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The map label for this gene is sdhA

Identifier: 15836322

GI number: 15836322

Start: 886760

End: 888640

Strand: Direct

Name: sdhA

Synonym: CPj0789

Alternate gene names: 15836322

Gene position: 886760-888640 (Clockwise)

Preceding gene: 15836321

Following gene: 15836323

Centisome position: 72.3

GC content: 44.23

Gene sequence:

>1881_bases
ATGGATGAGAATCGAAAAGTAATCGTTGTTGGTGGGGGATTGGCAGGATTATCCGCAGCTATGCAGTTAGCCAACCTTGG
GATTATTGTAGAGCTCGTATCTCTGACTAAAGTCAAGCGCTCCCATTCTGTATGTGCTCAAGGGGGAATCAACGCTGCCT
TAAATCTGAAGCCTGAGGAAGAGGATTCTCCCTACGTGCATGCCTATGATACGATTAAAGGTGGGGATTTTCTTGCAGAT
CAGCCTCCTGTCTTGGAAATGTGTCTTGCAGCACCCAGAATCATTAAAATGTTAGATAACTTTGGTTGTCCTTTTAACCG
TGGTCCTTCTGGGAACTTAGATGTTCGTAGATTTGGAGGTACGTTATACCACCGCACAGTATTCTGTGGAGCTTCTACAG
GGCAGCAGCTTATGTATACTTTAGATGAGCAAGTGCGACGGCGAGAACATGCGGGTAGGGTGATAAAACGAGAAAATCAT
GAATTTGTACGTTTAGTTACCGACCATTCCGGACGTGCTTGCGGCATTATATTAATGAACTTGTTTAATAACCGTCTGGA
GATTTTACGAGGCGATGCTGTCATTATAGCTACGGGAGGCCCCGGAGTGATCTTTAAGATGTCTACAAACTCGACTTTCT
GTACGGGAGCCGCGAACGGAAGACTCTTTTTACAAGGCATGGCCTATGCAAACCCAGAGTTTATACAAATTCACCCTACA
GCAATTCCTGGAAGGGATAAGCTACGATTAATTTCAGAGTCTGTGCGTGGTGAGGGCGGTCGTGTGTGGGTGCCTGGGGA
TTCTTCAAAGCGCATAGTATTTCCAGATGGTTCGGAACGTCCTTGTGGAGAGACAGGAGCTCCTTGGTATTTCTTAGAAG
ATATGTATCCTGCGTATGGGAATCTTGTCAGCCGAGATGTAGGAGCGCGTGCTATTTTACGTGTATGTGAAGCTGGATTA
GGAATTGATGGACGCATGGAAGCGTACTTAGATGTCACTCATCTTCCCGAGAAAACACGTCATAAGTTAGAAGTCGTTTT
AGATATTTATAAGAAATTTACTGGCGAGGACCCCAATACGGTTCCTATGAGGATTTTCCCTGCCGTGCACTATTCTATGG
GAGGTGCTTGGGTAGATTGGCCTGCTGCCGATGATCCTGATCGTGATAGTCGCTTCCGTCAGATGACGAATATTCCTGGA
TGTTTTAATTGTGGAGAATCTGATTTCCAATATCATGGAGCCAATCGCTTAGGTGCTAATTCTTTACTTTCCTGTTTGTT
TGCGGGTTTGGTTTCTGGAGATGAAGCTTCTCGTTTTATAGAGGCTTTTGGGGCATCACAGGCAACGTCTAGTGATTTTG
ATCGTGCTCTACAGCAGGAAAAAGAGGAGAACGCGCGTCTTTTATCTGCATCAGGAAAAGAGAATATTTTTGTTTTGCAT
GAGGAAATCGCAAAGATTATGGTGCGAAATGTTACGGTAAAACGAAATAATCGTGATCTCCAAGAAACTATGGATAAATT
GAAAGAATTTCGTGAGAGATTAAAAAATGTCTCTGTATTGGACTCTTCACCATTTGCGAATAAATCCTTCCATTTTGTAC
GGCAGATGGGACCCATGTTAGAACTCGCACTGGCGATTACTAAGGGAGCTCTTCTACGCAATGAGTTTCGGGGTTCCCAT
TACAAACCAGAATTTCCTGAGAGAGATGACGAGCATTGGCTGAAGACTACAGTCGCTGTTTATGCTCCTGAAGAACCTGA
GATTTCCTATCTTCCTGTGGATACTCGCCATGTAGCCCCGACTCTCCGGGATTACACAAAATCTTCAACAGGAAAAATAG
AACTCACGAATATTCCTGATAATATCCGTCTACCCATATAG

