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The map label for this gene is ribD

Identifier: 15836404

GI number: 15836404

Start: 988093

End: 989223

Strand: Direct

Name: ribD

Synonym: CPj0871

Alternate gene names: 15836404

Gene position: 988093-989223 (Clockwise)

Preceding gene: 15836400

Following gene: 15836405

Centisome position: 80.56

GC content: 45.62

Gene sequence:

>1131_bases
ATGGAAGATTTCTCTGAGCAACAACTCTTTTTTATGCGGCGTGCTATAGAAATCGGAGAAAAGGGTAGAATCACAGCCCC
CCCAAATCCTTGGGTAGGGTGTGTGGTCGTTCAAGAAAATCGCATCATAGGGGAGGGATTTCATGCGTATGCTGGAGGAC
CCCACGCTGAAGAGCTCGCCATACAAAACGCCTCTATGCCTATATCAGGATCCGATGTCTATGTTTCTCTAGAGCCTTGC
TCTCATTTTGGGTCATGCCCCCCATGTGCGAACTTACTAATCAAACATAAGGTCTCTAGAGTTTTTGTTGCTCTTGTTGA
TCCTGATCCCAAAGTCGCAGGTCAAGGAATCGCCATGCTACGTCAGGCAGGGATTCAGGTCTATGTCGGTATTGGAGAGA
GCGAAGCACAGGCGTCTCTACAGCCGTATCTATACCAAAGGACCCACAACTTCCCTTGGACAATATTGAAAAGTGCCGCA
AGTGTTGATGGTCAAGTTGCCGATTCTCAAGGGAAGTCTCAATGGATTACTTGTCCAGAGGCTCGTCATGATGTGGGAAA
ATTGCGAGCAGAGTCCCAAGCCATTCTTGTCGGTTCTCGTACGGTTCTTAGTGACGATCCGTGGCTCACAGCAAGACAAC
CTCAGGGAATGCTCTATCCCAAACAGCCTCTACGTGTCGTCTTAGACAGTCGTGGGAGCGTCCCTCCTACATCAAAAGTC
TTTGATAAGACCAGTCCGACTCTGTATGTAACCACAGAACGATGTCCTGAAAATTATATAAAAGTTTTAGATTCCTTAGA
CGTCCCCGTTTTACTCACAGAATCTACCCCATCAGGAGTGGATCTTCACAAGGTCTATGAGTATCTTGCTCAAAAAAAGA
TACTACAGGTTCTTGTAGAAGGAGGCACCACACTACATACGTCTTTGCTAAAAGAAAGATTTGTTAATTCTTTGGTTCTT
TACTCTGGGCCTATGATTCTTGGGGACCAAAAGAGACCTCTAGTCGGAGTATTAGGAAATTTGTTGGAATCTGCCTCTCC
TCTAACTCTGAAAAGTTCCCAAATTTTAGGAAATTCTTTGAAGGTCGTATGGGAGATTTCCCCTCAGGTTTTCGAGCCCA
TAAGGAATTGA

Upstream 100 bases:

>100_bases
ACGAAGTCGAGTTTCACATTCTTCGGGAGTCTTGCGTATAATTTTTATATCCAACATGCTTGTCTCATTGTTAAGTAGAA
GTGTGCAAAAGTGAGAGTAT

Downstream 100 bases:

>100_bases
AAGGAAAGGATTTTTAGAGTAGCATGCTTAGCATCGGAATCCGTTAATGCGAGGGAGTCAATGATAGAAACTCGAGAAGA
GGTAGGCTCTGCAAATTTTG

Product: riboflavin deaminase

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase

Number of amino acids: Translated: 376; Mature: 376

Protein sequence:

>376_residues
MEDFSEQQLFFMRRAIEIGEKGRITAPPNPWVGCVVVQENRIIGEGFHAYAGGPHAEELAIQNASMPISGSDVYVSLEPC
SHFGSCPPCANLLIKHKVSRVFVALVDPDPKVAGQGIAMLRQAGIQVYVGIGESEAQASLQPYLYQRTHNFPWTILKSAA
SVDGQVADSQGKSQWITCPEARHDVGKLRAESQAILVGSRTVLSDDPWLTARQPQGMLYPKQPLRVVLDSRGSVPPTSKV
FDKTSPTLYVTTERCPENYIKVLDSLDVPVLLTESTPSGVDLHKVYEYLAQKKILQVLVEGGTTLHTSLLKERFVNSLVL
YSGPMILGDQKRPLVGVLGNLLESASPLTLKSSQILGNSLKVVWEISPQVFEPIRN

Sequences:

>Translated_376_residues
MEDFSEQQLFFMRRAIEIGEKGRITAPPNPWVGCVVVQENRIIGEGFHAYAGGPHAEELAIQNASMPISGSDVYVSLEPC
SHFGSCPPCANLLIKHKVSRVFVALVDPDPKVAGQGIAMLRQAGIQVYVGIGESEAQASLQPYLYQRTHNFPWTILKSAA
SVDGQVADSQGKSQWITCPEARHDVGKLRAESQAILVGSRTVLSDDPWLTARQPQGMLYPKQPLRVVLDSRGSVPPTSKV
FDKTSPTLYVTTERCPENYIKVLDSLDVPVLLTESTPSGVDLHKVYEYLAQKKILQVLVEGGTTLHTSLLKERFVNSLVL
YSGPMILGDQKRPLVGVLGNLLESASPLTLKSSQILGNSLKVVWEISPQVFEPIRN
>Mature_376_residues
MEDFSEQQLFFMRRAIEIGEKGRITAPPNPWVGCVVVQENRIIGEGFHAYAGGPHAEELAIQNASMPISGSDVYVSLEPC
SHFGSCPPCANLLIKHKVSRVFVALVDPDPKVAGQGIAMLRQAGIQVYVGIGESEAQASLQPYLYQRTHNFPWTILKSAA
SVDGQVADSQGKSQWITCPEARHDVGKLRAESQAILVGSRTVLSDDPWLTARQPQGMLYPKQPLRVVLDSRGSVPPTSKV
FDKTSPTLYVTTERCPENYIKVLDSLDVPVLLTESTPSGVDLHKVYEYLAQKKILQVLVEGGTTLHTSLLKERFVNSLVL
YSGPMILGDQKRPLVGVLGNLLESASPLTLKSSQILGNSLKVVWEISPQVFEPIRN

