Click here to switch to the map view.

The map label for this gene is fghA [H]

Identifier: 158421728

GI number: 158421728

Start: 123394

End: 124230

Strand: Reverse

Name: fghA [H]

Synonym: AZC_0104

Alternate gene names: 158421728

Gene position: 124230-123394 (Counterclockwise)

Preceding gene: 158421729

Following gene: 158421725

Centisome position: 2.31

GC content: 69.89

Gene sequence:

>837_bases
ATGGAGACCCTCTCCACGGCGAAGTCCCACGGCGGCGTGCAGGGGGTGTACCGGCACGTCTCCGAGGCCACCGGAACCGA
GATGACCTTCGCCGTCTTCGTGCCGCCGCAGGCGGCGCGGGGACCGGTGCCGGTGCTCTGGTATCTCTCCGGCCTCACCT
GCACCCATGCCAATGTCATGGAGAAGGGCGAGTACCGGGCCGCCGCCGCCGCGCATGGCCTGATGATCGTGTGCCCGGAC
ACCTCCCCGCGCGGCCCCGGCGTGCCGGACGAGCCGGACAACTGGCAGTTCGGCTGCGGCGCCGGCTTCTATGTGGATGC
CACGCAGGCGCCTTACGCCGCCAACTACCGCATGGCGAGCTATGTGCGCGACGAACTGCCCGCGCTGGTGGCCAGACACT
TCCCGGCGGACATGGCGCGGCAGGGCATCTTCGGCCATTCCATGGGCGGCCACGGCGCGCTCACGCTGGCGCTGAAGAAC
CCGGACCGCTACCGGAGCTGCTCGGCCTTCGCCCCCATCGTCCAGCCCGCGACGGCAGGCTGGTCGCAGCCGGCGTTCGA
GAAATATCTCGGGGCCGATCCCGCCGCGTGGCGGGCCTATGACGCCACCGCCTTGATCGCGGACGGCGCGCGCTTTCCCG
GCTTTCTCGTGGATCAGGGATCGGCGGACCCCTTCCTCACCACCGGGCTGCGGCCCGGCCTGCTGGAAGTCGCCTGCCAG
GAGGCGGGCATCCCCCTCACGCTCCACATGCGCGAGGGCTATGACCACTCCTATTACTTCATCTCCACCTTCATGCCGGA
CCACATCGCCTGGCACGCGGAGCGGCTGAAGGGGTGA

Upstream 100 bases:

>100_bases
TCGATGATCTCATCACCCACACCATGCCACTCGACGAGATCAACACCGCCTTCGACCTGATGCACGAGGGCAAGTCCATC
CGCTCGGTGGTGATCTACTG

Downstream 100 bases:

>100_bases
GGATCAATGGAGGGGGCGCTTTTGCGGAGGCCGCGTGTACCCCCCTCCCCATCCCTCCCCCACAAGGGGGGAGGGGGTTA
ACGGACGGACCCCAGAGCCC

Product: esterase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
METLSTAKSHGGVQGVYRHVSEATGTEMTFAVFVPPQAARGPVPVLWYLSGLTCTHANVMEKGEYRAAAAAHGLMIVCPD
TSPRGPGVPDEPDNWQFGCGAGFYVDATQAPYAANYRMASYVRDELPALVARHFPADMARQGIFGHSMGGHGALTLALKN
PDRYRSCSAFAPIVQPATAGWSQPAFEKYLGADPAAWRAYDATALIADGARFPGFLVDQGSADPFLTTGLRPGLLEVACQ
EAGIPLTLHMREGYDHSYYFISTFMPDHIAWHAERLKG

Sequences:

>Translated_278_residues
METLSTAKSHGGVQGVYRHVSEATGTEMTFAVFVPPQAARGPVPVLWYLSGLTCTHANVMEKGEYRAAAAAHGLMIVCPD
TSPRGPGVPDEPDNWQFGCGAGFYVDATQAPYAANYRMASYVRDELPALVARHFPADMARQGIFGHSMGGHGALTLALKN
PDRYRSCSAFAPIVQPATAGWSQPAFEKYLGADPAAWRAYDATALIADGARFPGFLVDQGSADPFLTTGLRPGLLEVACQ
EAGIPLTLHMREGYDHSYYFISTFMPDHIAWHAERLKG
>Mature_278_residues
METLSTAKSHGGVQGVYRHVSEATGTEMTFAVFVPPQAARGPVPVLWYLSGLTCTHANVMEKGEYRAAAAAHGLMIVCPD
TSPRGPGVPDEPDNWQFGCGAGFYVDATQAPYAANYRMASYVRDELPALVARHFPADMARQGIFGHSMGGHGALTLALKN
PDRYRSCSAFAPIVQPATAGWSQPAFEKYLGADPAAWRAYDATALIADGARFPGFLVDQGSADPFLTTGLRPGLLEVACQ
EAGIPLTLHMREGYDHSYYFISTFMPDHIAWHAERLKG

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate (Probable) [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=282, Percent_Identity=50.709219858156, Blast_Score=297, Evalue=8e-81,
Organism=Escherichia coli, GI1786551, Length=277, Percent_Identity=49.4584837545126, Blast_Score=280, Evalue=9e-77,
Organism=Escherichia coli, GI1788477, Length=278, Percent_Identity=47.1223021582734, Blast_Score=239, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17510185, Length=277, Percent_Identity=46.9314079422383, Blast_Score=247, Evalue=5e-66,
Organism=Saccharomyces cerevisiae, GI6322393, Length=299, Percent_Identity=41.1371237458194, Blast_Score=213, Evalue=4e-56,
Organism=Drosophila melanogaster, GI45551932, Length=280, Percent_Identity=48.5714285714286, Blast_Score=260, Evalue=7e-70,
Organism=Drosophila melanogaster, GI24648347, Length=280, Percent_Identity=48.5714285714286, Blast_Score=259, Evalue=1e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 29982; Mature: 29982

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METLSTAKSHGGVQGVYRHVSEATGTEMTFAVFVPPQAARGPVPVLWYLSGLTCTHANVM
CCCCHHHHHCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEEEECCCEECCHHHH
EKGEYRAAAAAHGLMIVCPDTSPRGPGVPDEPDNWQFGCGAGFYVDATQAPYAANYRMAS
HCCCHHHHHHHCCEEEEECCCCCCCCCCCCCCCCEEEECCCCEEEECCCCCCCCCCHHHH
YVRDELPALVARHFPADMARQGIFGHSMGGHGALTLALKNPDRYRSCSAFAPIVQPATAG
HHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCEEEEEECCCHHHHCHHHHCHHHCCCCCC
WSQPAFEKYLGADPAAWRAYDATALIADGARFPGFLVDQGSADPFLTTGLRPGLLEVACQ
CCCHHHHHHHCCCCCHHEECCCEEEEECCCCCCCEEEECCCCCCEEECCCCCCHHHHHHH
EAGIPLTLHMREGYDHSYYFISTFMPDHIAWHAERLKG
HCCCCEEEEEECCCCCCEEEEEECCCHHHHHHHHHHCC
>Mature Secondary Structure
METLSTAKSHGGVQGVYRHVSEATGTEMTFAVFVPPQAARGPVPVLWYLSGLTCTHANVM
CCCCHHHHHCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEEEECCCEECCHHHH
EKGEYRAAAAAHGLMIVCPDTSPRGPGVPDEPDNWQFGCGAGFYVDATQAPYAANYRMAS
HCCCHHHHHHHCCEEEEECCCCCCCCCCCCCCCCEEEECCCCEEEECCCCCCCCCCHHHH
YVRDELPALVARHFPADMARQGIFGHSMGGHGALTLALKNPDRYRSCSAFAPIVQPATAG
HHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCEEEEEECCCHHHHCHHHHCHHHCCCCCC
WSQPAFEKYLGADPAAWRAYDATALIADGARFPGFLVDQGSADPFLTTGLRPGLLEVACQ
CCCHHHHHHHCCCCCHHEECCCEEEEECCCCCCCEEEECCCCCCEEECCCCCCHHHHHHH
EAGIPLTLHMREGYDHSYYFISTFMPDHIAWHAERLKG
HCCCCEEEEEECCCCCCEEEEEECCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8892832 [H]