Upstream 100 bases:

>100_bases
GATGCAAGGGGTATTGAGGATAGTATGTTACCTCGCTATGATTGTTGTGACTTTCATGGGAGTGAGTGCGGTTTGGAATT
TGTATAGTGTGGCATAGCAA

Downstream 100 bases:

>100_bases
AAAAAGAGAGATGATGGAGAATCTAGAGACTTTTATTTTAAAAATTTACAGAGGCGTTCCAGGGAAGCAATACTGGGAAA
GCTTTGAACTTCCTTTACAT

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 626; Mature: 626

Protein sequence:

>626_residues
MDENRKVIVVGGGLAGLSAAMQLANLGIIVELVSLTKVKRSHSVCAQGGINAALNLKPEEEDSPYVHAYDTIKGGDFLAD
QPPVLEMCLAAPRIIKMLDNFGCPFNRGPSGNLDVRRFGGTLYHRTVFCGASTGQQLMYTLDEQVRRREHAGRVIKRENH
EFVRLVTDHSGRACGIILMNLFNNRLEILRGDAVIIATGGPGVIFKMSTNSTFCTGAANGRLFLQGMAYANPEFIQIHPT
AIPGRDKLRLISESVRGEGGRVWVPGDSSKRIVFPDGSERPCGETGAPWYFLEDMYPAYGNLVSRDVGARAILRVCEAGL
GIDGRMEAYLDVTHLPEKTRHKLEVVLDIYKKFTGEDPNTVPMRIFPAVHYSMGGAWVDWPAADDPDRDSRFRQMTNIPG
CFNCGESDFQYHGANRLGANSLLSCLFAGLVSGDEASRFIEAFGASQATSSDFDRALQQEKEENARLLSASGKENIFVLH
EEIAKIMVRNVTVKRNNRDLQETMDKLKEFRERLKNVSVLDSSPFANKSFHFVRQMGPMLELALAITKGALLRNEFRGSH
YKPEFPERDDEHWLKTTVAVYAPEEPEISYLPVDTRHVAPTLRDYTKSSTGKIELTNIPDNIRLPI

Sequences:

>Translated_626_residues
MDENRKVIVVGGGLAGLSAAMQLANLGIIVELVSLTKVKRSHSVCAQGGINAALNLKPEEEDSPYVHAYDTIKGGDFLAD
QPPVLEMCLAAPRIIKMLDNFGCPFNRGPSGNLDVRRFGGTLYHRTVFCGASTGQQLMYTLDEQVRRREHAGRVIKRENH
EFVRLVTDHSGRACGIILMNLFNNRLEILRGDAVIIATGGPGVIFKMSTNSTFCTGAANGRLFLQGMAYANPEFIQIHPT
AIPGRDKLRLISESVRGEGGRVWVPGDSSKRIVFPDGSERPCGETGAPWYFLEDMYPAYGNLVSRDVGARAILRVCEAGL
GIDGRMEAYLDVTHLPEKTRHKLEVVLDIYKKFTGEDPNTVPMRIFPAVHYSMGGAWVDWPAADDPDRDSRFRQMTNIPG
CFNCGESDFQYHGANRLGANSLLSCLFAGLVSGDEASRFIEAFGASQATSSDFDRALQQEKEENARLLSASGKENIFVLH
EEIAKIMVRNVTVKRNNRDLQETMDKLKEFRERLKNVSVLDSSPFANKSFHFVRQMGPMLELALAITKGALLRNEFRGSH
YKPEFPERDDEHWLKTTVAVYAPEEPEISYLPVDTRHVAPTLRDYTKSSTGKIELTNIPDNIRLPI
>Mature_626_residues
MDENRKVIVVGGGLAGLSAAMQLANLGIIVELVSLTKVKRSHSVCAQGGINAALNLKPEEEDSPYVHAYDTIKGGDFLAD
QPPVLEMCLAAPRIIKMLDNFGCPFNRGPSGNLDVRRFGGTLYHRTVFCGASTGQQLMYTLDEQVRRREHAGRVIKRENH
EFVRLVTDHSGRACGIILMNLFNNRLEILRGDAVIIATGGPGVIFKMSTNSTFCTGAANGRLFLQGMAYANPEFIQIHPT
AIPGRDKLRLISESVRGEGGRVWVPGDSSKRIVFPDGSERPCGETGAPWYFLEDMYPAYGNLVSRDVGARAILRVCEAGL
GIDGRMEAYLDVTHLPEKTRHKLEVVLDIYKKFTGEDPNTVPMRIFPAVHYSMGGAWVDWPAADDPDRDSRFRQMTNIPG
CFNCGESDFQYHGANRLGANSLLSCLFAGLVSGDEASRFIEAFGASQATSSDFDRALQQEKEENARLLSASGKENIFVLH
EEIAKIMVRNVTVKRNNRDLQETMDKLKEFRERLKNVSVLDSSPFANKSFHFVRQMGPMLELALAITKGALLRNEFRGSH
YKPEFPERDDEHWLKTTVAVYAPEEPEISYLPVDTRHVAPTLRDYTKSSTGKIELTNIPDNIRLPI

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=645, Percent_Identity=27.906976744186, Blast_Score=192, Evalue=5e-49,
Organism=Escherichia coli, GI1790597, Length=585, Percent_Identity=30.7692307692308, Blast_Score=241, Evalue=1e-64,
Organism=Escherichia coli, GI1786942, Length=595, Percent_Identity=30.2521008403361, Blast_Score=213, Evalue=4e-56,
Organism=Escherichia coli, GI1788928, Length=577, Percent_Identity=27.0363951473137, Blast_Score=147, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17505833, Length=572, Percent_Identity=28.6713286713287, Blast_Score=190, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17550100, Length=638, Percent_Identity=28.6833855799373, Blast_Score=189, Evalue=3e-48,
Organism=Caenorhabditis elegans, GI71986328, Length=491, Percent_Identity=25.4582484725051, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6322701, Length=596, Percent_Identity=31.5436241610738, Blast_Score=233, Evalue=5e-62,
Organism=Saccharomyces cerevisiae, GI6322416, Length=597, Percent_Identity=30.4857621440536, Blast_Score=224, Evalue=4e-59,
Organism=Drosophila melanogaster, GI17137288, Length=657, Percent_Identity=29.5281582952816, Blast_Score=211, Evalue=9e-55,
Organism=Drosophila melanogaster, GI24655642, Length=657, Percent_Identity=29.5281582952816, Blast_Score=211, Evalue=9e-55,
Organism=Drosophila melanogaster, GI24655647, Length=657, Percent_Identity=29.5281582952816, Blast_Score=211, Evalue=9e-55,
Organism=Drosophila melanogaster, GI24663005, Length=583, Percent_Identity=30.7032590051458, Blast_Score=211, Evalue=1e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011280 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 69569; Mature: 69569