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate

COG id: COG1985

COG function: function code H; Pyrimidine reductase, riboflavin biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family

Homologues:

Organism=Escherichia coli, GI1786616, Length=343, Percent_Identity=40.2332361516035, Blast_Score=250, Evalue=1e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RIBD_CHLPN (Q9Z735)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   E86599
- PIR:   G72026
- RefSeq:   NP_225066.1
- RefSeq:   NP_300928.1
- RefSeq:   NP_445535.1
- RefSeq:   NP_877172.1
- ProteinModelPortal:   Q9Z735
- SMR:   Q9Z735
- GeneID:   1467579
- GeneID:   895231
- GeneID:   919634
- GeneID:   963471
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0998
- KEGG:   cpn:CPn0871
- KEGG:   cpt:CpB0900
- TIGR:   CP_0998
- HOGENOM:   HBG668075
- OMA:   KRMEHGL
- PhylomeDB:   Q9Z735
- ProtClustDB:   CLSK871565
- BioCyc:   CPNE115711:CP_0998-MONOMER
- BioCyc:   CPNE115713:CPN0871-MONOMER
- BioCyc:   CPNE138677:CPJ0871-MONOMER
- BioCyc:   CPNE182082:CPB0900-MONOMER
- BRENDA:   1.1.1.193
- BRENDA:   3.5.4.26
- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734
- PANTHER:   PTHR11079:SF10
- TIGRFAMs:   TIGR00326
- TIGRFAMs:   TIGR00227

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C; SSF53927 Cytidine_deaminase-like

EC number: =3.5.4.26; =1.1.1.193

Molecular weight: Translated: 41210; Mature: 41210

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: ACT_SITE 57-57 BINDING 159-159 BINDING 173-173 BINDING 175-175 BINDING 189-189 BINDING 201-201 BINDING 205-205 BINDING 209-209 BINDING 212-212 BINDING 230-230 BINDING 300-300

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDFSEQQLFFMRRAIEIGEKGRITAPPNPWVGCVVVQENRIIGEGFHAYAGGPHAEELA
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCEEECCCCCCCCCCCCHHHHE
IQNASMPISGSDVYVSLEPCSHFGSCPPCANLLIKHKVSRVFVALVDPDPKVAGQGIAML
EECCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCEEEEEEECCCCCCCCCHHHHH
RQAGIQVYVGIGESEAQASLQPYLYQRTHNFPWTILKSAASVDGQVADSQGKSQWITCPE
HHCCCEEEEECCCHHHHHHHCHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCEEECCH
ARHDVGKLRAESQAILVGSRTVLSDDPWLTARQPQGMLYPKQPLRVVLDSRGSVPPTSKV
HHHHHHHHHCCCCEEEEECCEEECCCCCEECCCCCCCCCCCCCHHHEECCCCCCCCCHHH
FDKTSPTLYVTTERCPENYIKVLDSLDVPVLLTESTPSGVDLHKVYEYLAQKKILQVLVE
HCCCCCEEEEEECCCCHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHC
GGTTLHTSLLKERFVNSLVLYSGPMILGDQKRPLVGVLGNLLESASPLTLKSSQILGNSL
CCCHHHHHHHHHHHHHHEEECCCCEEECCCCCCHHHHHHHHHHCCCCCEEEHHHHCCCCE
KVVWEISPQVFEPIRN
EEEEEECHHHHHHHCC
>Mature Secondary Structure
MEDFSEQQLFFMRRAIEIGEKGRITAPPNPWVGCVVVQENRIIGEGFHAYAGGPHAEELA
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCEEECCCCCCCCCCCCHHHHE
IQNASMPISGSDVYVSLEPCSHFGSCPPCANLLIKHKVSRVFVALVDPDPKVAGQGIAML
EECCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCEEEEEEECCCCCCCCCHHHHH
RQAGIQVYVGIGESEAQASLQPYLYQRTHNFPWTILKSAASVDGQVADSQGKSQWITCPE
HHCCCEEEEECCCHHHHHHHCHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCEEECCH
ARHDVGKLRAESQAILVGSRTVLSDDPWLTARQPQGMLYPKQPLRVVLDSRGSVPPTSKV
HHHHHHHHHCCCCEEEEECCEEECCCCCEECCCCCCCCCCCCCHHHEECCCCCCCCCHHH
FDKTSPTLYVTTERCPENYIKVLDSLDVPVLLTESTPSGVDLHKVYEYLAQKKILQVLVE
HCCCCCEEEEEECCCCHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHC
GGTTLHTSLLKERFVNSLVLYSGPMILGDQKRPLVGVLGNLLESASPLTLKSSQILGNSL
CCCHHHHHHHHHHHHHHEEECCCCEEECCCCCCHHHHHHHHHHCCCCCEEEHHHHCCCCE
KVVWEISPQVFEPIRN
EEEEEECHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362