Click here to switch to the map view.

The map label for this gene is groEL

Identifier: 15836310

GI number: 15836310

Start: 874922

End: 876502

Strand: Direct

Name: groEL

Synonym: CPj0777

Alternate gene names: 15836310

Gene position: 874922-876502 (Clockwise)

Preceding gene: 15836309

Following gene: 15836311

Centisome position: 71.33

GC content: 43.07

Gene sequence:

>1581_bases
GTGGTTTGGGTATTTAAAAGTCAATTTGAGGGACTTTCAGCATTAAAACGAGGAGTGCATGCTCTTACTAAAGCTGTAAC
CCCAGCATTTGGACCTCGAGGGTATAACGTAGTCATCAAAAAAGGAAAAGCTCCTATTGTCTTAACGAAAAACGGAATTC
GGATTGCTAAAGAAATCATACTTCAAGACGCATTCGAATCTCTTGGAGTAAAGCTTGCAAAGGAAGCCTTGCTAAAAGTT
GTAGAACAAACTGGAGATGGCTCAACAACAGCCCTTGTTGTTATCGATGCTCTTTTTACTCAGGGTCTAAAAGGCATTGC
TGCAGGTCTAGATCCTCAGGAGATCAAAGCAGGCATTCTCTTGTCAGTGGAGATGGTCTACCAGCAATTACAAAGGCAAG
CTATAGAGTTACAGTCTCCAAAAGACGTTTTGCATGTCGCTATGGTTGCGGCAAACCATGATGTTACTTTAGGTACCGTG
GTAGCAACTGTCATATCCCAAGCCGATCTTAAAGGCGTCTTCTCTAGCAAAGACTCTGGAATTTCCAAAACACGTGGTTT
AGGAAAAAGAGTAAAAAGTGGATACCTTTCTCCCTATTTTGTTACGCGTCCAGAGACAATGGATGTTGTGTGGGAAGAAG
CTTTAGTGCTCATCCTATCCCATAGCCTAGTGTCTTTAAGTGAAGAACTGATTCGGTATTTAGAACTCATCTCTGAACAG
AACACCCACCCCTTAGTGATCATAGCAGAAGATTTTGATCAGAATGTTTTAAGAACTCTGATTTTGAATAAGCTTAGAAA
CGGTCTTCCTGTTTGTGCTGTGAAGGCTCCAGGATCTAGAGAACTGCGACAAGTCGTTTTGGAAGATCTTGCTATTTTAA
CGGGAGCTACCCTTATAGGACAAGAATCAGAAAACTGTGAAATACCAGTTTCCTTAGATGTTTTGGGGCGTGTGAAACAG
GTCATGATTACTAAAGAAACGTTTACCTTCCTTGAGGGAGGGGGAGATGCTGAGATCATACAAGCTAGGAAACAGGAGCT
CTGTTTAGCGATAGCTGGGAGTACCTCAGAGAGTGAGTGTCAGGAATTAGAAGAACGGTTAGCGATCTTTATAGGAAGTA
TCCCGCAAGTGCAAATTACTGCCGATACGGATACAGAACAAAGGGAACGACAGTTCCAGTTAGAATCTGCCTTACGTGCT
ACAAAAGCTGCCATGAAAGGTGGGATAGTTCCTGGTGGGGGAGTGGCTTTCTTACGAGCAGCACACGCTATCGAGGTGCC
TGCAAACCTATCTTCGGGTATGACTTTTGGTTTTGAGACTCTCCTACAAGCGGTACGAACTCCCTTGAAGGTTTTAGCTC
AGAACTGTGGTAGATCTTCAGAAGAAGTCATTCATACCATTCTCTCTCACGAGAACCCTAGATTTGGCTATAATGGCATG
ACAGATACATTCGAGGATCTTGTAGATGCAGGGATCTGCGATCCCCTCATTGTAACAACCTCTTCATTAAAATGCGCAGT
TTCGGTATCATGCCTCTTGCTAACGAGTTCTTTTTTTATCAGCTCAAGGACGAAAACATAA

Upstream 100 bases:

>100_bases
TAAGATCCTCTACGGTTTGACAGGAATATTTCTTGTTTCTAAGATGACCTTTTCATGGCAGAAGCCTTTCCTGCATTAAG
AATAGACATCAGAGGATCGA

Downstream 100 bases:

>100_bases
TCAGTTGAGTTCTTAATAAGGCTGCCTAAAACATGCGTTGTTGATTGAGGACTCTCTTCTAAAACATCCTTGATTTGGGA
TGGTATAACGGAAATTTCTA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2

Number of amino acids: Translated: 526; Mature: 526

Protein sequence:

>526_residues
MVWVFKSQFEGLSALKRGVHALTKAVTPAFGPRGYNVVIKKGKAPIVLTKNGIRIAKEIILQDAFESLGVKLAKEALLKV
VEQTGDGSTTALVVIDALFTQGLKGIAAGLDPQEIKAGILLSVEMVYQQLQRQAIELQSPKDVLHVAMVAANHDVTLGTV
VATVISQADLKGVFSSKDSGISKTRGLGKRVKSGYLSPYFVTRPETMDVVWEEALVLILSHSLVSLSEELIRYLELISEQ
NTHPLVIIAEDFDQNVLRTLILNKLRNGLPVCAVKAPGSRELRQVVLEDLAILTGATLIGQESENCEIPVSLDVLGRVKQ
VMITKETFTFLEGGGDAEIIQARKQELCLAIAGSTSESECQELEERLAIFIGSIPQVQITADTDTEQRERQFQLESALRA
TKAAMKGGIVPGGGVAFLRAAHAIEVPANLSSGMTFGFETLLQAVRTPLKVLAQNCGRSSEEVIHTILSHENPRFGYNGM
TDTFEDLVDAGICDPLIVTTSSLKCAVSVSCLLLTSSFFISSRTKT

Sequences:

>Translated_526_residues
MVWVFKSQFEGLSALKRGVHALTKAVTPAFGPRGYNVVIKKGKAPIVLTKNGIRIAKEIILQDAFESLGVKLAKEALLKV
VEQTGDGSTTALVVIDALFTQGLKGIAAGLDPQEIKAGILLSVEMVYQQLQRQAIELQSPKDVLHVAMVAANHDVTLGTV
VATVISQADLKGVFSSKDSGISKTRGLGKRVKSGYLSPYFVTRPETMDVVWEEALVLILSHSLVSLSEELIRYLELISEQ
NTHPLVIIAEDFDQNVLRTLILNKLRNGLPVCAVKAPGSRELRQVVLEDLAILTGATLIGQESENCEIPVSLDVLGRVKQ
VMITKETFTFLEGGGDAEIIQARKQELCLAIAGSTSESECQELEERLAIFIGSIPQVQITADTDTEQRERQFQLESALRA
TKAAMKGGIVPGGGVAFLRAAHAIEVPANLSSGMTFGFETLLQAVRTPLKVLAQNCGRSSEEVIHTILSHENPRFGYNGM
TDTFEDLVDAGICDPLIVTTSSLKCAVSVSCLLLTSSFFISSRTKT
>Mature_526_residues
MVWVFKSQFEGLSALKRGVHALTKAVTPAFGPRGYNVVIKKGKAPIVLTKNGIRIAKEIILQDAFESLGVKLAKEALLKV
VEQTGDGSTTALVVIDALFTQGLKGIAAGLDPQEIKAGILLSVEMVYQQLQRQAIELQSPKDVLHVAMVAANHDVTLGTV
VATVISQADLKGVFSSKDSGISKTRGLGKRVKSGYLSPYFVTRPETMDVVWEEALVLILSHSLVSLSEELIRYLELISEQ
NTHPLVIIAEDFDQNVLRTLILNKLRNGLPVCAVKAPGSRELRQVVLEDLAILTGATLIGQESENCEIPVSLDVLGRVKQ
VMITKETFTFLEGGGDAEIIQARKQELCLAIAGSTSESECQELEERLAIFIGSIPQVQITADTDTEQRERQFQLESALRA
TKAAMKGGIVPGGGVAFLRAAHAIEVPANLSSGMTFGFETLLQAVRTPLKVLAQNCGRSSEEVIHTILSHENPRFGYNGM
TDTFEDLVDAGICDPLIVTTSSLKCAVSVSCLLLTSSFFISSRTKT

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family

Homologues:

Organism=Homo sapiens, GI41399285, Length=512, Percent_Identity=33.7890625, Blast_Score=281, Evalue=8e-76,
Organism=Homo sapiens, GI31542947, Length=512, Percent_Identity=33.7890625, Blast_Score=281, Evalue=8e-76,
Organism=Escherichia coli, GI1790586, Length=513, Percent_Identity=34.8927875243665, Blast_Score=316, Evalue=3e-87,
Organism=Caenorhabditis elegans, GI17555558, Length=517, Percent_Identity=34.6228239845261, Blast_Score=298, Evalue=4e-81,
Organism=Caenorhabditis elegans, GI193210679, Length=203, Percent_Identity=32.0197044334975, Blast_Score=112, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6323288, Length=531, Percent_Identity=33.8983050847458, Blast_Score=290, Evalue=4e-79,
Organism=Drosophila melanogaster, GI24641193, Length=510, Percent_Identity=33.3333333333333, Blast_Score=287, Evalue=1e-77,
Organism=Drosophila melanogaster, GI24641191, Length=510, Percent_Identity=33.3333333333333, Blast_Score=287, Evalue=1e-77,
Organism=Drosophila melanogaster, GI45550936, Length=510, Percent_Identity=32.3529411764706, Blast_Score=280, Evalue=2e-75,
Organism=Drosophila melanogaster, GI45550132, Length=510, Percent_Identity=32.3529411764706, Blast_Score=280, Evalue=2e-75,
Organism=Drosophila melanogaster, GI45550935, Length=510, Percent_Identity=32.3529411764706, Blast_Score=280, Evalue=2e-75,
Organism=Drosophila melanogaster, GI17864606, Length=513, Percent_Identity=31.5789473684211, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24584129, Length=515, Percent_Identity=29.5145631067961, Blast_Score=187, Evalue=2e-47,
Organism=Drosophila melanogaster, GI19921262, Length=515, Percent_Identity=29.5145631067961, Blast_Score=187, Evalue=2e-47,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): CH602_CHLPN (Q9Z7C9)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   D72036
- PIR:   F81504
- PIR:   G86587
- RefSeq:   NP_224972.1
- RefSeq:   NP_300834.1
- RefSeq:   NP_445632.1
- RefSeq:   NP_877077.1
- ProteinModelPortal:   Q9Z7C9
- SMR:   Q9Z7C9
- GeneID:   1467484
- GeneID:   895077
- GeneID:   919546
- GeneID:   963583
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP1095
- KEGG:   cpn:CPn0777
- KEGG:   cpt:CpB0805
- TIGR:   CP_1095
- HOGENOM:   HBG625289
- OMA:   IIAEDFD
- ProtClustDB:   PRK12849
- BioCyc:   CPNE115711:CP_1095-MONOMER
- BioCyc:   CPNE115713:CPN0777-MONOMER
- BioCyc:   CPNE138677:CPJ0777-MONOMER
- BioCyc:   CPNE182082:CPB0805-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00600
- InterPro:   IPR001844
- InterPro:   IPR002423
- PANTHER:   PTHR11353
- PRINTS:   PR00298

Pfam domain/function: PF00118 Cpn60_TCP1; SSF48592 GroEL-ATPase

EC number: NA

Molecular weight: Translated: 56827; Mature: 56827

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVWVFKSQFEGLSALKRGVHALTKAVTPAFGPRGYNVVIKKGKAPIVLTKNGIRIAKEII
CEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCEEEECCCHHHHHHHH
LQDAFESLGVKLAKEALLKVVEQTGDGSTTALVVIDALFTQGLKGIAAGLDPQEIKAGIL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHHHCCCCHHHHHHHHH
LSVEMVYQQLQRQAIELQSPKDVLHVAMVAANHDVTLGTVVATVISQADLKGVFSSKDSG
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
ISKTRGLGKRVKSGYLSPYFVTRPETMDVVWEEALVLILSHSLVSLSEELIRYLELISEQ
CHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NTHPLVIIAEDFDQNVLRTLILNKLRNGLPVCAVKAPGSRELRQVVLEDLAILTGATLIG
CCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCHHCC
QESENCEIPVSLDVLGRVKQVMITKETFTFLEGGGDAEIIQARKQELCLAIAGSTSESEC
CCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEEEECCCCHHHH
QELEERLAIFIGSIPQVQITADTDTEQRERQFQLESALRATKAAMKGGIVPGGGVAFLRA
HHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
AHAIEVPANLSSGMTFGFETLLQAVRTPLKVLAQNCGRSSEEVIHTILSHENPRFGYNGM
HHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCC
TDTFEDLVDAGICDPLIVTTSSLKCAVSVSCLLLTSSFFISSRTKT
CHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MVWVFKSQFEGLSALKRGVHALTKAVTPAFGPRGYNVVIKKGKAPIVLTKNGIRIAKEII
CEEEECHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCEEEECCCHHHHHHHH
LQDAFESLGVKLAKEALLKVVEQTGDGSTTALVVIDALFTQGLKGIAAGLDPQEIKAGIL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCHHHHHCCCCHHHHHHHHH
LSVEMVYQQLQRQAIELQSPKDVLHVAMVAANHDVTLGTVVATVISQADLKGVFSSKDSG
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
ISKTRGLGKRVKSGYLSPYFVTRPETMDVVWEEALVLILSHSLVSLSEELIRYLELISEQ
CHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NTHPLVIIAEDFDQNVLRTLILNKLRNGLPVCAVKAPGSRELRQVVLEDLAILTGATLIG
CCCCEEEEECCCCHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCHHCC
QESENCEIPVSLDVLGRVKQVMITKETFTFLEGGGDAEIIQARKQELCLAIAGSTSESEC
CCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHEEEEEECCCCHHHH
QELEERLAIFIGSIPQVQITADTDTEQRERQFQLESALRATKAAMKGGIVPGGGVAFLRA
HHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
AHAIEVPANLSSGMTFGFETLLQAVRTPLKVLAQNCGRSSEEVIHTILSHENPRFGYNGM
HHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCC
TDTFEDLVDAGICDPLIVTTSSLKCAVSVSCLLLTSSFFISSRTKT
CHHHHHHHHCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362