCCCTCTCCCTCGCCGCCATGATGAATGCGGCGCTGGC
CTGCACGGCCGTCGATATCGTCGCCGCCGACAGGACCGTCATCGCCGGACGCACCATGGAATGGGCGTTCGATATGAAAT
GGACGCTGGTGAGCCGCCCCAAGGGCTTTCCGGTGAAGCTCACCGCGCCCAAGGCCCTCAATCTGCCGGAGCGCACGGTG
GAGGCGAAATATGCGCTGGTGGGTGTCAGCGCCAACATCATACCCGGCGGGGCGCTGGTGGAGGGGCAGAATGCCGCCGG
CCTCGGCATGAGCGGCAATTTCCTGCCCGGCTTCACCACCTATCAGACCGTGACCCCGCAGGATAAGAATTATGTGGAGG
TGCTCTCCTTCGGCGCCTGGGCGCTCGGCAATTTCGCCACCATTGCCGAGGTGAAGGAGGCGCTGAAGACCACCAAGGTC
TGGTCCGATCCCTCCGCCGCCAGCGGCCCCACCGCGCCGCTGATGCACTTCGTGTTCACGGACCGCGCGGGCGCCAGCAT
CATCGTGGAATATGTGGAGGGGGAACTGCACATCCACGACAACGTGGCCCATGTGCTGACCAACGCCCCCACCTATGACT
GGCACCTCACCAACCTGCGCAATTATCTCAACCTCTCCACCGTGGGCGTGGAGCAGCGGCAGATCGGCAACGTGGACGTG
ACGGCGCTCGGCCAGGGCGGCGGCCTCGTGGGCCTGCCGGGCGATTATACGCCGCCCTCGCGCTTCGTGCGCGCCAGCGC
CCTGCGCCACGGCATGACCCCGCCCAAGGATGGCGCCGAAGCCGTGCAGGCGGTGGTGCATGTGCTGAACACGGTGGACA
TTCCGGTGGGCGTCGCCCAGTCGCGCCTGCCGAACGGGCAGCTTGTATCCGATTACACCCAGTGGGTGTCCATCAAGGAT
CTCACCAACAACCGGCTCCAGATCGCCGATTATGCCCACCGCACCAGCTATCTCACCATCGACCTCGCGCCCCTCTTCGC
GCTGGACAAGCCGGCCGAGCGGCTCATCACCGATCTGCCCTATCCGGCGGGCGTCGGGGCCGATGTGCTGAAGCCGTGA

Upstream 100 bases:

>100_bases
CCTCAGCTCTGGTTCACATCTGTTCACTCAGAAATGCTCCCACAACCCATCGGTGGCACTATAATCCCGCCGTCCGCCTA
GACCGGGAGCCACCCGGCCG

Downstream 100 bases:

>100_bases
GCGTGGAGGTCAGCCGCGCTTGAGGCGGCGGGCGGCGGCCATGAGGGTCGCGCGGTGGGTGCCGTGCCGGCGCACGAGAC
CCATCGCTTCCTCCCGCGAG

Product: choloylglycine hydrolase family protein precursor

Products: NA

Alternate protein names: Bile salt hydrolase; Conjugated bile acid hydrolase; CBAH [H]

Number of amino acids: Translated: 372; Mature: 372

Protein sequence:

>372_residues
MRTRRNPMLRTLTTALSLAAMMNAALACTAVDIVAADRTVIAGRTMEWAFDMKWTLVSRPKGFPVKLTAPKALNLPERTV
EAKYALVGVSANIIPGGALVEGQNAAGLGMSGNFLPGFTTYQTVTPQDKNYVEVLSFGAWALGNFATIAEVKEALKTTKV
WSDPSAASGPTAPLMHFVFTDRAGASIIVEYVEGELHIHDNVAHVLTNAPTYDWHLTNLRNYLNLSTVGVEQRQIGNVDV
TALGQGGGLVGLPGDYTPPSRFVRASALRHGMTPPKDGAEAVQAVVHVLNTVDIPVGVAQSRLPNGQLVSDYTQWVSIKD
LTNNRLQIADYAHRTSYLTIDLAPLFALDKPAERLITDLPYPAGVGADVLKP

Sequences:

>Translated_372_residues
MRTRRNPMLRTLTTALSLAAMMNAALACTAVDIVAADRTVIAGRTMEWAFDMKWTLVSRPKGFPVKLTAPKALNLPERTV
EAKYALVGVSANIIPGGALVEGQNAAGLGMSGNFLPGFTTYQTVTPQDKNYVEVLSFGAWALGNFATIAEVKEALKTTKV
WSDPSAASGPTAPLMHFVFTDRAGASIIVEYVEGELHIHDNVAHVLTNAPTYDWHLTNLRNYLNLSTVGVEQRQIGNVDV
TALGQGGGLVGLPGDYTPPSRFVRASALRHGMTPPKDGAEAVQAVVHVLNTVDIPVGVAQSRLPNGQLVSDYTQWVSIKD
LTNNRLQIADYAHRTSYLTIDLAPLFALDKPAERLITDLPYPAGVGADVLKP
>Mature_372_residues
MRTRRNPMLRTLTTALSLAAMMNAALACTAVDIVAADRTVIAGRTMEWAFDMKWTLVSRPKGFPVKLTAPKALNLPERTV
EAKYALVGVSANIIPGGALVEGQNAAGLGMSGNFLPGFTTYQTVTPQDKNYVEVLSFGAWALGNFATIAEVKEALKTTKV
WSDPSAASGPTAPLMHFVFTDRAGASIIVEYVEGELHIHDNVAHVLTNAPTYDWHLTNLRNYLNLSTVGVEQRQIGNVDV
TALGQGGGLVGLPGDYTPPSRFVRASALRHGMTPPKDGAEAVQAVVHVLNTVDIPVGVAQSRLPNGQLVSDYTQWVSIKD
LTNNRLQIADYAHRTSYLTIDLAPLFALDKPAERLITDLPYPAGVGADVLKP

Specific function: The enzyme catalyzes the degradation of conjugated bile acids in the mammalian gut [H]

COG id: COG3049

COG function: function code M; Penicillin V acylase and related amidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C59 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003199 [H]

Pfam domain/function: PF02275 CBAH [H]

EC number: =3.5.1.24 [H]

Molecular weight: Translated: 39968; Mature: 39968

Theoretical pI: Translated: 7.29; Mature: 7.29

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTRRNPMLRTLTTALSLAAMMNAALACTAVDIVAADRTVIAGRTMEWAFDMKWTLVSRP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEECCCEEEEEEEEEEEEECC
KGFPVKLTAPKALNLPERTVEAKYALVGVSANIIPGGALVEGQNAAGLGMSGNFLPGFTT
CCCEEEEECCCCCCCCHHHHHCEEEEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCE
YQTVTPQDKNYVEVLSFGAWALGNFATIAEVKEALKTTKVWSDPSAASGPTAPLMHFVFT
EEEECCCCCCHHHHHHHCCHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHEEEE
DRAGASIIVEYVEGELHIHDNVAHVLTNAPTYDWHLTNLRNYLNLSTVGVEQRQIGNVDV
CCCCCEEEEEEECCEEEEECCHHHHHHCCCCCEEEHHHHHHHHCCEEECCCHHHCCCEEE
TALGQGGGLVGLPGDYTPPSRFVRASALRHGMTPPKDGAEAVQAVVHVLNTVDIPVGVAQ
EEECCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHH
SRLPNGQLVSDYTQWVSIKDLTNNRLQIADYAHRTSYLTIDLAPLFALDKPAERLITDLP
HCCCCCCCHHHHHHEEEEEECCCCEEEEEEHHCCCEEEEEEEHHHHHCCCCHHHHHHCCC
YPAGVGADVLKP
CCCCCCCHHCCC
>Mature Secondary Structure
MRTRRNPMLRTLTTALSLAAMMNAALACTAVDIVAADRTVIAGRTMEWAFDMKWTLVSRP
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCEEEECCCEEEEEEEEEEEEECC
KGFPVKLTAPKALNLPERTVEAKYALVGVSANIIPGGALVEGQNAAGLGMSGNFLPGFTT
CCCEEEEECCCCCCCCHHHHHCEEEEEEEECCCCCCCEEEECCCCCCCCCCCCCCCCCCE
YQTVTPQDKNYVEVLSFGAWALGNFATIAEVKEALKTTKVWSDPSAASGPTAPLMHFVFT
EEEECCCCCCHHHHHHHCCHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHEEEE
DRAGASIIVEYVEGELHIHDNVAHVLTNAPTYDWHLTNLRNYLNLSTVGVEQRQIGNVDV
CCCCCEEEEEEECCEEEEECCHHHHHHCCCCCEEEHHHHHHHHCCEEECCCHHHCCCEEE
TALGQGGGLVGLPGDYTPPSRFVRASALRHGMTPPKDGAEAVQAVVHVLNTVDIPVGVAQ
EEECCCCCEEECCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCHHH
SRLPNGQLVSDYTQWVSIKDLTNNRLQIADYAHRTSYLTIDLAPLFALDKPAERLITDLP
HCCCCCCCHHHHHHEEEEEECCCCEEEEEEHHCCCEEEEEEEHHHHHCCCCHHHHHHCCC
YPAGVGADVLKP
CCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7618863; 11792842 [H]