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The map label for this gene is bioF_1

Identifier: 15836456

GI number: 15836456

Start: 1053332

End: 1054444

Strand: Direct

Name: bioF_1

Synonym: CPj0923

Alternate gene names: 15836456

Gene position: 1053332-1054444 (Clockwise)

Preceding gene: 15836455

Following gene: 15836459

Centisome position: 85.88

GC content: 40.79

Gene sequence:

>1113_bases
TTGACTACCAGTGATGTTATAGATTTTGTAACAAATGATTTTCTAGGTTTCGCTCGTTCTCCCACAATATACTGTGAGGT
AAGTAAGCGTTTCCAAATACATTGTCAGCAGTTTCCTCATGAGAAGCTCGGGATCCGAGGTTCTCGGCTTATGGTAGGGC
CTTCTTCAGTTATCGACGATCTTGAGTCTAAAATCGCAAGCTATCATGGAGCTCCTAATGCTTTCATAGTCAATAGTGGC
TATATGGCGAACCTAGGCTTATGTCATCACGTATCACGATCTACAGATGTCCTTTTGTGGGATGAAGAAGTGCATATGTC
AGTAGTGCACAGCCTATCTGCAATCTCTGGGCAACATCATACTTTTCATCATAACAATCTGGAACACTTAGAATCTCTAT
TACAGTGTTACAGGATAAGCTCTAAGGGAAGAATTTTTATCTTTGTCTCTTCTGTATATTCTTTTAGGGGGACTTTAGCT
CCTCTTGAGCAAATCATAGCACTATCAAAGAAGTATCATGCCCACTTAATTGTAGATGAAGCTCATGCTATGGGAATTTT
TGGAGACGATGGTAAAGGACTGTGCCATGCCTTAGGTTATGAGAATTTTTATGCTGTATTGGTTACTTACGGAAAAGCTT
TAGGGACGATGGGAGCCTCTTTATTAACGTCATCAGAAGTGAAGTACGATTTAATGCAAAATTCTCCGCCCTTGCGTTAT
TCTACATCTTTATCTCCTCATACTCTAATTTCTATAGGCACGGCGTATGATTTTCTAGCCTCTGAAGGGGAAATCGCACG
GAAGCAAGTCTTTAAGTTAAAAGAGCACTTTCATGAGTGTTTCGACTCTCATGCTCCAGGATGTGTGCAGCCTATATTTT
TACCACACACCTGCTTGGAAGAAGCAATTTCTGTTTTAGAAACTACAGGGATCCATGTAGGCGTTGTTGCCTTTGCTAAG
CATCCTTTCTTACGTGTGAACTTGCACGCTTACAATACTGTCGATGAAGTGAACCTGTTGGCTCAAGTTATGAAGCCATA
CTTAGAAAAAAGTAGTCATAGGGTCCACATCAATCATGAATTTCACCTTTGGCGAGAGCTTTGCCAGCATTAA

Upstream 100 bases:

>100_bases
CTGATTACGTTTCATTAAATGCGCTGGCTGTTTCATTATTTGGGTAAGTAGCCGTTTCTCTGGGTAGGTTGATACATAGT
GAGTTTGCAAGGAGAGTTTC

Downstream 100 bases:

>100_bases
GGCGTGATGGAGTTTCTTATTCACTGGAATGACATAAGCACTCTTAATTAAAAACTGATAGCGGAACGTATCCTTGATTT
TAAAATGACCGCAAGGAGTC

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MTTSDVIDFVTNDFLGFARSPTIYCEVSKRFQIHCQQFPHEKLGIRGSRLMVGPSSVIDDLESKIASYHGAPNAFIVNSG
YMANLGLCHHVSRSTDVLLWDEEVHMSVVHSLSAISGQHHTFHHNNLEHLESLLQCYRISSKGRIFIFVSSVYSFRGTLA
PLEQIIALSKKYHAHLIVDEAHAMGIFGDDGKGLCHALGYENFYAVLVTYGKALGTMGASLLTSSEVKYDLMQNSPPLRY
STSLSPHTLISIGTAYDFLASEGEIARKQVFKLKEHFHECFDSHAPGCVQPIFLPHTCLEEAISVLETTGIHVGVVAFAK
HPFLRVNLHAYNTVDEVNLLAQVMKPYLEKSSHRVHINHEFHLWRELCQH

Sequences:

>Translated_370_residues
MTTSDVIDFVTNDFLGFARSPTIYCEVSKRFQIHCQQFPHEKLGIRGSRLMVGPSSVIDDLESKIASYHGAPNAFIVNSG
YMANLGLCHHVSRSTDVLLWDEEVHMSVVHSLSAISGQHHTFHHNNLEHLESLLQCYRISSKGRIFIFVSSVYSFRGTLA
PLEQIIALSKKYHAHLIVDEAHAMGIFGDDGKGLCHALGYENFYAVLVTYGKALGTMGASLLTSSEVKYDLMQNSPPLRY
STSLSPHTLISIGTAYDFLASEGEIARKQVFKLKEHFHECFDSHAPGCVQPIFLPHTCLEEAISVLETTGIHVGVVAFAK
HPFLRVNLHAYNTVDEVNLLAQVMKPYLEKSSHRVHINHEFHLWRELCQH
>Mature_369_residues
TTSDVIDFVTNDFLGFARSPTIYCEVSKRFQIHCQQFPHEKLGIRGSRLMVGPSSVIDDLESKIASYHGAPNAFIVNSGY
MANLGLCHHVSRSTDVLLWDEEVHMSVVHSLSAISGQHHTFHHNNLEHLESLLQCYRISSKGRIFIFVSSVYSFRGTLAP
LEQIIALSKKYHAHLIVDEAHAMGIFGDDGKGLCHALGYENFYAVLVTYGKALGTMGASLLTSSEVKYDLMQNSPPLRYS
TSLSPHTLISIGTAYDFLASEGEIARKQVFKLKEHFHECFDSHAPGCVQPIFLPHTCLEEAISVLETTGIHVGVVAFAKH
PFLRVNLHAYNTVDEVNLLAQVMKPYLEKSSHRVHINHEFHLWRELCQH

