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The map label for this gene is pyrH

Identifier: 15836230

GI number: 15836230

Start: 782779

End: 783525

Strand: Direct

Name: pyrH

Synonym: CPj0698

Alternate gene names: 15836230

Gene position: 782779-783525 (Clockwise)

Preceding gene: 15836229

Following gene: 15836231

Centisome position: 63.82

GC content: 39.89

Gene sequence:

>747_bases
ATGGCTAAGCAAACTAGACGAGTCTTGTTTAAAATTTCTGGGGAAGCATTATCTAAAGATTCTAGCAATAGAATTGATGA
AATGCGTTTATCCCGACTGGTATCAGAGCTAAGAGCAGTTCGTAATAATGATATAGAAATCGCCCTTGTAATCGGCGGTG
GCAATATTTTAAGAGGACTCGCTGAGCAAAAGGAACTTCAAATTAATCGTGTATCGGCAGATCAAATGGGAATGCTGGCT
ACCTTGATCAATGGTATGGCAGTAGCAGATGCTTTAAAAGCTGAGGATATCCCTTGTCTTTTGACATCTACCCTATCGTG
CCCACAGTTAGCTGATCTTTATACTCCACAAAAATCAATAGAAGCTTTAGACCAGGGAAAGATTCTTATCTGCACCACTG
GAGCTGGTTCTCCTTATCTGACTACAGATACTGGAGCTGCTTTACGAGCTTGTGAGCTTAATGTTGACGTTTTAATCAAA
GCGACTATGCATGTAGACGGTGTCTATGATAAAGATCCTAGGCTCTTTCCAGATGCTGTAAAATATGATTTTGTTTCCTA
TAAGGATTTTTTGAGCAATCAACTAGGGGTAATGGATGCATCAGCAATTTCCCTATGTATGGATTCTCATATTCCAATTC
GTGTCTTTAGCTTTTTACAGCACTCTCTAGAAAAGGCTCTATTTGACCCTACGATTGGAACATTAGTTAGCGAGGATGTA
AACCATGTCTGTTCTCCAAGACACTGA

Upstream 100 bases:

>100_bases
CTTTCTATTCAAAGTTTAATAGATGATTTCTCCAAAACCTCTGGAAGCTCTGTTGCAATAGAACAGTTCATTTTATGGAA
AATAGGAGCCTAATAAAAAC

Downstream 100 bases:

>100_bases
GAAAAAAATGGCTGCGGCTTTAGATTTTTTTCATAAAGAAGTAAAGTCCTTTAGAACAGGAAAAGCTCATCCAGCATTAG
TAGAAACTGTTGTAGTCGAT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MAKQTRRVLFKISGEALSKDSSNRIDEMRLSRLVSELRAVRNNDIEIALVIGGGNILRGLAEQKELQINRVSADQMGMLA
TLINGMAVADALKAEDIPCLLTSTLSCPQLADLYTPQKSIEALDQGKILICTTGAGSPYLTTDTGAALRACELNVDVLIK
ATMHVDGVYDKDPRLFPDAVKYDFVSYKDFLSNQLGVMDASAISLCMDSHIPIRVFSFLQHSLEKALFDPTIGTLVSEDV
NHVCSPRH

Sequences:

>Translated_248_residues
MAKQTRRVLFKISGEALSKDSSNRIDEMRLSRLVSELRAVRNNDIEIALVIGGGNILRGLAEQKELQINRVSADQMGMLA
TLINGMAVADALKAEDIPCLLTSTLSCPQLADLYTPQKSIEALDQGKILICTTGAGSPYLTTDTGAALRACELNVDVLIK
ATMHVDGVYDKDPRLFPDAVKYDFVSYKDFLSNQLGVMDASAISLCMDSHIPIRVFSFLQHSLEKALFDPTIGTLVSEDV
NHVCSPRH
>Mature_247_residues
AKQTRRVLFKISGEALSKDSSNRIDEMRLSRLVSELRAVRNNDIEIALVIGGGNILRGLAEQKELQINRVSADQMGMLAT
LINGMAVADALKAEDIPCLLTSTLSCPQLADLYTPQKSIEALDQGKILICTTGAGSPYLTTDTGAALRACELNVDVLIKA
TMHVDGVYDKDPRLFPDAVKYDFVSYKDFLSNQLGVMDASAISLCMDSHIPIRVFSFLQHSLEKALFDPTIGTLVSEDVN
HVCSPRH

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=234, Percent_Identity=38.034188034188, Blast_Score=162, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_CHLPN (Q9Z7K7)

Other databases:

- EMBL:   AE001363
- EMBL:   AE002161
- EMBL:   BA000008
- EMBL:   AE009440
- PIR:   B72045
- PIR:   G86577
- RefSeq:   NP_224894.1
- RefSeq:   NP_300754.1
- RefSeq:   NP_444600.1
- RefSeq:   NP_876997.1
- ProteinModelPortal:   Q9Z7K7
- SMR:   Q9Z7K7
- PHCI-2DPAGE:   Q9Z7K7
- GeneID:   1467404
- GeneID:   895268
- GeneID:   919465
- GeneID:   963670
- GenomeReviews:   AE001363_GR
- GenomeReviews:   AE002161_GR
- GenomeReviews:   AE009440_GR
- GenomeReviews:   BA000008_GR
- KEGG:   cpa:CP0048
- KEGG:   cpn:CPn0698
- KEGG:   cpt:CpB0725
- TIGR:   CP_0048
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- ProtClustDB:   PRK00358
- BioCyc:   CPNE115711:CP_0048-MONOMER
- BioCyc:   CPNE115713:CPN0698-MONOMER
- BioCyc:   CPNE138677:CPJ0698-MONOMER
- BioCyc:   CPNE182082:CPB0725-MONOMER
- BRENDA:   2.7.4.22
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 27099; Mature: 26967

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: BINDING 53-53 BINDING 54-54 BINDING 58-58 BINDING 74-74 BINDING 162-162 BINDING 169-169 BINDING 172-172

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKQTRRVLFKISGEALSKDSSNRIDEMRLSRLVSELRAVRNNDIEIALVIGGGNILRGL
CCCHHHEEEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHH
AEQKELQINRVSADQMGMLATLINGMAVADALKAEDIPCLLTSTLSCPQLADLYTPQKSI
HHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHCCCHHHH
EALDQGKILICTTGAGSPYLTTDTGAALRACELNVDVLIKATMHVDGVYDKDPRLFPDAV
HHHCCCCEEEEECCCCCCEEECCCCCEEEEEECCCEEEEEEEEEECCCCCCCCCCCCHHH
KYDFVSYKDFLSNQLGVMDASAISLCMDSHIPIRVFSFLQHSLEKALFDPTIGTLVSEDV
HHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
NHVCSPRH
HHHCCCCC
>Mature Secondary Structure 
AKQTRRVLFKISGEALSKDSSNRIDEMRLSRLVSELRAVRNNDIEIALVIGGGNILRGL
CCHHHEEEEEECCHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHHHH
AEQKELQINRVSADQMGMLATLINGMAVADALKAEDIPCLLTSTLSCPQLADLYTPQKSI
HHHHHHHHEECCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHCCCHHHH
EALDQGKILICTTGAGSPYLTTDTGAALRACELNVDVLIKATMHVDGVYDKDPRLFPDAV
HHHCCCCEEEEECCCCCCEEECCCCCEEEEEECCCEEEEEEEEEECCCCCCCCCCCCHHH
KYDFVSYKDFLSNQLGVMDASAISLCMDSHIPIRVFSFLQHSLEKALFDPTIGTLVSEDV
HHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
NHVCSPRH
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362