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDENRKVIVVGGGLAGLSAAMQLANLGIIVELVSLTKVKRSHSVCAQGGINAALNLKPEE
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
EDSPYVHAYDTIKGGDFLADQPPVLEMCLAAPRIIKMLDNFGCPFNRGPSGNLDVRRFGG
CCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHECCC
TLYHRTVFCGASTGQQLMYTLDEQVRRREHAGRVIKRENHEFVRLVTDHSGRACGIILMN
EEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEECCCCEEEEEEECCCCCCHHHHHHH
LFNNRLEILRGDAVIIATGGPGVIFKMSTNSTFCTGAANGRLFLQGMAYANPEFIQIHPT
HHCCHHHEEECCEEEEEECCCEEEEEEECCCEEEECCCCCEEEEEEECCCCCCEEEEECC
AIPGRDKLRLISESVRGEGGRVWVPGDSSKRIVFPDGSERPCGETGAPWYFLEDMYPAYG
CCCCCHHHHHHHHHHCCCCCEEEECCCCCCEEECCCCCCCCCCCCCCCEEEHHHHCCHHH
NLVSRDVGARAILRVCEAGLGIDGRMEAYLDVTHLPEKTRHKLEVVLDIYKKFTGEDPNT
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCC
VPMRIFPAVHYSMGGAWVDWPAADDPDRDSRFRQMTNIPGCFNCGESDFQYHGANRLGAN
CCEEEEEEHHHHCCCCEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCHH
SLLSCLFAGLVSGDEASRFIEAFGASQATSSDFDRALQQEKEENARLLSASGKENIFVLH
HHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCEEEECCCCCCEEEEH
EEIAKIMVRNVTVKRNNRDLQETMDKLKEFRERLKNVSVLDSSPFANKSFHFVRQMGPML
HHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHH
ELALAITKGALLRNEFRGSHYKPEFPERDDEHWLKTTVAVYAPEEPEISYLPVDTRHVAP
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHEEEEEEEECCCCCCEEEECCCHHHHCH
TLRDYTKSSTGKIELTNIPDNIRLPI
HHHHHCCCCCCEEEEECCCCCCCCCC
>Mature Secondary Structure
MDENRKVIVVGGGLAGLSAAMQLANLGIIVELVSLTKVKRSHSVCAQGGINAALNLKPEE
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCC
EDSPYVHAYDTIKGGDFLADQPPVLEMCLAAPRIIKMLDNFGCPFNRGPSGNLDVRRFGG
CCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHECCC
TLYHRTVFCGASTGQQLMYTLDEQVRRREHAGRVIKRENHEFVRLVTDHSGRACGIILMN
EEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCEECCCCEEEEEEECCCCCCHHHHHHH
LFNNRLEILRGDAVIIATGGPGVIFKMSTNSTFCTGAANGRLFLQGMAYANPEFIQIHPT
HHCCHHHEEECCEEEEEECCCEEEEEEECCCEEEECCCCCEEEEEEECCCCCCEEEEECC
AIPGRDKLRLISESVRGEGGRVWVPGDSSKRIVFPDGSERPCGETGAPWYFLEDMYPAYG
CCCCCHHHHHHHHHHCCCCCEEEECCCCCCEEECCCCCCCCCCCCCCCEEEHHHHCCHHH
NLVSRDVGARAILRVCEAGLGIDGRMEAYLDVTHLPEKTRHKLEVVLDIYKKFTGEDPNT
HHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCC
VPMRIFPAVHYSMGGAWVDWPAADDPDRDSRFRQMTNIPGCFNCGESDFQYHGANRLGAN
CCEEEEEEHHHHCCCCEEECCCCCCCCHHHHHHHHHCCCCCCCCCCCCCEECCCCCCCHH
SLLSCLFAGLVSGDEASRFIEAFGASQATSSDFDRALQQEKEENARLLSASGKENIFVLH
HHHHHHHHHHCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCEEEECCCCCCEEEEH
EEIAKIMVRNVTVKRNNRDLQETMDKLKEFRERLKNVSVLDSSPFANKSFHFVRQMGPML
HHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHCCCEEECCCCCCCCHHHHHHHHHHHH
ELALAITKGALLRNEFRGSHYKPEFPERDDEHWLKTTVAVYAPEEPEISYLPVDTRHVAP
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHEEEEEEEECCCCCCEEEECCCHHHHCH
TLRDYTKSSTGKIELTNIPDNIRLPI
HHHHHCCCCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3027051; 8969504; 9384377; 3086287; 3021212 [H]