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The map label for this gene is folP

Identifier: 15836291

GI number: 15836291

Start: 854431

End: 855783

Strand: Direct

Name: folP

Synonym: CPj0758

Alternate gene names: 15836291

Gene position: 854431-855783 (Clockwise)

Preceding gene: 15836290

Following gene: 15836292

Centisome position: 69.66

GC content: 41.91

Gene sequence:

>1353_bases
ATGTCCGAGCCCCGTTTTGTCTGCTTAAGTTTAGGATCAAATTTAGGAAATCGTTTTAAAAATCTACAGATTGCTCGTAC
TTTATTAGGCGAACAAGCTGTTTTAGGTCTACGTAGTTCGGTAATTCTAGAAACAGAAGCCTTGTTATTACCGGGATCTC
CTCCAGAGTGGGACCTTCCTTATTTTAATTCGGTACTTGTAGGGGAAACCACCCTATCTTTGCGAGAACTACTGGTTACT
ATCAAACAGATAGAGAAGGTGGTAGGTAGAGCAGAGGAGTCGCCCCCATGGTCTCCTCGAACCATAGATGTAGATATTTT
GCTTTATGGTGACGAGTCTTTTTGTTGTGATCACACCGAGATAACGATTCCTTTGTCCAATTTGTTATCACGTCCTTTTT
TGATTGCTTTAATAGCATCTCTTTGTCCTTATCGTCGATTTTGCACTCAAGGTTCTCCTTATCACAACTTTACATTTGGA
GAGTTGGCGCATCACCTTCCCTCACCTCCAGGGATGATTCGTAGGAGTTTATCTCCAGATACGATGTTGATGGGGGTGGT
AAATGTGACTAACGACTCTATGTCTGATGGGGGCATGTTTTTAGATCCAGAAAAAGCAGTGGCTCAAGCTGAGAAGTTAT
TTACAGAGGGCGCTGCAGTTATAGATTTTGGAGCTCAAGCAACAAACCCTAAAGTAAAGCAGTTTTTATCTGTAGATCAA
GAATGGGAGCGTCTGGAGCCTGTTTTAAGGTTGTTAAAAGAGACTTGGTCCAATAGAAAACAATATCCAATCATCTCTTT
AGATACGTTTTATCCTGAAATTATTCTTAGGGCTATGGATATTTATCCGATCCAGTGGATTAATGATGTCTCTGGGGGAT
CACAGTCTATGGCTGAGGTCGCTAGGGATTGTGAGCTATCCTTGGTTATGAATCACTCGTCTTCGCTTCCTGTGGATCCT
AAAAATATCTTGTCGTTTTCTGTCCCTATTGGAGAGCAACTGTTGAGCTGGGGTGAGAAGCAACTTAAGATGTTTTCTGA
TGTTGGTCTGAACGCAAATCAGGTGATTTTTGATCCCGGTATAGGTTTTGGGAAGGGGGCTGCGCAATCTTTGGCTACTT
TGTATGAGATTGCGAAATTTAAGCGTTTGGGATGCCCTATCCTTATTGGACATTCTCGAAAATCGTTCTTATCTTTATTT
GGTAATCATGATCCCAAGGATCGTGATTGGGAAACCGTAGGTCTATCTATACTCTTACAACAACAAGGTGTGGACTACTT
GCGAGTGCATAATGTTGCTGCTCATCAAAAAGCTTTATCAGTAGCTGCTTGTGAAGCCTGTGCACCCATCTAA

Upstream 100 bases:

>100_bases
TTGGAGATAAAGCCTCCAAGATAGATCTAGAGGTAGAAAAAGAACGGCCACCTGTTCCCAACCTATTAAATCCTATAAAA
TTTACAATTAGTAAAGAGCT

Downstream 100 bases:

>100_bases
TTTTGAAAATCCTCTAGGTGTCGAGATGTGTAAAAATAGAGGGGTCCGCGGGATCGTGGCTTGTGATCCTAGAGGGGTGA
TAGGTTTAGAAGGAAAGCTT

Product: dihydropteroate synthase

Products: NA

Alternate protein names: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase; 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK; Dihydropteroate synthase; DHPS; Dihydropteroate pyrophosphorylase

Number of amino acids: Translated: 450; Mature: 449

Protein sequence:

>450_residues
MSEPRFVCLSLGSNLGNRFKNLQIARTLLGEQAVLGLRSSVILETEALLLPGSPPEWDLPYFNSVLVGETTLSLRELLVT
IKQIEKVVGRAEESPPWSPRTIDVDILLYGDESFCCDHTEITIPLSNLLSRPFLIALIASLCPYRRFCTQGSPYHNFTFG
ELAHHLPSPPGMIRRSLSPDTMLMGVVNVTNDSMSDGGMFLDPEKAVAQAEKLFTEGAAVIDFGAQATNPKVKQFLSVDQ
EWERLEPVLRLLKETWSNRKQYPIISLDTFYPEIILRAMDIYPIQWINDVSGGSQSMAEVARDCELSLVMNHSSSLPVDP
KNILSFSVPIGEQLLSWGEKQLKMFSDVGLNANQVIFDPGIGFGKGAAQSLATLYEIAKFKRLGCPILIGHSRKSFLSLF
GNHDPKDRDWETVGLSILLQQQGVDYLRVHNVAAHQKALSVAACEACAPI

Sequences:

>Translated_450_residues
MSEPRFVCLSLGSNLGNRFKNLQIARTLLGEQAVLGLRSSVILETEALLLPGSPPEWDLPYFNSVLVGETTLSLRELLVT
IKQIEKVVGRAEESPPWSPRTIDVDILLYGDESFCCDHTEITIPLSNLLSRPFLIALIASLCPYRRFCTQGSPYHNFTFG
ELAHHLPSPPGMIRRSLSPDTMLMGVVNVTNDSMSDGGMFLDPEKAVAQAEKLFTEGAAVIDFGAQATNPKVKQFLSVDQ
EWERLEPVLRLLKETWSNRKQYPIISLDTFYPEIILRAMDIYPIQWINDVSGGSQSMAEVARDCELSLVMNHSSSLPVDP
KNILSFSVPIGEQLLSWGEKQLKMFSDVGLNANQVIFDPGIGFGKGAAQSLATLYEIAKFKRLGCPILIGHSRKSFLSLF
GNHDPKDRDWETVGLSILLQQQGVDYLRVHNVAAHQKALSVAACEACAPI
>Mature_449_residues
SEPRFVCLSLGSNLGNRFKNLQIARTLLGEQAVLGLRSSVILETEALLLPGSPPEWDLPYFNSVLVGETTLSLRELLVTI
KQIEKVVGRAEESPPWSPRTIDVDILLYGDESFCCDHTEITIPLSNLLSRPFLIALIASLCPYRRFCTQGSPYHNFTFGE
LAHHLPSPPGMIRRSLSPDTMLMGVVNVTNDSMSDGGMFLDPEKAVAQAEKLFTEGAAVIDFGAQATNPKVKQFLSVDQE
WERLEPVLRLLKETWSNRKQYPIISLDTFYPEIILRAMDIYPIQWINDVSGGSQSMAEVARDCELSLVMNHSSSLPVDPK
NILSFSVPIGEQLLSWGEKQLKMFSDVGLNANQVIFDPGIGFGKGAAQSLATLYEIAKFKRLGCPILIGHSRKSFLSLFG
NHDPKDRDWETVGLSILLQQQGVDYLRVHNVAAHQKALSVAACEACAPI

Specific function: Dhps Catalyzes The Formation Of The Immediate Precursor Of Folic Acid. It Is Implicated In Resistance To Sulfonamide. [C]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain

Homologues:

Organism=Escherichia coli, GI87082224, Length=263, Percent_Identity=29.277566539924, Blast_Score=112, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FOLKP_CHLPN (Q9Z7E8)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   D86585
- PIR:   G72039
- RefSeq:   NP_224953.1
- RefSeq:   NP_300815.1
- RefSeq:   NP_445651.1
- RefSeq:   NP_877058.1
- ProteinModelPortal:   Q9Z7E8
- SMR:   Q9Z7E8
- PHCI-2DPAGE:   Q9Z7E8
- GeneID:   1467465
- GeneID:   894959
- GeneID:   919529
- GeneID:   963111
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP1114
- KEGG:   cpn:CPn0758
- KEGG:   cpt:CpB0786
- TIGR:   CP_1114
- HOGENOM:   HBG665963
- OMA:   QATNPKV
- PhylomeDB:   Q9Z7E8
- ProtClustDB:   CLSK871487
- BioCyc:   CPNE115711:CP_1114-MONOMER
- BioCyc:   CPNE115713:CPN0758-MONOMER
- BioCyc:   CPNE138677:CPJ0758-MONOMER
- BioCyc:   CPNE182082:CPB0786-MONOMER
- BRENDA:   2.5.1.15
- BRENDA:   2.7.6.3
- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000550
- InterPro:   IPR000489
- Gene3D:   G3DSA:3.20.20.20
- Gene3D:   G3DSA:3.30.70.560
- PANTHER:   PTHR20941:SF1
- TIGRFAMs:   TIGR01496
- TIGRFAMs:   TIGR01498

Pfam domain/function: PF01288 HPPK; PF00809 Pterin_bind; SSF51717 DHP_synth_like; SSF55083 Hppk

EC number: =2.7.6.3; =2.5.1.15

Molecular weight: Translated: 49816; Mature: 49685

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: PS00792 DHPS_1; PS00793 DHPS_2; PS00794 HPPK; PS50972 PTERIN_BINDING

Important sites: BINDING 196-196 BINDING 268-268 BINDING 288-288 BINDING 358-358 BINDING 394-394 BINDING 428-428 BINDING 430-430

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEPRFVCLSLGSNLGNRFKNLQIARTLLGEQAVLGLRSSVILETEALLLPGSPPEWDLP
CCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECEEEECCCCCCCCCC
YFNSVLVGETTLSLRELLVTIKQIEKVVGRAEESPPWSPRTIDVDILLYGDESFCCDHTE
CCCCEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCEECCCCE
ITIPLSNLLSRPFLIALIASLCPYRRFCTQGSPYHNFTFGELAHHLPSPPGMIRRSLSPD
EEEEHHHHHCCHHHHHHHHHHCHHHHHHCCCCCCCCCCHHHHHHHCCCCHHHHHHCCCCC
TMLMGVVNVTNDSMSDGGMFLDPEKAVAQAEKLFTEGAAVIDFGAQATNPKVKQFLSVDQ
EEEEEEEEECCCCCCCCCEEECHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHCCCH
EWERLEPVLRLLKETWSNRKQYPIISLDTFYPEIILRAMDIYPIQWINDVSGGSQSMAEV
HHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHCCCCHHCCCCCCCHHHHHHH
ARDCELSLVMNHSSSLPVDPKNILSFSVPIGEQLLSWGEKQLKMFSDVGLNANQVIFDPG
HHCCEEEEEEECCCCCCCCHHHHEEEECCHHHHHHHCCHHHHHHHHHCCCCCCEEEECCC
IGFGKGAAQSLATLYEIAKFKRLGCPILIGHSRKSFLSLFGNHDPKDRDWETVGLSILLQ
CCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHCCCCCCCCCHHHHHHEEEEH
QQGVDYLRVHNVAAHQKALSVAACEACAPI
HCCCCEEHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SEPRFVCLSLGSNLGNRFKNLQIARTLLGEQAVLGLRSSVILETEALLLPGSPPEWDLP
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECEEEECCCCCCCCCC
YFNSVLVGETTLSLRELLVTIKQIEKVVGRAEESPPWSPRTIDVDILLYGDESFCCDHTE
CCCCEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEEECCCCEECCCCE
ITIPLSNLLSRPFLIALIASLCPYRRFCTQGSPYHNFTFGELAHHLPSPPGMIRRSLSPD
EEEEHHHHHCCHHHHHHHHHHCHHHHHHCCCCCCCCCCHHHHHHHCCCCHHHHHHCCCCC
TMLMGVVNVTNDSMSDGGMFLDPEKAVAQAEKLFTEGAAVIDFGAQATNPKVKQFLSVDQ
EEEEEEEEECCCCCCCCCEEECHHHHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHCCCH
EWERLEPVLRLLKETWSNRKQYPIISLDTFYPEIILRAMDIYPIQWINDVSGGSQSMAEV
HHHHHHHHHHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHCCCCHHCCCCCCCHHHHHHH
ARDCELSLVMNHSSSLPVDPKNILSFSVPIGEQLLSWGEKQLKMFSDVGLNANQVIFDPG
HHCCEEEEEEECCCCCCCCHHHHEEEECCHHHHHHHCCHHHHHHHHHCCCCCCEEEECCC
IGFGKGAAQSLATLYEIAKFKRLGCPILIGHSRKSFLSLFGNHDPKDRDWETVGLSILLQ
CCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHCCCCCCCCCHHHHHHEEEEH
QQGVDYLRVHNVAAHQKALSVAACEACAPI
HCCCCEEHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362