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI284448556, Length=280, Percent_Identity=28.5714285714286, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI7657118, Length=280, Percent_Identity=27.8571428571429, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI4758668, Length=259, Percent_Identity=28.5714285714286, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI83977444, Length=334, Percent_Identity=23.3532934131737, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI83977440, Length=334, Percent_Identity=23.3532934131737, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI83977442, Length=334, Percent_Identity=23.3532934131737, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI119220554, Length=253, Percent_Identity=28.4584980237154, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI4502025, Length=273, Percent_Identity=26.3736263736264, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI40316939, Length=273, Percent_Identity=26.3736263736264, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI5454084, Length=226, Percent_Identity=23.0088495575221, Blast_Score=76, Evalue=6e-14,
Organism=Escherichia coli, GI1790046, Length=321, Percent_Identity=25.2336448598131, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1786993, Length=273, Percent_Identity=28.9377289377289, Blast_Score=104, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71994529, Length=265, Percent_Identity=30.5660377358491, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17560914, Length=392, Percent_Identity=26.2755102040816, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17560912, Length=392, Percent_Identity=26.2755102040816, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI32566772, Length=291, Percent_Identity=24.7422680412371, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71982617, Length=187, Percent_Identity=26.7379679144385, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71982625, Length=187, Percent_Identity=26.7379679144385, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320438, Length=299, Percent_Identity=24.7491638795987, Blast_Score=89, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6323954, Length=290, Percent_Identity=24.1379310344828, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6320267, Length=225, Percent_Identity=23.5555555555556, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24662918, Length=353, Percent_Identity=27.7620396600567, Blast_Score=111, Evalue=9e-25,
Organism=Drosophila melanogaster, GI17136286, Length=241, Percent_Identity=28.2157676348548, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17137420, Length=264, Percent_Identity=26.5151515151515, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24653280, Length=271, Percent_Identity=23.9852398523985, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24653276, Length=271, Percent_Identity=23.9852398523985, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24653278, Length=271, Percent_Identity=23.9852398523985, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 41483; Mature: 41352

Theoretical pI: Translated: 6.90; Mature: 6.90

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSDVIDFVTNDFLGFARSPTIYCEVSKRFQIHCQQFPHEKLGIRGSRLMVGPSSVIDD
CCCHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHCCCHHHCCCCCEEEECCHHHHHH
LESKIASYHGAPNAFIVNSGYMANLGLCHHVSRSTDVLLWDEEVHMSVVHSLSAISGQHH
HHHHHHHHCCCCCEEEEECCCEECCHHHHHCCCCCEEEEECHHHHHHHHHHHHHHCCCCC
TFHHNNLEHLESLLQCYRISSKGRIFIFVSSVYSFRGTLAPLEQIIALSKKYHAHLIVDE
EECCCCHHHHHHHHHHHHCCCCCEEEEEEEHHHHHCCCHHHHHHHHHHHHCCCEEEEEEC
AHAMGIFGDDGKGLCHALGYENFYAVLVTYGKALGTMGASLLTSSEVKYDLMQNSPPLRY
CCEEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEE
STSLSPHTLISIGTAYDFLASEGEIARKQVFKLKEHFHECFDSHAPGCVQPIFLPHTCLE
ECCCCCCCEEEECHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
EAISVLETTGIHVGVVAFAKHPFLRVNLHAYNTVDEVNLLAQVMKPYLEKSSHRVHINHE
HHHHHHHHCCCEEEEEECCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEECCH
FHLWRELCQH
HHHHHHHHCC
>Mature Secondary Structure 
TTSDVIDFVTNDFLGFARSPTIYCEVSKRFQIHCQQFPHEKLGIRGSRLMVGPSSVIDD
CCHHHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHCCCHHHCCCCCEEEECCHHHHHH
LESKIASYHGAPNAFIVNSGYMANLGLCHHVSRSTDVLLWDEEVHMSVVHSLSAISGQHH
HHHHHHHHCCCCCEEEEECCCEECCHHHHHCCCCCEEEEECHHHHHHHHHHHHHHCCCCC
TFHHNNLEHLESLLQCYRISSKGRIFIFVSSVYSFRGTLAPLEQIIALSKKYHAHLIVDE
EECCCCHHHHHHHHHHHHCCCCCEEEEEEEHHHHHCCCHHHHHHHHHHHHCCCEEEEEEC
AHAMGIFGDDGKGLCHALGYENFYAVLVTYGKALGTMGASLLTSSEVKYDLMQNSPPLRY
CCEEEEECCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCEE
STSLSPHTLISIGTAYDFLASEGEIARKQVFKLKEHFHECFDSHAPGCVQPIFLPHTCLE
ECCCCCCCEEEECHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHH
EAISVLETTGIHVGVVAFAKHPFLRVNLHAYNTVDEVNLLAQVMKPYLEKSSHRVHINHE
HHHHHHHHCCCEEEEEECCCCCEEEEEEEECCCHHHHHHHHHHHHHHHCCCCCEEEECCH
FHLWRELCQH
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA